Research graph
References from White hyacinth bean polysaccharide mitigates high-fat diet-induced myocardial injury by modulating the gut microbiota-phenylalanine-heart axis in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
A natural polyphenol, Chlorogenic acid, attenuates obesity-related metabolic disorders in male rats via miR-146a-IRAK1-TRAF6 and NRF2-mediated antioxidant pathways
10.3390/biom15081086 · 2025 · External reference
Decoding the liver-heart axis in cardiometabolic diseases
10.1161/circresaha.125.325492 · 2025 · External reference
Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function
10.1186/s13578-023-00974-z · 2023 · External reference
Phenylalanine homeostasis in metabolic disorders: Epidemiological trends, pathophysiological mechanisms, and clinical treatment
2026 · External reference
Mitochondrial dysfunction in heart failure: From pathophysiological mechanisms to therapeutic opportunities
10.3390/ijms25052667 · 2024 · External reference
Lactococcus lactis Subsp. lactis LL-1 and Lacticaseibacillus paracasei LP-16 influence the gut microbiota and metabolites for anti-obesity and Hypolipidemic effects in mice
10.3390/antiox14050547 · 2025 · External reference
Auricularia auricula polysaccharides attenuate ventricular remodeling in mice by suppressing oxidative stress and apoptosis via activation of the Keap1/Nrf2/HO-1 pathway
10.1016/j.jff.2026.107342 · 2026 · External reference
Sarcosine, Trigonelline and phenylalanine as urinary metabolites related to visceral fat in overweight and obesity
10.3390/metabo14090491 · 2024 · External reference
Soybean soluble polysaccharide prevents obesity in high-fat diet-induced rats via lipid metabolism regulation
10.1016/j.ijbiomac.2022.10.080 · 2022 · External reference
Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice
10.1080/19490976.2021.1930874 · 2021 · External reference
Curcumin simultaneously improves mitochondrial dynamics and myocardial cell bioenergy after sepsis via the SIRT1-DRP1/PGC-1α pathway
10.1016/j.heliyon.2024.e28501 · 2024 · External reference
Generic diagramming platform (GDP): A comprehensive database of high-quality biomedical graphics
10.1093/nar/gkae973 · 2025 · External reference
Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy
10.1186/s12964-025-02326-5 · 2025 · External reference
Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway
10.1016/j.phymed.2023.155285 · 2024 · External reference
Quercetin-driven Akkermansia Muciniphila alleviates obesity by modulating bile acid metabolism via an ILA/m(6)a/CYP8B1 signaling
10.1002/advs.202412865 · 2025 · External reference
Wild Cordyceps polysaccharides alleviate atherosclerosis by attenuating macrophage cholesterol accumulation through the PPARγ-LXRα-ABCA1/ABCG1 pathway
10.1177/1096620x251380195 · 2025 · External reference
Effects of Xuezhikang in patients with dyslipidemia: A multicenter, randomized, placebo-controlled study
10.1016/j.jacl.2014.09.002 · 2014 · External reference
A simple practice guide for dose conversion between animals and human
10.4103/0976-0105.177703 · 2016 · External reference
Harnessing Lactobacillus-derived SCFAs for food and health: Pathways, genes, and functional implications
2025 · External reference
Dietary patterns to promote cardiometabolic health
10.1038/s41569-024-01061-7 · 2025 · External reference
Therapeutic potential of Sheng-Xian-Tang in doxorubicin-induced chronic heart failure by regulation of phenylalanine metabolism disruption
10.1186/s13020-025-01316-6 · 2026 · External reference
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
10.1038/s41392-024-01756-w · 2024 · External reference
Advances in mitochondrial dysfunction and its role in cardiovascular diseases
10.3390/cells14201621 · 2025 · External reference
Desulfovibrio in the gut: The enemy within?
