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References from Anti-TGF-β improves bone architecture without detectable restoration of cortical bone lamellar nanomechanical organization in Col1a1+/− osteogenesis imperfecta. Local targets link to admitted publications; unresolved targets remain external evidence.
Structure–mechanics relationships of collagen fibrils in the osteogenesis imperfecta mouse model
10.1098/rsif.2015.0701 · 2015 · External reference
Tensile yield strain of human cortical bone from the femoral diaphysis is constant among healthy adults and across the anatomical quadrants
10.3390/bioengineering11040395 · 2024 · External reference
TGF- regulates the mechanical properties and composition of bone matrix
10.1073/pnas.0507417102 · 2005 · External reference
Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization, misaligned mineral crystals, and altered osteoblast differentiation
10.1038/s41413-026-00531-7 · 2026 · External reference
Multi-scale analysis of bone chemistry, morphology and mechanics in the oim model of osteogenesis imperfecta
10.3109/03008207.2014.923860 · 2014 · External reference
Digital volume correlation : three-dimensional strain mapping using X-ray tomography
10.1007/bf02323555 · 1999 · External reference
Correlations between bone mechanical properties and bone composition parameters in mouse models of dominant and recessive osteogenesis imperfecta and the response to Anti‐TGF‐β treatment
10.1002/jbmr.2997 · 2017 · External reference
Advancements in composition and structural characterization of bone to inform mechanical outcomes and modeling
10.1016/j.cobme.2019.09.011 · 2019 · External reference
Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
10.1002/jbmr.141 · 2010 · External reference
Anti-TGF-β treatment shows increased bone mass and strength in a novel mouse model for osteogenesis imperfecta type I
10.1093/jbmr/zjaf068 · 2025 · External reference
The material basis for reduced mechanical properties in oim mice bones
10.1359/jbmr.1999.14.2.264 · 1999 · External reference
How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone
10.1002/jbmr.2172 · 2014 · External reference
Structural and mechanical differences between collagen Homo- and heterotrimers: relevance for the molecular origin of brittle bone disease
10.1016/j.bpj.2011.11.3999 · 2012 · External reference
BoneJ: free and extensible bone image analysis in ImageJ
10.1016/j.bone.2010.08.023 · 2010 · External reference
Computing local thickness of 3D structures with ImageJ
10.1017/s1431927607074430 · 2007 · External reference
Osteonal lamellae elementary units: lamellar microstructure, curvature and mechanical properties
10.1016/j.actbio.2012.11.032 · 2013 · External reference
Mechanical characterization of Col1a1 osteogenesis imperfecta bone revealed altered mechanical stiffness heterogeneity across scales
2025 · External reference
The microstructure of metastatic bone lesions suggests tumor mediated alterations in bone mineralization
10.1016/j.bone.2025.117625 · 2025 · External reference
Fracture rates and fracture sites in patients with osteogenesis imperfecta: a nationwide register-based cohort study
10.1002/jbmr.2920 · 2017 · External reference
Bone mass and mineralization in osteogenesis imperfecta
10.1007/s10354-015-0369-2 · 2015 · External reference
Mineral particle size in children with osteogenesis imperfecta type I is not increased independently of specific collagen mutations
10.1016/j.bone.2013.11.023 · 2014 · External reference
Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils
10.1098/rsif.2016.0088 · 2016 · External reference
Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta
10.1038/nm.3544 · 2014 · External reference
Excessive TGFβ signaling is a common mechanism in Osteogenesis Imperfecta
10.1038/nm.3544 · 2014 · External reference
Age-related changes in human trabecular bone: relationship between microstructural stress and strain and damage morphology
10.1016/j.jbiomech.2011.05.034 · 2011 · External reference
Inhibition of TGF‐β increases bone volume and strength in a mouse model of osteogenesis imperfecta
10.1002/jbm4.10530 · 2021 · External reference
Bone microstructural and strength changes over 1 year in children with osteogenesis imperfecta are comparable to age- and sex-matched healthy controls
2025 · External reference
