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References from p16INK4a: A central player in cellular senescence and a promising aging biomarker in elderly cancer patients. Local targets link to admitted publications; unresolved targets remain external evidence.
Evaluating the older patient with cancer: understanding frailty and the geriatric assessment
10.3322/caac.20059 · 2010 · External reference
Possible acceleration of aging by adjuvant chemotherapy: a cause of early onset frailty?
10.1016/j.mehy.2006.01.045 · 2006 · External reference
Involvement of the INK4a/Arf gene locus in senescence
10.1046/j.1474-9728.2003.00048.x · 2003 · External reference
Ink4a/Arf links senescence and aging
10.1016/j.exger.2004.06.025 · 2004 · External reference
A cell cycle regulator potentially involved in genesis of many tumor types
10.1126/science.8153634 · 1994 · External reference
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
10.1016/0092-8674(95)90214-7 · 1995 · External reference
Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors
10.1016/j.coph.2005.04.009 · 2005 · External reference
INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
10.1080/15216540701488358 · 2007 · External reference
G1 cell-cycle control and cancer
10.1038/nature03094 · 2004 · External reference
CDK inhibitors: positive and negative regulators of G1-phase progression
10.1101/gad.13.12.1501 · 1999 · External reference
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
10.1016/s0092-8674(00)81519-6 · 1999 · External reference
The Arf/p53 pathway in cancer and aging
10.1158/0008-5472.can-07-6851 · 2008 · External reference
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
10.1038/nrc2012 · 2006 · External reference
The serial cultivation of human diploid cell strains
10.1016/0014-4827(61)90192-6 · 1961 · External reference
The signals and pathways activating cellular senescence
10.1016/j.biocel.2004.10.013 · 2005 · External reference
The persistence of senescence
2003 · External reference
DNA damage is able to induce senescence in tumor cells in vitro and in vivo
2002 · External reference
Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
10.1038/sj.onc.1201862 · 1998 · External reference
Contribution of p16(INK4a) to replicative senescence of human fibroblasts
10.1016/j.yexcr.2004.04.035 · 2004 · External reference
p16INK4a as a second effector of the telomere damage pathway
10.4161/cc.4.10.2104 · 2005 · External reference
A DNA damage checkpoint response in telomere-initiated senescence
10.1038/nature02118 · 2003 · External reference
Different telomere damage signaling pathways in human and mouse cells
10.1093/emboj/cdf433 · 2002 · External reference
The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression
10.2152/jmi.51.146 · 2004 · External reference
Oxidative DNA damage and senescence of human diploid fibroblast cells
10.1073/pnas.92.10.4337 · 1995 · External reference
Superoxide dismutase 1 knock-down induces senescence in human fibroblasts
10.1074/jbc.m307146200 · 2003 · External reference
Signaling functions of reactive oxygen species
10.1021/bi9020378 · 2010 · External reference
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I—Effects of proliferative senescence
10.1096/fj.00-0209com · 2000 · External reference
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1
10.1128/mcb.23.1.389-401.2003 · 2003 · External reference
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
10.1046/j.1365-2443.2003.00620.x · 2003 · External reference
The evolution of diverse biological responses to DNA damage: insights from yeast and p53
10.1038/ncb1201-e277 · 2001 · External reference
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
10.1093/emboj/cdf289 · 2002 · External reference
Normal human fibroblasts are resistant to RAS-induced senescence
10.1128/mcb.24.7.2842-2852.2004 · 2004 · External reference
Mitogen-activated protein kinase p38 defines the common senescence-signaling pathway
10.1046/j.1365-2443.2003.00620.x · 2003 · External reference
Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway
10.1016/s0002-9440(10)63736-4 · 2004 · External reference
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
10.1101/gad.310304 · 2004 · External reference
P53 mutant mice that display early ageing-associated phenotypes
10.1038/415045a · 2002 · External reference
The p16INK4a/CDKN2A tumor suppressor and its relatives
1998 · External reference
Cellular senescence in cancer treatment: friend or foe?
