Research graph
References from Zearalenone suppresses pituitary follicle-stimulating hormone synthesis via ALKBH5-YTHDF2-SMAD4 axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Biological detoxification and application of emerging control strategies of zearalenone in food
10.1016/j.foodchem.2025.146170 · 2025 · External reference
Estrogenic and non-estrogenic disruptor effect of zearalenone on male reproduction: a review
10.3390/ijms24021578 · 2023 · External reference
Toxicokinetics of α-zearalenol and its masked form in rats and the comparative biotransformation in liver microsomes from different livestock and humans
10.1016/j.jhazmat.2019.121403 · 2020 · External reference
Zearalenone disrupts the placental function of rats: a possible mechanism causing intrauterine growth restriction
10.1016/j.fct.2020.111698 · 2020 · External reference
Effects of Fusarium mycotoxins on steroid production by porcine granulosa cells
10.1016/j.anireprosci.2007.06.023 · 2008 · External reference
Influence of in vitro exposure to mycotoxin zearalenone and its derivatives on swine sperm quality
10.1016/j.reprotox.2008.04.009 · 2008 · External reference
vitro effect of zearalenone and alpha-zearalenol on boar sperm characteristics and acrosome reaction
10.1111/j.1439-0531.2006.00679.x · 2006 · External reference
Single-cell transcriptomic profiling provides insights into the toxic effects of Zearalenone exposure on primordial follicle assembly
10.7150/thno.58433 · 2021 · External reference
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
10.1073/pnas.0409330102 · 2005 · External reference
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
10.1038/ng0297-201 · 1997 · External reference
Analysis of the testicular phenotype of the follicle-stimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis
10.1210/endo.142.7.8230 · 2001 · External reference
Molecular regulation of follicle-stimulating hormone synthesis, secretion and action
10.1530/jme-17-0308 · 2018 · External reference
The nature of FSH induction by GnRH
10.1016/s1043-2760(02)00614-8 · 2002 · External reference
Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin
10.1038/321779a0 · 1986 · External reference
Acute regulation of murine follicle-stimulating hormone beta subunit transcription by activin A
10.1677/jme.1.01961 · 2006 · External reference
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
10.1093/emboj/17.11.3091 · 1998 · External reference
Zearalenone and alpha-zearalenol inhibit the synthesis and secretion of pig follicle stimulating hormone via the non-classical estrogen membrane receptor GPR30
10.1016/j.mce.2017.08.010 · 2018 · External reference
Post-transcriptional gene regulation by mRNA modifications
10.1038/nrm.2016.132 · 2017 · External reference
The role of m6A modification in the biological functions and diseases
10.1038/s41392-020-00450-x · 2021 · External reference
The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance
10.1158/0008-5472.can-20-4107 · 2021 · External reference
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease
10.1186/s13059-020-02249-z · 2021 · External reference
Delayed puberty-phenotypic diversity, molecular genetic mechanisms, and recent discoveries
10.1210/er.2018-00248 · 2019 · External reference
RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential
10.1186/s13045-022-01224-4 · 2022 · External reference
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
10.1016/j.molcel.2012.10.015 · 2013 · External reference
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells
10.1073/pnas.1717794115 · 2018 · External reference
GnRH-driven FTO-mediated RNA m6A modification promotes gonadotropin synthesis and secretion
10.1186/s12915-024-01905-1 · 2024 · External reference
The effect of acute administration of the mycotoxin zearalenone to female pigs
10.1080/03601238109372255 · 1981 · External reference
Zearalenone depresses lactation capacity through the ROS-mediated PI3K/AKT pathway
10.3390/ani15071050 · 2025 · External reference
Zearalenone exposure induces the apoptosis of porcine granulosa cells and changes long noncoding RNA expression to promote antiapoptosis by activating the JAK2-STAT3 pathway
10.1021/acs.jafc.9b05189 · 2019 · External reference
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells
10.1080/15548627.2020.1720431 · 2021 · External reference
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3
10.1038/s41557-025-02021-5 · 2026 · External reference
m6A RNA methylation modulates autophagy by targeting Map1lc3b in bisphenol A induced Leydig cell dysfunction