10.3390/microorganisms11071772 · 2023 · External reference
Gut-heart axis: The role of gut microbiota and metabolites in heart failure
10.1161/circresaha.125.325516 · 2025 · External reference
10.1038/s41467-025-60670-z
10.1038/s41467-025-60670-z · External reference
L-phenylalanine promotes liver steatosis by inhibiting BNIP3-mediated mitophagy
10.1186/s10020-025-01303-5 · 2025 · External reference
Gut microbiota Dysbiosis in patients with biopsy-proven nonalcoholic fatty liver disease: A cross-sectional study in Taiwan
10.3390/nu12030820 · 2020 · External reference
Palmatine protects against atherosclerosis by gut microbiota and phenylalanine metabolism
2024 · External reference
Ganoderma atrum polysaccharide interferes with TLR4 against PD-1 inhibitors-induced carditis via NF-κB-NLRP3 pathway driven by IRF1/VEGFA/14–3-3γ axis in Lewis lung carcinoma mice
10.1016/j.jff.2025.106732 · 2025 · External reference
Hypoglycemic effects of white hyacinth bean polysaccharide on type 2 diabetes mellitus rats involvement with entero-insular axis and GLP-1 via metabolomics study
2024 · External reference
Activity fingerprinting of polysaccharides on oral, gut, pancreas and lung microbiota in diabetic rats
10.1016/j.biopha.2022.113681 · 2022 · External reference
Soybean sprout peptides alleviate obesity via PI3K-Akt and JAK-STAT pathway modulation, gut microbiota regulation, and metabolic reprogramming
10.1021/acs.jafc.5c00695 · 2025 · External reference
The gut microbiota-aromatic amino acid axis in cardiovascular disease: Pathophysiological roles, translational biomarkers, and therapeutic targeting
10.3389/fcvm.2026.1846519 · 2026 · External reference
Solids retention times shift methanogenic ethanol oxidation: Novel insights into metabolic pathways, microbial community dynamics, and energy metabolisms
10.1021/acssuschemeng.1c05535 · 2021 · External reference
Autophagy-driven lipid regulation by an herbal decoction alleviates cardiac lipotoxicity in severe acute pancreatitis
10.7150/thno.117243 · 2025 · External reference
Physicochemical properties, antioxidant and antibacterial capacities of non-starch polysaccharide from Dolichos lablab L
2020 · External reference
Research progress of polysaccharide detection methods in traditional Chinese medicine
10.1016/j.chmed.2026.02.009 · 2026 · External reference
Ziziphus jujuba polysaccharide degradation products exert neuroprotective and anti-aging effects via modulating gut microbiota and metabolomics in C. Elegans
10.1016/j.jff.2026.107213 · 2026 · External reference
Effects of intestinal Desulfovibrio bacteria on host health and its potential regulatory strategies: A review
10.1016/j.micres.2024.127725 · 2024 · External reference
Microbiota-gut-lung axis involvement with lung protection of Houttuynia cordata Thunb. essential oil in vivo, confirmed by 16S rRNA sequencing combined with UPLC-Q-TOF/MS-based serum metabolomics
10.1111/1750-3841.70858 · 2026 · External reference
Quercetin-driven Akkermansia Muciniphila alleviates obesity by modulating bile acid metabolism via an ILA/m(6)a/CYP8B1 signaling
10.1002/advs.202412865 · ExternalCitation · doi-reference
Activity fingerprinting of polysaccharides on oral, gut, pancreas and lung microbiota in diabetic rats
10.1016/j.biopha.2022.113681 · ExternalCitation · doi-reference
Research progress of polysaccharide detection methods in traditional Chinese medicine
10.1016/j.chmed.2026.02.009 · ExternalCitation · doi-reference
Curcumin simultaneously improves mitochondrial dynamics and myocardial cell bioenergy after sepsis via the SIRT1-DRP1/PGC-1α pathway
10.1016/j.heliyon.2024.e28501 · ExternalCitation · doi-reference
Soybean soluble polysaccharide prevents obesity in high-fat diet-induced rats via lipid metabolism regulation
10.1016/j.ijbiomac.2022.10.080 · ExternalCitation · doi-reference
Effects of Xuezhikang in patients with dyslipidemia: A multicenter, randomized, placebo-controlled study
10.1016/j.jacl.2014.09.002 · ExternalCitation · doi-reference
Ganoderma atrum polysaccharide interferes with TLR4 against PD-1 inhibitors-induced carditis via NF-κB-NLRP3 pathway driven by IRF1/VEGFA/14–3-3γ axis in Lewis lung carcinoma mice
10.1016/j.jff.2025.106732 · ExternalCitation · doi-reference
Ziziphus jujuba polysaccharide degradation products exert neuroprotective and anti-aging effects via modulating gut microbiota and metabolomics in C. Elegans
10.1016/j.jff.2026.107213 · ExternalCitation · doi-reference
Auricularia auricula polysaccharides attenuate ventricular remodeling in mice by suppressing oxidative stress and apoptosis via activation of the Keap1/Nrf2/HO-1 pathway
