Research graph
References from Evidence that IL-4/IL-13-Responsive IGFLs Promote Allergic Skin Inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling
10.1016/j.jaci.2015.03.051 · 2015 · External reference
A key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis
10.1126/sciimmunol.aaw2938 · 2020 · External reference
Distinct Roles of IL-4, IL-13, and IL-22 in Human Skin Barrier Dysfunction and Atopic Dermatitis
2025 · External reference
Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment
10.1172/jci.insight.86355 · 2016 · External reference
Interplay between barrier epithelial cells and dendritic cells in allergic sensitization through the lung and the skin
10.1111/imr.12542 · 2017 · External reference
Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies
10.1016/j.jaad.2014.03.023 · 2014 · External reference
IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily
10.1016/j.ygeno.2006.05.012 · 2006 · External reference
Multiple Roles for Cytokines in Atopic Dermatitis: From Pathogenic Mediators to Endotype-Specific Biomarkers to Therapeutic Targets
10.3390/ijms23052684 · 2022 · External reference
Burden of Atopic Dermatitis in Adults and Adolescents: a Systematic Literature Review
10.1007/s13555-022-00819-6 · 2022 · External reference
Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis
10.1016/j.jaci.2012.07.012 · 2012 · External reference
Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin
10.1172/jci.insight.142067 · 2020 · External reference
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation
10.1126/scitranslmed.3005374 · 2013 · External reference
Epidermal PPARgamma Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin
10.3390/ijms22168634 · 2021 · External reference
Dupilumab-Associated Adverse Events During Treatment of Allergic Diseases
10.1007/s12016-022-08934-0 · 2022 · External reference
IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy
10.1073/pnas.1606608113 · 2016 · External reference
Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis
10.1172/jci.insight.124497 · 2019 · External reference
Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1
10.1074/jbc.m111.224626 · 2011 · External reference
IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis
10.1096/fj.202101800r · 2022 · External reference
Spatial transcriptomics combined with single-cell RNA-sequencing unravels the complex inflammatory cell network in atopic dermatitis
10.1111/all.15781 · 2023 · External reference
Atopic dermatitis displays stable and dynamic skin transcriptome signatures
10.1016/j.jaci.2020.06.012 · 2021 · External reference
Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review)
1998 · External reference
The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis
10.3390/jcm11195633 · 2022 · External reference
Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response
10.1016/j.jdermsci.2021.10.001 · 2021 · External reference
Long-term real-world experience of the side effects of dupilumab in 128 patients with atopic dermatitis and related conditions aged 6 years and above: Retrospective chart analysis from a single tertiary care center
10.1111/dth.15415 · 2022 · External reference
Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation
10.1038/mi.2014.109 · 2015 · External reference
JAK inhibitors and the risk of malignancy: a meta-analysis across disease indications
10.1136/ard-2023-224049 · 2023 · External reference
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses
10.1038/nature08901 · 2010 · External reference
Dupilumab for treatment of atopic dermatitis
10.1080/17512433.2018.1449642 · 2018 · External reference
IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation
10.4049/jimmunol.0901860 · 2010 · External reference
Systemic therapy for atopic dermatitis
10.1111/all.12339 · 2014 · External reference
In vivo evidence that ultraviolet B-induced suppression of allergic contact sensitivity is associated with functional inactivation of Th1 cells
1994 · External reference
Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes
10.2340/00015555-2963 · 2018 · External reference
Tralokinumab Treatment of Atopic Dermatitis Induces a Progressive Transcriptomic Response
10.1016/j.jid.2024.12.005 · 2025 · External reference
Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
10.1016/j.jid.2018.12.018 · 2019 · External reference
Insights into molecular mechanisms of contact hypersensitivity gained from gene knockout studies
10.1189/jlb.70.2.185 · 2001 · External reference
Skin-infiltrating basophils promote atopic dermatitis-like inflammation via IL-4 production in mice
10.1111/all.14362 · 2020 · External reference
Lipase M Is Essential for Skin Barrier Function in Mice
10.1111/exd.70133 · 2025 · External reference
Single-cell RNA-seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis
10.1111/jdv.19256 · 2023 · External reference
