Research graph
References from Combined Anti-inflammatory and Anti-depressant Treatment Reduces Pain and Spinal Cord Nociceptive and Inflammatory Markers in a Rat Discogenic Pain Model. Local targets link to admitted publications; unresolved targets remain external evidence.
Lumbar disc degeneration and genetic factors are the main risk factors for low back pain in women: the UK Twin Spine Study
10.1136/ard.2010.137836 · 2011 · External reference
Discogenic Back Pain: Literature Review of Definition, Diagnosis, and Treatment
10.1002/jbm4.10180 · 2019 · External reference
Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions?
10.1007/s11999-014-3774-8 · 2015 · External reference
Chronic Low Back Pain: A Narrative Review of Recent International Guidelines for Diagnosis and Conservative Treatment
10.3390/jcm12041685 · 2023 · External reference
Inhibiting tumor necrosis factor-alpha at time of induced intervertebral disc injury limits long-term pain and degeneration in a rat model
10.1002/jsp2.1014 · 2018 · External reference
Disk injury in rats produces persistent increases in pain-related neuropeptides in dorsal root ganglia and spinal cord glia but only transient increases in inflammatory mediators: pathomechanism of chronic diskogenic low back pain
10.1097/brs.0b013e31820e68c7 · 2011 · External reference
ISSLS Prize winner: Increased innervation and sensory nervous system plasticity in a mouse model of low back pain due to intervertebral disc degeneration
10.1097/brs.0000000000000334 · 2014 · External reference
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
10.1097/aln.0000000000002130 · 2018 · External reference
Central sensitization: a generator of pain hypersensitivity by central neural plasticity
10.1016/j.jpain.2009.06.012 · 2009 · External reference
Annulus Fibrosus Injury Induces Acute Neuroinflammation and Chronic Glial Response in Dorsal Root Ganglion and Spinal Cord-An In Vivo Rat Discogenic Pain Model
10.3390/ijms25031762 · 2024 · External reference
Effects of Long-Term Etanercept Treatment on Clinical Outcomes and Objective Signs of Inflammation in Early Nonradiographic Axial Spondyloarthritis: 104-Week Results From a Randomized, Placebo-Controlled Study
10.1002/acr.23276 · 2017 · External reference
Regulating Fibrocartilage Stem Cells via TNF-alpha/Nf-kappaB in TMJ Osteoarthritis
10.1177/00220345211037248 · 2022 · External reference
Etanercept reduces thermal and mechanical orofacial hyperalgesia following inflammation and neuropathic injury
10.1002/j.1532-2149.2013.00441.x · 2014 · External reference
Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study
10.1097/brs.0b013e318238af83 · 2012 · External reference
Single Intradiscal Administration of the Tumor Necrosis Factor-Alpha Inhibitor, Etanercept, for Patients with Discogenic Low Back Pain
10.1111/pme.12892 · 2016 · External reference
A double-blind, placebo-controlled, dose-response pilot study evaluating intradiscal etanercept in patients with chronic discogenic low back pain or lumbosacral radiculopathy
10.1097/01.anes.0000267518.20363.0d · 2007 · External reference
Randomized, double-blind, placebo-controlled, trial of transforaminal epidural etanercept for the treatment of symptomatic lumbar disc herniation
10.1097/01.brs.0000435140.61593.4c · 2013 · External reference
Duloxetine 60 mg for chronic low back pain: post hoc responder analysis of double-blind, placebo-controlled trials
10.2147/jpr.s138297 · 2017 · External reference
Randomized, Double-blind, Placebo-controlled Phase III Trial of Duloxetine Monotherapy in Japanese Patients With Chronic Low Back Pain
10.1097/brs.0000000000001707 · 2016 · External reference
Efficacy of Duloxetine in Chronic Low Back Pain with a Neuropathic Component: A Randomized, Double-blind, Placebo-controlled Crossover Trial
10.1097/aln.0000000000000902 · 2016 · External reference
Efficacy and safety of duloxetine in patients with chronic low back pain
10.1097/brs.0b013e3181d3cef6 · 2010 · External reference
Response to duloxetine in chronic low back pain: exploratory post hoc analysis of a Japanese Phase III randomized study
10.2147/jpr.s138172 · 2017 · External reference
