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References from Alpinia oxyphylla Miq. promotes angiogenesis and preserves neurons in subacute ischemic stroke in rats: possible involvement of the HIF-1α/Nrf2/VEGF-A-mediated signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke
10.1016/j.bbr.2016.12.037 · 2017 · External reference
Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat
10.1016/s0002-9440(10)64786-4 · 2000 · External reference
NMDA and AMPA/kainate glutamate receptors modulate dentate neurogenesis and CA3 synapsin-I in normal and ischemic hippocampus
10.1097/00004647-200012000-00006 · 2000 · External reference
The contributions of the tissue inhibitor of metalloproteinase-1 genotypes to triple negative breast cancer risk
10.7603/s40681-016-0004-6 · 2016 · External reference
Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1alpha abundance in rats following focal cerebral ischaemia
10.1016/j.bbi.2018.04.009 · 2018 · External reference
Tert-butylhydroquinone enhanced angiogenesis and astrocyte activation by activating nuclear factor-E2-related factor 2/heme oxygenase-1 after focal cerebral ischemia in mice
2019 · External reference
Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats
10.1186/s13020-021-00495-2 · 2021 · External reference
Angelica sinensis Exerts Angiogenic and Anti-apoptotic Effects Against Cerebral Ischemia-Reperfusion Injury by Activating p38MAPK/HIF-1[Formula: see text]/VEGF-A Signaling in Rats
10.1142/s0192415x17500914 · 2017 · External reference
Angelica sinensis extract protects against ischemia-reperfusion injury in the hippocampus by activating p38 MAPK-mediated p90RSK/p-Bad and p90RSK/CREB/BDNF signaling after transient global cerebral ischemia in rats
10.1016/j.jep.2020.112612 · 2020 · External reference
A novel strategy of integrating network pharmacology and transcriptome reveals antiapoptotic mechanisms of Buyang Huanwu Decoction in treating intracerebral hemorrhage
2024 · External reference
The Involvement of HIF-1α and BDNF in Neonatal Hypoxic–Ischemic Insult to the Cerebral Germinal Matrix
10.3390/ijms27115125 · 2026 · External reference
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
10.1093/nar/gkz382 · 2019 · External reference
HIF-1alpha in cerebral ischemia
10.3892/mmr.2021.12557 · 2022 · External reference
Treadmill exercise promotes angiogenesis in the ischemic penumbra of rat brains through caveolin-1/VEGF signaling pathways
10.1016/j.brainres.2014.08.032 · 2014 · External reference
Transplantation of layer-by-layer assembled neural stem cells tethered with vascular endothelial growth factor reservoir promotes neurogenesis and angiogenesis after ischemic stroke in mice
2022 · External reference
Early Rehabilitation Exercise after Stroke Improves Neurological Recovery through Enhancing Angiogenesis in Patients and Cerebral Ischemia Rat Model
10.3390/ijms231810508 · 2022 · External reference
Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2-VEGF Pathway
10.1007/s11064-018-2523-x · 2018 · External reference
Synergistic microglial modulation by laminarin-based platinum nanozymes for potential intracerebral hemorrhage therapy
10.1016/j.biomaterials.2025.123212 · 2025 · External reference
Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury
10.1080/13880209.2023.2229379 · 2023 · External reference
A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example
10.1186/s13020-023-00745-5 · 2023 · External reference
Effect of combined VEGF(165)/ SDF-1 gene therapy on vascular remodeling and blood perfusion in cerebral ischemia
10.3171/2016.9.jns161234 · 2017 · External reference
Neuroprotective effects of Gastrodia elata Blume on promoting M2 microglial polarization by inhibiting JNK/TLR4/T3JAM/NF-kappaB signaling after transient ischemic stroke in rats
10.3389/fphar.2024.1469602 · 2024 · External reference
Association Between Living Environmental Factors and Stroke in Middle-Aged and Older Chinese Adults: A Nationwide Prospective Cohort Study
10.1161/jaha.125.043867 · 2026 · External reference
Chrysin promotes angiogenesis in rat hindlimb ischemia: Impact on PI3K/Akt/mTOR signaling pathway and autophagy
10.1002/ddr.21954 · 2022 · External reference
