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References from Parallel bioassay-guided discovery and mechanistic characterization of a dual DPP-IV and ACE inhibitory peptide from defatted Nigella sativa seed cake. Local targets link to admitted publications; unresolved targets remain external evidence.
An antihypertensive heptapeptide from tree bean (Parkia timoriana) seeds: isolation, mechanism, and stability
10.1007/s00217-025-05009-0 · 2025 · External reference
Stable noncompetitive DPP-IV inhibitory hexapeptide from Parkia timoriana seeds: a candidate for functional food development in type 2 diabetes
10.3390/pr13103079 · 2025 · External reference
Determination of the degree of hydrolysis of food protein hydrolysates by trinitrobenzenesulfonic acid
10.1021/jf60226a042 · 1979 · External reference
A review on therapeutic potential of Nigella sativa: a miracle herb
10.1016/s2221-1691(13)60075-1 · 2013 · External reference
Effect of thymoquinone on high fat diet and STZ-induced experimental type 2 diabetes: a mechanistic insight by in vivo and in silico studies
10.1111/jfbc.13807 · 2021 · External reference
A comprehensive review of the antioxidant, antimicrobial, and therapeutic efficacies of black cumin (Nigella sativa L.) seed oil and its thymoquinone
10.1089/jmf.2024.k.0149 · 2025 · External reference
Evaluation of the antihypertensive and antidiabetic potential of peptides from the globulin fraction of quinoa (Chenopodium quinoa) by an in silico and in vitro approach
10.1111/ijfs.16544 · 2023 · External reference
Assessment and prediction of human proteotypic peptide stability for proteomics quantification
10.1021/acs.analchem.3c02269 · 2023 · External reference
Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung
10.1016/0006-2952(71)90292-9 · 1971 · External reference
The inhibitory effects of lycopene and thymoquinone on angiotensin converting enzyme from human plasma (an in vitro study)
2022 · External reference
Review on plant-derived bioactive peptides: biological activities, mechanisms of action, and utilization in food development
10.1016/j.jfutfo.2022.03.003 · 2022 · External reference
Unresolved reference
2010 · External reference
Unresolved reference
2001 · External reference
Identification of VAYPQCV, a gastrointestinally stable competitive DPP-IV inhibitory peptide from bitter leaf (Vernonia amygdalina)
10.1007/s11130-026-01542-9 · 2026 · External reference
Production of dipeptidyl peptidase-IV inhibitory peptides from defatted rice bran
10.1016/j.foodchem.2012.02.183 · 2012 · External reference
The crystal structure of human dipeptidyl peptidase-IV complexed with diprotin A
10.1515/bc.2004.068 · 2004 · External reference
An efficient peptidomics screening for exogenous substrates and inhibitory peptides of the dipeptidase ACE from milk hydrolysate
10.3390/pharmaceutics15020425 · 2023 · External reference
Discovery and characterization of a dual-function peptide derived from bitter gourd seed protein using two orthogonal bioassay-guided fractionations coupled with in silico analysis
10.3390/ph16111629 · 2023 · External reference
Mechanisms and pharmacotherapy of hypertension associated with type 2 diabetes
10.1016/j.bcp.2022.115304 · 2022 · External reference
Ethnobotanical survey and therapeutic ranking of medicinal plants in Muzaffargarh, Pakistan: from traditional use to research priority
2026 · External reference
Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase, and lipid levels in non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled clinical trial
10.1016/j.jep.2019.01.009 · 2019 · External reference
Antidiabetic potential of a Chinese giant salamander (Andrias davidianus)-derived peptide: isolation and characterization of DPP-IV inhibitory peptides
10.3390/pr13020453 · 2025 · External reference
BIOPEP-UWM Virtual: a novel database of food-derived peptides with in silico-predicted biological activity
10.3390/app12147204 · 2022 · External reference
Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus: a review
10.1016/j.jep.2020.112585 · 2020 · External reference
Efficacy and safety of a honey-based formulation of Nigella sativa seed oil in functional dyspepsia: a double-blind randomized controlled clinical trial
10.1016/j.jep.2015.09.022 · 2015 · External reference
Thermolysin: kinetic study with oligopeptides
10.1111/j.1432-1033.1970.tb01018.x · 1970 · External reference
Crystal structure of the human angiotensin-converting enzyme–lisinopril complex
10.1038/nature01370 · 2003 · External reference