The effect of serotonin-noradrenaline reuptake inhibitor duloxetine on the intervertebral disk-related radiculopathy in rats
10.1007/s00586-015-4239-9 · 2016 · External reference
Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via alpha1- and alpha2-Adrenergic Receptors
10.1021/acschemneuro.2c00780 · 2023 · External reference
ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls
10.1007/s00586-023-07542-6 · 2023 · External reference
Qualitative sex differences in pain processing: emerging evidence of a biased literature
10.1038/s41583-020-0310-6 · 2020 · External reference
Different immune cells mediate mechanical pain hypersensitivity in male and female mice
10.1038/nn.4053 · 2015 · External reference
Sex Differences in Pain
10.1002/jnr.23841 · 2017 · External reference
Analgesic Effect of Duloxetine on an Animal Model of Monosodium Iodoacetate-Induced Hip Osteoarthritis
10.1002/jor.24480 · 2020 · External reference
Axial hypersensitivity is associated with aberrant nerve sprouting in a novel model of disc degeneration in female Sprague Dawley rats
10.1002/jsp2.1212 · 2022 · External reference
Development of a standardized histopathology scoring system for intervertebral disc degeneration in rat models: An initiative of the ORS spine section
10.1002/jsp2.1150 · 2021 · External reference
Spinal Cord Sensitization and Spinal Inflammation from an In Vivo Rat Endplate Injury Associated with Painful Intervertebral Disc Degeneration
10.3390/ijms24043425 · 2023 · External reference
Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System
10.3390/ijms20040822 · 2019 · External reference
Analgesic Mechanisms of Antidepressants for Neuropathic Pain
10.3390/ijms18112483 · 2017 · External reference
Study of emotional and cognitive impairments in mononeuropathic rats: effect of duloxetine and gabapentin
10.1016/j.pain.2012.04.023 · 2012 · External reference
Repeated Administration of Duloxetine Suppresses Neuropathic Pain by Accumulating Effects of Noradrenaline in the Spinal Cord
10.1213/ane.0000000000002380 · 2018 · External reference
Preventive and alleviative effect of tramadol on neuropathic pain in rats: roles of alpha(2)-adrenoceptors and spinal astrocytes
10.1254/jphs.13223fp · 2014 · External reference
Crosstalk between spinal astrocytes and neurons in nerve injury-induced neuropathic pain
10.1371/journal.pone.0006973 · 2009 · External reference
Microglial-induced apoptosis is potentially responsible for hyperalgesia variations during CFA-induced inflammation
10.1007/s10787-019-00623-3 · 2020 · External reference
Efficacy and safety of etanercept in the treatment of sciatica: A systematic review and meta-analysis
10.1016/j.jocn.2017.06.054 · 2017 · External reference
An Update on Multimodal Pain Management After Total Joint Arthroplasty
10.2106/jbjs.19.01423 · 2021 · External reference
Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation
10.2106/00004623-199072030-00013 · 1990 · External reference
Osteoarthritis associated with estrogen deficiency
10.1186/ar2791 · 2009 · External reference
Development of osteoarthritic features in estrogen receptor knockout mice
10.1016/j.joca.2009.04.008 · 2009 · External reference
Comparison of joint degeneration and pain in male and female mice in DMM model of osteoarthritis
10.1016/j.joca.2021.02.007 · 2021 · External reference
Role of Etanercept and Infliximab on Nociceptive Changes Induced by the Experimental Model of Fibromyalgia
10.3390/ijms23116139 · 2022 · External reference
Etanercept attenuates pain-related behavior following compression of the dorsal root ganglion in the rat
10.1007/s00586-011-1854-y · 2011 · External reference
Effect of etanercept, a tumor necrosis factor-alpha inhibitor, on neuropathic pain in the rat chronic constriction injury model
10.1097/brs.0b013e318162340a · 2008 · External reference
ISSLS PRIZE in Clinical Science 2022: Epidemiology, risk factors and clinical impact of juvenile Modic changes in paediatric patients with low back pain
10.1007/s00586-022-07125-x · 2022 · External reference
A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status
10.2106/jbjs.i.01568 · 2011 · External reference
