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References from Selenium deficiency induces PANoptosis in porcine myocardial tissue via Sirt3-mediated YME1L1 acetylation under oxidative stress. Local targets link to admitted publications; unresolved targets remain external evidence.
Selenoprotein K Confers Protection against Iron Dyshomeostasis-Related Neurotoxicity by Regulating the Palmitoylation of TfR-1 [J]
10.1021/acs.jafc.4c08266 · 2025 · External reference
Selenium and human health [J]
10.1016/s0140-6736(11)61452-9 · 2012 · External reference
The green seaweed Ulva: tomorrow's "wheat of the sea" in foods, feeds, nutrition, and biomaterials [J]
10.1080/10408398.2024.2370489 · 2025 · External reference
Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology [J]
10.1089/ars.2023.0285 · 2024 · External reference
Mulberry Heart Disease and Hepatosis Dietetica in Farm Pigs (Sus scrofa domesticus) in a Research Setting [J]
10.30802/aalas-jaalas-19-000162 · 2020 · External reference
Effect of dietary selenium on the progression of heart failure in the ageing spontaneously hypertensive rat [J]
10.1002/mnfr.201000012 · 2010 · External reference
Co-supplementation of Vitamin K2 and Selenium Synergistically Improves Metabolic Status and Reduces Cardiovascular Risk Markers in Dyslipidemic Rabbits [J]
10.1007/s12011-023-03569-4 · 2023 · External reference
lnc-3215 Suppression Leads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart Lesion via the lnc-3215-miR-1594-TNN2 Pathway [J]
10.1016/j.omtn.2019.08.003 · 2019 · External reference
Effects of selenium deficiency and low protein intake on the apoptosis through a mitochondria-dependent pathway [J]
10.1016/j.jtemb.2019.06.019 · 2019 · External reference
ROS-Induced Oxidative Damage and Mitochondrial Dysfunction Mediated by Inhibition of SIRT3 in Cultured Cochlear Cells [J]
2022 · External reference
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase [J]
10.1126/science.1207861 · 2011 · External reference
NRH attenuates age-related hearing loss by suppressing cochlear ferroptosis and cellular senescence via Sirt3 activation [J]
10.1016/j.freeradbiomed.2026.02.051 · 2026 · External reference
The protection of selenium against cadmium-induced mitophagy via modulating nuclear xenobiotic receptors response and oxidative stress in the liver of rabbits [J]
10.1016/j.envpol.2021.117301 · 2021 · External reference
Selenium alleviates cadmium-induced aging via mitochondrial quality control in the livers of sheep [J]
10.1016/j.jinorgbio.2022.111818 · 2022 · External reference
Mitochondrial Sirtuin-3 (SIRT3) Prevents Doxorubicin-Induced Dilated Cardiomyopathy by Modulating Protein Acetylation and Oxidative Stress [J]
10.1161/circheartfailure.121.008547 · 2022 · External reference
The role of sirtuins in mitochondrial function and doxorubicin-induced cardiac dysfunction [J]
10.1515/hsz-2016-0316 · 2017 · External reference
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice [J]
10.1126/science.aad0116 · 2015 · External reference
Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) [J]
10.3389/fcimb.2020.00237 · 2020 · External reference
S100A8/A9(hi) neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis [J]
10.1038/s41419-024-06849-6 · 2024 · External reference
ASIC1a Induces Excessive Mitophagy and PANoptosis of Chondrocyte by the Inhibition of SIRT3 Mitochondrial Translocation [J]
10.7150/thno.116712 · 2025 · External reference
Epithelial mitochondrial fission-mediated PANoptosis is crucial for ulcerative colitis and its inhibition by saquinavir through Drp1 [J]
2024 · External reference
Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma [J]
2023 · External reference
Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes [J]
10.1016/j.molmed.2023.10.001 · 2024 · External reference
Disruption of BACH1 Protects AC16 Cardiomyocytes Against Hypoxia/Reoxygenation-Evoked Injury by Diminishing CDKN3 Transcription [J]
10.1007/s12012-024-09900-2 · 2024 · External reference
KLF4-induced upregulation of SOCS1 ameliorates myocardial ischemia/reperfusion injury by attenuating AC16 cardiomyocyte damage and enhancing M2 macrophage polarization [J]
10.1002/jbt.23816 · 2024 · External reference
Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine [J]
10.1016/j.aninu.2021.05.005 · 2021 · External reference
Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli [J]
10.1111/j.1399-3089.2009.00556.x · 2009 · External reference
Sulforaphane improves post-resuscitation myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the Nrf2/IRF1/GPX4 pathway [J]
10.1016/j.biopha.2024.117408 · 2024 · External reference
Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis [J]
10.1016/j.redox.2021.102003 · 2021 · External reference
Dietary Selenium deficiency activates the NLRP3 inflammasome to induce gallbladder pyroptosis by regulating glycolysis and histone lactylation through ROS/HIF-1α pathway [J]
