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References from Neuroprotective eremophilane sesquiterpenoids from Ligularia species attenuate glutamate-induced oxidative stress via MAPK signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
OMIM. org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders
10.1093/nar/gku1205 · 2015 · External reference
Theoretical study of radical inactivation, LOX inhibition, and iron chelation: the role of ferulic acid in skin protection against UVA induced oxidative stress
10.3390/antiox10081303 · 2021 · External reference
SpecDis: quantifying the comparison of calculated and experimental electronic circular dichroism spectra
10.1002/chir.22138 · 2013 · External reference
Chemical constituents from the Korean endemic plant pseudolysimachion pusanensis inhibit diffuse-type gastric cancer cells
10.1016/j.biopha.2025.118005 · 2025 · External reference
Ligularia fischeri extract protects against oxidative-stress-induced neurotoxicity in mice and pc12 cells
10.1089/jmf.2013.3014 · 2014 · External reference
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
10.1093/nar/gkz382 · 2019 · External reference
Therapeutic effects of Ligularia stenocephala against inflammatory bowel disease by regulating antioxidant and inflammatory mediators
10.1080/09540105.2017.1332008 · 2017 · External reference
New eremophilane sesquiterpenes from the roots of Ligularia fischeri
10.1002/hlca.200800286 · 2009 · External reference
DAVID: database for annotation, visualization, and integrated discovery
10.1186/gb-2003-4-9-r60 · 2003 · External reference
Eremophilane and cadinane sesquiterpenoids from the fruits of Alpinia oxyphylla and their anti-inflammatory activities
10.1039/d3fo01221b · 2023 · External reference
SIRIUS 4: a rapid tool for turning tandem mass spectra into metabolite structure information
10.1038/s41592-019-0344-8 · 2019 · External reference
Systematic classification of unknown metabolites using high-resolution fragmentation mass spectra
10.1038/s41587-020-0740-8 · 2021 · External reference
Eremophilane-type sesquiterpene derivatives from the roots of Ligularia lapathifolia
10.1021/np060304k · 2007 · External reference
Calcineurin-dependent homeostatic response of C. elegans muscle cells upon prolonged activation of acetylcholine receptors
10.3390/cells12172201 · 2023 · External reference
Unresolved reference
2009 · External reference
ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support
10.1093/nar/gkae236 · 2024 · External reference
Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells
10.1016/j.ejphar.2009.06.059 · 2009 · External reference
admetSAR3. 0: a comprehensive platform for exploration, prediction and optimization of chemical ADMET properties
10.1093/nar/gkae298 · 2024 · External reference
Glutamate-induced oxidative stress, but not cell death, is largely dependent upon extracellular calcium in mouse neuronal HT22 cells
10.1016/j.neulet.2005.09.056 · 2006 · External reference
Identification of compounds using HPLC-QTOF-MS online antioxidant activity mapping from aerial parts of Ligularia stenocephala
10.1186/s13765-023-00814-1 · 2023 · External reference
Unresolved reference
2014 · External reference
Screening and identification of an anti-inflammatory and anti-adipogenic constituent from Ligularia taquetii Nakai
2020 · External reference
Neuroprotective effect of Decalepis hamiltonii aqueous root extract and purified 2-hydroxy-4-methoxy benzaldehyde on 6-OHDA induced neurotoxicity in Caenorhabditis elegans
10.1016/j.biopha.2018.06.002 · 2018 · External reference
Analysis of phenolic compounds in chwinamul by HPLC/UV
10.1007/s13580-013-0155-2 · 2013 · External reference
3, 3′-Diindolylmethane improves intestinal permeability dysfunction in cultured human intestinal cells and the model animal Caenorhabditis elegans
10.1021/acs.jafc.9b03039 · 2019 · External reference
Protective effect of GIP against monosodium glutamate-induced ferroptosis in mouse hippocampal HT-22 cells through the MAPK signaling pathway
10.3390/antiox11020189 · 2022 · External reference
Phenolic constituents isolated from Senna tora sprouts and their neuroprotective effects against glutamate-induced oxidative stress in HT22 and R28 cells
10.1016/j.bioorg.2021.105112 · 2021 · External reference
Analgesic and anti-inflammatory effects of Ligularia fischeri leaves in experimental animals
10.1016/j.jep.2008.07.038 · 2008 · External reference
Toxicological evaluation of the topoisomerase inhibitor, etoposide, in the model animal Caenorhabditis elegans and 3T3‐L1 normal murine cells
10.1002/tox.22406 · 2017 · External reference
New eremophilane-type sesquiterpenes from Ligularia lapathifolia
10.1055/s-2004-815541 · 2004 · External reference
The chemistry and pharmacology of Ligularia przewalskii: a review