10.1016/j.jhazmat.2024.136748 · 2025 · External reference
Zearalenone induces testicular injury via METTL3-mediated dysregulation of m6A modification
10.1021/acs.jafc.5c13221 · 2025 · External reference
FTO mediates bisphenol F-induced blood-testis barrier impairment through regulating ferroptosis via YTHDF1/TfRc and YTHDF2/SLC7A11 signal axis
10.1016/j.envpol.2024.124531 · 2024 · External reference
ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity
10.1186/s11658-022-00404-x · 2022 · External reference
FTO-mediated m6A demethylation regulates GnRH expression in the hypothalamus via the PLCβ3/Ca2+/CAMK signalling pathway
10.1038/s42003-023-05677-2 · 2023 · External reference
FTO regulates testosterone secretion in Leydig cells: insights into the role of m6A modifications and the therapeutic potential of hCG
10.1186/s12958-025-01456-2 · 2025 · External reference
Triclosan inhibits testosterone biosynthesis in adult rats via inducing m6A methylation-mediated autophagy
10.1016/j.envint.2024.108827 · 2024 · External reference
ALKBH5 reduces BMP15 mRNA stability and regulates bovine puberty initiation through an m6A-dependent pathway
10.3390/ijms252111605 · 2024 · External reference
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
10.1038/29814 · 1998 · External reference
Activin A regulates porcine follicle-stimulating hormone beta-subunit transcription via cooperative actions of SMADs and FOXL2
10.1210/en.2010-0605 · 2010 · External reference
N6-methyladenosine-dependent regulation of messenger RNA stability
10.1038/nature12730 · 2014 · External reference
The biological function of m6A reader YTHDF2 and its role in human disease
10.1186/s12935-021-01807-0 · 2021 · External reference
ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer
10.7150/thno.77441 · 2023 · External reference
Mechanisms of deubiquitinase specificity and regulation
10.1146/annurev-biochem-061516-044916 · 2017 · External reference
USP36 promotes tumorigenesis and drug sensitivity of glioblastoma by deubiquitinating and stabilizing ALKBH5
10.1093/neuonc/noac238 · 2023 · External reference
BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression
10.1016/j.apsb.2024.12.037 · 2025 · External reference
Effects of Fusarium mycotoxins on steroid production by porcine granulosa cells
10.1016/j.anireprosci.2007.06.023 · ExternalCitation · doi-reference
BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression
10.1016/j.apsb.2024.12.037 · ExternalCitation · doi-reference
Triclosan inhibits testosterone biosynthesis in adult rats via inducing m6A methylation-mediated autophagy
10.1016/j.envint.2024.108827 · ExternalCitation · doi-reference
FTO mediates bisphenol F-induced blood-testis barrier impairment through regulating ferroptosis via YTHDF1/TfRc and YTHDF2/SLC7A11 signal axis
10.1016/j.envpol.2024.124531 · ExternalCitation · doi-reference
Zearalenone disrupts the placental function of rats: a possible mechanism causing intrauterine growth restriction
10.1016/j.fct.2020.111698 · ExternalCitation · doi-reference
Biological detoxification and application of emerging control strategies of zearalenone in food
10.1016/j.foodchem.2025.146170 · ExternalCitation · doi-reference
Toxicokinetics of α-zearalenol and its masked form in rats and the comparative biotransformation in liver microsomes from different livestock and humans
10.1016/j.jhazmat.2019.121403 · ExternalCitation · doi-reference
m6A RNA methylation modulates autophagy by targeting Map1lc3b in bisphenol A induced Leydig cell dysfunction
10.1016/j.jhazmat.2024.136748 · ExternalCitation · doi-reference
Zearalenone and alpha-zearalenol inhibit the synthesis and secretion of pig follicle stimulating hormone via the non-classical estrogen membrane receptor GPR30
10.1016/j.mce.2017.08.010 · ExternalCitation · doi-reference
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
10.1016/j.molcel.2012.10.015 · ExternalCitation · doi-reference
Influence of in vitro exposure to mycotoxin zearalenone and its derivatives on swine sperm quality
10.1016/j.reprotox.2008.04.009 · ExternalCitation · doi-reference
The nature of FSH induction by GnRH
10.1016/s1043-2760(02)00614-8 · ExternalCitation · doi-reference
Zearalenone induces testicular injury via METTL3-mediated dysregulation of m6A modification
10.1021/acs.jafc.5c13221 · ExternalCitation · doi-reference
Zearalenone exposure induces the apoptosis of porcine granulosa cells and changes long noncoding RNA expression to promote antiapoptosis by activating the JAK2-STAT3 pathway
10.1021/acs.jafc.9b05189 · ExternalCitation · doi-reference
