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References from Oncolytic Viruses: A New Weapon to Fight Cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
1996 · External reference
Rabdoviridae: the viruses and their replication
1996 · External reference
Picornaviridae: the viruses and their replication
1996 · External reference
Paramyxoviridae: the viruses and their replication
1996 · External reference
Herpes simplex viruses and their replication
1996 · External reference
Adenoviridae: the viruses and their replication
1996 · External reference
A new class of fusion-associated small transmembrane (FAST) proteins encoded by the non-enveloped fusogenic reoviruses
10.1093/emboj/19.5.902 · 2000 · External reference
The S4 genome segment of baboon reovirus is bicistronic and encodes a novel fusion-associated small transmembrane protein
10.1128/jvi.76.5.2131-2140.2002 · 2002 · External reference
Reptilian reovirus: a new fusogenic orthoreovirus species
10.1016/j.virol.2003.10.025 · 2004 · External reference
Extensive sequence divergence and phylogenetic relationships between the fusogenic and nonfusogenic orthoreoviruses: a species proposal
10.1006/viro.1999.9832 · 1999 · External reference
To replicate or not to replicate: achieving selective oncolytic virus replication in cancer cells through translational control
10.1038/sj.onc.1209053 · 2005 · External reference
History of oncolytic viruses: genesis to genetic engineering
10.1038/sj.mt.6300108 · 2007 · External reference
Oncolytic viruses in cancer therapy
10.1016/j.canlet.2007.02.002 · 2007 · External reference
Getting oncolytic virus therapies off the ground
10.1016/s1535-6108(03)00170-3 · 2003 · External reference
The influence of complicating diseases upon leukemia
10.1097/00000441-190412740-00001 · 1996 · External reference
Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress
10.1038/ncponc0736 · 2007 · External reference
Regression of Burkitt's lymphoma in association with measles infection
10.1016/s0140-6736(71)92086-1 · 1971 · External reference
Viruses in the treatment of cancer
10.1016/s0140-6736(71)92788-7 · 1971 · External reference
Studies on the use of viruses in the treatment of carcinoma of the cervix
10.1002/1097-0142(195611/12)9:6<1211::aid-cncr2820090624>3.0.co;2-7 · 1956 · External reference
Treatment of human cancer with mumps virus
10.1002/1097-0142(197412)34:6<1907::aid-cncr2820340609>3.0.co;2-4 · 1974 · External reference
Present status of oncolytic virus studies
10.1111/j.2164-0947.1960.tb00739.x · 1960 · External reference
Recent progress in the battle between oncolytic viruses and tumours
10.1038/nrc1750 · 2005 · External reference
Naturally oncolytic viruses
2006 · External reference
RNA viruses as virotherapy agents
10.1038/sj.cgt.7700535 · 2002 · External reference
Viruses as anticancer drugs
10.1016/j.tips.2007.05.005 · 2007 · External reference
Progressive development of viral therapy of human cancers-a personal narrative account
2005 · External reference
Unresolved reference
External reference
An adenovirus mutant that replicates selectively in p53-deficient human tumour cells
10.1126/science.274.5286.373 · 1996 · External reference
Exploiting tumour-specific defects in the interferon pathway with a previously unknown oncolytic virus
10.1038/77558 · 2000 · External reference
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB
10.1093/emboj/16.2.406 · 1997 · External reference
TIR, CARD and PYRIN: three domains for an antimicrobial triad
10.1038/sj.cdd.4401890 · 2006 · External reference
Antiviral innate immunity pathways
10.1038/sj.cr.7310019 · 2006 · External reference
TLR3 in antiviral immunity: key player or bystander?