10.1016/j.jff.2026.107342 · ExternalCitation · doi-reference
Effects of intestinal Desulfovibrio bacteria on host health and its potential regulatory strategies: A review
10.1016/j.micres.2024.127725 · ExternalCitation · doi-reference
Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway
10.1016/j.phymed.2023.155285 · ExternalCitation · doi-reference
Soybean sprout peptides alleviate obesity via PI3K-Akt and JAK-STAT pathway modulation, gut microbiota regulation, and metabolic reprogramming
10.1021/acs.jafc.5c00695 · ExternalCitation · doi-reference
Solids retention times shift methanogenic ethanol oxidation: Novel insights into metabolic pathways, microbial community dynamics, and energy metabolisms
10.1021/acssuschemeng.1c05535 · ExternalCitation · doi-reference
Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases
10.1038/s41392-024-01756-w · ExternalCitation · doi-reference
10.1038/s41467-025-60670-z
10.1038/s41467-025-60670-z · ExternalCitation · doi-reference
Dietary patterns to promote cardiometabolic health
10.1038/s41569-024-01061-7 · ExternalCitation · doi-reference
Desulfovibrio vulgaris, a potent acetic acid-producing bacterium, attenuates nonalcoholic fatty liver disease in mice
10.1080/19490976.2021.1930874 · ExternalCitation · doi-reference
Generic diagramming platform (GDP): A comprehensive database of high-quality biomedical graphics
10.1093/nar/gkae973 · ExternalCitation · doi-reference
Microbiota-gut-lung axis involvement with lung protection of Houttuynia cordata Thunb. essential oil in vivo, confirmed by 16S rRNA sequencing combined with UPLC-Q-TOF/MS-based serum metabolomics
10.1111/1750-3841.70858 · ExternalCitation · doi-reference
Decoding the liver-heart axis in cardiometabolic diseases
10.1161/circresaha.125.325492 · ExternalCitation · doi-reference
Gut-heart axis: The role of gut microbiota and metabolites in heart failure
10.1161/circresaha.125.325516 · ExternalCitation · doi-reference
Wild Cordyceps polysaccharides alleviate atherosclerosis by attenuating macrophage cholesterol accumulation through the PPARγ-LXRα-ABCA1/ABCG1 pathway
10.1177/1096620x251380195 · ExternalCitation · doi-reference
L-phenylalanine promotes liver steatosis by inhibiting BNIP3-mediated mitophagy
10.1186/s10020-025-01303-5 · ExternalCitation · doi-reference
Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy
10.1186/s12964-025-02326-5 · ExternalCitation · doi-reference
Therapeutic potential of Sheng-Xian-Tang in doxorubicin-induced chronic heart failure by regulation of phenylalanine metabolism disruption
10.1186/s13020-025-01316-6 · ExternalCitation · doi-reference
Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function
10.1186/s13578-023-00974-z · ExternalCitation · doi-reference
The gut microbiota-aromatic amino acid axis in cardiovascular disease: Pathophysiological roles, translational biomarkers, and therapeutic targeting
10.3389/fcvm.2026.1846519 · ExternalCitation · doi-reference
Lactococcus lactis Subsp. lactis LL-1 and Lacticaseibacillus paracasei LP-16 influence the gut microbiota and metabolites for anti-obesity and Hypolipidemic effects in mice
10.3390/antiox14050547 · ExternalCitation · doi-reference
A natural polyphenol, Chlorogenic acid, attenuates obesity-related metabolic disorders in male rats via miR-146a-IRAK1-TRAF6 and NRF2-mediated antioxidant pathways
10.3390/biom15081086 · ExternalCitation · doi-reference
Advances in mitochondrial dysfunction and its role in cardiovascular diseases
10.3390/cells14201621 · ExternalCitation · doi-reference
Mitochondrial dysfunction in heart failure: From pathophysiological mechanisms to therapeutic opportunities
10.3390/ijms25052667 · ExternalCitation · doi-reference
Sarcosine, Trigonelline and phenylalanine as urinary metabolites related to visceral fat in overweight and obesity
10.3390/metabo14090491 · ExternalCitation · doi-reference
Desulfovibrio in the gut: The enemy within?
10.3390/microorganisms11071772 · ExternalCitation · doi-reference
Gut microbiota Dysbiosis in patients with biopsy-proven nonalcoholic fatty liver disease: A cross-sectional study in Taiwan
10.3390/nu12030820 · ExternalCitation · doi-reference
A simple practice guide for dose conversion between animals and human
10.4103/0976-0105.177703 · ExternalCitation · doi-reference
Autophagy-driven lipid regulation by an herbal decoction alleviates cardiac lipotoxicity in severe acute pancreatitis
10.7150/thno.117243 · ExternalCitation · doi-reference
