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References from Per- and polyfluoroalkyl substances, seminal plasma metabolome, and sperm telomere length and mitochondrial DNA copy number: a cohort study. Local targets link to admitted publications; unresolved targets remain external evidence.
Is telomere length a biomarker of sperm quality? A systematic review and meta-analysis of observational studies
10.1111/andr.13482 · 2024 · External reference
Sperm telomere length as a parameter of sperm quality in normozoospermic men
10.1093/humrep/dew061 · 2016 · External reference
Sperm mitochondrial DNA measures and semen parameters among men undergoing fertility treatment - PubMed
2019 · External reference
Assessing the human health risks of per- and polyfluoroalkyl substances: A need for greater focus on their interactions as mixtures
10.1016/j.jhazmat.2020.124863 · 2021 · External reference
Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts
10.1016/j.tem.2024.07.021 · 2025 · External reference
Sex-specific cellular and molecular mechanisms of PFAS-induced reproductive toxicity
10.1016/j.tox.2026.154535 · 2026 · External reference
Associations of Serum Per- and Polyfluoroalkyl Substances with Genotoxic Biomarkers: New Insights from Cross-Sectional and In Vivo Evidence
10.1021/acs.est.5c02054 · 2025 · External reference
Association of Serum Per- and Polyfluoroalkyl Substances Exposure with Leukocyte Telomere Length in Chinese Middle-Aged and Older Adults: Role of Genetic Susceptibility and Healthy Diet
10.1021/acs.est.5c05958 · 2025 · External reference
Per- and polyfluoroalkyl substances exposure in hexavalent chromium exposed workers and the effects of exposure mixtures on oxidative stress and genomic instability
10.1016/j.envpol.2025.127255 · 2025 · External reference
Accelerated placental aging mediated the association between prenatal exposure to per- and polyfluoroalkyl substances and small-for-gestational age newborns
10.1016/j.ecoenv.2025.118338 · 2025 · External reference
Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones
10.1016/j.envpol.2020.115330 · 2020 · External reference
Biomonitoring PFAAs in blood and semen samples: Investigation of a potential link between PFAAs exposure and semen mobility in China
10.1016/j.envint.2018.01.010 · 2018 · External reference
Profiles of Emerging and Legacy Per-/Polyfluoroalkyl Substances in Matched Serum and Semen Samples: New Implications for Human Semen Quality
10.1289/ehp4431 · 2019 · External reference
Molecular Determinants in Seminal Plasma and Spermatozoa: Nontargeted Metabolomics
10.1007/978-1-0716-4406-5_42 · 2025 · External reference
Non-targeted metabolomics and associations with per- and polyfluoroalkyl substances (PFAS) exposure in humans: A scoping review
10.1016/j.envint.2022.107159 · 2022 · External reference
PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies
10.1007/s40726-023-00269-4 · 2023 · External reference
Hypertension and semen quality among 1381 young men: A cohort study with repeated measurements
10.59717/j.xinn-med.2024.100099 · 2024 · External reference
Association of handgrip strength with semen characteristics: a study with repeated measurements among healthy Chinese men
10.4103/aja20221 · 2022 · External reference
Exogenous Metals Indirectly Affect Human Semen Quality via Immune Cells at Single-Cell Resolution
10.1021/envhealth.5c00082 · 2025 · External reference
Per- and Polyfluoroalkyl Substances in Semen Associated with Repeated Measures of Semen Quality in Healthy Adult Men
10.1021/acs.est.4c10425 · 2025 · External reference
Target Exposome for Characterizing Early Gestational Exposure to Contaminants of Emerging Concern and Association with Gestational Diabetes Mellitus
10.1021/acs.est.3c04492 · 2023 · External reference
Ozone exposure associates with sperm quality indicators: Sperm telomere length as a potential mediating factor
10.1016/j.jhazmat.2023.132292 · 2023 · External reference
