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References from Temporal assessment of spatial and single-cell transcriptomes identifies CD226-NECTIN2 T cell-cholangiocyte interaction in bile duct inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Primary sclerosing cholangitis - a comprehensive review
10.1016/j.jhep.2017.07.022 · 2017 · External reference
Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis: a systematic review
10.1016/j.jhep.2011.10.025 · 2012 · External reference
Current Concepts in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
10.1038/ctg.2015.33 · 2015 · External reference
Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis
10.1111/apt.12581 · 2014 · External reference
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
10.1038/ng.728 · 2011 · External reference
Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis
10.1002/hep.24299 · 2011 · External reference
The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review
10.1055/s-0039-1697617 · 2020 · External reference
Cholangiocyte pathobiology
10.1038/s41575-019-0125-y · 2019 · External reference
Long-term effects of mid-dose ursodeoxycholic acid in primary biliary cirrhosis: a meta-analysis of randomized controlled trials
10.1111/j.1572-0241.2006.00634.x · 2006 · External reference
Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group
10.1056/nejm199405123301903 · 1994 · External reference
Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid
10.1053/j.gastro.2014.12.005 · 2015 · External reference
NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis
10.1084/jem.20051911 · 2006 · External reference
Animal models in primary biliary cirrhosis and primary sclerosing cholangitis
10.1007/s12016-014-8442-y · 2015 · External reference
The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation
10.14814/phy2.13117 · 2017 · External reference
A Novel Pkhd1 Mutation Interacts with the Nonobese Diabetic Genetic Background To Cause Autoimmune Cholangitis
10.4049/jimmunol.1701087 · 2018 · External reference
The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
10.1016/j.jhep.2016.09.020 · 2017 · External reference
DIRECTIVE 2010/63/EU OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 22 September 2010 on the protection of animals used for scientific purposes
2010 · External reference
Unresolved reference
External reference
Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice
10.1111/j.1478-3231.2003.00876.x · 2003 · External reference
Tissue-specific recognition of mouse CD1 molecules
10.4049/jimmunol.160.7.3128 · 1998 · External reference
Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis
10.1002/hep4.2001 · 2022 · External reference
Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver
10.1016/j.isci.2021.103233 · 2021 · External reference
Spatially informed cell-type deconvolution for spatial transcriptomics
10.1038/s41587-022-01273-7 · 2022 · External reference
QuPath: Open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · 2017 · External reference
Single-cell reconstruction of the early maternal-fetal interface in humans
10.1038/s41586-018-0698-6 · 2018 · External reference
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
10.1038/ng.2616 · 2013 · External reference
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs
10.1016/j.jhep.2021.04.055 · 2021 · External reference
Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation
10.1053/j.gastro.2023.11.283 · 2024 · External reference
TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation
10.1038/s41467-023-40755-3 · 2023 · External reference
The biliary epithelium presents antigens to and activates natural killer T cells
10.1002/hep.27840 · 2015 · External reference
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
10.1007/s00125-024-06329-8 · 2025 · External reference
New Treatment Paradigms in Primary Biliary Cholangitis
10.1016/j.cgh.2023.02.005 · 2023 · External reference
Recent Advances in the Management of Primary Sclerosing Cholangitis
10.1016/j.cgh.2023.04.004 · 2023 · External reference
Characterization of animal models for primary sclerosing cholangitis (PSC)
10.1016/j.jhep.2014.02.006 · 2014 · External reference
TLiSA1, a human T lineage-specific activation antigen involved in the differentiation of cytotoxic T lymphocytes and anomalous killer cells from their precursors
10.1084/jem.161.5.1063 · 1985 · External reference
DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes
10.1016/s1074-7613(00)70060-4 · 1996 · External reference
CD226: An Emerging Role in Immunologic Diseases
10.3389/fcell.2020.00564 · 2020 · External reference
Low expression of CD112 is associated with poor overall survival in patients with hepatocellular carcinoma
10.1016/j.humpath.2014.06.001 · 2014 · External reference
Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)
10.1182/blood-2004-09-3548 · 2005 · External reference
Emergence of the CD226 Axis in Cancer Immunotherapy
10.3389/fimmu.2022.914406 · 2022 · External reference
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
10.1038/ng2068 · 2007 · External reference
Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function
10.1093/brain/awv256 · 2015 · External reference
Association between the CTLA-4, CD226, FAS polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis
10.1016/j.humimm.2015.01.023 · 2015 · External reference
Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
10.1084/jem.20030788 · 2003 · External reference
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
10.1126/scitranslmed.abb0036 · 2021 · External reference
