Research graph
References from Investigating the mechanism of Xiongfu formula and its active ingredient Z-Ligustilide alleviates chronic migraine by modulating the MAPK/ERK/CREB pathway and microglia-mediated neuroinflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Migraine
10.1056/nejmra1915327 · 2020 · External reference
Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis
10.1080/19585969.2026.2636459 · 2026 · External reference
Migraine: multiple processes, complex pathophysiology
10.1523/jneurosci.0373-15.2015 · 2015 · External reference
Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine
10.1212/wnl.0b013e3182a6cb72 · 2013 · External reference
SIRT1 activation by Ligustrazine ameliorates migraine via the paracrine interaction of microglia and neurons
10.1016/j.phymed.2024.156069 · 2024 · External reference
Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-κB activation pathways
10.1007/s12272-012-0417-z · 2012 · External reference
[Chronic migraine]
10.1007/s00115-012-3625-3 · 2013 · External reference
Migraine
10.1016/s0140-6736(18)30478-1 · 2018 · External reference
Migraine
10.1038/s41572-021-00328-4 · 2022 · External reference
Role of MAP kinase in neurons
10.1007/bf02740604 · 1998 · External reference
Activation of JNK pathway in persistent pain
10.1016/j.neulet.2008.03.017 · 2008 · External reference
c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury?
10.2174/1876386300902010011 · 2009 · External reference
CGRP and its receptors
10.1111/head.13064 · 2017 · External reference
Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model
10.1186/s12974-019-1459-7 · 2019 · External reference
MAP kinase and pain
10.1016/j.brainresrev.2008.12.011 · 2009 · External reference
Lycopene regulates microglial M1/M2 polarization by inhibiting MAPK/NF-κB signaling and alleviates neuroinflammation
10.1016/j.intimp.2026.116940 · 2026 · External reference
Migraine and neuroinflammation: the inflammasome perspective
10.1186/s10194-021-01271-1 · 2021 · External reference
Mitogen-activated protein kinase signaling
10.1016/s0074-7742(04)59008-6 · 2004 · External reference
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
10.1016/j.jpain.2009.06.012 · 2009 · External reference
Real-world study of adverse events associated with triptan use in migraine treatment based on the U.S. Food and Drug Administration (FDA) adverse event reporting system (FAERS) database
10.1186/s10194-024-01913-0 · 2024 · External reference
Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model
10.1186/s10194-019-1070-4 · 2020 · External reference
The association study of chemical compositions and their pharmacological effects of Cyperi Rhizoma (Xiangfu), a potential traditional Chinese medicine for treating depression
10.1016/j.jep.2021.114962 · 2022 · External reference
Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway
10.1186/1742-2094-9-274 · 2012 · External reference
San Pian decoction can treat nitroglycerin-induced migraine in rats by inhibiting the PI3K/AKT and MAPK signaling pathways
10.1016/j.jep.2022.115470 · 2022 · External reference
Neurotrophins and migraine
10.1016/bs.vh.2016.10.003 · 2017 · External reference
Repeated inflammatory dural stimulation-induced cephalic allodynia causes alteration of gut microbial composition in rats
10.1186/s10194-022-01441-9 · 2022 · External reference
Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?
10.1007/s10194-011-0352-2 · 2011 · External reference
Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine
10.1111/j.1476-5381.2011.01633.x · 2012 · External reference
Metabotropic glutamate receptor 5 regulates synaptic plasticity in a chronic migraine rat model through the PKC/NR2B signal
10.1186/s10194-020-01206-2 · 2020 · External reference
Episodic dural stimulation in awake rats: a model for recurrent headache
10.1111/j.1526-4610.2007.00871.x · 2007 · External reference
Targeted nitric oxide synthase inhibitors for migraine
10.1007/s13311-018-0614-7 · 2018 · External reference
ERK1/2 MAP kinases: structure, function, and regulation
10.1016/j.phrs.2012.04.005 · 2012 · External reference
P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways
10.1111/j.1471-4159.2010.06809.x · 2010 · External reference
Pharmacologic management of acute attacks of migraine and prevention of migraine headache
10.7326/0003-4819-137-10-200211190-00014 · 2002 · External reference
BRAF mutation predicts sensitivity to MEK inhibition
10.1038/nature04304 · 2006 · External reference
Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid
10.1186/s10194-021-01229-3 · 2021 · External reference
Sex differences in behavior and expression of CGRP-related genes in a rodent model of chronic migraine
10.1111/j.1526-4610.2011.01882.x · 2011 · External reference
Rizatriptan overuse promotes hyperalgesia induced by dural inflammatory stimulation in rats by modulation of the serotonin system
10.1111/ejn.13296 · 2016 · External reference
Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways
10.1016/j.intimp.2011.03.014 · 2011 · External reference
Human hematopoietic stem cells enhance maturational differentiation of hiPSC-Derived cardiomyocytes on Xeno-Free MatriClone-Plastic via EGFR/MAPK/ERK signaling pathway
10.3390/ph19060964 · 2026 · External reference
Senkyunolide H inhibits activation of microglia and attenuates lipopolysaccharide-mediated neuroinflammation and oxidative stress in BV2 microglia cells via regulating ERK and NF-κB pathway
10.1002/kjm2.12477 · 2022 · External reference
SRplot: a free online platform for data visualization and graphing
10.1371/journal.pone.0294236 · 2023 · External reference
Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model
10.1186/s10194-022-01403-1 · 2022 · External reference
Association between MAPK and PI3K/Akt signaling pathway-related gene polymorphisms and migraine
2024 · External reference
Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong
10.1111/j.2042-7158.2010.01191.x · 2011 · External reference
Puerariae Lobatae Radix-Gastrodiae Rhizoma ameliorates nitroglycerin-induced chronic migraine by modulating p38 MAPK/CREB signaling pathway in the prefrontal cortex-thalamus neural circuit
10.1016/j.jep.2025.121043 · 2026 · External reference
Anti-migraine effect of the herbal combination of Chuanxiong Rhizoma and Cyperi Rhizoma and UPLC-MS/MS method for the simultaneous quantification of the active constituents in rat serum and cerebral cortex
10.3390/molecules24122230 · 2019 · External reference
Exploring the synergistic effects of chuanxiong rhizoma and Cyperi rhizoma in eliciting a rapid anti-migraine action based on pharmacodynamics and pharmacokinetics
10.1016/j.jep.2024.118608 · 2024 · External reference
Z-ligustilide: a review of its pharmacokinetics and pharmacology
10.1002/ptr.6662 · 2020 · External reference
Metabolomic profiling integrated with molecular exploring delineates the action of Ligusticum chuanxiong hort
2024 · External reference
Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat
10.1124/dmd.107.017707 · 2008 · External reference
TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway
10.1177/17448069251346373 · 2025 · External reference
Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells
10.1177/0394632015617065 · 2016 · External reference
Research progress on the role of microglia membrane proteins or receptors in neuroinflammation and degeneration
10.3389/fncel.2022.831977 · 2022 · External reference
Exploring the role of ubiquitination modifications in migraine headaches
2025 · External reference
The role of mitogen-activated protein kinase pathways in Alzheimer's disease
10.1159/000067426 · 2002 · External reference
