Research graph
References from Comorbidity and polypharmacy in elderly cancer patients: The significance on treatment outcome and tolerance. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Entry and evaluation of elderly patients in European Organization for Research and Treatment of Cancer (EORTC) new-drug-development studies
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Representation of older patients in cancer treatment trials
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Treatment tolerance and efficacy in geriatric oncology: a systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groups
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Understanding the attitudes of the elderly towards enrolment into cancer clinical trials
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Aging, frailty, and chemotherapy
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Greater risks of chemotherapy toxicity in elderly patients with cancer
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Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study
10.1200/jco.20.2.494 · 2002 · External reference
Impairment in functional status and survival in patients with acute myeloid leukaemia
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10.1016/j.critrevonc.2008.07.003 · 2008 · External reference
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10.1200/jco.2005.02.527
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A practical approach to geriatric assessment in oncology
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Comprehensive geriatric assessment for older patients with cancer
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Effect of age and comorbidity in postmenopausal breast cancer patients aged 55years and older
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Comorbidity in patients with cancer: prevalence and severity measured by cumulative illness rating scale
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Measurement and impact of comorbidity in older cancer patients
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Comorbidity and functional status are independent in older cancer patients
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Gemcitabine and cisplatin in the treatment of elderly patients with advanced non-small cell lung cancer: impact of comorbidities on safety and efficacy outcome
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Measurement and impact of co-morbidity in elderly patients with advanced non-small cell lung cancer treated with chemotherapy. A phase II study of weekly paclitaxel
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Effects of comorbidity on screening and early diagnosis of cancer in elderly people
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Charlson scores based on ICD-10 administrative data were valid in assessing comorbidity in patients undergoing urological cancer surgery
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Cumulative illness rating scale
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Participation of patients 65years of age or older in cancer clinical trials
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International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency
10.1016/j.ejca.2006.11.004 · 2007 · External reference
Prognostic impact of increasing age and co-morbidity in cancer patients: a population-based approach
10.1016/j.critrevonc.2005.04.008 · 2005 · External reference
Comorbidity and survival of Danish breast cancer patients from 1995 to 2005
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Breast cancer treatment of older women in integrated health care settings
10.1200/jco.2006.06.3065 · 2006 · External reference
The effects of mammographic detection and comorbidity on the survival of older women with breast cancer
10.1046/j.1532-5415.2002.50261.x · 2002 · External reference
Phase 2 trial of docetaxel and gefitinib in the first-line treatment of patients with advanced nonsmall-cell lung cancer (NSCLC) who are 70years of age or older
10.1002/cncr.23360 · 2008 · External reference
Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer
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Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems
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Unresolved reference
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Aging biology and geriatric clinical pharmacology
10.1124/pr.56.2.4 · 2004 · External reference
Unresolved reference
2005 · External reference
Polypharmacy in the older patient with cancer
10.1177/107327489700400505 · 1997 · External reference
Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients
10.1002/cncr.21847 · 2006 · External reference
Polypharmacy and the risk of drug–drug interactions among Danish elderly. A prescription database study
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The consumption of drugs by 75-year-old individuals living in their own homes
10.1007/s002280000157 · 2000 · External reference
Herb and supplement use in the US adult population
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Complementary and alternative medicine among Singapore cancer patients
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Clinically based evidence of drug–herb interactions: a systematic review
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Polypharmacy in older oncology patients and the need for an interdisciplinary approach to side-effect management
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Polypharmacy in hospitalized older adult cancer patients: experience from a prospective, observational study of an oncology-acute care for elders unit
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Medication problems in older, newly diagnosed cancer patients in Canada: how common are they? A prospective pilot study
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Polypharmacy in elderly cancer patients. 2010 ASCO Annual Meeting; June 2010. Chicago, poster
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Drug–drug interactions in oncology: why are they important and can they be minimized?