The Substructure of the Endothelial Glycocalyx in Rat Aorta and Its Interaction with the Low-Density Lipoproteins
10.1016/j.ajpath.2025.06.005 · 2025 · External reference
Pharmacological Postconditioning by Protocatechuic Acid Attenuates Brain Injury in Ischemia-Reperfusion (I/R) Mice Model: Implications of Nuclear Factor Erythroid-2-Related Factor Pathway
10.1016/j.neuroscience.2022.03.016 · 2022 · External reference
Over-expression of VEGF in marrow stromal cells promotes angiogenesis in rats with cerebral infarction via the synergistic effects of VEGF and Ang-2
10.1007/s11596-012-1025-3 · 2012 · External reference
Effects of bone marrow mesenchymal stem cells (BM-MSCs) on rat pial microvascular remodeling after transient middle cerebral artery occlusion
10.3389/fncel.2015.00329 · 2015 · External reference
Long-term remodeling of rat pial microcirculation after transient middle cerebral artery occlusion and reperfusion
10.1159/000353295 · 2013 · External reference
Activation of cerebral recovery by matrix metalloproteinase-9 after intracerebral hemorrhage
10.1016/j.neuroscience.2012.11.008 · 2013 · External reference
Alpiniae oxyphyllae Fructus and Alzheimer's disease: An update and current perspective on this traditional Chinese medicine
10.1016/j.biopha.2020.111167 · 2021 · External reference
Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension
2016 · External reference
Metabolomics integrated with network pharmacology of blood-entry constituents reveals the bioactive component of Xuefu Zhuyu decoction and its angiogenic effects in treating traumatic brain injury
10.1186/s13020-024-01001-0 · 2024 · External reference
Therapeutic potential of natural products in ischemic stroke: targeting angiogenesis
2025 · External reference
Zinc improves neurological recovery by promoting angiogenesis via the astrocyte-mediated HIF-1alpha/VEGF signaling pathway in experimental stroke
10.1111/cns.13918 · 2022 · External reference
Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway
10.3389/fphar.2019.00395 · 2019 · External reference
Growth differentiation factor 11 improves neurobehavioral recovery and stimulates angiogenesis in rats subjected to cerebral ischemia/reperfusion
10.1016/j.brainresbull.2018.02.011 · 2018 · External reference
VEGF expression in human brain tissue after acute ischemic stroke
2011 · External reference
Intravenous injection of neural progenitor cells facilitates angiogenesis after cerebral ischemia
10.1002/brb3.113 · 2013 · External reference
Dual therapeutic potential of Scoparia dulcis in combating hyperglycemia and inflammation in diabetes through network pharmacology and in silico analysis
10.1038/s41598-025-06862-5 · 2025 · External reference
MIF Promotes Phenotypic Switching of VSMCs via AKT/mTOR-Mediated Autophagy Regulation in Aortic Dissection
10.1096/fj.202501761r · 2025 · External reference
Comparative pharmacokinetic study of the components in Alpinia oxyphylla Miq.-Schisandra chinensis (Turcz.) Baill. herb pair and its single herb between normal and Alzheimer's disease rats by UPLC-MS/MS
10.1016/j.jpba.2019.112874 · 2020 · External reference
Von Willebrand factor and angiogenesis: basic and applied issues
2017 · External reference
GeneCards Version 3: the human gene integrator
10.1093/database/baq020 · 2010 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
An integrated computational workflow for myocardial perfusion combining the multiple-network poroelastic theory and subject-specific imaging data
10.1063/5.0300204 · 2026 · External reference
Catalpol Alleviates Ischemic Stroke Through Promoting Angiogenesis and Facilitating Proliferation and Differentiation of Neural Stem Cells via the VEGF-A/KDR Pathway
10.1007/s12035-023-03459-9 · 2023 · External reference
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
10.1172/jci200317977 · 2003 · External reference
The Role of Nrf2 in Relieving Cerebral Ischemia-Reperfusion Injury
10.2174/1570159x21666221129100308 · 2023 · External reference
Post-stroke endothelial cell plasticity: A transformational lineage from complete to partial EndoMT
10.1016/j.tice.2026.103729 · 2026 · External reference
