Research graph
References from Bisphenol A exposure confers resistance to cisplatin in ovarian cancer via ERα-dependent DDIT4-mTOR-AKT signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
PRDX6 prevents NNMT ubiquitination and degradation as a nonenzymatic mechanism to promote ovarian cancer progression
10.1002/advs.202416484 · 2025 · External reference
YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification
10.1016/j.canlet.2024.217064 · 2024 · External reference
Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation
10.7150/thno.104858 · 2025 · External reference
Nanodrugs based on co-delivery strategies to combat cisplatin resistance
10.1016/j.jconrel.2024.04.020 · 2024 · External reference
Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling
10.1186/s11658-021-00271-y · 2021 · External reference
Endocrine-disrupting chemicals and endocrine neoplasia: A forty-year systematic review
10.1016/j.envres.2022.114869 · 2023 · External reference
Food grade plastics and Bisphenol A: Associated risks, toxicity, and bioremediation approaches
10.1016/j.jhazmat.2024.133474 · 2024 · External reference
Exposure to bisphenol A associated with multiple health-related outcomes in humans: An umbrella review of systematic reviews with meta-analyses
2023 · External reference
Multiphase Ozonolysis of Bisphenol A: Chemical Transformations on Surfaces in the Environment
10.1021/acs.est.3c08932 · 2024 · External reference
Oxidative Stress, Endocrine Disturbance, and Immune Interference in Humans Showed Relationships to Serum Bisphenol Concentrations in a Dense Industrial Area
10.1021/acs.est.0c07587 · 2021 · External reference
Exploring the Biological Activity and Mechanism of Xenoestrogens and Phytoestrogens in Cancers: Emerging Methods and Concepts
10.3390/ijms22168798 · 2021 · External reference
Effects of low-dose Bisphenol A on calcium ion influx and on genes of proliferation and differentiation in immortalized human gingival cells in vitro: The role of estrogen receptor beta
10.1016/j.dental.2017.06.011 · 2017 · External reference
Co-exposure to BPA and DEHP enhances susceptibility of mammary tumors via up-regulating Esr1/HDAC6 pathway in female rats
10.1016/j.ecoenv.2021.112453 · 2021 · External reference
Exploring the impact of estrogenic endocrine disruptors on cervical cancer progression: A transcriptome analysis and prognostic model development
10.1016/j.ecoenv.2024.117025 · 2024 · External reference
Bisphenol A drives di(2-ethylhexyl) phthalate promoting thyroid tumorigenesis via regulating HDAC6/PTEN and c-MYC signaling
10.1016/j.jhazmat.2021.127911 · 2022 · External reference
Exploring the carcinogenic potential of bisphenol A in lung adenocarcinoma: molecular mechanisms, key gene insights, and immune microenvironment impacts
2025 · External reference
Exploring the relationships between exposure levels of bisphenols and phthalates and prostate cancer occurrence
10.1016/j.jhazmat.2024.134736 · 2024 · External reference
Low-dose BPA and its substitute BPS promote ovarian cancer cell stemness via a non-canonical PINK1/p53 mitophagic signaling
10.1016/j.jhazmat.2023.131288 · 2023 · External reference
Bisphenols exposure at environmentally relevant dose promoted ovarian cancer progression and modulated tumor microenvironment through β-catenin/SPP1 axis
10.1016/j.jhazmat.2025.137824 · 2025 · External reference
Investigating the potential causal link between BPA and ovarian carcinogenesis: a network toxicology and mendelian randomization study on the CTRC/PRDX1/SKP1 pathway
10.1186/s13048-025-01814-z · 2025 · External reference
A comprehensive overview of ovarian cancer stem cells: correlation with high recurrence rate, underlying mechanisms, and therapeutic opportunities
10.1186/s12943-025-02345-3 · 2025 · External reference
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer
10.1016/j.jconrel.2023.03.017 · 2023 · External reference
The stress-responsive protein REDD1 and its pathophysiological functions
10.1038/s12276-023-01056-3 · 2023 · External reference
Sustained overexpression of Redd1 leads to Akt activation involved in cell survival
10.1016/j.canlet.2013.03.021 · 2013 · External reference
Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway
10.1038/s41419-022-05545-7 · 2023 · External reference
Platinum-resistant ovarian cancer: From mechanisms to treatment strategies
2026 · External reference
Clinical and molecular features of platinum resistance in ovarian cancer
10.1016/j.critrevonc.2024.104434 · 2024 · External reference
AhR and STAT3: A Dangerous Duo in Chemical Carcinogenesis
10.3390/ijms26062744 · 2025 · External reference
Repeated exposure to 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) accelerates ligand-independent activation of estrogen receptors in long-term estradiol-deprived MCF-7 cells
10.1016/j.toxlet.2023.02.008 · 2023 · External reference
Environmental endocrine disruptors and endometrial cancer: a systematic review of epidemiological studies
10.3389/fendo.2026.1719784 · 2026 · External reference
Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women
10.1016/j.envres.2009.04.014 · 2009 · External reference
BPA exposure enhances the metastatic aggression of ovarian cancer through the ERα/AKT/mTOR/HIF-1α signaling axis
10.1016/j.fct.2023.113792 · 2023 · External reference
Bisphenol A Promotes Ovarian Cancer Proliferation and Migration through the HK2/H3K18la/IGF2BP3 Sequential Regulatory Axis
2026 · External reference
Targeting DNA Damage and Repair Machinery via Delivering WEE1 Inhibitor and Platinum (IV) Prodrugs to Stimulate STING Pathway for Maximizing Chemo-Immunotherapy in Bladder Cancer
10.1002/adma.202308762 · 2024 · External reference
Cancer-associated mesothelial cells promote ovarian cancer chemoresistance through paracrine osteopontin signaling
10.1172/jci146186 · 2021 · External reference
NTNG1 Modulates Cisplatin Resistance in Epithelial Ovarian Cancer Cells via the GAS6/AXL/Akt Pathway
10.3389/fcell.2021.652325 · 2021 · External reference
DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance
10.1593/neo.111032 · 2011 · External reference
Bisphenol A-induced cancer-associated adipocytes promotes breast carcinogenesis via CXCL12/AKT signaling
10.1016/j.mce.2025.112473 · 2025 · External reference
Bisphenol A drives thyroid carcinogenesis through oxidative stress-lipid metabolic reprogramming via the PTEN/PI3K/AKT axis: Therapeutic reversal by a curcumin-modified quercetin nanomicelle system
10.1016/j.freeradbiomed.2026.04.025 · 2026 · External reference
Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers
10.1126/sciadv.adq3802 · 2025 · External reference
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway
10.1007/s11427-020-1978-4 · 2021 · External reference
Nutritional Sensor REDD1 in cancer and inflammation: friend or foe?
10.3390/ijms23179686 · 2022 · External reference
Exosomal CCT6A secreted by cancer-associated fibroblasts interacts with β-catenin to enhance chemoresistance and tumorigenesis in gastric cancer
10.1002/advs.202506674 · 2025 · External reference
Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells
10.1016/j.canlet.2014.12.033 · 2015 · External reference
Regulation of mTOR and cell growth in response to energy stress by REDD1
10.1128/mcb.25.14.5834-5845.2005 · 2005 · External reference
Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells
10.1007/s10495-019-01559-3 · 2019 · External reference
Inhibition of REDD1 sensitizes bladder urothelial carcinoma to paclitaxel by inhibiting autophagy
10.1158/1078-0432.ccr-17-0419 · 2018 · External reference
A Key Role of DNA damage-inducible transcript 4 (DDIT4) connects autophagy and GLUT3-mediated stemness to desensitize temozolomide efficacy in glioblastomas
10.1007/s13311-019-00826-0 · 2020 · External reference
REDD1 and p-AKT over-expression may predict poor prognosis in ovarian cancer
2014 · External reference
Low concentrations of bisphenol A promote human ovarian cancer cell proliferation and glycolysis-based metabolism through the estrogen receptor-α pathway
10.1016/j.chemosphere.2017.07.027 · 2017 · External reference
Estrogen- and estrogen receptor (ER)-mediated cisplatin chemoresistance in cancer
10.1016/j.lfs.2021.120029 · 2021 · External reference
Activation of estrogen receptor α by estradiol and cisplatin induces platinum-resistance in ovarian cancer cells
