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References from Cardiometabolic health–frailty phenotypes and bidirectional transitions between atrial fibrillation and heart failure: multistate trajectories and proteomic signatures. Local targets link to admitted publications; unresolved targets remain external evidence.
Prevention of pathological atrial remodeling and atrial fibrillation: JACC State-of-the-Art review
10.1016/j.jacc.2021.04.012 · 2021 · External reference
Epidemiology of atrial fibrillation and heart failure: a growing and important problem
2019 · External reference
Atrial fibrillation burden specifically determines human ventricular cellular remodeling
10.1016/j.jacep.2022.07.016 · 2022 · External reference
Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort
10.1161/01.cir.100.1.87 · 1999 · External reference
Heart failure, female sex, and atrial fibrillation are the main drivers of human atrial cardiomyopathy: results from the CATCH ME consortium
10.1161/jaha.123.031220 · 2023 · External reference
Frailty in older adults: evidence for a phenotype
10.1093/gerona/56.3.m146 · 2001 · External reference
Cardiovascular-kidney-metabolic health: a presidential advisory from the American Heart association
10.1161/cir.0000000000001184 · 2023 · External reference
Burden of cardiometabolic disorders and lifetime risk of new-onset atrial fibrillation among men and women: the Rotterdam Study
10.1093/eurjpc/zwae045 · 2024 · External reference
Metabolic syndrome and the risk of incident heart failure: a prospective cohort study
10.1016/j.ajpc.2025.101279 · 2025 · External reference
Long-term changes in frailty and incident atrial fibrillation, heart failure, coronary heart disease, and stroke: a prospective follow-up study
10.1016/j.hrthm.2025.01.004 · 2025 · External reference
Cardiovascular health factors and altered proteomic landscapes in the progression of cardiovascular-kidney-metabolic syndrome: Evidence from multi-cohorts in China, the UK, and the US
10.1016/j.metabol.2026.156596 · 2026 · External reference
UK Biobank: opportunities for cardiovascular research
10.1093/eurheartj/ehx254 · 2019 · External reference
Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts
10.1136/gutjnl-2025-336127 · 2026 · External reference
Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants
10.1016/s2468-2667(18)30091-4 · 2018 · External reference
Frailty, genetic predisposition, and incident atrial fibrillation
10.1093/eurheartj/ehae130 · 2024 · External reference
Comorbidity trajectories before and after the diagnosis of heart failure: A UK Biobank cohort study
10.1002/ejhf.3601 · 2025 · External reference
Plasma proteomic associations with genetics and health in the UK Biobank
10.1038/s41586-023-06592-6 · 2023 · External reference
Physical frailty, genetic predisposition, and incident heart failure
10.1016/j.jacasi.2024.03.005 · 2024 · External reference
Association between frailty and atrial fibrillation in older adults: the framingham heart study offspring cohort
10.1161/jaha.120.018557 · 2021 · External reference
The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis
10.1016/j.jacc.2010.05.034 · 2010 · External reference
Heart failure with preserved ejection fraction: JACC scientific statement
10.1016/j.jacc.2023.01.049 · 2023 · External reference
Cellular and molecular pathobiology of heart failure with preserved ejection fraction
10.1038/s41569-020-00480-6 · 2021 · External reference
Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation
10.1016/j.jacc.2007.09.064 · 2008 · External reference
Targeting the substrate for atrial fibrillation: JACC review topic of the week
10.1016/j.jacc.2024.02.050 · 2024 · External reference
FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and Ca(2+) dynamic changes
10.1161/circep.123.012683 · 2024 · External reference
Fatty acid-binding protein 4 in cardiovascular and metabolic diseases
10.5551/jat.48710 · 2019 · External reference
The adiponectin paradox for all-cause and cardiovascular mortality
10.2337/dbi17-0016 · 2018 · External reference
Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip
10.1136/heartjnl-2016-309764 · 2017 · External reference
Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy
10.1161/circheartfailure.114.001274 · 2015 · External reference
Matricellular protein CCN5 reverses established cardiac fibrosis
10.1016/j.jacc.2016.01.030 · 2016 · External reference