Sperm mitochondrial DNA copy number in relation to semen quality: A cross-sectional study of 1164 potential sperm donors
10.1111/1471-0528.17139 · 2022 · External reference
Blood trihalomethane concentrations in relation to sperm mitochondrial DNA copy number and telomere length among 958 healthy men
10.1016/j.envres.2022.114737 · 2023 · External reference
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
10.1006/meth.2001.1262 · 2001 · External reference
Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men
10.1016/j.envint.2019.05.043 · 2019 · External reference
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
10.1038/s41467-022-34537-6 · 2022 · External reference
Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data - PubMed
2019 · External reference
Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals
10.1038/s41467-023-41515-z · 2023 · External reference
Filtering procedures for untargeted LC-MS metabolomics data
10.1186/s12859-019-2871-9 · 2019 · External reference
Unresolved reference
External reference
Defining risk drinking
2011 · External reference
Unresolved reference
2015 · External reference
Blood trihalomethane and urinary haloacetic acid concentrations in relation to hypertension: An observational study among 1162 healthy men
10.1016/j.jhazmat.2024.135411 · 2024 · External reference
Sperm mitochondrial DNA copy number mediates the association between seminal plasma selenium concentrations and semen quality among healthy men
10.1016/j.ecoenv.2023.114532 · 2023 · External reference
Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study
10.1136/bmj-2023-078797 · 2024 · External reference
10.1289/ehp14945
10.1289/ehp14945 · External reference
A Quantile-Based g-Computation Approach to Addressing the Effects of Exposure Mixtures - PubMed
2020 · External reference
Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco
10.1186/s12940-021-00778-z · 2021 · External reference
Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans
10.1093/molehr/gas028 · 2012 · External reference
Effects of arsenic on telomerase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro
10.1093/carcin/bgg141 · 2003 · External reference
Organic Pollutants and Telomere Length: A New Facet of Carcinogenesis
10.1016/j.ebiom.2015.11.046 · 2015 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells
10.1080/15287390490514598 · 2004 · External reference
Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells
10.1093/carcin/bgr109 · 2011 · External reference
A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation
10.1007/s10545-010-9061-2 · 2010 · External reference
Short- and medium-chain fatty acids in energy metabolism: the cellular perspective
10.1194/jlr.r067629 · 2016 · External reference
Carnitine transport and fatty acid oxidation
10.1016/j.bbamcr.2016.01.023 · 2016 · External reference
Substrate specificity of human carnitine acetyltransferase: Implications for fatty acid and branched-chain amino acid metabolism
10.1016/j.bbadis.2013.02.012 · 2013 · External reference
Omega-3 fatty acids and inflammatory processes
10.3390/nu2030355 · 2010 · External reference
Eicosanoid storm in infection and inflammation
10.1038/nri3859 · 2015 · External reference
Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance
10.1016/j.bbalip.2014.08.010 · 2015 · External reference
Mitochondrial TCA cycle metabolites control physiology and disease
10.1038/s41467-019-13668-3 · 2020 · External reference
The multifaceted contributions of mitochondria to cellular metabolism
10.1038/s41556-018-0124-1 · 2018 · External reference
Mitochondria: in sickness and in health
10.1016/j.cell.2012.02.035 · 2012 · External reference
The impact of oxidative DNA damage and stress on telomere homeostasis
10.1016/j.mad.2018.03.013 · 2019 · External reference
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
10.1093/nar/gkm893 · 2007 · External reference
Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature
10.1007/s40572-022-00371-7 · 2022 · External reference
