Research graph
References from MED12 somatic mutation promotes human uterine leiomyoma’s growth by trigging canonical Wnt4/β-catenin and TGF-β signaling through the EMT pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas
10.1126/science.1208930 · 2011 · External reference
MED12 mutations in uterine leiomyoma’ss – their relationship to cytogenetic subgroups
10.1002/ijc.27424 · 2012 · External reference
Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas
10.1371/journal.pone.0033251 · 2012 · External reference
Mutations in Exon-1 highlight the role of MED 12 in uterine leiomyoma’s
10.1002/humu.22612 · 2014 · External reference
Exomic landscape of MED12 mutation-negative and positive uterine leiomyomas
10.1002/ijc.28410 · 2014 · External reference
Med12 gain-of-function mutation causes leiomyoma’s and genomic instability
10.1172/jci81534 · 2015 · External reference
The human Mediator complex: a versatile, genome-wide regulator of transcription
10.1016/j.tibs.2010.02.004 · 2010 · External reference
Behavioral features in young adults with FG syndrome (Opitz-Kaveggia syndrome)
10.1002/ajmg.c.30284 · 2010 · External reference
Mediator kinase module and human tumorigenesis
10.3109/10409238.2015.1064854 · 2015 · External reference
Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells
10.1073/pnas.0704472104 · 2007 · External reference
Developmental exposure to endocrine disruptors expands murine myometrial stem cell compartment as a prerequisite to leiomyoma tumorigenesis
10.1002/stem.2519 · 2017 · External reference
Mediator is a transducer of Wnt/beta-catenin signaling
10.1074/jbc.m602696200 · 2006 · External reference
Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling
10.1242/dev.053660 · 2010 · External reference
Uterine leiomyoma’ss
2016 · External reference
Extracellular matrix (ECM) activates β-catenin signaling in uterine leiomyoma’ss
10.1530/rep-17-0339 · 2018 · External reference
Uterine Leiomyoma’ss: burden and unmet medical need
10.1055/s-0037-1607264 · 2017 · External reference
Introduction of somatic mutation in MED12 induces Wnt4/beta-catenin and disrupts autophagy in human uterine myometrial cell
10.1007/s43032-019-00084-7 · 2020 · External reference
Expression and intracellular localization of Nanos2-homologue protein in primordial germ cells and spermatogonial stem cells
10.1017/s0967199419000066 · 2020 · External reference
Uterine leiomyoma’s: isolation, culture and characterization
2019 · External reference
Paracrine activation of WNT/beta-catenin pathway in uterine leiomyoma stem cells promotes tumor growth
10.1073/pnas.1313650110 · 2013 · External reference
Convergence of Wnt, beta-catenin, and cadherin pathways
10.1126/science.1094291 · 2004 · External reference
Wnt/beta-catenin signaling in development and disease
10.1016/j.cell.2006.10.018 · 2006 · External reference
β-catenin/TCF-coordinated chromatin loop at MYC integrates 5’ and 3’ Wnt responsive enhancers
10.1073/pnas.0912294107 · 2010 · External reference
TGF-β and fibrosis in different organs molecular pathway imprints
10.1016/j.bbadis.2009.06.004 · 2009 · External reference
WNT/β-catenin signaling promotes TGF-β-mediated activation of human cardiac fibroblasts by enhancing IL-11 production
10.3390/ijms221810072 · 2021 · External reference
TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis
10.3390/ijms20112767 · 2019 · External reference
Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
2009 · External reference
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling
10.1016/j.cell.2012.10.035 · 2012 · External reference
Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation
10.1016/s0015-0282(00)00418-0 · 2000 · External reference
Structure and function of matrix metalloproteinases and TIMPs
10.1016/j.cardiores.2005.12.002 · 2006 · External reference
Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics
10.1016/j.bbamcr.2009.09.015 · 2010 · External reference
Biological role of matrix metalloproteinase: a critical balance
10.1183/09031936.00146510 · 2011 · External reference
Matrix metalloproteinases of human leiomyoma in various stages of tumor growth
10.1159/000077177 · 2004 · External reference
Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium
10.1080/09513590701557416 · 2007 · External reference
Gene expression studies in leiomyomata: new directions for research
10.1055/s-2004-828614 · 2004 · External reference
β‐Catenin signaling is required for TGF‐β1‐induced extracellular matrix production by airway smooth muscle cells
10.1152/ajplung.00123.2011 · 2011 · External reference
