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References from Tandem–Affinity Crosslinking Mass Spectrometry Supports a Model of a DNA–PKcs–PP6 Regulatory Complex. Local targets link to admitted publications; unresolved targets remain external evidence.
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Unresolved reference
External reference
IHMValidation: Assessment of Integrative Structure Models Deposited to the Protein Data Bank
2025 · External reference
Advances in integrative structural biology: Towards understanding protein complexes in their cellular context
10.1016/j.csbj.2020.11.052 · 2021 · External reference
Structure and mechanism in non-homologous end joining
10.1016/j.dnarep.2023.103547 · 2023 · External reference
How to fix DNA breaks: new insights into the mechanism of non-homologous end joining
10.1042/bst20220741 · 2023 · External reference
10.1126/sciadv.adg2838
10.1126/sciadv.adg2838 · External reference
The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex
10.1016/j.str.2020.12.006 · 2021 · External reference
Purification of DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) from HeLa Cells
10.1007/978-1-0716-2063-2_14 · 2022 · External reference
DNA-PK interacts with cyclic dinucleotides and inhibits type I interferon responses
10.1084/jem.20251796 · 2026 · External reference
DNA-PK participates in pre-rRNA biogenesis independent of DNA double-strand break repair
10.1093/nar/gkae316 · 2024 · External reference
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
10.1038/s41586-020-2041-2 · 2020 · External reference
The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer
10.1172/jci169200 · 2023 · External reference
PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA
10.1038/s41419-022-04852-3 · 2022 · External reference
DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia
10.1242/jcs.261931 · 2024 · External reference
DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells
10.1016/j.jbc.2021.101209 · 2021 · External reference
A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer
10.1158/1078-0432.ccr-21-1846 · 2022 · External reference
DNA-PKcs, a player winding and dancing with RNA metabolism and diseases
10.1186/s11658-025-00703-z · 2025 · External reference
High-Efficiency Enrichment by Saturating Nanoliters of Protein Affinity Media
10.1021/acs.analchem.3c01736 · 2023 · External reference
The multiple functions of protein phosphatase 6
10.1016/j.bbamcr.2018.07.015 · 2019 · External reference
Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae
10.1073/pnas.95.11.6245 · 1998 · External reference
A protein kinase-phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells
10.1073/pnas.0910601106 · 2009 · External reference
Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation
10.1016/j.celrep.2015.03.052 · 2015 · External reference
10.1126/scisignal.aab3138
10.1126/scisignal.aab3138 · External reference
PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase
10.1074/jbc.m111.333708 · 2012 · External reference
Analysis of protein complexes using mass spectrometry
10.1038/nrm2208 · 2007 · External reference
Affinity-Purification Combined with Crosslinking Mass Spectrometry for Identification and Structural Modeling of Host-Pathogen Protein-Protein Complexes
10.1007/978-1-0716-3243-7_12 · 2023 · External reference
Mass spectrometric detection of affinity purified crosslinked peptides
10.1016/j.jasms.2004.02.008 · 2004 · External reference
Leveraging crosslinking mass spectrometry in structural and cell biology
10.1016/j.str.2021.11.007 · 2022 · External reference
A strategy for dissecting the architectures of native macromolecular assemblies
10.1038/nmeth.3617 · 2015 · External reference
Mapping protein-protein interactions by mass spectrometry
10.1002/mas.21887 · 2026 · External reference
Subcellular Interactomes Revealed by Merging APEX with Cross-Linking Mass Spectrometry
10.1021/acs.analchem.2c02116 · 2022 · External reference
Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2
10.1073/pnas.2103554118 · 2021 · External reference
10.7554/elife.87086
10.7554/elife.87086 · External reference
Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6
10.1371/journal.pone.0004395 · 2009 · External reference
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX
10.1128/mcb.00741-09 · 2010 · External reference
Cross-linking immunoprecipitation-MS (xIP-MS): Topological Analysis of Chromatin-associated Protein Complexes Using Single Affinity Purification
10.1074/mcp.m115.053082 · 2016 · External reference
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
10.1128/mcb.23.16.5836-5848.2003 · 2003 · External reference
Reliable identification of protein-protein interactions by crosslinking mass spectrometry
10.1038/s41467-021-23666-z · 2021 · External reference
Distance restraints from crosslinking mass spectrometry: mining a molecular dynamics simulation database to evaluate lysine-lysine distances
10.1002/pro.2458 · 2014 · External reference
Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM
10.1016/j.pbiomolbio.2020.09.003 · 2021 · External reference
Cross-linking mass spectrometry for mapping protein complex topologies in situ
10.1042/ebc20220168 · 2023 · External reference
Signal Attrition in Whole Cell Cross-Linking Mass Spectrometry
10.1021/acs.analchem.5c06462 · 2026 · External reference
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryo-electron microscopy
10.1016/j.molcel.2026.06.032 · 2026 · External reference
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
10.1126/science.aak9654 · 2017 · External reference
Structural basis of long-range to short-range synaptic transition in NHEJ
10.1038/s41586-021-03458-7 · 2021 · External reference
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair
10.1016/j.molcel.2021.07.005 · 2021 · External reference
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
10.1083/jcb.201008106 · 2010 · External reference
PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size
10.1083/jcb.202205117 · 2023 · External reference
Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining
10.1016/j.molcel.2023.01.012 · 2023 · External reference
An immobilized antibody-based affinity grid strategy for on-grid purification of target proteins enables high-resolution cryo-EM
10.1038/s42003-024-06406-z · 2024 · External reference
A 3D-printed flow-cell for on-grid purification of electron microscopy samples directly from lysate
10.1016/j.jsb.2023.107999 · 2023 · External reference
A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides
10.1038/s41467-019-11337-z · 2019 · External reference
Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries
10.1016/j.bmcl.2004.09.060 · 2004 · External reference