10.1016/j.jnutbio.2025.110118 · 2026 · External reference
NCOA4-dependent ferritinophagy: A key mechanism of selenium deficiency-induced ferroptosis and porcine phlebitis via the AMPK-mTOR pathway [J]
10.1016/j.jnutbio.2026.110311 · 2026 · External reference
Selenium-deficient diet induces necroptosis in the pig brain by activating TNFR1 via mir-29a-3p [J]
10.1039/d0mt00032a · 2020 · External reference
Regulation of H(2)S-induced necroptosis and inflammation in broiler bursa of Fabricius by the miR-15b-5p/TGFBR3 axis and the involvement of oxidative stress in this process [J]
10.1016/j.jhazmat.2020.124682 · 2021 · External reference
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development [J]
10.1038/s41467-021-24619-2 · 2021 · External reference
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis [J]
10.1038/s41392-024-01816-1 · 2024 · External reference
Patulin induces ROS-dependent cardiac cell toxicity by inducing DNA damage and activating endoplasmic reticulum stress apoptotic pathway [J]
10.1016/j.ecoenv.2023.115784 · 2024 · External reference
Systematic transcriptomic and phenotypic characterization of human and murine cardiac myocyte cell lines and primary cardiomyocytes reveals serious limitations and low resemblances to adult cardiac phenotype [J]
10.1016/j.yjmcc.2021.12.007 · 2022 · External reference
Selenium Deficiency via the ROS/NLRP3/IL-1β Signaling Pathway Leads to Pyroptosis Injury in Pig Spleen [J]
10.1007/s12011-023-03595-2 · 2023 · External reference
Recent progress in the biology and physiology of sirtuins [J]
10.1038/nature08197 · 2009 · External reference
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation [J]
10.1128/mcb.01636-07 · 2007 · External reference
Oxidative stress induces Z-DNA-binding protein 1-dependent activation of microglia via mtDNA released from retinal pigment epithelial cells [J]
10.1016/j.jbc.2021.101523 · 2022 · External reference
Beyond antioxidants: Selenium and skeletal muscle mitochondria [J]
10.3389/fvets.2022.1011159 · 2022 · External reference
The importance of selenium to human health [J]
10.1016/s0140-6736(00)02490-9 · 2000 · External reference
Selenium Deficiency Induces Apoptosis, Mitochondrial Dynamic Imbalance, and Inflammatory Responses in Calf Liver [J]
10.1007/s12011-021-03059-5 · 2022 · External reference
Acute mitochondrial reactive oxygen species emissions drive mitochondrial dysfunction after traumatic muscle injury in male mice [J]
10.1152/ajpcell.00407.2025 · 2025 · External reference
Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS-NADPH Dysregulation [J]
2025 · External reference
BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway [J]
10.1016/j.jare.2024.01.029 · 2025 · External reference
SIRT3 ameliorates hepatic inflammation, oxidative stress, and fibrosis in HFD- or MCD diet-fed mice [J]
10.1016/j.jnutbio.2026.110276 · 2026 · External reference
1,25(OH)(2)D(3) ameliorates DSS-induced intestinal ferroptosis through the SIRT3-SOD2-mtROS pathway [J]
10.1016/j.jnutbio.2025.109999 · 2025 · External reference
Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress [J]
10.1093/jmcb/mjaa074 · 2021 · External reference
Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury [J]
10.1016/j.trsl.2024.03.005 · 2024 · External reference
Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1 [J]
10.1111/cpr.13362 · 2023 · External reference
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission [J]
10.1083/jcb.201308006 · 2014 · External reference
The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy [J]
10.7150/ijbs.89253 · 2024 · External reference
Loss of Yme1L perturbates mitochondrial dynamics [J]
10.1038/cddis.2013.414 · 2013 · External reference
Conjugated Linoleic Acid Ameliorates Hydrogen Peroxide-Induced Mitophagy and Inflammation via the DRP1-mtDNA-STING Pathway in Bovine Hepatocytes [J]
10.1021/acs.jafc.3c02755 · 2024 · External reference
PANoptosis: a novel target for cardiovascular diseases [J]
10.1016/j.tips.2024.06.002 · 2024 · External reference
Quercetin Protects against Silicon dioxide Particles-induced spleen ZBP1-Mediated PANoptosis by regulating the Nrf2/Drp1/mtDNA axis [J]
2024 · External reference
Mitochondrial dysfunction drives ZBP1-mediated PANoptosis to increase the susceptibility of heart failure with preserved ejection fraction-associated atrial fibrillation [J]
10.1016/j.jare.2025.09.016 · 2026 · External reference
Z-DNA-binding protein 1 exacerbates myocardial ischemia‒reperfusion injury by inducing noncanonical cardiomyocyte PANoptosis [J]
10.1038/s41392-025-02430-5 · 2025 · External reference
The mtDNA-ZBP1 axis in alzheimer's disease: Mechanisms, pathogenesis, and therapeutic implications [J]
2026 · External reference
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity [J]
10.1016/j.cell.2023.05.039 · 2023 · External reference