Toxic effects of per- and polyfluoroalkyl substances on sperm: Epidemiological and experimental evidence
2023 · External reference
PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics
10.1055/s-0044-1801363 · 2024 · External reference
The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis
10.1016/j.reprotox.2019.08.005 · 2019 · External reference
Perfluorooctane sulfonate effects on the reproductive axis in adult male rats
10.1016/j.envres.2014.07.006 · 2014 · External reference
Testicular Signaling Is the Potential Target of Perfluorooctanesulfonate-Mediated Subfertility in Male Mice1
10.1095/biolreprod.110.089219 · 2011 · External reference
Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease
10.1677/jme.0.0250001 · 2000 · External reference
Perfluoroalkyl Substances, Sex Hormones, and Insulin-like Growth Factor-1 at 6–9 Years of Age: A Cross-Sectional Analysis within the C8 Health Project
10.1289/ehp.1509869 · 2016 · External reference
Telomeres, sex, reactive oxygen species, and human cardiovascular aging
10.1007/s00109-002-0377-8 · 2002 · External reference
Nitric Oxide Activates Telomerase and Delays Endothelial Cell Senescence
10.1161/01.res.87.7.540 · 2000 · External reference
Gestational PFAS exposure and newborn size: The modifying effect of cord blood fatty acids
10.1016/j.ese.2024.100476 · 2024 · External reference
Targeting Metabolic Diseases: The Role of Nutraceuticals in Modulating Oxidative Stress and Inflammation
10.3390/nu16040507 · 2024 · External reference
Omega-9 fatty acids: potential roles in inflammation and cancer management
10.1186/s43141-022-00329-0 · 2022 · External reference
Determinants of serum half-lives for linear and branched perfluoroalkyl substances after long-term high exposure—A study in Ronneby, Sweden
10.1016/j.envint.2022.107198 · 2022 · External reference
Assessment of the Emerging Threat Posed by Perfluoroalkyl and Polyfluoroalkyl Substances to Male Reproduction in Humans
2021 · External reference
Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
10.1186/s13058-018-0955-5 · 2018 · External reference
Metabolomics in epidemiology: sources of variability in metabolite measurements and implications
10.1158/1055-9965.epi-12-1109 · 2013 · External reference
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
10.1006/meth.2001.1262 · ExternalCitation · doi-reference
Molecular Determinants in Seminal Plasma and Spermatozoa: Nontargeted Metabolomics
10.1007/978-1-0716-4406-5_42 · ExternalCitation · doi-reference
Telomeres, sex, reactive oxygen species, and human cardiovascular aging
10.1007/s00109-002-0377-8 · ExternalCitation · doi-reference
A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation
10.1007/s10545-010-9061-2 · ExternalCitation · doi-reference
Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature
10.1007/s40572-022-00371-7 · ExternalCitation · doi-reference
PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies
10.1007/s40726-023-00269-4 · ExternalCitation · doi-reference
Substrate specificity of human carnitine acetyltransferase: Implications for fatty acid and branched-chain amino acid metabolism
10.1016/j.bbadis.2013.02.012 · ExternalCitation · doi-reference
Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance
10.1016/j.bbalip.2014.08.010 · ExternalCitation · doi-reference
Carnitine transport and fatty acid oxidation
10.1016/j.bbamcr.2016.01.023 · ExternalCitation · doi-reference
Mitochondria: in sickness and in health
10.1016/j.cell.2012.02.035 · ExternalCitation · doi-reference
Organic Pollutants and Telomere Length: A New Facet of Carcinogenesis
10.1016/j.ebiom.2015.11.046 · ExternalCitation · doi-reference
Sperm mitochondrial DNA copy number mediates the association between seminal plasma selenium concentrations and semen quality among healthy men
10.1016/j.ecoenv.2023.114532 · ExternalCitation · doi-reference
Accelerated placental aging mediated the association between prenatal exposure to per- and polyfluoroalkyl substances and small-for-gestational age newborns
