Research graph
References from Combined network pharmacology, transcriptomics and machine learning suggests Danggui Buxue Tang may suppress oxidative stress and inflammation through Nrf2/HO-1 and IL-17 pathways in pulmonary fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Reducing protein oxidation reverses lung fibrosis
10.1038/s41591-018-0090-y · 2018 · External reference
The anti-inflammatory effects of isoflavonoids from Radix Astragali in hepatoprotective potential against LPS/D-gal-induced acute liver injury
10.1055/a-1953-0369 · 2023 · External reference
UniProt: the universal protein knowledgebase in 2023
10.1093/nar/gkac1052 · 2023 · External reference
Current and future treatment landscape for idiopathic pulmonary fibrosis
10.1007/s40265-023-01950-0 · 2023 · External reference
Comprehensive gene expression profiling identifies distinct and overlapping transcriptional profiles in non-specific interstitial pneumonia and idiopathic pulmonary fibrosis
10.1186/s12931-018-0857-1 · 2018 · External reference
Astragali Radix (Huangqi): a promising edible immunomodulatory herbal medicine
10.1016/j.jep.2020.112895 · 2020 · External reference
Unresolved reference
2020 · External reference
Rapid chemical characterization of danggui buxue decoction using processed astragali radix and angelicae sinensis radix based on diagnostic ion and molecular network
10.1002/bmc.5640 · 2023 · External reference
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
10.1038/srep42717 · 2017 · External reference
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
10.1093/nar/gkz382 · 2019 · External reference
Danggui Buxue Tang restores antibiotic-induced metabolic disorders by remodeling the gut microbiota
10.1016/j.jep.2020.112953 · 2020 · External reference
Identification of non-coding RNA signatures in idiopathic pulmonary fibrosis
10.1007/s11845-024-03675-9 · 2024 · External reference
Network pharmacology-guided lipidomics and molecular docking reveals the involvement of sphingolipid metabolism and HIF-1 signaling in Xiaoyao San's blood-nourishing mechanism against depression
10.1016/j.jep.2025.120534 · 2026 · External reference
Ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2
10.1093/bioinformatics/btac409 · 2022 · External reference
[Idiopathic pulmonary fibrosis]
2022 · External reference
Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets
10.1186/s12881-017-0449-9 · 2017 · External reference
Dang Gui Bu Xue Tang, a conventional Chinese herb decoction, ameliorates radiation-induced heart disease via Nrf2/HMGB1 pathway
2022 · External reference
Adjusting batch effects in microarray expression data using empirical Bayes methods
10.1093/biostatistics/kxj037 · 2007 · External reference
KEGG: biological systems database as a model of the real world
10.1093/nar/gkae909 · 2025 · External reference
Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research
10.1111/j.1939-165x.2012.00418.x · 2012 · External reference
PubChem 2023 update
10.1093/nar/gkac956 · 2023 · External reference
A Chinese classical prescription Maimendong decoction in treatment of pulmonary fibrosis: an overview
10.3389/fphar.2024.1329743 · 2024 · External reference
Idiopathic pulmonary fibrosis
10.1056/nejmra1705751 · 2018 · External reference
Phthalide compounds from the roots of Angelica sinensis and their blood-replenishing bioactivities
10.1016/j.fitote.2025.107026 · 2026 · External reference
NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
10.1016/j.bbamcr.2008.01.002 · 2008 · External reference
Neurogenic dysphagia in traditional Chinese medicine
10.1002/brb3.1812 · 2020 · External reference
The latest research advances of Danggui Buxue Tang as an effective prescription for various diseases: a comprehensive review
10.1007/s11596-022-2642-0 · 2022 · External reference
Plumbagin attenuates Bleomycin-induced lung fibrosis in mice
10.1186/s13223-022-00734-7 · 2022 · External reference
Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle
10.1186/1755-8794-4-70 · 2011 · External reference
A simple practice guide for dose conversion between animals and human
10.4103/0976-0105.177703 · 2016 · External reference
SmulTCan: a shiny application for multivariable survival analysis of TCGA data with gene sets
10.1016/j.compbiomed.2021.104793 · 2021 · External reference
Idiopathic pulmonary fibrosis mortality: update on trends in the modern treatment era
10.1183/13993003.01305-2024 · 2024 · External reference
Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells
10.1093/carcin/21.6.1247 · 2000 · External reference
Limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
10.1186/1758-2946-6-13 · 2014 · External reference
Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats
10.1002/jat.2733 · 2013 · External reference
Immune dysregulation as a driver of idiopathic pulmonary fibrosis
10.1172/jci143226 · 2021 · External reference
The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets
10.1093/nar/gkaa1074 · 2021 · External reference
Historical database cohort study addressing the clinical patterns prior to idiopathic pulmonary fibrosis (IPF) diagnosis in UK primary care
10.1136/bmjopen-2019-034428 · 2020 · External reference
Structural analysis and blood-enriching effects comparison based on biological potency of Angelica sinensis polysaccharides
10.3389/fphar.2024.1405342 · 2024 · External reference
MMP13 expression and activity suggest its role in bone resorption in ameloblastomas
10.1111/jop.13577 · 2024 · External reference
Danggui Buxue Tang ameliorates bleomycin-induced pulmonary fibrosis in rats through inhibiting transforming growth factor-β1/Smad3/plasminogen activator inhibitor-1 signaling pathway
2020 · External reference
Danggui Buxue Tang ameliorates Bleomycin-induced pulmonary fibrosis by suppressing the TLR4/NLRP3 signaling pathway in rats
2021 · External reference
A review of the botany, phytochemistry, traditional uses, pharmacology, toxicology, and quality control of the Astragalus memeranaceus
2023 · External reference
Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
10.1042/bst20150014 · 2015 · External reference
[Review of chemical constituents,pharmacological effects and clinical applications of Danggui buxue decoction and prediction and analysis of its Q-markers]
2021 · External reference
Astragalus mongholicusbunge and Angelica sinensis botanical drug decoction mitigates lung inflammation through NOX4/TGF-β1/SMAD3 signaling
2025 · External reference
Danggui buxue decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway
10.1016/j.jep.2025.120384 · 2025 · External reference
Integrated pathological assessment and multi-omics analysis of the effects of Pinellia ternata aqueous extract on lung and spleen dysfunction in a rat model of phlegm-dampness obstruction
10.1016/j.jep.2026.121443 · 2026 · External reference
Danggui buxue decoction ameliorates idiopathic pulmonary fibrosis through MicroRNA and messenger RNA regulatory network
2022 · External reference
Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine
2024 · External reference
Investigation of the molecular mechanism of Danggui Buxue tang in treating lung cancer using network pharmacology and molecular docking techniques
10.1080/14786419.2024.2305660 · 2024 · External reference