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Understanding and preventing drug interactions in elderly patients
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Predictors of tolerance to chemotherapy in older cancer patients: a prospective pilot study
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Polypharmacy: the cure becomes the disease
10.1007/bf02600099 · 1993 · External reference
National surveillance of emergency department visits for outpatient adverse drug events
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Drug-induced illness as a cause for admission to a community hospital
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Impact of comorbidity on survival of Danish prostate cancer patients, 1995–2006: a population-based cohort study
10.1016/j.urology.2007.12.018 · 2008 · External reference
Greater influence of age than co-morbidity on primary treatment and complications of prostate cancer patients: an in-depth population-based study
10.1038/sj.pcan.4500868 · 2006 · External reference
Comorbidity and ovarian cancer survival in Denmark, 1995–2005: a population-based cohort study
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Multimorbidity and survival in older persons with colorectal cancer
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Age, severe comorbidity and functional impairment independently contribute to poor survival in cancer patients
10.1007/s00432-007-0233-x · 2007 · External reference
International Society of Geriatric Oncology Chemotherapy Taskforce: evaluation of chemotherapy in older patients—an analysis of the medical literature
10.1200/jco.2007.10.6583 · 2007 · External reference
Patterns of toxicity in older patients with breast cancer receiving adjuvant chemotherapy
10.1007/s10549-005-1410-8 · 2005 · External reference
Improved tolerance of primary chemotherapy with reduced-dose carboplatin and paclitaxel in elderly ovarian cancer patients
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Age and comorbidity as independent prognostic factors in the treatment of non small-cell lung cancer: a review of National Cancer Institute of Canada Clinical Trials Group trials
10.1200/jco.2007.12.8322 · 2008 · External reference
Predictors of treatment failures during chemotherapy: a prospective study on 110 older cancer patients
10.1016/j.archger.2008.01.011 · 2003 · External reference
10.1016/j.ejca.2010.04.009
10.1016/j.ejca.2010.04.009 · External reference
Feasibility, toxicity and quality of life of first-line chemotherapy with platinum/paclitaxel in elderly patients aged >=70years with advanced ovarian cancer—a study by the AGO OVAR Germany
10.1093/annonc/mdl401 · 2007 · External reference
Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial
10.1093/jnci/94.3.173 · 2002 · External reference
Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer
10.1200/jco.2006.06.9039 · 2006 · External reference
First and subsequent cycle use of pegfilgrastim prevents febrile neutropenia in patients with breast cancer: a multicenter, double-blind, placebo-controlled phase III study
10.1200/jco.2005.09.102 · 2005 · External reference
Risk of febrile neutropenia among patients with intermediate-grade non-Hodgkin's lymphoma receiving CHOP chemotherapy
10.1080/1042819031000119262 · 2003 · External reference
Increased myelosuppression during cytostatic treatment and pleural effusion in patients with small cell lung cancer
10.1016/0959-8049(92)90459-f · 1992 · External reference
Dose intensity and hematologic toxicity in older cancer patients receiving systemic chemotherapy
10.1002/cncr.22939 · 2007 · External reference
EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphomas and solid tumours
10.1016/j.ejca.2006.05.002 · 2006 · External reference
2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline
10.1200/jco.2006.06.4451 · 2006 · External reference
NCCN clinical practice guidelines in oncology
2008 · External reference
On behalf of the ESMO Guidelines Working Group: erythropoiesis-stimulating agents in cancer patients: ESMO recommendations for use
10.1093/annonc/mdp161 · 2009 · External reference
Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia
10.1001/jama.299.8.914 · 2008 · External reference
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Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes
10.1038/sj.bjc.6605498 · 2010 · External reference
Epoetin-beta treatment in patients with cancer chemotherapy-induced anaemia: the impact of initial haemoglobin and target haemoglobin levels on survival, tumour progression and thromboembolic events
10.1038/sj.bjc.6605255 · 2009 · External reference
Erythropoietin or Darbepoetin for patients with cancer—meta-analysis based on individual patient data
2009 · External reference
Renal insufficiency in elderly cancer patients: International Society of Geriatric Oncology clinical practice recommendations
10.1093/annonc/mdm011 · 2007 · External reference
Dose adjustment and supportive care before and during treatment
10.1016/j.ctrv.2009.04.009 · 2009 · External reference
Updated clinical practice guidelines for the prevention and treatment of mucositis
10.1002/cncr.22484 · 2007 · External reference
Protection from nausea and vomiting in cisplatin-treated patients: high-dose metoclopramide combined with methylprednisolone versus metoclopramide combined with dexamethasone and diphenhydramine: a study of the Italian Oncology Group for Clinical Research
10.1200/jco.1989.7.11.1693 · 1989 · External reference
Chemotherapy-induced nausea and vomiting in breast cancer patients: a prospective observational study
2007 · External reference
Prevention of chemotherapy- and radiotherapy-induced emesis: results of the 2004 Perugia International Antiemetic Consensus Conference
10.1093/annonc/mdj078 · 2006 · External reference
American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006
10.1200/jco.2006.06.9591 · 2006 · External reference
On behalf of the ESMO Guidelines Working Group: chemotherapy-induced nausea and vomiting: ESMO clinical recommendations for prophylaxis
10.1093/annonc/mdp160 · 2009 · External reference
Prevention of chemotherapy-induced nausea and vomiting in elderly cancer patients
10.1016/j.critrevonc.2008.12.006 · 2009 · External reference
Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
10.1200/jco.2004.07.173 · 2004 · External reference
Relationship between cytochrome 3A activity, inflammatory status and the risk of docetaxel-induced febrile neutropenia: a prospective study
10.1093/annonc/mdl321 · 2007 · External reference
Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia
10.1016/j.ejca.2006.06.017 · 2006 · External reference
Cisplatin-induced long-term hearing impairment is associated with specific glutathione S-transferase genotypes in testicular cancer survivors
10.1200/jco.2006.08.9599 · 2007 · External reference
Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes
10.1200/jco.2002.09.064 · 2002 · External reference
Coprescription of tamoxifen and medications that inhibit CYP2D6
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