10.1016/j.it.2005.07.002 · 2005 · External reference
VSV-tumour selective replication and protein translation
10.1038/sj.onc.1209042 · 2005 · External reference
Reoviruses and the interferon system
1998 · External reference
The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon
10.1128/jvi.65.9.5102-5104.1991 · 1991 · External reference
Reovirus induction of and sensitivity to beta interferon in cardiac myocyte cultures correlate with induction of myocarditis and are determined by viral core proteins
10.1128/jvi.72.2.1314-1323.1998 · 1998 · External reference
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents
10.1016/s1535-6108(03)00241-1 · 2003 · External reference
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
10.1126/science.275.5304.1320 · 1997 · External reference
Genetic replacement of the adenovirus shaft fiber reduces liver tropism in ovarian cancer gene therapy
10.1089/10430340460745829 · 2004 · External reference
Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells
10.1002/jgm.543 · 2004 · External reference
Cancer genes and the pathways they control
10.1038/nm1087 · 2004 · External reference
Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumour selectivity
10.1016/j.ccr.2004.11.012 · 2004 · External reference
Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene
1994 · External reference
The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34
10.1128/jvi.71.12.9442-9449.1997 · 1997 · External reference
Development of transcriptionally regulated oncolytic adenoviruses
10.1038/sj.onc.1209048 · 2005 · External reference
A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer
10.1016/j.ymthe.2006.02.011 · 2006 · External reference
Beyond oncolytic virotherapy: replication-competent retrovirus vectors for selective and stable transduction of tumours
10.2174/156652305774964659 · 2005 · External reference
Viruses—seeking and destroying the tumour program
10.1038/sj.onc.1209047 · 2005 · External reference
The adenovirus death protein (E3–11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells
10.1128/jvi.70.4.2296-2306.1996 · 1996 · External reference
The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis
10.1128/jvi.72.9.7144-7153.1998 · 1998 · External reference
Newcastle disease virus as an antineoplastic agent: induction of tumour necrosis factor-alpha and augmentation of its cytotoxicity
10.1093/jnci/80.16.1305 · 1988 · External reference
The “bystander effect”: tumour regression when a fraction of the tumour mass is genetically modified
1993 · External reference
Oncolytic viruses: what's next?
10.2174/156800907780058844 · 2007 · External reference
Oncolytic viral therapies - the clinical experience
10.1038/sj.onc.1209037 · 2005 · External reference
Tumour chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy
1986 · External reference
VEGF-specific short hairpin RNA-expressing oncolytic adenovirus elicits potent inhibition of angiogenesis and tumour growth
10.1038/sj.mt.6300023 · 2007 · External reference
Cancer: mixing cocktails
10.1038/449993a · 2007 · External reference
Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer
2003 · External reference
ReVOLT: radiation-enhanced viral oncolytic therapy
10.1016/j.ijrobp.2006.06.034 · 2006 · External reference
Image-guided radioiodide therapy of medullary thyroid cancer after carcinoembryonic antigen promoter-targeted sodium iodide symporter gene expression
10.1089/hum.2007.081 · 2007 · External reference
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging
10.1016/j.ymthe.2006.08.008 · 2006 · External reference
Oncolytic virus therapy of multiple tumours in the brain requires suppression of innate and elicited antiviral responses
10.1038/11320 · 1999 · External reference
Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis
10.1038/sj.gt.3302143 · 2004 · External reference
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
10.1073/pnas.0605496103 · 2006 · External reference
New biological therapeutics: competitors or collaborators of viral therapy for human cancers
2005 · External reference
A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumourally to patients with recurrent head and neck cancer
2000 · External reference
China approves world's first oncolytic virus therapy for cancer treatment
10.1093/jnci/djj111 · 2006 · External reference
A phase I clinical trial evaluating intralesional Reolysin (reovirus) in histologically confirmed malignancies
2007 · External reference
MTH-68/H oncolytic viral treatment in human high-grade gliomas
10.1023/b:neon.0000021735.85511.05 · 2004 · External reference
Unresolved reference
External reference
Future prospects for oncolytic therapy
10.1038/sj.onc.1209064 · 2005 · External reference
a controlled trial of intratumoural ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
10.1038/78638 · 2000 · External reference