Tensile mechanical properties of dry cortical bone extracellular matrix: a comparison among two osteogenesis imperfecta and one healthy control Iliac crest biopsies
10.1002/jbm4.10826 · 2023 · External reference
Osteogenesis imperfecta: mechanisms and signaling pathways connecting classical and rare OI types
10.1210/endrev/bnab017 · 2022 · External reference
Bone structure assessed by HR-pQCT, TBS and DXL in adult patients with different types of osteogenesis imperfecta
10.1007/s00198-015-3156-4 · 2015 · External reference
Osteogenesis imperfecta murine: interaction between type I collagen homotrimers
10.1006/jmbi.2001.4682 · 2001 · External reference
Collagen piezoelectricity in osteogenesis imperfecta and its role in intrafibrillar mineralization
2022 · External reference
Studies of chain substitution caused sub-fibril level differences in stiffness and ultrastructure of wildtype and oim/oim collagen fibers using multifrequency-AFM and molecular modeling
10.1016/j.biomaterials.2016.08.038 · 2016 · External reference
Genetic causes and mechanisms of osteogenesis imperfecta
10.1016/j.bone.2017.02.004 · 2017 · External reference
Biomechanics and mechanobiology of the bone matrix
10.1038/s41413-022-00223-y · 2022 · External reference
Intrafibrillar mineralization deficiency and osteogenesis Imperfecta mouse bone fragility
10.1016/j.jmbbm.2021.104377 · 2021 · External reference
Abnormal mineral-matrix interactions are a significant contributor to fragility in oim/oim bone
10.1007/s00223-007-9045-x · 2007 · External reference
Differential effects of alendronate treatment on bone from growing osteogenesis imperfecta and wild-type mouse
10.1016/j.bone.2004.10.006 · 2005 · External reference
Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis Imperfecta
10.1016/j.bone.2025.117641 · 2026 · External reference
Bone mechanical properties in healthy and diseased states
10.1146/annurev-bioeng-062117-121139 · 2018 · External reference
Trabecular bone microdamage and microstructural stresses under uniaxial compression
10.1016/j.jbiomech.2004.05.013 · 2005 · External reference
Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions
10.1016/8756-3282(93)90245-6 · 1993 · External reference
Toughening materials: enhancing resistance to fracture
10.1098/rsta.2020.0437 · 2021 · External reference
Targeting TGF-β for treatment of osteogenesis imperfecta
10.1172/jci152571 · 2022 · External reference
Quantifying the relation between aging-related trabecular bone microstructure and mechanical properties with digital volume correlation approach
10.1016/j.eml.2024.102265 · 2024 · External reference
Multi-scale investigation of orientation-dependent mechanical properties and fracture propagation in cortical bone using digital volume correlation and atomic force microscopy
10.1016/j.eml.2025.102338 · 2025 · External reference
Effect of Anti-TGF-β treatment in a mouse model of severe osteogenesis imperfecta
10.1002/jbmr.3617 · 2019 · External reference
Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failure
10.1073/pnas.1520539113 · 2016 · External reference
Ultrastructural studies of bones from patients with osteogenesis imperfecta
10.1016/0945-053x(94)90200-3 · 1994 · External reference
Fragility of bone material controlled by internal interfaces, calcif
10.1007/s00223-015-9978-4 · 2015 · External reference
Osteoclast regulation of osteoblasts via RANK-RANKL reverse signal transduction in vitro
2017 · External reference
Microstructure and mechanical behaviors of tibia for collagen-induced arthritic mice treated with gingiva-derived mesenchymal stem cells
10.1016/j.jmbbm.2021.104719 · 2021 · External reference
3D full-field strain in bone-implant and bone-tooth constructs and their morphological influential factors
10.1016/j.jmbbm.2020.103858 · 2020 · External reference
3D full-field biomechanical testing of a glenoid before and after implant placement
10.1016/j.eml.2019.100614 · 2020 · External reference
Elastic modulus mapping for bovine cortical bone from submillimeter- to submicron-scales using PeakForce Tapping atomic force microscopy
10.1016/j.eml.2020.101031 · 2020 · External reference
Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales
10.1073/pnas.1107966108 · 2011 · External reference
Experimentally determined microcracking around a circular hole in a flat plate of bone: comparison with predicted stresses
10.1098/rstb.1995.0031 · 1995 · External reference