Research graph
References from Protocatechualdehyde ameliorates temporal lobe epilepsy via synergistic regulation of HMGB1-TLR4-NF-κB pathway and metabolic reprogramming. Local targets link to admitted publications; unresolved targets remain external evidence.
OMIM.org: leveraging knowledge across phenotype-gene relationships
10.1093/nar/gky1151 · 2019 · External reference
Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study
10.1016/j.ejmech.2019.111650 · 2019 · External reference
UniProt: the Universal Protein Knowledgebase in 2025
2024 · External reference
Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC-MS/MS
10.1038/s41467-019-13973-x · 2020 · External reference
Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank
10.1093/nar/gkae1091 · 2024 · External reference
Astrocytes as a target for therapeutic strategies in epilepsy: current insights
10.3389/fnmol.2023.1183775 · 2023 · External reference
Natural product-derived therapies for treating drug-resistant epilepsies: from ethnopharmacology to evidence-based medicine
10.1016/j.jep.2023.116740 · 2023 · External reference
Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice
10.1016/j.celrep.2024.114144 · 2024 · External reference
Pharmacological effects and mechanisms of Gastrodia elata and its active ingredients in the treatment of cardiovascular diseases
10.53388/tmr20230425001 · 2023 · External reference
Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation
10.1038/s41401-023-01087-6 · 2023 · External reference
Swiss Target Prediction: updated data and new features for efficient prediction of protein targets of small molecules
10.1093/nar/gkz382 · 2019 · External reference
Comparative Toxicogenomics Database (CTD): update 2023
10.1093/nar/gkac833 · 2023 · External reference
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
10.1038/s41592-019-0638-x · 2020 · External reference
HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine
10.1093/nar/gkaa1063 · 2021 · External reference
Mitigating seizure-induced cognitive deficits in mice induced with pentylenetetrazol by roflumilast through targeting the NLRP3 inflammasome/BDNF/SIRT3 pathway and regulating ferroptosis
2025 · External reference
Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy
10.1016/j.celrep.2024.115131 · 2025 · External reference
Motor learning impairment in rats under a high sucrose diet
10.1016/j.physbeh.2021.113384 · 2021 · External reference
Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice
10.1038/s41598-017-01325-y · 2017 · External reference
Evaluation of Wnt/B-catenin signaling and its modulators in repeated dose lithium-pilocarpine rat model of status epilepticus: an acute phase study
10.1016/j.ejphar.2024.176375 · 2024 · External reference
Uncovering mitochondrial defects induced by chemicals: a case Study of low-dose medium-chain chlorinated paraffin exposure
10.1021/acs.est.4c09460 · 2025 · External reference
Mass spectrometry-based draft of the mouse proteome
10.1038/s41592-022-01526-y · 2022 · External reference
Microglia regulate neuronal activity via structural remodeling of astrocytes
10.1016/j.neuron.2025.07.024 · 2025 · External reference
Anticonvulsant activities of α-asaronol ((E)-3′-hydroxyasarone), an active constituent derived from α-asarone
10.1016/j.pharep.2017.08.004 · 2018 · External reference
Gastrodia elata Blume and Acorus tatarinowii Schott mixtures alleviate pentylenetetrazol-induced seizures in mice: association with NLRP3 inflammasome signaling changes
10.1093/jpp/rgag096 · 2026 · External reference
Chemical composition and anticonvulsant activities of herb pair of Gastrodia elata Blume-Acorus tatarinowii Schott decoction on experimentally induced seizures in mice
10.1007/s11011-023-01211-9 · 2023 · External reference
Overview article astrocytes as initiators of epilepsy
10.1007/s11064-022-03773-z · 2023 · External reference
Wogonin mitigates microglia-mediated synaptic over-pruning and cognitive impairment following epilepsy
10.1016/j.phymed.2024.156222 · 2024 · External reference
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
10.1038/nprot.2008.211 · 2009 · External reference
KEGG: kyoto encyclopedia of Genes and genomes
10.1093/nar/28.1.27 · 2000 · External reference
Potential anti-epileptic phytoconstituents: an updated review