Regulatory aspects of oncolytic virus products
10.2174/156800907780058790 · 2007 · External reference
Meeting product development challenges in manufacturing clinical grade oncolytic adenoviruses
10.1038/sj.onc.1209045 · 2005 · External reference
Striking out at disseminated metastases: the systemic delivery of oncolytic viruses
2006 · External reference
Liver bypass significantly increases the transduction efficiency of recombinant adenoviral vectors in the lung, intestine, and kidney
10.1089/10430340050015806 · 2000 · External reference
Pre-existent adenovirus antibody inhibits systemic toxicity and antitumour activity of CN706 in the nude mouse LNCaP xenograft model: implications and proposals for human therapy
10.1089/10430340050083289 · 2000 · External reference
Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies
10.1016/j.ymthe.2004.08.015 · 2004 · External reference
Complement depletion facilitates the infection of multiple brain tumours by an intravascular, replication-conditional herpes simplex virus mutant
10.1128/jvi.74.10.4765-4775.2000 · 2000 · External reference
Adenovirus type 5 interactions with human blood cells may compromise systemic delivery
10.1016/j.ymthe.2006.01.003 · 2006 · External reference
Cell-based delivery of oncolytic viruses: a new strategic alliance for a biological strike against cancer
10.1038/sj.mt.6300098 · 2007 · External reference
Carrier cell-based delivery of an oncolytic virus circumvents antiviral immunity
10.1038/sj.mt.6300039 · 2007 · External reference
Oncolytic adenoviruses - selective retargeting to tumour cells
10.1038/sj.onc.1209044 · 2005 · External reference
Systemic efficacy with oncolytic virus therapeutics: clinical proof-of-concept and future directions
10.1158/0008-5472.can-06-2871 · 2007 · External reference
Pharmacokinetics of oncolytic measles virotherapy: eventual equilibrium between virus and tumour in an ovarian cancer xenograft model
10.1038/sj.cgt.7700948 · 2006 · External reference
Non-invasive in vivo monitoring of trackable viruses expressing soluble marker peptides
10.1038/nm0502-527 · 2002 · External reference
Radioiodide imaging and radiovirotherapy of multiple myeloma using VSV(Delta51)-NIS, an attenuated vesicular stomatitis virus encoding the sodium iodide symporter gene
10.1182/blood-2007-01-065573 · 2007 · External reference
Image-guided radiovirotherapy for multiple myeloma using a recombinant measles virus expressing the thyroidal sodium iodide symporter
10.1182/blood-2003-07-2233 · 2004 · External reference
Virus evolution
2001 · External reference
Fighting cancer with oncolytic viruses
10.1136/bmj.332.7534.170 · 2006 · External reference
Intravascular adenoviral agents in cancer patients: lessons from clinical trials
10.1038/sj.cgt.7700539 · 2002 · External reference
Synergistic antitumour effects of immune cell-viral biotherapy
10.1126/science.1121411 · 2006 · External reference
Adaptability costs in immune escape variants of vesicular stomatitis virus
10.1016/j.virusres.2004.06.007 · 2005 · External reference
Unresolved reference
External reference
Morphogens, morphostats, microarchitecture and malignancy
10.1038/nrc2146 · 2007 · External reference
Targeting the mechanisms of tumoural immune tolerance with small-molecule inhibitors
10.1038/nrc1929 · 2006 · External reference
Drug penetration in solid tumours
10.1038/nrc1893 · 2006 · External reference
Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumours in vivo
2001 · External reference
The relationship between extracellular lactate and tumour pH in a murine tumour model of ischaemia-reperfusion
10.1038/bjc.1997.53 · 1997 · External reference
Microenvironmental and cellular consequences of altered blood flow in tumours
10.1259/bjr/12913493 · 2003 · External reference
Targeted inflammation during oncolytic virus therapy severely compromises tumour blood flow
10.1038/sj.mt.6300215 · 2007 · External reference
Targeted therapy for cancer stem cells: the patched pathway and ABC transporters
10.1038/sj.onc.1210200 · 2007 · External reference
Molecular targets in radiation oncology
10.1038/sj.onc.1206662 · 2003 · External reference
Viruses: tools for tumour target discovery, and agents for oncolytic therapies—an introduction
10.1038/sj.onc.1209035 · 2005 · External reference
A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy
2001 · External reference
Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients
10.1038/sj.cgt.7700585 · 2003 · External reference
Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints
2002 · External reference
Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial
10.1038/sj.gt.3301512 · 2001 · External reference
Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas
10.1038/sj.gt.3302436 · 2005 · External reference
Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma
10.1038/sj.cgt.7700431 · 2002 · External reference