Characterization of Allium tuberosum Rottl. peptides with dual inhibitory activities against angiotensin-I-converting enzyme and dipeptidyl peptidase-IV
10.1007/s00044-024-03284-2 · 2024 · External reference
Inhibition of dipeptidyl peptidase-IV by proline-containing casein-derived peptides
10.1016/j.jff.2013.09.012 · 2013 · External reference
Design of substrate-type ACE inhibitory pentapeptides with an antepenultimate C-terminal proline for efficient release of inhibitory activity
10.1016/j.bej.2011.09.018 · 2012 · External reference
ToxinPred 3.0: an improved method for predicting peptide toxicity
10.1016/j.compbiomed.2024.108926 · 2024 · External reference
Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies
10.3389/fphar.2021.625386 · 2021 · External reference
Polyphenol composition of Cuphea spp. leaves and their in vitro angiotensin-I-converting enzyme inhibitory potential
10.1016/j.jep.2020.112781 · 2020 · External reference
Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from natto using DPP-IV from Aspergillus oryzae
10.1016/j.foodchem.2018.04.029 · 2018 · External reference
Characterization of novel angiotensin-I-converting enzyme inhibitory peptides derived from Taiwan red quinoa (Chenopodium formosanum Koidz.) seed proteins using two sequential bioassay-guided fractionations
10.1007/s00044-023-03167-y · 2024 · External reference
A simple tandem bioassay-guided SCX-RP SPE fractionation for efficient active peptide screening from Inca nut cake protein hydrolysate
10.1016/j.jchromb.2024.124061 · 2024 · External reference
Chemical characterization and DPP-IV inhibitory activity evaluation of tripeptides from Gynura divaricata (L.) DC
10.1016/j.jep.2022.115203 · 2022 · External reference
Nigella sativa L. (black cumin): a promising natural remedy for a wide range of illnesses
10.1155/2019/1528635 · 2019 · External reference
Preparation and identification of dipeptidyl peptidase-IV inhibitory peptides from quinoa protein
10.1016/j.foodres.2022.111176 · 2022 · External reference
Associations of concurrent hypertension and type 2 diabetes with mortality outcomes: a prospective study of U.S. adults
10.2337/dca24-0118 · 2025 · External reference
Effects of Nigella sativa fixed oil on blood homeostasis in rats
10.1016/s0378-8741(01)00342-7 · 2002 · External reference
Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries
10.1073/pnas.2009279117 · 2020 · External reference
Characterization of novel angiotensin-I-converting enzyme inhibitory peptides derived from Taiwan red quinoa (Chenopodium formosanum Koidz.) seed proteins using two sequential bioassay-guided fractionations
10.1007/s00044-023-03167-y · ExternalCitation · doi-reference
Characterization of Allium tuberosum Rottl. peptides with dual inhibitory activities against angiotensin-I-converting enzyme and dipeptidyl peptidase-IV
10.1007/s00044-024-03284-2 · ExternalCitation · doi-reference
An antihypertensive heptapeptide from tree bean (Parkia timoriana) seeds: isolation, mechanism, and stability
10.1007/s00217-025-05009-0 · ExternalCitation · doi-reference
Identification of VAYPQCV, a gastrointestinally stable competitive DPP-IV inhibitory peptide from bitter leaf (Vernonia amygdalina)
10.1007/s11130-026-01542-9 · ExternalCitation · doi-reference
Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung
10.1016/0006-2952(71)90292-9 · ExternalCitation · doi-reference
Mechanisms and pharmacotherapy of hypertension associated with type 2 diabetes
10.1016/j.bcp.2022.115304 · ExternalCitation · doi-reference
Design of substrate-type ACE inhibitory pentapeptides with an antepenultimate C-terminal proline for efficient release of inhibitory activity
10.1016/j.bej.2011.09.018 · ExternalCitation · doi-reference
ToxinPred 3.0: an improved method for predicting peptide toxicity
10.1016/j.compbiomed.2024.108926 · ExternalCitation · doi-reference
Production of dipeptidyl peptidase-IV inhibitory peptides from defatted rice bran
10.1016/j.foodchem.2012.02.183 · ExternalCitation · doi-reference
Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from natto using DPP-IV from Aspergillus oryzae
10.1016/j.foodchem.2018.04.029 · ExternalCitation · doi-reference
Preparation and identification of dipeptidyl peptidase-IV inhibitory peptides from quinoa protein
10.1016/j.foodres.2022.111176 · ExternalCitation · doi-reference
A simple tandem bioassay-guided SCX-RP SPE fractionation for efficient active peptide screening from Inca nut cake protein hydrolysate