10.1016/j.ecoenv.2025.118338 · ExternalCitation · doi-reference
Biomonitoring PFAAs in blood and semen samples: Investigation of a potential link between PFAAs exposure and semen mobility in China
10.1016/j.envint.2018.01.010 · ExternalCitation · doi-reference
Seminal plasma metabolome in relation to semen quality and urinary phthalate metabolites among Chinese adult men
10.1016/j.envint.2019.05.043 · ExternalCitation · doi-reference
Non-targeted metabolomics and associations with per- and polyfluoroalkyl substances (PFAS) exposure in humans: A scoping review
10.1016/j.envint.2022.107159 · ExternalCitation · doi-reference
Determinants of serum half-lives for linear and branched perfluoroalkyl substances after long-term high exposure—A study in Ronneby, Sweden
10.1016/j.envint.2022.107198 · ExternalCitation · doi-reference
Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones
10.1016/j.envpol.2020.115330 · ExternalCitation · doi-reference
Per- and polyfluoroalkyl substances exposure in hexavalent chromium exposed workers and the effects of exposure mixtures on oxidative stress and genomic instability
10.1016/j.envpol.2025.127255 · ExternalCitation · doi-reference
Perfluorooctane sulfonate effects on the reproductive axis in adult male rats
10.1016/j.envres.2014.07.006 · ExternalCitation · doi-reference
Blood trihalomethane concentrations in relation to sperm mitochondrial DNA copy number and telomere length among 958 healthy men
10.1016/j.envres.2022.114737 · ExternalCitation · doi-reference
Gestational PFAS exposure and newborn size: The modifying effect of cord blood fatty acids
10.1016/j.ese.2024.100476 · ExternalCitation · doi-reference
Assessing the human health risks of per- and polyfluoroalkyl substances: A need for greater focus on their interactions as mixtures
10.1016/j.jhazmat.2020.124863 · ExternalCitation · doi-reference
Ozone exposure associates with sperm quality indicators: Sperm telomere length as a potential mediating factor
10.1016/j.jhazmat.2023.132292 · ExternalCitation · doi-reference
Blood trihalomethane and urinary haloacetic acid concentrations in relation to hypertension: An observational study among 1162 healthy men
10.1016/j.jhazmat.2024.135411 · ExternalCitation · doi-reference
The impact of oxidative DNA damage and stress on telomere homeostasis
10.1016/j.mad.2018.03.013 · ExternalCitation · doi-reference
The effects of perfluorooctanoic acid (PFOA) on fetal and adult rat testis
10.1016/j.reprotox.2019.08.005 · ExternalCitation · doi-reference
Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts
10.1016/j.tem.2024.07.021 · ExternalCitation · doi-reference
Sex-specific cellular and molecular mechanisms of PFAS-induced reproductive toxicity
10.1016/j.tox.2026.154535 · ExternalCitation · doi-reference
Target Exposome for Characterizing Early Gestational Exposure to Contaminants of Emerging Concern and Association with Gestational Diabetes Mellitus
10.1021/acs.est.3c04492 · ExternalCitation · doi-reference
Per- and Polyfluoroalkyl Substances in Semen Associated with Repeated Measures of Semen Quality in Healthy Adult Men
10.1021/acs.est.4c10425 · ExternalCitation · doi-reference
Associations of Serum Per- and Polyfluoroalkyl Substances with Genotoxic Biomarkers: New Insights from Cross-Sectional and In Vivo Evidence
10.1021/acs.est.5c02054 · ExternalCitation · doi-reference
Association of Serum Per- and Polyfluoroalkyl Substances Exposure with Leukocyte Telomere Length in Chinese Middle-Aged and Older Adults: Role of Genetic Susceptibility and Healthy Diet
10.1021/acs.est.5c05958 · ExternalCitation · doi-reference
Exogenous Metals Indirectly Affect Human Semen Quality via Immune Cells at Single-Cell Resolution
10.1021/envhealth.5c00082 · ExternalCitation · doi-reference
Eicosanoid storm in infection and inflammation
10.1038/nri3859 · ExternalCitation · doi-reference
Mitochondrial TCA cycle metabolites control physiology and disease
10.1038/s41467-019-13668-3 · ExternalCitation · doi-reference
