Research graph
References from SETDB1: an epigenetic gatekeeper of antitumor immune organization in HCC. Local targets link to admitted publications; unresolved targets remain external evidence.
Tertiary lymphoid structures improve immunotherapy and survival in melanoma
10.1038/s41586-019-1914-8 · 2020 · External reference
Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma
10.1038/s41590-024-01992-w · 2024 · External reference
Dendritic cells control tertiary lymphoid structure development and maintenance in cancer
10.1126/science.ady1678 · 2026 · External reference
Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
10.1038/s41591-023-02345-0 · 2023 · External reference
CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity
2026 · External reference
The activity of tertiary lymphoid structures in high grade serous ovarian cancer is governed by site, stroma, and cellular interactions
10.1016/j.ccell.2024.09.007 · 2024 · External reference
Setdb1 represses anti-tumor immunity and tertiary lymphoid structures in hepatocellular carcinoma
10.1016/j.jhep.2026.07.007 · 2026 · External reference
SETDB1-Mediated Silencing of Retroelements
10.3390/v12060596 · 2020 · External reference
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions
10.1038/s41556-018-0261-6 · 2019 · External reference
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity
10.1038/s41586-021-03520-4 · 2021 · External reference
The epigenetic regulator SETDB1 as a key component of cancer stem cells and drug resistance in primary liver cancer
10.1007/s13402-025-01157-3 · 2026 · External reference
Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma
10.1158/2326-6066.cir-23-0514 · 2025 · External reference
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements
10.1038/s41586-021-03994-2 · 2021 · External reference
Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells
10.1038/s41467-025-57005-3 · 2025 · External reference
β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma
10.1158/2159-8290.cd-19-0074 · 2019 · External reference
Pan-cancer spatial atlas of tertiary lymphoid structures
10.1126/science.adz2742 · 2026 · External reference