10.1172/jci200420784 · 2004 · External reference
Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner
10.1172/jci0216588 · 2002 · External reference
Survival of monocytes and macrophages and their role in health and disease
10.2741/3514 · 2009 · External reference
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
10.1371/journal.pbio.0060301 · 2008 · External reference
Cell-cycle arrest versus cell death in cancer therapy
10.1038/nm0997-1034 · 1997 · External reference
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
10.1073/pnas.211053698 · 2001 · External reference
Reversal of human cellular senescence: roles of the p53 and p16 pathways
10.1093/emboj/cdg417 · 2003 · External reference
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
10.1016/s0092-8674(02)00734-1 · 2002 · External reference
Cellular senescence and organismal aging
10.1016/j.mad.2008.04.001 · 2008 · External reference
Cellular senescence in cancer and aging
10.1016/j.cell.2007.07.003 · 2007 · External reference
Frequency of the Bcl-2/IgH rearrangement in normal individuals: implications for the monitoring of disease in patients with follicular lymphoma
10.1200/jco.2001.19.2.420 · 2001 · External reference
The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease
10.1182/blood.v92.9.3362 · 1998 · External reference
Senescence as an anticancer mechanism
10.1200/jco.2006.10.3101 · 2007 · External reference
Senescence of the human immune system
10.1016/j.jcpa.2009.09.005 · 2010 · External reference
Immunosenescence and cancer
10.1016/j.critrevonc.2010.06.012 · 2010 · External reference
10.1186/1742-4933-5-11 · 2008 · Admitted local publication
Ageing or cancer: a review on the role of caretakers and gatekeepers
10.1016/j.ejca.2007.07.011 · 2007 · External reference
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction
10.1038/ng.871 · 2011 · External reference
Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk
10.1371/journal.pgen.1001233 · 2010 · External reference
9p21 DNA variants associated with coronary artery disease impair interferon-γ signaling response
10.1038/nature09753 · 2011 · External reference
Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging
10.1111/j.1474-9726.2009.00489.x · 2009 · External reference
Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood
10.1111/j.1474-9726.2010.00583.x · 2010 · External reference
A quantitative model for age-dependent expression of the p16INK4a tumor suppressor
10.1073/pnas.0904405106 · 2009 · External reference
p16INK4a is a robust in vivo biomarker of cellular aging in human skin
10.1111/j.1474-9726.2006.00231.x · 2006 · External reference
Bisphosphonates induce senescence in normal human oral keratinocytes
10.1177/0022034511402995 · 2011 · External reference
Biomarkers of aging: from primitive organisms to humans
10.1093/gerona/59.6.b560 · 2004 · External reference
Disentangling the genetic determinants of human aging: biological age as an alternative to the use of survival measures
10.1093/gerona/60.5.574 · 2005 · External reference
Association between telomere length in blood and mortality in people aged 60years or older
10.1016/s0140-6736(03)12384-7 · 2003 · External reference
Telomere length as an indicator of biological aging—the gender effect and relation with pulse pressure and pulse wave velocity
10.1161/01.hyp.37.2.381 · 2001 · External reference
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
10.18632/aging.100007 · 2008 · External reference
Leukocyte telomere length is associated with cognitive performance in healthy women
10.1016/j.neurobiolaging.2008.07.012 · 2010 · External reference
Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease
10.1164/rccm.200809-1398oc · 2009 · External reference
Telomere shortening in chronic obstructive pulmonary disease
10.1016/j.rmed.2008.09.003 · 2009 · External reference
Association of longer telomeres with better health in centenarians
10.1093/gerona/63.8.809 · 2008 · External reference
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study
10.1111/j.1474-9726.2005.00171.x · 2005 · External reference
The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
10.1016/j.neulet.2006.07.055 · 2006 · External reference
Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study
10.1093/gerona/glp061 · 2009 · External reference
Telomere uncapping during in vitro T-lymphocyte senescence
10.1111/j.1474-9726.2008.00448.x · 2009 · External reference
Inflammation, ageing and cancer
10.1016/j.mad.2008.06.003 · 2009 · External reference
Inflammation and immune system alterations in frailty
10.1016/j.cger.2010.08.002 · 2011 · External reference
A meta-analysis of cytokines in Alzheimer's disease
10.1016/j.biopsych.2010.06.012 · 2010 · External reference
Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review
10.1371/journal.pmed.0050078 · 2008 · External reference
Inflammation and the incidence of type 2 diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)
10.2337/dc09-1679 · 2010 · External reference
Cumulative inflammatory load is associated with short leukocyte telomere length in the health, aging and body composition study
10.1371/journal.pone.0019687 · 2011 · External reference
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease
10.1073/pnas.0801457105 · 2008 · External reference
Role of telomere dysfunction in aging and its detection by biomarkers
10.1007/s00109-009-0509-5 · 2009 · External reference
The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease
10.1002/pmic.200800560 · 2009 · External reference
Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies
10.1016/j.mad.2007.12.002 · 2008 · External reference
