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References from Lipid droplet-associated proteins integrate lipid metabolism, cell cycle, and cytoskeletal remodeling in colon cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Driver Gene Mutations and Epigenetics in Colorectal Cancer
10.1097/sla.0000000000003393 · 2020 · External reference
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018 · External reference
Changes in lipids composition and metabolism in colorectal cancer: a review
10.1186/s12944-019-0977-8 · 2019 · External reference
Reprogrammed Lipid Metabolism and the Lipid-Associated Hallmarks of Colorectal Cancer
10.3390/cancers14153714 · 2022 · External reference
Lipid Droplets in Cancer
10.1007/112_2020_51 · 2020 · External reference
Lipid Droplets in Disease
10.3390/cells8090974 · 2019 · External reference
Lipid droplets: a cellular organelle vital in cancer cells
10.1038/s41420-023-01493-z · 2023 · External reference
Expanding Roles for Lipid Droplets
10.1016/j.cub.2015.04.004 · 2015 · External reference
Dynamics and functions of lipid droplets
10.1038/s41580-018-0085-z · 2019 · External reference
Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis
10.1038/modpathol.2009.191 · 2010 · External reference
FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density
10.1074/jbc.m113.470617 · 2013 · External reference
Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity
10.1038/s41389-021-00373-4 · 2021 · External reference
Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels
10.1053/j.gastro.2024.09.011 · 2025 · External reference
Mechanisms of lipid droplet biogenesis
10.1042/bcj20180021 · 2019 · External reference
10.1177/2515256419895688
10.1177/2515256419895688 · External reference
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
10.1073/pnas.95.22.13018 · 1998 · External reference
Hints on ATGL implications in cancer: beyond bioenergetic clues
10.1038/s41419-018-0345-z · 2018 · External reference
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
10.1126/science.1100747 · 2004 · External reference
A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes
10.1016/j.devcel.2017.11.020 · 2018 · External reference
TIMER3: an enhanced resource for tumor immune analysis
10.1093/nar/gkaf388 · 2025 · External reference
Proteomics. Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
FOXO3 Deficiency in Neutrophils Drives Colonic Inflammation and Tumorigenesis
10.3390/ijms24119730 · 2023 · External reference
FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis
10.3390/metabo12030250 · 2022 · External reference
UniProt: the Universal Protein Knowledgebase in 2025
10.1093/nar/gkae1010 · 2025 · External reference
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
10.1096/fj.10-159806 · 2010 · External reference
PNPLA3/adiponutrin functions in lipid droplet formation
10.1111/boc.201200036 · 2013 · External reference
PRR11 is a novel gene implicated in cell cycle progression and lung cancer
10.1016/j.biocel.2012.12.002 · 2013 · External reference
Rho family-associated kinases PAK1 and rock
2003 · External reference
CC3/TIP30 affects DNA damage repair
10.1186/1471-2121-11-23 · 2010 · External reference
Nitidine chloride inhibits G2/M phase by regulating the p53/14-3-3 Sigma/CDK1 axis for hepatocellular carcinoma treatment
10.1016/j.heliyon.2024.e24012 · 2024 · External reference
Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly
10.1083/jcb.134.4.985 · 1996 · External reference
MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion
10.18632/oncotarget.6577 · 2016 · External reference
Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146
10.1074/jbc.m209009200 · 2003 · External reference
LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator
10.3390/cells11233817 · 2022 · External reference
Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis
2021 · External reference
Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6
10.1016/j.bbrc.2015.11.119 · 2016 · External reference
Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
10.1038/s41467-017-02732-5 · 2018 · External reference
Mechanistic roles of mutant p53 governing lipid metabolism
10.1016/j.jbior.2021.100839 · 2022 · External reference
Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer
10.1016/j.cmet.2019.11.010 · 2020 · External reference
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment