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
10.1038/29814 · ExternalCitation · doi-reference
Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin
10.1038/321779a0 · ExternalCitation · doi-reference
N6-methyladenosine-dependent regulation of messenger RNA stability
10.1038/nature12730 · ExternalCitation · doi-reference
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility
10.1038/ng0297-201 · ExternalCitation · doi-reference
Post-transcriptional gene regulation by mRNA modifications
10.1038/nrm.2016.132 · ExternalCitation · doi-reference
The role of m6A modification in the biological functions and diseases
10.1038/s41392-020-00450-x · ExternalCitation · doi-reference
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3
10.1038/s41557-025-02021-5 · ExternalCitation · doi-reference
FTO-mediated m6A demethylation regulates GnRH expression in the hypothalamus via the PLCβ3/Ca2+/CAMK signalling pathway
10.1038/s42003-023-05677-2 · ExternalCitation · doi-reference
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
10.1073/pnas.0409330102 · ExternalCitation · doi-reference
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells
10.1073/pnas.1717794115 · ExternalCitation · doi-reference
The effect of acute administration of the mycotoxin zearalenone to female pigs
10.1080/03601238109372255 · ExternalCitation · doi-reference
m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells
10.1080/15548627.2020.1720431 · ExternalCitation · doi-reference
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
10.1093/emboj/17.11.3091 · ExternalCitation · doi-reference
USP36 promotes tumorigenesis and drug sensitivity of glioblastoma by deubiquitinating and stabilizing ALKBH5
10.1093/neuonc/noac238 · ExternalCitation · doi-reference
vitro effect of zearalenone and alpha-zearalenol on boar sperm characteristics and acrosome reaction
10.1111/j.1439-0531.2006.00679.x · ExternalCitation · doi-reference
Mechanisms of deubiquitinase specificity and regulation
10.1146/annurev-biochem-061516-044916 · ExternalCitation · doi-reference
The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance
10.1158/0008-5472.can-20-4107 · ExternalCitation · doi-reference
ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity
10.1186/s11658-022-00404-x · ExternalCitation · doi-reference
GnRH-driven FTO-mediated RNA m6A modification promotes gonadotropin synthesis and secretion
10.1186/s12915-024-01905-1 · ExternalCitation · doi-reference
The biological function of m6A reader YTHDF2 and its role in human disease
10.1186/s12935-021-01807-0 · ExternalCitation · doi-reference
FTO regulates testosterone secretion in Leydig cells: insights into the role of m6A modifications and the therapeutic potential of hCG
10.1186/s12958-025-01456-2 · ExternalCitation · doi-reference
RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential
10.1186/s13045-022-01224-4 · ExternalCitation · doi-reference
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease
10.1186/s13059-020-02249-z · ExternalCitation · doi-reference
Activin A regulates porcine follicle-stimulating hormone beta-subunit transcription via cooperative actions of SMADs and FOXL2
10.1210/en.2010-0605 · ExternalCitation · doi-reference
Analysis of the testicular phenotype of the follicle-stimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis
10.1210/endo.142.7.8230 · ExternalCitation · doi-reference
Delayed puberty-phenotypic diversity, molecular genetic mechanisms, and recent discoveries
10.1210/er.2018-00248 · ExternalCitation · doi-reference
Molecular regulation of follicle-stimulating hormone synthesis, secretion and action
10.1530/jme-17-0308 · ExternalCitation · doi-reference
Acute regulation of murine follicle-stimulating hormone beta subunit transcription by activin A
10.1677/jme.1.01961 · ExternalCitation · doi-reference
Zearalenone depresses lactation capacity through the ROS-mediated PI3K/AKT pathway
10.3390/ani15071050 · ExternalCitation · doi-reference
Estrogenic and non-estrogenic disruptor effect of zearalenone on male reproduction: a review
10.3390/ijms24021578 · ExternalCitation · doi-reference
ALKBH5 reduces BMP15 mRNA stability and regulates bovine puberty initiation through an m6A-dependent pathway
10.3390/ijms252111605 · ExternalCitation · doi-reference
Single-cell transcriptomic profiling provides insights into the toxic effects of Zearalenone exposure on primordial follicle assembly
10.7150/thno.58433 · ExternalCitation · doi-reference
ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node metastasis in ovarian cancer
10.7150/thno.77441 · ExternalCitation · doi-reference