10.1080/15384047.2016.1235656 · 2017 · External reference
ERα-dependent estrogen-TNFα signaling crosstalk increases cisplatin tolerance and migration of lung adenocarcinoma cells
10.1016/j.bbagrm.2021.194715 · 2021 · External reference
Targeting DNA Damage and Repair Machinery via Delivering WEE1 Inhibitor and Platinum (IV) Prodrugs to Stimulate STING Pathway for Maximizing Chemo-Immunotherapy in Bladder Cancer
10.1002/adma.202308762 · ExternalCitation · doi-reference
PRDX6 prevents NNMT ubiquitination and degradation as a nonenzymatic mechanism to promote ovarian cancer progression
10.1002/advs.202416484 · ExternalCitation · doi-reference
Exosomal CCT6A secreted by cancer-associated fibroblasts interacts with β-catenin to enhance chemoresistance and tumorigenesis in gastric cancer
10.1002/advs.202506674 · ExternalCitation · doi-reference
Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells
10.1007/s10495-019-01559-3 · ExternalCitation · doi-reference
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway
10.1007/s11427-020-1978-4 · ExternalCitation · doi-reference
A Key Role of DNA damage-inducible transcript 4 (DDIT4) connects autophagy and GLUT3-mediated stemness to desensitize temozolomide efficacy in glioblastomas
10.1007/s13311-019-00826-0 · ExternalCitation · doi-reference
ERα-dependent estrogen-TNFα signaling crosstalk increases cisplatin tolerance and migration of lung adenocarcinoma cells
10.1016/j.bbagrm.2021.194715 · ExternalCitation · doi-reference
Sustained overexpression of Redd1 leads to Akt activation involved in cell survival
10.1016/j.canlet.2013.03.021 · ExternalCitation · doi-reference
Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells
10.1016/j.canlet.2014.12.033 · ExternalCitation · doi-reference
YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification
10.1016/j.canlet.2024.217064 · ExternalCitation · doi-reference
Low concentrations of bisphenol A promote human ovarian cancer cell proliferation and glycolysis-based metabolism through the estrogen receptor-α pathway
10.1016/j.chemosphere.2017.07.027 · ExternalCitation · doi-reference
Clinical and molecular features of platinum resistance in ovarian cancer
10.1016/j.critrevonc.2024.104434 · ExternalCitation · doi-reference
Effects of low-dose Bisphenol A on calcium ion influx and on genes of proliferation and differentiation in immortalized human gingival cells in vitro: The role of estrogen receptor beta
10.1016/j.dental.2017.06.011 · ExternalCitation · doi-reference
Co-exposure to BPA and DEHP enhances susceptibility of mammary tumors via up-regulating Esr1/HDAC6 pathway in female rats
10.1016/j.ecoenv.2021.112453 · ExternalCitation · doi-reference
Exploring the impact of estrogenic endocrine disruptors on cervical cancer progression: A transcriptome analysis and prognostic model development
10.1016/j.ecoenv.2024.117025 · ExternalCitation · doi-reference
Bisphenol A exposure is associated with oxidative stress and inflammation in postmenopausal women
10.1016/j.envres.2009.04.014 · ExternalCitation · doi-reference
Endocrine-disrupting chemicals and endocrine neoplasia: A forty-year systematic review
10.1016/j.envres.2022.114869 · ExternalCitation · doi-reference
BPA exposure enhances the metastatic aggression of ovarian cancer through the ERα/AKT/mTOR/HIF-1α signaling axis
10.1016/j.fct.2023.113792 · ExternalCitation · doi-reference
Bisphenol A drives thyroid carcinogenesis through oxidative stress-lipid metabolic reprogramming via the PTEN/PI3K/AKT axis: Therapeutic reversal by a curcumin-modified quercetin nanomicelle system
10.1016/j.freeradbiomed.2026.04.025 · ExternalCitation · doi-reference
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer
10.1016/j.jconrel.2023.03.017 · ExternalCitation · doi-reference
Nanodrugs based on co-delivery strategies to combat cisplatin resistance
10.1016/j.jconrel.2024.04.020 · ExternalCitation · doi-reference
Bisphenol A drives di(2-ethylhexyl) phthalate promoting thyroid tumorigenesis via regulating HDAC6/PTEN and c-MYC signaling
10.1016/j.jhazmat.2021.127911 · ExternalCitation · doi-reference
