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References from Analytical methods for biomarker-based diagnosis of pulpitis in minimally invasive biological fluids: a systematic review. Local targets link to admitted publications; unresolved targets remain external evidence.
Understanding dental pulp inflammation: from signaling to structure
10.3389/fimmu.2024.1474466 · 2024 · External reference
Pulp Inflammation Diagnosis from Clinical to Inflammatory Mediators: A Systematic Review
10.1016/j.joen.2017.02.009 · 2017 · External reference
Present status and future directions—Vital pulp treatment and pulp preservation strategies
10.1111/iej.13688 · 2022 · External reference
Objectively Diagnosing Pulpitis: Opportunities and Methodological Challenges in the Development of Point-of-Care Assays
10.3390/ijms27010355 · 2026 · External reference
Effectiveness of diagnosing pulpitis: A systematic review
10.1111/iej.13762 · 2023 · External reference
Molecular biomarkers for objective assessment of symptomatic pulpitis: A systematic review and meta‐analysis
10.1111/iej.13950 · 2023 · External reference
Characteristics of inflammatory mediators in dental pulp inflammation and the potential for their control
10.3389/fdmed.2024.1426887 · 2024 · External reference
Dental Pulp Defence and Repair Mechanisms in Dental Caries
10.1155/2015/230251 · 2015 · External reference
Comparison of vehicles to collect dentinal fluid for molecular analysis
10.1016/j.jdent.2014.01.014 · 2014 · External reference
The detection of pro-inflammatory cytokines in exudates from dental pulp tissues
10.1016/j.cyto.2022.155846 · 2022 · External reference
Cytokines as diagnostic markers of pulpal inflammation
10.1111/iej.12030 · 2013 · External reference
Discriminatory performance of the pulpal inflammatory biomarkers; Interleukin‐8 and TNF ‐α in patients with symptoms indicative of reversible and irreversible pulpitis: A diagnostic accuracy study
10.1111/iej.14078 · 2024 · External reference
Symptom correlation and spatial distribution of inflammatory mediators in pulpitis—A preliminary study
10.1111/iej.14275 · 2025 · External reference
Clinical and technical considerations in the analysis of gingival crevicular fluid
10.1111/prd.12109 · 2000 · External reference
Investigations into the cellular contribution to host tissue proteases and inhibitors in gingival crevicular fluid
10.1111/j.1600-051x.1997.tb00207.x · 1997 · External reference
Inflammatory Biomarkers in Irreversible Pulpitis and Pulp Necrosis: A Systematic Review and Meta-Analysis
10.1016/j.identj.2026.109453 · 2026 · External reference
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
10.1136/bmj.n71 · 2021 · External reference
Unresolved reference
External reference
Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs
10.1111/iej.12793 · 2017 · External reference
QUADAS-3: A Revised Tool for the Quality Assessment of Diagnostic Test Accuracy Studies
10.7326/annals-25-02104 · 2026 · External reference
Grading quality of evidence and strength of recommendations for diagnostic tests and strategies
10.1136/bmj.39500.677199.ae · 2008 · External reference
Screening for objective indicators in pulp blood to distinguish the degree of pulpitis
10.1007/s00784-025-06632-7 · 2025 · External reference
Evaluating the Concentration of MMP-9 and TNF- α in Pulpal Blood at Various Stages of Pulpal Inflammation in Diabetics: A Cross Sectional Study
10.14744/eej.2023.41736 · 2023 · External reference
Interleukin-8 Is Increased in Gingival Crevicular Fluid from Patients with Acute Pulpitis
10.1016/j.joen.2007.10.022 · 2008 · External reference
GCF NLRP3 as a Biomarker for Assessing Endodontic Treatment Outcomes in Symptomatic Irreversible Pulpitis: A Comparative Nonrandomized, Observational Cross-Sectional Study
10.4103/jispcd.jispcd_31_25 · 2025 · External reference