10.1016/j.jep.2018.03.002 · 2018 · External reference
Role of ROS and nutritional antioxidants in human diseases
10.3389/fphys.2018.00477 · 2018 · External reference
Mitochondrial dysfunction and oxidative stress in Alzheimer's disease
10.3389/fnagi.2021.617588 · 2021 · External reference
Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans
10.1073/pnas.042497999 · 2002 · External reference
Feature-based molecular networking in the GNPS analysis environment
10.1038/s41592-020-0933-6 · 2020 · External reference
Anti-inflammatory and antioxidant properties of leaf extracts of eleven South African medicinal plants used traditionally to treat inflammation
10.1016/j.jep.2018.12.030 · 2019 · External reference
Machine learning-based chemical binding similarity using evolutionary relationships of target genes
10.1093/nar/gkz743 · 2019 · External reference
Oxidative stress in Alzheimer' s and Parkinson' s diseases: insights from the yeast Saccharomyces cerevisiae
2012 · External reference
Activation of apoptosis signalling pathways by reactive oxygen species
10.1016/j.bbamcr.2016.09.012 · 2016 · External reference
Twelve new compounds from Ligularia melanothyrsa; isolation of melanothyrsins A–E, normelanothyrsin A, and other eremophilane sesquiterpenoids
10.1016/j.tet.2014.02.080 · 2014 · External reference
NMR and CD spectral studies of conformational isomers of isoligularone and fukinone, naturally occurring cis-decalin derivatives
10.1246/cl.1977.1191 · 1977 · External reference
Integrative analysis of multimodal mass spectrometry data in MZmine 3
10.1038/s41587-023-01690-2 · 2023 · External reference
Novel procedure for modeling ligand/receptor induced fit effects
10.1021/jm050540c · 2006 · External reference
Assigning the stereochemistry of pairs of diastereoisomers using GIAO NMR shift calculation
10.1021/jo900408d · 2009 · External reference
Astragalus membranaceus sprouts and their unique constituents regulate reactive oxygen species production, inflammation-related senescence-associated secretory phenotype components, and extracellular matrix in fibroblasts
10.1016/j.foodres.2026.118390 · 2026 · External reference
Protective effect of casuarinin against glutamate-induced apoptosis in HT22 cells through inhibition of oxidative stress-mediated MAPK phosphorylation
10.1016/j.bmcl.2017.10.075 · 2017 · External reference
The GeneCards suite: from gene data mining to disease genome sequence analyses
10.1002/cpbi.5 · 2016 · External reference
Eremophilenolides from Petasites japonicus
10.1016/s0031-9422(00)81060-2 · 1985 · External reference
ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries
10.1093/bioinformatics/btae416 · 2024 · External reference
The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
Diversity of Ligularia kanaitzensis in sesquiterpenoid composition and neutral DNA sequences
10.1016/j.tet.2008.02.036 · 2008 · External reference
Schisandrin C alleviates depressive-like behaviors by modulating the AKT/CREB/BDNF pathway, the serotonin pathway of tryptophan metabolism, and the gut microbiota composition
10.1016/j.phymed.2025.157581 · 2026 · External reference
Antioxidant and antidiabetic activities of flavonoid derivatives from the outer skins of Allium cepa L
10.1021/acs.jafc.0c02122 · 2020 · External reference
Isolation, characterization, and neuroprotective activities of sesquiterpenes from Petasites japonicus
10.1016/j.foodchem.2013.04.116 · 2013 · External reference
Eremophilenolides from Ligularia fischeri
10.1055/s-0029-1243131 · 2000 · External reference
Efficient implementation of the gauge-independent atomic orbital method for NMR chemical shift calculations
10.1021/ja00179a005 · 1990 · External reference
Eremophilane sesquiterpenes from the genus Ligularia
10.1002/cbdv.201500169 · 2016 · External reference
Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update
2025 · External reference
Eremophilane sesquiterpenoids from Ligularia fischeri
10.1002/hlca.201000010 · 2010 · External reference
Eremophilane sesquiterpenes from agarwood of Aquilaria agallocha with neuroprotective effect
10.1016/j.phytochem.2025.114527 · 2025 · External reference
Phytochemicals and biological activities of Ligularia species
10.1007/s13659-011-0003-y · 2011 · External reference
TargetNet: a web service for predicting potential drug–target interaction profiling via multi-target SAR models
10.1007/s10822-016-9915-2 · 2016 · External reference
Structures of new eremophilane derivatives from the rhizomes of Petasites japonicus MAXIM
10.1248/cpb.43.1738 · 1995 · External reference
Chemical constituents of the roots of Ligularia lapathifolia
10.1007/s10600-015-1289-5 · 2015 · External reference
Eight new eremophilane derivatives from the roots of Ligularia przewalskii
10.1021/np50123a004 · 1995 · External reference