Low-dose BPA and its substitute BPS promote ovarian cancer cell stemness via a non-canonical PINK1/p53 mitophagic signaling
10.1016/j.jhazmat.2023.131288 · ExternalCitation · doi-reference
Food grade plastics and Bisphenol A: Associated risks, toxicity, and bioremediation approaches
10.1016/j.jhazmat.2024.133474 · ExternalCitation · doi-reference
Exploring the relationships between exposure levels of bisphenols and phthalates and prostate cancer occurrence
10.1016/j.jhazmat.2024.134736 · ExternalCitation · doi-reference
Bisphenols exposure at environmentally relevant dose promoted ovarian cancer progression and modulated tumor microenvironment through β-catenin/SPP1 axis
10.1016/j.jhazmat.2025.137824 · ExternalCitation · doi-reference
Estrogen- and estrogen receptor (ER)-mediated cisplatin chemoresistance in cancer
10.1016/j.lfs.2021.120029 · ExternalCitation · doi-reference
Bisphenol A-induced cancer-associated adipocytes promotes breast carcinogenesis via CXCL12/AKT signaling
10.1016/j.mce.2025.112473 · ExternalCitation · doi-reference
Repeated exposure to 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) accelerates ligand-independent activation of estrogen receptors in long-term estradiol-deprived MCF-7 cells
10.1016/j.toxlet.2023.02.008 · ExternalCitation · doi-reference
Oxidative Stress, Endocrine Disturbance, and Immune Interference in Humans Showed Relationships to Serum Bisphenol Concentrations in a Dense Industrial Area
10.1021/acs.est.0c07587 · ExternalCitation · doi-reference
Multiphase Ozonolysis of Bisphenol A: Chemical Transformations on Surfaces in the Environment
10.1021/acs.est.3c08932 · ExternalCitation · doi-reference
The stress-responsive protein REDD1 and its pathophysiological functions
10.1038/s12276-023-01056-3 · ExternalCitation · doi-reference
Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway
10.1038/s41419-022-05545-7 · ExternalCitation · doi-reference
Activation of estrogen receptor α by estradiol and cisplatin induces platinum-resistance in ovarian cancer cells
10.1080/15384047.2016.1235656 · ExternalCitation · doi-reference
Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers
10.1126/sciadv.adq3802 · ExternalCitation · doi-reference
Regulation of mTOR and cell growth in response to energy stress by REDD1
10.1128/mcb.25.14.5834-5845.2005 · ExternalCitation · doi-reference
Inhibition of REDD1 sensitizes bladder urothelial carcinoma to paclitaxel by inhibiting autophagy
10.1158/1078-0432.ccr-17-0419 · ExternalCitation · doi-reference
Cancer-associated mesothelial cells promote ovarian cancer chemoresistance through paracrine osteopontin signaling
10.1172/jci146186 · ExternalCitation · doi-reference
Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling
10.1186/s11658-021-00271-y · ExternalCitation · doi-reference
A comprehensive overview of ovarian cancer stem cells: correlation with high recurrence rate, underlying mechanisms, and therapeutic opportunities
10.1186/s12943-025-02345-3 · ExternalCitation · doi-reference
Investigating the potential causal link between BPA and ovarian carcinogenesis: a network toxicology and mendelian randomization study on the CTRC/PRDX1/SKP1 pathway
10.1186/s13048-025-01814-z · ExternalCitation · doi-reference
DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance
10.1593/neo.111032 · ExternalCitation · doi-reference
NTNG1 Modulates Cisplatin Resistance in Epithelial Ovarian Cancer Cells via the GAS6/AXL/Akt Pathway
10.3389/fcell.2021.652325 · ExternalCitation · doi-reference
Environmental endocrine disruptors and endometrial cancer: a systematic review of epidemiological studies
10.3389/fendo.2026.1719784 · ExternalCitation · doi-reference
Exploring the Biological Activity and Mechanism of Xenoestrogens and Phytoestrogens in Cancers: Emerging Methods and Concepts
10.3390/ijms22168798 · ExternalCitation · doi-reference
Nutritional Sensor REDD1 in cancer and inflammation: friend or foe?
10.3390/ijms23179686 · ExternalCitation · doi-reference
AhR and STAT3: A Dangerous Duo in Chemical Carcinogenesis
10.3390/ijms26062744 · ExternalCitation · doi-reference
Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation
10.7150/thno.104858 · ExternalCitation · doi-reference