Comparison of Neurokinin A, Substance P, Interleukin 8, and Matrix Metalloproteinase-8 Changes in Pulp tissue and Gingival Crevicular Fluid Samples of Healthy and Symptomatic Irreversible Pulpitis Teeth
10.1016/j.joen.2020.07.013 · 2020 · External reference
Matrix metalloproteinase 8 production of cariously-exposed irreversible pulpitis
2025 · External reference
Diagnostic utility of Th2 cytokines (IL-4, IL-5, IL-10, and IL-13) in pulpal blood for assessing pulpitis severity
10.1186/s12903-025-05936-0 · 2025 · External reference
A First Study on the Usefulness of Matrix Metalloproteinase 9 from Dentinal Fluid to Indicate Pulp Inflammation
10.1016/j.joen.2010.10.003 · 2011 · External reference
A Prospective Clinical Pilot Study on the Level of Matrix Metalloproteinase-9 in Dental Pulpal Blood as a Marker for the State of Inflammation in the Pulp Tissue
10.1016/j.joen.2015.10.020 · 2016 · External reference
Association between concentration of active MMP‐9 in pulpal blood and pulpotomy outcome in permanent mature teeth with irreversible pulpitis – a preliminary study
10.1111/iej.13437 · 2021 · External reference
Inflammatory biomarkers in dentinal fluid as an approach to molecular diagnostics in pulpitis
10.1111/iej.13343 · 2020 · External reference
Evaluation of Inflammatory Mediators, Pulpal Blood pH, and Oxygen Saturation in Teeth with Pulpitis
10.1016/j.joen.2026.01.018 · 2026 · External reference
Expression of Selected Inflammatory Mediators with Different Clinical Characteristics of Pulpal Inflammation
10.1016/j.joen.2023.11.016 · 2024 · External reference
The Relationship Between Pulpal Diagnostic Conditions and Potential Inflammatory Biomarkers
10.1111/iej.70030 · 2026 · External reference
Proteomic Profiling of Dentinal Fluid for the Identification of Biomarkers in Pulpal Inflammation: An Exploratory Study
10.1111/iej.70017 · 2025 · External reference
Biological Markers for Pulpal Inflammation: A Systematic Review
10.1371/journal.pone.0167289 · 2016 · External reference
Inflammatory cytokines in normal and irreversibly inflamed pulps: A systematic review
10.1016/j.archoralbio.2017.05.008 · 2017 · External reference
Dentine as a bioactive extracellular matrix
10.1016/j.archoralbio.2011.07.008 · 2012 · External reference
TGF-β1 Inhibits TLR-mediated Odontoblast Responses to Oral Bacteria
10.1177/0022034509334846 · 2009 · External reference
Increased interleukin-8 expression in inflamed human dental pulps
10.1016/s1079-2104(99)70118-6 · 1999 · External reference
Deciphering Reparative Processes in the Inflamed Dental Pulp
10.3389/fdmed.2021.651219 · 2021 · External reference
MMP-9 Levels and NaOCl Lavage in Randomized Trial on Direct Pulp Capping
10.1177/00220345211046874 · 2022 · External reference
Treatment of pulpal and apical disease: The European Society of Endodontology (ESE) S3‐level clinical practice guideline
10.1111/iej.13974 · 2023 · External reference
Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: A systematic review
10.1016/j.jdent.2019.06.005 · 2019 · External reference
A critical analysis of research methods to study clinical molecular biomarkers in Endodontic research
10.1111/iej.13647 · 2022 · External reference
Clinical signs and symptoms in pulp disease
10.1111/j.1365-2591.1980.tb00834.x · 1980 · External reference
Diagnosis of the condition of the dental pulp: a systematic review
10.1111/j.1365-2591.2012.02016.x · 2012 · External reference
Correlation between Clinical and Histologic Pulp Diagnoses
10.1016/j.joen.2014.08.010 · 2014 · External reference
STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration
10.1136/bmjopen-2016-012799 · 2016 · External reference
Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio
10.1111/j.1600-051x.2007.01061.x · 2007 · External reference
Saliva as a diagnostic tool for periodontal disease: current state and future directions
10.1111/j.1600-0757.2008.00288.x · 2000 · External reference