Gene expression analysis of nidus of cerebral arteriovenous malformations reveals vascular structures with deficient differentiation and maturation
10.1371/journal.pone.0198617 · 2018 · External reference
Neuroprotective Effects of Alpinia oxyphylla Miq against Mitochondria-Related Apoptosis by the Interactions between Upregulated p38 MAPK Signaling and Downregulated JNK Signaling in the Subacute Phase of Cerebral Ischemia-Reperfusion in Rats
10.1142/s0192415x22500884 · 2022 · External reference
Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action
2026 · External reference
Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats
10.1161/01.str.0000132196.49028.a4 · 2004 · External reference
Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis
10.1016/j.neuroscience.2019.05.005 · 2019 · External reference
VEGF overexpression enhances striatal neurogenesis in brain of adult rat after a transient middle cerebral artery occlusion
10.1002/jnr.21091 · 2007 · External reference
Protective effects of Alpinae Oxyphyllae Fructus extracts on lipopolysaccharide-induced animal model of Alzheimer's disease
10.1016/j.jep.2018.02.015 · 2018 · External reference
Buyang huanwu decoction promotes remyelination via miR-760-3p/GPR17 axis after intracerebral hemorrhage
10.1016/j.jep.2024.118126 · 2024 · External reference
Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke
10.1161/strokeaha.112.652545 · 2012 · External reference
Houshiheisan promotes angiogenesis via HIF-1alpha/VEGF and SDF-1/CXCR4 pathways: in vivo and in vitro
10.1042/bsr20191006 · 2019 · External reference
Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2
10.1155/2021/9925561 · 2021 · External reference
Treadmill exercise ameliorates focal cerebral ischemia/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1/VEGF signaling pathways
10.1016/j.expneurol.2018.12.005 · 2019 · External reference
Postsynaptic density protein (PSD)-95 expression is markedly decreased in the hippocampal CA1 region after experimental ischemia-reperfusion injury
10.1016/j.jns.2013.04.023 · 2013 · External reference
Protective effect of Shouwu Yizhi decoction against vascular dementia by promoting angiogenesis
2017 · External reference
Nootkatone alleviates rotenone-induced Parkinson's disease symptoms through activation of the PI3K/Akt signaling pathway
10.1002/ptr.7552 · 2022 · External reference
Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats
10.1016/j.trsl.2015.12.002 · 2016 · External reference
Neuroprotective effects of the salidroside derivative SHPL-49 via the BDNF/TrkB/Gap43 pathway in rats with cerebral ischemia
10.1016/j.biopha.2024.116460 · 2024 · External reference
Mangiferin alleviated poststroke cognitive impairment by modulating lipid metabolism in cerebral ischemia/reperfusion rats
10.1016/j.ejphar.2024.176724 · 2024 · External reference
DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress
2022 · External reference
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats
10.1016/j.ejphar.2023.175801 · 2023 · External reference
Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-kappaB/AIM2 pathways in cerebral ischemia/reperfusion injury
2025 · External reference
Huoluo Xiaoling Pellet improves ischemic stroke by regulating metabolic disorders through integrins and ICAM1
10.1016/j.jep.2025.120178 · 2025 · External reference
Iron/ROS/Itga3 mediated accelerated depletion of hippocampal neural stem cell pool contributes to cognitive impairment after hemorrhagic stroke
10.1016/j.redox.2024.103086 · 2024 · External reference
Protocatechuic acid suppresses ferroptosis to protect against hypoxic-ischemic encephalopathy by targeting the HIF-1alpha/VEGFA axis
10.1016/j.phymed.2025.156900 · 2025 · External reference
Nootkatone confers MAOB-dependent neuroprotection against ferroptotic injury via brain-targeted nanoparticle delivery in ischemic stroke
10.1186/s12951-026-04520-0 · 2026 · External reference
Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia
10.1097/00004647-200204000-00002 · 2002 · External reference
Integrated metabolomics and network pharmacology analysis of Yulan Jiangtang capsules in diabetic nephropathy
10.1016/j.phymed.2025.157189 · 2025 · External reference