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References from Complementary Antihypertensive Mechanisms of the Tianma-Gouteng Herb Pair Targeting the Endothelium and Smooth Muscle: Emphasizing Endothelial Protection by Tianma Involving the PGR-Associated PI3K/Akt/eNOS Pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
An organotypic atlas of human vascular cells
10.1038/s41591-024-03376-x · 2024 · External reference
Endothelium
10.1161/atvbaha.116.306940 · 2016 · External reference
Arterial Stiffness and Cardiovascular Risk in Hypertension
10.1161/circresaha.121.318061 · 2021 · External reference
Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension
10.1161/atvbaha.118.311229 · 2018 · External reference
Gastrodin prevents homocysteine-induced human umbilical vein endothelial cells injury via PI3K/Akt/eNOS and Nrf2/ARE pathway
10.1111/jcmm.16073 · 2021 · External reference
Tianma Gouteng Decoction regulates oxidative stress and inflammation in AngII-induced hypertensive mice via transcription factor EB to exert anti-hypertension effect
10.1016/j.biopha.2021.112383 · 2022 · External reference
Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats
10.1155/2020/3439191 · 2020 · External reference
Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension
10.1161/circresaha.123.323596 · 2024 · External reference
Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells
10.1016/j.jep.2024.118896 · 2025 · External reference
Progesterone Receptor in the Vascular Endothelium Triggers Physiological Uterine Permeability Preimplantation
10.1016/j.cell.2013.12.025 · 2014 · External reference
Topical and transdermal botanical formulations of the Chinese pharmacopoeia-A review
10.1002/ptr.8286 · 2024 · External reference
Gastrodin attenuates angiotensin II-induced vascular contraction and MLCK/p-MLC(2) pathway activation
10.1080/13880209.2023.2207591 · 2023 · External reference
Tail-Cuff Versus Radiotelemetry to Measure Blood Pressure in Mice and Rats
10.1161/hypertensionaha.123.22329 · 2024 · External reference
Full component analysis of Tianma-Gouteng-Yin
10.1186/s13020-016-0115-8 · 2016 · External reference
Isolation of Murine Primary Aortic Smooth Muscle Cells
10.21769/bioprotoc.3907 · 2021 · External reference
Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
10.1038/s41467-020-15816-6 · 2020 · External reference
Lycorine hydrochloride reveals a novel role in preventing neointimal hyperplasia through MAPK-mediated phenotypic switching of smooth muscle cells
10.1016/j.yjmcc.2026.04.008 · 2026 · External reference
Endothelial-Vascular Smooth Muscle Cells Interactions in Atherosclerosis
10.3389/fcvm.2018.00151 · 2018 · External reference
Rhynchophylline-induced vasodilation in human mesenteric artery is mainly due to blockage of L-type calcium channels in vascular smooth muscle cells
10.1007/s00210-013-0888-6 · 2013 · External reference
Serum pharmacochemistry and network pharmacology reveal the effect and mechanism of licorice extracts on colorectal cancer
10.1016/j.phymed.2025.156860 · 2025 · External reference
Pharmacodynamic components and molecular mechanism of Gastrodia elata Blume in treating hypertension: Absorbed components, network pharmacology analysis, molecular docking and in vivo experimental verification
10.1016/j.jep.2025.119583 · 2025 · External reference
Gastrodin Alleviates Oxidative Stress-Induced Apoptosis and Cellular Dysfunction in Human Umbilical Vein Endothelial Cells via the Nuclear Factor-Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway and Accelerates Wound Healing In Vivo
10.3389/fphar.2019.01273 · 2019 · External reference
Correlation of mRNA and protein in complex biological samples
10.1016/j.febslet.2009.10.036 · 2009 · External reference
2024 ESC Guidelines for the management of elevated blood pressure and hypertension
10.1093/eurheartj/ehae178 · 2024 · External reference
Evaluation of Blood Pressure Control, Medication Adherence, and Therapeutic Inertia in US Patients With Hypertension Prescribed Multiple Antihypertensives
10.1161/jaha.124.034787 · 2025 · External reference
[Research progress on common traditional Chinese medicine syndrome types of hypertension and their treatment with Chinese herbal medicine]
2025 · External reference
Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension
10.1161/01.hyp.20.3.298 · 1992 · External reference
Nitric Oxide Reversibly Inhibits the Migration of Cultured Vascular Smooth Muscle Cells
10.1161/01.res.78.2.225 · 1996 · External reference
[Study on the curative effect of Gastrodia elata and Uncaria on hypertensive rats]
2018 · External reference
Differential Signal Transduction of Progesterone and Medroxyprogesterone Acetate in Human Endothelial Cells
10.1210/en.2004-0510 · 2004 · External reference
Intervention of Uncaria and Its Components on Liver Lipid Metabolism in Spontaneously Hypertensive Rats
10.3389/fphar.2020.00910 · 2020 · External reference
Vascular smooth muscle contraction in hypertension
10.1093/cvr/cvy023 · 2018 · External reference
Vascular endothelial cell development and diversity
10.1038/s41569-022-00770-1 · 2023 · External reference
2020 International Society of Hypertension Global Hypertension Practice Guidelines
10.1161/hypertensionaha.120.15026 · 2020 · External reference
Gender differences in the cardiovascular effect of sex hormones
10.1038/nrcardio.2009.105 · 2009 · External reference
Single-cell atlas of the human brain vasculature across development, adulthood and disease
10.1038/s41586-024-07493-y · 2024 · External reference
Tianma Gouteng Yin as Adjunctive Treatment for Essential Hypertension: A Systematic Review of Randomized Controlled Trials
2013 · External reference
Wutou decoction ameliorates experimental rheumatoid arthritis via regulating NF-kB and Nrf2: Integrating efficacy-oriented compatibility of traditional Chinese medicine
10.1016/j.phymed.2021.153522 · 2021 · External reference
Danhong formula alleviates endothelial dysfunction and reduces blood pressure in hypertension by regulating MicroRNA 24 - Phosphatidylinositol 3-Kinase-Serine/Threonine Kinase- Endothelial Nitric Oxide Synthase axis
10.1016/j.jep.2023.117615 · 2024 · External reference
Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP-1 formation
10.1152/ajpheart.00206.2020 · 2020 · External reference
Consensus on diagnostic criteria for deficiency syndrome in hypertension: a modified Delphi study
2023 · External reference
The inhibition effect of uncarialin A on voltage-dependent L-type calcium channel subunit alpha-1C: Inhibition potential and molecular stimulation
10.1016/j.ijbiomac.2020.05.100 · 2020 · External reference
Tianma Gouteng Yin Formula for treating primary hypertension
2012 · External reference
Progesterone enhances vascular endothelial cell migration via activation of focal adhesion kinase
10.1111/j.1582-4934.2011.01305.x · 2012 · External reference
Advances in Hypertension Management: Insights from the Latest European Guidelines
10.3390/jcdd12040155 · 2025 · External reference
