Research graph
References from Jiawei Dingzhi Wan ameliorates chronic cerebral hypoperfusion-induced vascular cognitive impairment by modulating ACER2 and S1P-mediated microvascular angiogenesis and aortic vasoconstriction. Local targets link to admitted publications; unresolved targets remain external evidence.
An unraveled mystery: what's the role of brain sphingolipids in neurodegenerative and psychiatric disorders
10.1016/j.nbd.2025.106852 · 2025 · External reference
Sphingosine-1-Phosphate (S1P) and S1P signaling pathway modulators, from current insights to future perspectives
10.3390/cells11132058 · 2022 · External reference
Learning dynamical models of single and collective cell migration: a review
2024 · External reference
Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia
10.1515/revneuro-2024-0028 · 2024 · External reference
Sphingosine 1-phosphate: lipid signaling in pathology and therapy
10.1126/science.aar5551 · 2019 · External reference
Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer's disease
10.1038/s12276-024-01176-4 · 2024 · External reference
Ceramide: a central regulator in Alzheimer's disease pathogenesis
10.1007/s10787-025-01719-9 · 2025 · External reference
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
10.1152/physrev.00022.2020 · 2021 · External reference
Ceramidases, roles in sphingolipid metabolism and in health and disease
10.1016/j.jbior.2016.10.002 · 2017 · External reference
S1P receptor modulators and the cardiovascular autonomic nervous system in multiple sclerosis: a narrative review
10.1177/17562864221133163 · 2022 · External reference
Asymmetric division coordinates collective cell migration in angiogenesis
10.1038/ncb3443 · 2016 · External reference
Sphingolipid metabolism: a new therapeutic opportunity for brain degenerative disorders
10.3389/fnins.2018.00249 · 2018 · External reference
Using "Xiang Thinking" as a bridge: exploring the convergence points between TCM pathogenesis and western medical pathogenesis of vascular cognitive impairment
2026 · External reference
Transplantation of layer-by-layer assembled neural stem cells tethered with vascular endothelial growth factor reservoir promotes neurogenesis and angiogenesis after ischemic stroke in mice
2022 · External reference
Vascular endothelial growth factor: an attractive target in the treatment of hypoxic/ischemic brain injury
10.4103/1673-5374.175067 · 2016 · External reference
Neuro protective effect and action mechanism of Siwu decoction in rat with vascular dementia
2015 · External reference
Lysophospholipids and their G-Coupled protein signaling in Alzheimer's disease: from physiological performance to pathological impairment
10.3389/fnmol.2020.00058 · 2020 · External reference
Study progress on compounds, pharmacological action and clinical application of Siwu decoction
2020 · External reference
Analysis of potential mechanism of herbal formula taohong siwu decoction against vascular dementia based on network pharmacology and molecular docking
10.1155/2023/1235552 · 2023 · External reference
Using metabolomics in diabetes management with traditional Chinese medicine: a review
10.1142/s0192415x21500865 · 2021 · External reference
Vascular cognitive impairment and dementia: JACC scientific expert panel
10.1016/j.jacc.2019.04.034 · 2019 · External reference
Assessing potential liver injury induced by Polygonum multiflorum using potential biomarkers via targeted sphingolipidomics
10.1080/13880209.2022.2099908 · 2022 · External reference
High-density lipoprotein (HDL) promotes angiogenesis via S1P3-dependent VEGFR2 activation
10.1007/s10456-018-9603-z · 2018 · External reference
The substructure of the endothelial glycocalyx in rat Aorta and its interaction with the low-density lipoproteins
10.1016/j.ajpath.2025.06.005 · 2025 · External reference
The pharmacokinetics effects of the MCAO model on senkyunolide I in pseudo germ-free rats after oral co-administration of Chuanxiong and warfarin
2025 · External reference
The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system
2025 · External reference
Mitochondrial protection and against glutamate neurotoxicity via Shh/Ptch1 signaling pathway to ameliorate cognitive dysfunction by Kaixin San in multi-infarct dementia rats
2021 · External reference
Optimization of extraction process for Guizhi prescription based on the integration of AHP-CRITIC and BP-ANN
2025 · External reference
Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow
10.1038/s41467-019-13956-y · 2020 · External reference
Intracranial mechanisms for preserving brain blood flow in health and disease
10.1111/apha.12706 · 2017 · External reference
Vascular dementia: from pathobiology to emerging perspectives
10.1016/j.arr.2024.102278 · 2024 · External reference
Unresolved reference
2016 · External reference
Sphingolipids and atherosclerosis: the dual role of ceramide and Sphingosine-1-Phosphate
10.3390/antiox12010143 · 2023 · External reference
Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment
10.1186/s40478-023-01590-1 · 2023 · External reference
Molecular mechanisms underlying the heterogeneous barrier responses of two primary endothelial cell types to sphingosine-1-phosphate
10.1016/j.ejcb.2022.151233 · 2022 · External reference
Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)
10.1074/jbc.m109.069203 · 2010 · External reference
The role of sphingosine 1-phosphate receptors on retinal pigment epithelial cells barrier function and angiogenic effects
2019 · External reference
The bidirectional role of hypoxia-inducible factor 1 alpha in vascular dementia caused by chronic cerebral hypoperfusion
10.1007/s12035-025-04914-5 · 2025 · External reference
Age-related alterations of cerebral autoregulation
2025 · External reference
Research progress on pharmacodynamic material basis and pharmacological action mechanism of Kai-Xin-San
2020 · External reference
Animal models of chronic cerebral hypoperfusion: from mouse to primate
10.3390/ijms20246176 · 2019 · External reference
Rapid screening the chemical components in Jiawei Dingzhi pills using precursor ion selection UHPLC-Q-TOF-MS/MS
2024 · External reference
Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function
10.1016/j.jbc.2023.104775 · 2023 · External reference
Leonurus japonicus Houtt. modulates neuronal apoptosis in intracerebral hemorrhage: insights from network pharmacology and molecular docking
10.1016/j.jep.2024.118223 · 2024 · External reference
Network pharmacology-based and experimental validation elucidate the target mechanism of vinorine in ameliorating secondary brain injury after intracerebral hemorrhage
10.1111/cns.70609 · 2025 · External reference
Alkaline ceramidase family: the first two decades
10.1016/j.cellsig.2020.109860 · 2021 · External reference
Efficacy observation of Kaixin powder mixture on vascular dementia
2023 · External reference
Postsynaptic GluR2 involved in amelioration of Aβ-Induced memory dysfunction by KAIXIN-San through rescuing hippocampal LTP in mice
10.1089/rej.2018.2080 · 2019 · External reference
Mangiferin alleviated poststroke cognitive impairment by modulating lipid metabolism in cerebral ischemia/reperfusion rats
10.1016/j.ejphar.2024.176724 · 2024 · External reference
DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress
10.3389/fphar.2022.987293 · 2023 · External reference
TAK-242 alleviates neuroinflammation and poststroke cognitive impairment by targeting the TLR4/SYK/NF-κB pathway in a cerebral ischemia/reperfusion rat model
10.1016/j.ejphar.2026.178813 · 2026 · External reference
Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury
2025 · External reference
New insight into ischemic stroke: circadian rhythm in post-stroke angiogenesis
2022 · External reference
