Research graph
References from Potential links between gut microbiota-derived propionate and succinate and CXCL8, IL1B, and IL6 in NMOSD: An integrated network pharmacology and mendelian randomization study. Local targets link to admitted publications; unresolved targets remain external evidence.
Blockade of IL-6 signaling in neuromyelitis optica
10.1016/j.neuint.2018.10.012 · 2019 · External reference
VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R
10.1186/1471-2105-12-35 · 2011 · External reference
Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica
10.1073/pnas.1017385108 · 2011 · External reference
Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability
10.1371/journal.pone.0238301 · 2020 · External reference
Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology
10.1212/nxi.0000000000000841 · 2020 · External reference
A urinary metabolic signature for multiple sclerosis and neuromyelitis Optica
10.1021/acs.jproteome.5b01111 · 2016 · External reference
Interleukin 6: at the interface of human health and disease
10.3389/fimmu.2023.1255533 · 2023 · External reference
Orienting the causal relationship between imprecisely measured traits using GWAS summary data
10.1371/journal.pgen.1007081 · 2017 · External reference
Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) - revised recommendations of the neuromyelitis Optica study group (NEMOS). Part I: diagnosis and differential diagnosis
10.1007/s00415-023-11634-0 · 2023 · External reference
Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation
10.1016/j.biopha.2023.115210 · 2023 · External reference
Single-cell RNA sequencing reveals cell type-specific immune regulation associated with human neuromyelitis optica spectrum disorder
2024 · External reference
Integration strategy of network pharmacology in traditional Chinese medicine: a narrative review
2022 · External reference
Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats
10.1186/2051-5960-1-5 · 2013 · External reference
4-octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders
10.1002/acn3.52080 · 2024 · External reference
Potential molecular mechanisms of plantain in the treatment of gout and hyperuricemia based on network pharmacology
10.1155/2020/3023127 · 2020 · External reference
Warfarin use and vestibular dysfunction insights from NHANES data, network pharmacology, mendelian randomization, and molecular docking
10.1038/s41598-025-96681-5 · 2025 · External reference
Anti-IL-6 therapies for neuromyelitis optica spectrum disorders: a systematic review of safety and efficacy
10.2174/18756190mta2cmjam1 · 2021 · External reference
Causal inference in health and disease: a review of the principles and applications of mendelian randomization
10.1093/jbmr/zjae136 · 2024 · External reference
Characteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis
10.1371/journal.pone.0061835 · 2013 · External reference
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
10.1016/j.cell.2016.08.064 · 2016 · External reference
Role of microbiota-derived short-chain fatty acids in nervous system disorders
2021 · External reference
Anti-aquaporin-4 immune complex stimulates complement-dependent Th17 cytokine release in neuromyelitis optica spectrum disorders
10.1038/s41598-024-53661-5 · 2024 · External reference
GPR43 stimulation on TCRαβ(+) intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity
10.1186/s12974-023-02815-9 · 2023 · External reference
GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
10.1093/bioinformatics/btt055 · 2013 · External reference
Ligand docking and binding site analysis with PyMOL and Autodock/Vina
10.1007/s10822-010-9352-6 · 2010 · External reference
Family planning in neuromyelitis optica spectrum disorder
10.1016/j.msard.2025.106568 · 2025 · External reference
Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation
10.1038/s41598-020-70203-x · 2020 · External reference
A comprehensive review of the advances in neuromyelitis optica spectrum disorder
10.1016/j.autrev.2023.103465 · 2023 · External reference
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
10.1038/nature11986 · 2013 · External reference
Emerging role of gut microbiota in autoimmune diseases
2024 · External reference
Succinate activates uncoupling protein 2 to suppress neuroinflammation and confer protection following intracerebral Hemorrhage
10.1089/ars.2024.0573 · 2025 · External reference
Succinate metabolism and its regulation of host-microbe interactions
10.1080/19490976.2023.2190300 · 2023 · External reference
clusterProfiler 4.0: a universal enrichment tool for interpreting omics data
2021 · External reference
Perturbed microbial ecology in neuromyelitis optica spectrum disorder: evidence from the gut microbiome and fecal metabolome
10.1016/j.msard.2024.105936 · 2024 · External reference
Genetic causal association between iron status and osteoarthritis: a two-sample mendelian randomization
10.3390/nu14183683 · 2022 · External reference
A real-world study of interleukin-6 receptor blockade in patients with neuromyelitis optica spectrum disorder
10.1007/s00415-022-11364-9 · 2023 · External reference
GV-971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities
10.1111/cns.14847 · 2024 · External reference
Update on diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) - recommendations of section of multiple sclerosis and neuroimmunology of Polish neurological society
10.5603/pjnns.100945 · 2025 · External reference