Phase I trial of intraperitoneal injection of the E1B-55-kd-gene-deleted adenovirus ONYX-015 (dl1520) given on days 1 through 5 every 3 weeks in patients with recurrent/refractory epithelial ovarian cancer
10.1200/jco.20.6.1562 · 2002 · External reference
Assessment of growth inhibition and morphological changes in in vitro and in vivo hepatocellular carcinoma models post treatment with dl1520 adenovirus
10.1038/sj.cgt.7700455 · 2002 · External reference
Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial
10.1038/sj.gt.3301398 · 2001 · External reference
A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumourally to patients with recurrent head and neck cancer
2000 · External reference
Selective replication and oncolysis in p53 mutant tumours with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial
2000 · External reference
Phase II trial of intratumoural administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer
10.1200/jco.2001.19.2.289 · 2001 · External reference
[Safety of an E1B deleted adenovirus administered intratumourally to patients with cancer]
2003 · External reference
Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer
2002 · External reference
[Phase II clinical study of intratumoural H101, an E1B deleted adenovirus, in combination with chemotherapy in patients with cancer]
2003 · External reference
[Phase III randomized clinical trial of intratumoural injection of E1B gene-deleted adenovirus (H101) combined with cisplatin-based chemotherapy in treating squamous cell cancer of head and neck or esophagus.]
2004 · External reference
A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoural region of recurrent malignant gliomas, in the adjuvant setting
10.1016/j.ymthe.2004.07.021 · 2004 · External reference
The dl1520 virus is found preferentially in tumour tissue after direct intratumoural injection in oral carcinoma
10.1158/1078-0432.ccr-03-0443 · 2004 · External reference
E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumours
10.1089/10430340150218369 · 2001 · External reference
Phase II trial of intravenous CI-1042 in patients with metastatic colorectal cancer
10.1200/jco.2003.09.114 · 2003 · External reference
A phase I/II trial of intratumoural endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma
2003 · External reference
Persistent replication of the modified chimeric adenovirus ONYX-015 in both tumour and stromal cells from a patient with gall bladder carcinoma implants
2003 · External reference
HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: safety data and long-term survival
10.1038/sj.gt.3302289 · 2004 · External reference
Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial
10.1038/sj.gt.3301205 · 2000 · External reference
Intralesional injection of herpes simplex virus 1716 in metastatic melanoma
10.1016/s0140-6736(00)04048-4 · 2001 · External reference
The potential for efficacy of the modified (ICP 34.5(-)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study
10.1038/sj.gt.3301664 · 2002 · External reference
Oncolytic viruses: clinical applications as vectors for the treatment of malignant gliomas
10.1023/b:neon.0000003651.97832.6c · 2003 · External reference
Phase i study of intravesical vaccinia virus as a vector for gene therapy of bladder cancer
10.1016/s0022-5347(05)65755-2 · 2001 · External reference
Intratumoural recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma
10.1038/sj.cgt.7700066 · 1999 · External reference
Replication-restricted vaccinia as a cytokine gene therapy vector in cancer: persistent transgene expression despite antibody generation
10.1038/sj.cgt.7700133 · 2000 · External reference
Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme
10.1016/j.ymthe.2005.08.016 · 2006 · External reference
Overview of phase I studies of intravenous administration of PV701, an oncolytic virus
2003 · External reference
Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers
10.1200/jco.2002.08.042 · 2002 · External reference
Unresolved reference
External reference
Clinical studies of viruses as antineoplastic agents with particular reference to Egypt 101 virus
10.1002/1097-0142(195209)5:5<1025::aid-cncr2820050518>3.0.co;2-q · 1952 · External reference
Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumour cells
10.1128/jvi.01408-06 · 2007 · External reference
Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor
10.1073/pnas.0509341103 · 2006 · External reference
Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumours
10.1158/1078-0432.ccr-07-1330 · 2008 · External reference
Interferon resistance promotes oncolysis by influenza virus NS1-deletion mutants
10.1002/ijc.20078 · 2004 · External reference
Combined HSV-TK/IL-2 gene therapy in patients with recurrent glioblastoma multiforme: biological and clinical results
10.1038/sj.cgt.7700851 · 2005 · External reference