10.3389/fonc.2020.577420 · 2020 · External reference
Lipids: Driving Forces in the Underlying Biology of Carcinogenesis
10.1021/acsptsci.5c00170 · 2025 · External reference
ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis
10.3389/fphar.2025.1594419 · 2025 · External reference
Inhibition of CARM1-Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer
2023 · External reference
ACSL family: The regulatory mechanisms and therapeutic implications in cancer
10.1016/j.ejphar.2021.174397 · 2021 · External reference
ACSL3 is an unfavorable prognostic marker in cholangiocarcinoma patients and confers ferroptosis resistance in cholangiocarcinoma cells
10.1038/s41698-024-00783-8 · 2024 · External reference
Inhibition of acyl-CoA synthetase long-chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction
10.1002/1878-0261.13794 · 2025 · External reference
Monounsaturated fatty acids promote cancer radioresistance by inhibiting ferroptosis through ACSL3
10.1038/s41419-025-07516-0 · 2025 · External reference
Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis
10.1016/j.celrep.2016.07.009 · 2016 · External reference
Acyl-CoA synthetase long-chain 3-mediated fatty acid oxidation is required for TGFbeta1-induced epithelial-mesenchymal transition and metastasis of colorectal carcinoma
10.7150/ijbs.69802 · 2022 · External reference
Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy
10.1158/0008-5472.can-05-0120 · 2005 · External reference
Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer
10.1016/j.canlet.2020.06.013 · 2020 · External reference
PNPLA3 I148M and Hepatocellular Carcinoma
10.1111/liv.70051 · 2025 · External reference
PNPLA3 Gene Polymorphism and Liver- and Extrahepatic Cancer-Related Mortality in the United States
10.1016/j.cgh.2020.04.058 · 2021 · External reference
Lipid droplets: platforms with multiple functions in cancer hallmarks
10.1038/s41419-020-2297-3 · 2020 · External reference
Intestinal inflammation requires FOXO3 and Prostaglandin E2 dependent lipogenesis and elevated lipid droplets
10.1152/ajpgi.00407.2015 · 2016 · External reference
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance
10.1038/s41467-023-44412-7 · 2024 · External reference
Cancer radioresistance is characterized by a differential lipid droplet content along the cell cycle
10.1186/s13008-024-00116-y · 2024 · External reference
Characterization of lipid droplet metabolism patterns identified prognosis and tumor microenvironment infiltration in gastric cancer
2022 · External reference
PRR11 Promotes Proliferation and Migration of Colorectal Cancer through Activating the EGFR/ERK/AKT Pathway via Increasing CTHRC1
2022 · External reference
Cdc42-mediated supracellular cytoskeleton induced cancer cell migration under low shear stress
10.1016/j.bbrc.2019.08.149 · 2019 · External reference
Stratifin (SFN) Regulates Cervical Cancer Cell Proliferation, Apoptosis, and Cytoskeletal Remodeling and Metastasis Progression Through LIMK2/Cofilin Signaling
10.1007/s12033-023-00946-1 · 2024 · External reference
Impact of stratifin/14-3-3sigma on survival and interstitial lung disease in patients with non-small cell lung cancer receiving immune checkpoint inhibitors
10.1007/s00262-025-04093-1 · 2025 · External reference
Correction: Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer
10.1038/s41388-025-03555-1 · 2025 · External reference
A sterol-PI(4)P exchanger modulates the Tel1/ATM axis of the DNA damage response
10.15252/embj.2022112684 · 2023 · External reference
Regulation of Cell Adhesion and Migration via Microtubule Cytoskeleton Organization, Cell Polarity, and Phosphoinositide Signaling
10.3390/biom13101430 · 2023 · External reference
Proteomic Characterization of Cytoplasmic Lipid Droplets in Human Metastatic Breast Cancer Cells
10.3389/fonc.2021.576326 · 2021 · External reference
Role of desmosomal components in the initiation and metastasis of oral cancer-A review
10.4103/jomfp.jomfp_8_23 · 2023 · External reference
MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/beta-catenin signaling pathway
10.1186/s12964-022-00952-x · 2022 · External reference
LASP1 induces colorectal cancer proliferation and invasiveness through Hippo signaling and Nanog mediated EMT
2020 · External reference
LIMK/cofilin pathway and Slingshot are implicated in human colorectal cancer progression and chemoresistance
10.1007/s00428-018-2298-0 · 2018 · External reference