Identification of metabolites from the gut microbiota in hypertension via network pharmacology and molecular docking
10.1186/s40643-024-00815-y · 2024 · External reference
Network pharmacology combined with mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy
2024 · External reference
4-octyl itaconate inhibits inflammation via the NLRP3 pathway in neuromyelitis optica spectrum disorders
10.1002/acn3.52080 · ExternalCitation · doi-reference
A real-world study of interleukin-6 receptor blockade in patients with neuromyelitis optica spectrum disorder
10.1007/s00415-022-11364-9 · ExternalCitation · doi-reference
Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) - revised recommendations of the neuromyelitis Optica study group (NEMOS). Part I: diagnosis and differential diagnosis
10.1007/s00415-023-11634-0 · ExternalCitation · doi-reference
Ligand docking and binding site analysis with PyMOL and Autodock/Vina
10.1007/s10822-010-9352-6 · ExternalCitation · doi-reference
A comprehensive review of the advances in neuromyelitis optica spectrum disorder
10.1016/j.autrev.2023.103465 · ExternalCitation · doi-reference
Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation
10.1016/j.biopha.2023.115210 · ExternalCitation · doi-reference
Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages
10.1016/j.cell.2016.08.064 · ExternalCitation · doi-reference
Perturbed microbial ecology in neuromyelitis optica spectrum disorder: evidence from the gut microbiome and fecal metabolome
10.1016/j.msard.2024.105936 · ExternalCitation · doi-reference
Family planning in neuromyelitis optica spectrum disorder
10.1016/j.msard.2025.106568 · ExternalCitation · doi-reference
Blockade of IL-6 signaling in neuromyelitis optica
10.1016/j.neuint.2018.10.012 · ExternalCitation · doi-reference
A urinary metabolic signature for multiple sclerosis and neuromyelitis Optica
10.1021/acs.jproteome.5b01111 · ExternalCitation · doi-reference
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
10.1038/nature11986 · ExternalCitation · doi-reference
Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation
10.1038/s41598-020-70203-x · ExternalCitation · doi-reference
Anti-aquaporin-4 immune complex stimulates complement-dependent Th17 cytokine release in neuromyelitis optica spectrum disorders
10.1038/s41598-024-53661-5 · ExternalCitation · doi-reference
Warfarin use and vestibular dysfunction insights from NHANES data, network pharmacology, mendelian randomization, and molecular docking
10.1038/s41598-025-96681-5 · ExternalCitation · doi-reference
Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica
10.1073/pnas.1017385108 · ExternalCitation · doi-reference
Succinate metabolism and its regulation of host-microbe interactions
10.1080/19490976.2023.2190300 · ExternalCitation · doi-reference
Succinate activates uncoupling protein 2 to suppress neuroinflammation and confer protection following intracerebral Hemorrhage
10.1089/ars.2024.0573 · ExternalCitation · doi-reference
GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
10.1093/bioinformatics/btt055 · ExternalCitation · doi-reference
Causal inference in health and disease: a review of the principles and applications of mendelian randomization
10.1093/jbmr/zjae136 · ExternalCitation · doi-reference
GV-971 attenuates the progression of neuromyelitis optica in murine models and reverses alterations in gut microbiota and associated peripheral abnormalities
10.1111/cns.14847 · ExternalCitation · doi-reference
Potential molecular mechanisms of plantain in the treatment of gout and hyperuricemia based on network pharmacology
10.1155/2020/3023127 · ExternalCitation · doi-reference
VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R
10.1186/1471-2105-12-35 · ExternalCitation · doi-reference
Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats
10.1186/2051-5960-1-5 · ExternalCitation · doi-reference
GPR43 stimulation on TCRαβ(+) intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity
10.1186/s12974-023-02815-9 · ExternalCitation · doi-reference
Identification of metabolites from the gut microbiota in hypertension via network pharmacology and molecular docking
10.1186/s40643-024-00815-y · ExternalCitation · doi-reference
Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology
10.1212/nxi.0000000000000841 · ExternalCitation · doi-reference
Orienting the causal relationship between imprecisely measured traits using GWAS summary data
10.1371/journal.pgen.1007081 · ExternalCitation · doi-reference
Characteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis
10.1371/journal.pone.0061835 · ExternalCitation · doi-reference
Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability
10.1371/journal.pone.0238301 · ExternalCitation · doi-reference
Anti-IL-6 therapies for neuromyelitis optica spectrum disorders: a systematic review of safety and efficacy
10.2174/18756190mta2cmjam1 · ExternalCitation · doi-reference
Interleukin 6: at the interface of human health and disease
10.3389/fimmu.2023.1255533 · ExternalCitation · doi-reference
Genetic causal association between iron status and osteoarthritis: a two-sample mendelian randomization
10.3390/nu14183683 · ExternalCitation · doi-reference
Update on diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) - recommendations of section of multiple sclerosis and neuroimmunology of Polish neurological society
10.5603/pjnns.100945 · ExternalCitation · doi-reference