10.1016/j.jchromb.2024.124061 · ExternalCitation · doi-reference
Efficacy and safety of a honey-based formulation of Nigella sativa seed oil in functional dyspepsia: a double-blind randomized controlled clinical trial
10.1016/j.jep.2015.09.022 · ExternalCitation · doi-reference
Standardized Nigella sativa seed oil ameliorates hepatic steatosis, aminotransferase, and lipid levels in non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled clinical trial
10.1016/j.jep.2019.01.009 · ExternalCitation · doi-reference
Effects of Nigella sativa on endothelial dysfunction in diabetes mellitus: a review
10.1016/j.jep.2020.112585 · ExternalCitation · doi-reference
Polyphenol composition of Cuphea spp. leaves and their in vitro angiotensin-I-converting enzyme inhibitory potential
10.1016/j.jep.2020.112781 · ExternalCitation · doi-reference
Chemical characterization and DPP-IV inhibitory activity evaluation of tripeptides from Gynura divaricata (L.) DC
10.1016/j.jep.2022.115203 · ExternalCitation · doi-reference
Inhibition of dipeptidyl peptidase-IV by proline-containing casein-derived peptides
10.1016/j.jff.2013.09.012 · ExternalCitation · doi-reference
Review on plant-derived bioactive peptides: biological activities, mechanisms of action, and utilization in food development
10.1016/j.jfutfo.2022.03.003 · ExternalCitation · doi-reference
Effects of Nigella sativa fixed oil on blood homeostasis in rats
10.1016/s0378-8741(01)00342-7 · ExternalCitation · doi-reference
A review on therapeutic potential of Nigella sativa: a miracle herb
10.1016/s2221-1691(13)60075-1 · ExternalCitation · doi-reference
Assessment and prediction of human proteotypic peptide stability for proteomics quantification
10.1021/acs.analchem.3c02269 · ExternalCitation · doi-reference
Determination of the degree of hydrolysis of food protein hydrolysates by trinitrobenzenesulfonic acid
10.1021/jf60226a042 · ExternalCitation · doi-reference
Crystal structure of the human angiotensin-converting enzyme–lisinopril complex
10.1038/nature01370 · ExternalCitation · doi-reference
Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries
10.1073/pnas.2009279117 · ExternalCitation · doi-reference
A comprehensive review of the antioxidant, antimicrobial, and therapeutic efficacies of black cumin (Nigella sativa L.) seed oil and its thymoquinone
10.1089/jmf.2024.k.0149 · ExternalCitation · doi-reference
Evaluation of the antihypertensive and antidiabetic potential of peptides from the globulin fraction of quinoa (Chenopodium quinoa) by an in silico and in vitro approach
10.1111/ijfs.16544 · ExternalCitation · doi-reference
Thermolysin: kinetic study with oligopeptides
10.1111/j.1432-1033.1970.tb01018.x · ExternalCitation · doi-reference
Effect of thymoquinone on high fat diet and STZ-induced experimental type 2 diabetes: a mechanistic insight by in vivo and in silico studies
10.1111/jfbc.13807 · ExternalCitation · doi-reference
Nigella sativa L. (black cumin): a promising natural remedy for a wide range of illnesses
10.1155/2019/1528635 · ExternalCitation · doi-reference
The crystal structure of human dipeptidyl peptidase-IV complexed with diprotin A
10.1515/bc.2004.068 · ExternalCitation · doi-reference
Associations of concurrent hypertension and type 2 diabetes with mortality outcomes: a prospective study of U.S. adults
10.2337/dca24-0118 · ExternalCitation · doi-reference
Nigella plants – traditional uses, bioactive phytoconstituents, preclinical and clinical studies
10.3389/fphar.2021.625386 · ExternalCitation · doi-reference
BIOPEP-UWM Virtual: a novel database of food-derived peptides with in silico-predicted biological activity
10.3390/app12147204 · ExternalCitation · doi-reference
Discovery and characterization of a dual-function peptide derived from bitter gourd seed protein using two orthogonal bioassay-guided fractionations coupled with in silico analysis
10.3390/ph16111629 · ExternalCitation · doi-reference
An efficient peptidomics screening for exogenous substrates and inhibitory peptides of the dipeptidase ACE from milk hydrolysate
10.3390/pharmaceutics15020425 · ExternalCitation · doi-reference
Antidiabetic potential of a Chinese giant salamander (Andrias davidianus)-derived peptide: isolation and characterization of DPP-IV inhibitory peptides
10.3390/pr13020453 · ExternalCitation · doi-reference
Stable noncompetitive DPP-IV inhibitory hexapeptide from Parkia timoriana seeds: a candidate for functional food development in type 2 diabetes
10.3390/pr13103079 · ExternalCitation · doi-reference
