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References from Isodon rosthornii accelerates wound healing via dual antimicrobial activity and NF-κB/MAPK suppression. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Unresolved reference
External reference
Best practice in research: consensus statement on ethnopharmacological field studies
2020 · External reference
Why traditional herbal medicine promotes wound healing: Research from immune response, wound microbiome to controlled delivery
10.1016/j.addr.2023.114764 · 2023 · External reference
Bioactive ent-Kaurane diterpenoids from Isodon rosthornii
10.1021/np400190n · 2013 · External reference
Diterpenoid constituents from Rabdosia rosthornii
10.1016/0031-9422(89)80316-4 · 1989 · External reference
Oridonin: a review of its pharmacology, pharmacokinetics and toxicity
2021 · External reference
Therapeutic potential of oridonin and its analogs: from anticancer and anti-inflammation to neuroprotection
10.3390/molecules23020474 · 2018 · External reference
Wound repair and regeneration: mechanisms, signaling, and translation
10.1126/scitranslmed.3009337 · 2014 · External reference
Biofilm therapy for chronic wounds
10.1111/iwj.14667 · 2024 · External reference
Staphylococcus aureus biofilm: Formulation, regulatory, and emerging natural products-derived therapeutics
10.1016/j.bioflm.2023.100175 · 2024 · External reference
Transition from inflammation to proliferation: a critical step during wound healing
10.1007/s00018-016-2268-0 · 2016 · External reference
Towards advances in medicinal plant antimicrobial activity: a review study on challenges and future perspectives
10.3390/microorganisms9102041 · 2021 · External reference
Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism
10.3892/mmr.2017.6488 · 2017 · External reference
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
10.1186/1758-2946-6-13 · 2014 · External reference
SwissTargetPrediction: a web server for target prediction of bioactive small molecules
10.1093/nar/gku293 · 2014 · External reference
PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database
10.1093/nar/gkx374 · 2017 · External reference
Unresolved reference
External reference
Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices
10.1128/jcm.22.6.996-1006.1985 · 1985 · External reference
Research techniques made simple: animal models of wound healing
10.1016/j.jid.2018.08.005 · 2018 · External reference
Inflammation and wound healing: the role of the macrophage
10.1017/s1462399411001943 · 2011 · External reference
Macrophages in tissue repair, regeneration, and fibrosis
10.1016/j.immuni.2016.02.015 · 2016 · External reference
Three new cytotoxic steroidal alkaloids from Sarcococca hookeriana
10.3390/molecules23051181 · 2018 · External reference
Three Flavone Glycosides from Citrus sudachi
10.1016/s0031-9422(00)84522-7 · 1986 · External reference
Ent-kaurane-based diterpenoids, dimers, and meroditerpenoids from Isodon xerophilus
10.1021/acs.jnatprod.0c00983 · 2020 · External reference
Amethystoidina, a new ent-kaurane diterpenoid from Isodon amethystoides
1991 · External reference
Diterpenoids from Isodon species and their biological activities
10.1039/b604174d · 2006 · External reference
The GeneCards suite: from gene data mining to disease genome sequence analyses
2016 · External reference
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
10.1093/nar/gky1131 · 2019 · External reference
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
10.1038/nprot.2008.211 · 2009 · External reference
10.1089/omi.2011.0118
10.1089/omi.2011.0118 · External reference
AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants
10.1093/nar/gkw943 · 2017 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
The ARRIVE guidelines 2.0: updated guidelines for reporting animal research
2020 · External reference
Biofilm and wounds: an identification algorithm and potential treatment options
10.1089/wound.2014.0574 · 2015 · External reference
Staphylococcus aureus biofilms: recent developments in biofilm dispersal
10.3389/fcimb.2014.00178 · 2014 · External reference
Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management
10.1128/cmr.00134-14 · 2015 · External reference
Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways
10.1016/j.intimp.2017.11.040 · 2018 · External reference
Bioactive compounds from A. dahurica attenuate LPS-induced inflammation via dual inhibition of MAPK and NF-κB signaling pathways
10.1016/j.jep.2026.121361 · 2026 · External reference
The wound healing effect of botanicals and pure natural substances used in in vivo models
10.1007/s10787-023-01157-5 · 2023 · External reference
Hit-to-lead optimization of the natural product oridonin as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activity
2024 · External reference
The bioavailability enhancement and insight into the action mechanism of poorly soluble natural compounds from crosstalk preparations: oridonin as an example
10.1016/j.phymed.2023.155179 · 2024 · External reference
Angelica dahurica regulated the polarization of macrophages and accelerated wound healing in diabetes: a network pharmacology study and in vivo experimental validation
10.3389/fphar.2021.678713 · 2021 · External reference
Effect of silver on burn wound infection control and healing: review of the literature
10.1016/j.burns.2006.06.010 · 2007 · External reference
Silver in Wound Care - Friend or Foe?: A Comprehensive Review
2019 · External reference
Approach to chronic wound infections
10.1111/bjd.13677 · 2015 · External reference
Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds
10.1111/wrr.12590 · 2017 · External reference
Milieu matters: an in vitro wound milieu to recapitulate key features of, and probe new insights into, mixed-species bacterial biofilms
10.1016/j.bioflm.2021.100047 · 2021 · External reference
Accelerated healing of full-thickness skin wounds in a wet environment
10.1097/00006534-200009010-00012 · 2000 · External reference
Randomized controlled trial and cost-effectiveness analysis of silver-donating antimicrobial dressings for venous leg ulcers (VULCAN trial)
10.1002/bjs.6786 · 2009 · External reference
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
10.1038/s41577-019-0165-0 · 2019 · External reference
Microneedles incorporating oridonin micelles and Cu(II)-polydopamine provide effective inflammatory regulation and antibacterial effects for the healing of infected diabetic wounds
10.1016/j.colsurfb.2025.114814 · 2025 · External reference
Promoting oral mucosal wound healing with a hydrogel adhesive based on a phototriggered s-nitroxylation coupling reaction
2021 · External reference
Transcriptional regulation of macrophage polarization: enabling diversity with identity
10.1038/nri3088 · 2011 · External reference
Network pharmacology databases for traditional Chinese medicine: review and assessment
10.3389/fphar.2019.00123 · 2019 · External reference
Low levels of β-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus
10.1128/mbio.00198-12 · 2012 · External reference
Ciprofloxacin enhances biofilm formation of Staphylococcus aureus via an agrC-dependent mechanism
10.3389/fmicb.2023.1328947 · 2023 · External reference
Antifungal compounds of Chinese prickly ash against drug-resistant Candida albicans
10.1016/j.fochx.2022.100400 · 2022 · External reference
Identifying small molecules via high resolution mass spectrometry: communicating confidence
10.1021/es5002105 · 2014 · External reference
Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species
2010 · External reference
Percutaneous absorption. On the relevance of in vitro data
10.1111/1523-1747.ep12533356 · 1975 · External reference
Synergy, antagonism, and what the chequerboard puts between them
10.1093/jac/dkg301 · 2003 · External reference
The antibacterial mechanism of oridonin against methicillin-resistant Staphylococcus aureus (MRSA)
10.1080/13880209.2019.1674342 · 2019 · External reference
