Research graph
References from Gardenia jasminoides Ellis 70% ethanolic fraction alleviates hyperuricemia by upregulating PPARγ and modulating its downstream urate transporters and anti-inflammatory pathways. Local targets link to admitted publications; unresolved targets remain external evidence.
Benzbromarone in the treatment of gout
10.1186/s42358-019-0080-x · 2019 · External reference
Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis
10.1016/j.ejmech.2022.114379 · 2022 · External reference
Gardenia jasminoides Ellis: ethnopharmacology, phytochemistry, and pharmacological and industrial applications of an important traditional Chinese medicine
10.1016/j.jep.2020.112829 · 2020 · External reference
New perspectives in rheumatology: implications of the cardiovascular safety of febuxostat and allopurinol in patients with gout and cardiovascular morbidities trial and the associated food and drug administration public safety alert
10.1002/art.40583 · 2018 · External reference
The ménage à trois of autophagy, lipid droplets and liver disease
10.1080/15548627.2021.1895658 · 2022 · External reference
2020 American college of Rheumatology guideline for the management of gout
10.1002/art.41247 · 2020 · External reference
HLA-B*58:01 is a risk factor for allopurinol-induced DRESS and Stevens-Johnson syndrome/toxic epidermal necrolysis in a Portuguese population
10.1111/bjd.12389 · 2013 · External reference
GLUT9b- and ABCG2-mediated collecting duct urate transport uncovers a vasopressin-independent mechanism of renal water reabsorption
10.1172/jci197021 · 2026 · External reference
Assessment of drugs toxicity and associated biomarker genes using hierarchical clustering
2019 · External reference
Novel xanthine oxidase-based cell model using HK-2 cell for screening antihyperuricemic functional compounds
10.1016/j.freeradbiomed.2019.04.007 · 2019 · External reference
Harnessing hyperuricemia to atherosclerosis and understanding its mechanistic dependence
10.1002/med.21742 · 2021 · External reference
Gardenia (Gardenia jasminoides Ellis) fruit: a critical review of its functional nutrients, processing methods, health-promoting effects, comprehensive application and future tendencies
10.1080/10408398.2023.2270530 · 2025 · External reference
Expert consensus for the diagnosis and treatment of patients with hyperuricemia and high cardiovascular risk: 2025 update
10.1016/j.ejim.2026.106727 · 2026 · External reference
Emerging roles of Xanthine oxidoreductase in chronic kidney disease
2024 · External reference
Anti-hyperuricemic and nephroprotective effect of geniposide in chronic hyperuricemia mice
10.1016/j.jff.2019.05.011 · 2019 · External reference
Inflammatory response and oxidative stress as mechanism of reducing hyperuricemia of Gardenia jasminoides-Poria cocos with network pharmacology
10.1155/2021/8031319 · 2021 · External reference
The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats
10.1016/j.fct.2014.05.004 · 2014 · External reference
Regulation of uric acid metabolism and excretion
10.1016/j.ijcard.2015.08.109 · 2016 · External reference
Uric acid: a new perspective for exploring the pathological process of anthracycline-induced cardiotoxicity
10.3390/cimb48010040 · 2025 · External reference
Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-β/SMAD3 signaling
10.1016/j.phymed.2021.153552 · 2021 · External reference
Dietary interventions for hyperuricemia in adolescents and young adults (14-35 years): a narrative review of prevalence and dietary mechanisms for lowering uric acid
10.1177/02601060261450004 · 2026 · External reference
SIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathway
10.1007/s12020-016-0896-7 · 2016 · External reference
Associations and pathways between residential greenness and hyperuricemia among adults in rural and urban China
2022 · External reference
The inhibitory effect of Astragalus flavone extract on hyperuricemia and its underlying molecular mechanism by targeting JNK/AP-1/NLRP3/IL-1β signaling pathway
10.1016/j.phymed.2025.156622 · 2025 · External reference
Chemistry and bioactivity of Gardenia jasminoides
10.1016/j.jfda.2016.11.005 · 2017 · External reference
Analysis of cantharidin-induced kidney injury and the protective mechanism of resveratrol in mice determined by liquid chromatography/mass spectrometry-based metabonomics
10.1002/jat.4596 · 2024 · External reference
Insights into renal damage in hyperuricemia: focus on renal protection
10.3892/mmr.2024.13424 · 2025 · External reference
Influence of Gut microbiota-derived butyrate on intestinal uric acid excretion and hyperuricemia regulation by Cichorium intybus L
10.3390/ijms26136413 · 2025 · External reference
Crocin improves renal function by declining Nox-4, IL-18, and p53 expression levels in an experimental model of diabetic nephropathy
10.1002/jcb.26806 · 2018 · External reference
Prevalence of hyperuricemia among Chinese adults: findings from two nationally representative cross-sectional surveys in 2015-16 and 2018-19
10.3389/fimmu.2021.791983 · 2022 · External reference