Metabolite annotation from knowns to unknowns through knowledge-guided multi-layer metabolic networking
10.1038/s41467-022-34537-6 · ExternalCitation · doi-reference
Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals
10.1038/s41467-023-41515-z · ExternalCitation · doi-reference
The multifaceted contributions of mitochondria to cellular metabolism
10.1038/s41556-018-0124-1 · ExternalCitation · doi-reference
PFAS Exposure and Male Reproductive Health: Implications for Sperm Epigenetics
10.1055/s-0044-1801363 · ExternalCitation · doi-reference
2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells
10.1080/15287390490514598 · ExternalCitation · doi-reference
Effects of arsenic on telomerase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro
10.1093/carcin/bgg141 · ExternalCitation · doi-reference
Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells
10.1093/carcin/bgr109 · ExternalCitation · doi-reference
Sperm telomere length as a parameter of sperm quality in normozoospermic men
10.1093/humrep/dew061 · ExternalCitation · doi-reference
Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans
10.1093/molehr/gas028 · ExternalCitation · doi-reference
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
10.1093/nar/gkm893 · ExternalCitation · doi-reference
Testicular Signaling Is the Potential Target of Perfluorooctanesulfonate-Mediated Subfertility in Male Mice1
10.1095/biolreprod.110.089219 · ExternalCitation · doi-reference
Sperm mitochondrial DNA copy number in relation to semen quality: A cross-sectional study of 1164 potential sperm donors
10.1111/1471-0528.17139 · ExternalCitation · doi-reference
Is telomere length a biomarker of sperm quality? A systematic review and meta-analysis of observational studies
10.1111/andr.13482 · ExternalCitation · doi-reference
Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study
10.1136/bmj-2023-078797 · ExternalCitation · doi-reference
Metabolomics in epidemiology: sources of variability in metabolite measurements and implications
10.1158/1055-9965.epi-12-1109 · ExternalCitation · doi-reference
Nitric Oxide Activates Telomerase and Delays Endothelial Cell Senescence
10.1161/01.res.87.7.540 · ExternalCitation · doi-reference
Filtering procedures for untargeted LC-MS metabolomics data
10.1186/s12859-019-2871-9 · ExternalCitation · doi-reference
Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco
10.1186/s12940-021-00778-z · ExternalCitation · doi-reference
Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
10.1186/s13058-018-0955-5 · ExternalCitation · doi-reference
Omega-9 fatty acids: potential roles in inflammation and cancer management
10.1186/s43141-022-00329-0 · ExternalCitation · doi-reference
Short- and medium-chain fatty acids in energy metabolism: the cellular perspective
10.1194/jlr.r067629 · ExternalCitation · doi-reference
Perfluoroalkyl Substances, Sex Hormones, and Insulin-like Growth Factor-1 at 6–9 Years of Age: A Cross-Sectional Analysis within the C8 Health Project
10.1289/ehp.1509869 · ExternalCitation · doi-reference
10.1289/ehp14945
10.1289/ehp14945 · ExternalCitation · doi-reference
Profiles of Emerging and Legacy Per-/Polyfluoroalkyl Substances in Matched Serum and Semen Samples: New Implications for Human Semen Quality
10.1289/ehp4431 · ExternalCitation · doi-reference
Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease
10.1677/jme.0.0250001 · ExternalCitation · doi-reference
Targeting Metabolic Diseases: The Role of Nutraceuticals in Modulating Oxidative Stress and Inflammation
10.3390/nu16040507 · ExternalCitation · doi-reference
Omega-3 fatty acids and inflammatory processes
10.3390/nu2030355 · ExternalCitation · doi-reference
Association of handgrip strength with semen characteristics: a study with repeated measurements among healthy Chinese men
10.4103/aja20221 · ExternalCitation · doi-reference
Hypertension and semen quality among 1381 young men: A cohort study with repeated measurements
10.59717/j.xinn-med.2024.100099 · ExternalCitation · doi-reference