10.1016/j.jep.2020.113565 · 2021 · External reference
DrugBank 6.0: the DrugBank Knowledgebase for 2024
10.1093/nar/gkad976 · 2024 · External reference
Acute anticonvulsant effects of dapsone on PTZ- and MES-induced seizures in mice: NLRP3 inflammasome inhibition and Nrf2/HO-1 pathway preservation
10.1007/s43440-025-00698-6 · 2025 · External reference
Neuroinflammation in epileptogenesis: from pathophysiology to therapeutic strategies
10.3389/fimmu.2023.1269241 · 2023 · External reference
11-keto-beta-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury
10.2991/978-94-6463-932-2 · 2025 · External reference
Microglia in microbiota-gut-brain axis: a hub in epilepsy
10.1007/s12035-024-04022-w · 2024 · External reference
Cynarin protects against seizures and neuronal death in a rat model of kainic acid-induced seizures
10.1039/d4fo05464d · 2025 · External reference
Gastrodia elata and epilepsy: rationale and therapeutic potential
10.1016/j.phymed.2016.09.001 · 2016 · External reference
Unlocking the therapeutic potential of protocatechualdehyde: pharmacological applications and mechanism insights
10.1007/s00210-025-04267-9 · 2025 · External reference
Interaction between neurons and microglia in healthy and disease states
2025 · External reference
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
10.1093/nar/gkab382 · 2021 · External reference
Edaravone dexborneol exerts anti-epileptic effects on rodent temporal lobe epilepsy by promoting NMDAR deactivation and inhibiting oxidative stress
10.1016/j.phymed.2025.156558 · 2025 · External reference
MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search
10.1093/nar/gkw1012 · 2017 · External reference
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
10.1186/1758-2946-6-13 · 2014 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test
10.1186/s13041-020-00721-2 · 2021 · External reference
The GeneCards suite: from gene data mining to disease genome sequence analyses
2016 · External reference
The processing methods, phytochemistry and pharmacology of Gastrodia elata Bl.: a comprehensive review
10.1016/j.jep.2023.116467 · 2023 · External reference
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
10.1093/nar/gky1131 · 2019 · External reference
The STRING database in 2025: protein networks with directionality of regulation
10.1093/nar/gkae1113 · 2024 · External reference
α-Asaronol alleviates seizures, neuroinflammation and cognitive deficits in a mice model of lithium-pilocarpine-induced seizures
10.1016/j.jep.2026.121456 · 2026 · External reference
Software news and update AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
Astrocytes in the initiation and progression of epilepsy
10.1038/s41582-022-00727-5 · 2022 · External reference
PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database
10.1093/nar/gkx374 · 2017 · External reference
Phytotherapeutic options for the treatment of epilepsy: pharmacology, targets, and mechanism of action
10.3389/fphar.2024.1403232 · 2024 · External reference
The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus
10.1002/glia.23955 · 2021 · External reference
Disrupted astrocyte-neuron signaling reshapes brain activity in epilepsy and Alzheimer's disease
10.1016/j.neuroscience.2025.02.029 · 2025 · External reference
Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission
10.1016/j.jep.2020.113751 · 2021 · External reference
Characterization of the inhibitory effect of gastrodigenin and gastrodin on M-type K+ currents in pituitary cells and hippocampal neurons
10.3390/ijms21010117 · 2020 · External reference
Protective role of L-3-n-Butylphthalide in cognitive function and dysthymic disorders in mouse with chronic epilepsy
10.3389/fphar.2018.00734 · 2018 · External reference
The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods
10.1093/nar/gkad1004 · 2024 · External reference
ETCM v2.0: an update with comprehensive resource and rich annotations for traditional Chinese medicine
10.1016/j.apsb.2023.03.012 · 2023 · External reference
The traditional uses, phytochemistry and pharmacology of Gastrodia elata Blume: a comprehensive review
10.1016/j.arabjc.2024.106086 · 2025 · External reference
Evaluation of commercial micro-flow liquid chromatography columns for mass spectrometry-based proteomics
10.1016/j.chroma.2025.465789 · 2025 · External reference
