Research graph
References from Designing lysate-based hydrogels for on-demand therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Hydrogels for delivery of bioactive agents: a historical perspective
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2024 · External reference
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Platelet lysate: a promising candidate in regenerative medicine
10.2217/rme-2020-0065 · 2021 · External reference
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Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy
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Cancer vaccines
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Human adipose tissue lysate-based hydrogel for lasting immunomodulation to effectively improve spinal cord injury repair
2024 · External reference
The osteocyte and its osteoclastogenic potential
10.3389/fendo.2023.1121727 · 2023 · External reference
BCG and alternative therapies to BCG therapy for non-muscle-invasive bladder cancer
10.3390/curroncol31020079 · 2024 · External reference
Platelet lysate: a promising candidate in regenerative medicine
10.2217/rme-2020-0065 · 2021 · External reference
CpG ODN activates TLR9 and upregulates TLR3 via the p38 MAPK-ATF3 signaling axis to synergistically enhance dendritic cell vaccine efficacy
10.3390/cells14221785 · 2025 · External reference
Human platelet lysate: replacing fetal bovine serum as a gold standard for human cell propagation?
10.1016/j.biomaterials.2015.10.065 · 2016 · External reference
Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice
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Serum contains a platelet-derived transforming growth factor
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TGF-β signaling in health, disease, and therapeutics
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BDNF - a key transducer of antidepressant effects
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Brain-derived neurotrophic factor and neuropsychiatric disorders
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BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity
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BDNF and activity-dependent synaptic modulation: figure 1, learn
2003 · External reference
Hepatokines and metabolism: deciphering communication from the liver
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The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity
10.1172/jci20660 · 2004 · External reference
Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity
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Metabolic effects of IGF-I deficiency: lessons from mouse models
2005 · External reference
Lymphangiogenesis in development and human disease
10.1038/nature04480 · 2005 · External reference
Evidence for pro-angiogenic functions of VEGF-Ax
10.1016/j.cell.2016.08.054 · 2016 · External reference
Epidermal growth factor therapy and wound healing: past, present and future perspectives
10.1016/s1479-666x(08)80114-x · 2008 · External reference
Amivantamab, an epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition factor (MET) bispecific antibody, designed to enable multiple mechanisms of action and broad clinical applications
10.1016/j.cllc.2022.11.004 · 2023 · External reference
Epidermal growth factor, innovation and safety
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EGF, a veteran of wound healing: highlights on its mode of action, clinical applications with focus on wound treatment, and recent drug delivery strategies
10.1007/s12272-023-01444-3 · 2023 · External reference
Epidermal growth factor receptor cell proliferation signaling pathways
10.3390/cancers9050052 · 2017 · External reference
A therapy-grade protocol for differentiation of pluripotent stem cells into mesenchymal stem cells using platelet lysate as supplement
10.1186/scrt540 · 2015 · External reference
Comparative analysis of different platelet lysates and platelet rich preparations to stimulate tendon cell biology: an in vitro study
10.3390/ijms19010212 · 2018 · External reference
A double-virally-inactivated (Intercept–solvent/detergent) human platelet lysate for in vitro expansion of human mesenchymal stromal cells
10.1111/trf.15251 · 2019 · External reference
Alopecia and platelet-derived therapies
10.21037/sci.2017.11.01 · 2017 · External reference
Use of platelet lysate for bone regeneration - are we ready for clinical translation?
10.4252/wjsc.v8.i2.47 · 2016 · External reference
Advances in cancer immunotherapy: historical perspectives, current developments, and future directions
10.1186/s12943-025-02305-x · 2025 · External reference
A vaccine targeting resistant tumours by dual T cell plus NK cell attack
10.1038/s41586-022-04772-4 · 2022 · External reference
Alternative tumour-specific antigens
10.1038/s41568-019-0162-4 · 2019 · External reference
Neoantigen vaccine: an emerging tumor immunotherapy
10.1186/s12943-019-1055-6 · 2019 · External reference
Immunotherapy and prevention of cancer by nanovaccines loaded with whole-cell components of tumor tissues or cells
2021 · External reference
Across-cancer specific immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis
10.1016/j.isci.2022.105511 · 2022 · External reference
Rethinking antigen source: cancer vaccines based on whole tumor cell/tissue lysate or whole tumor cell
2023 · External reference
Antitumour dendritic cell vaccination in a priming and boosting approach
10.1038/s41573-020-0074-8 · 2020 · External reference
Tumor cell lysate-based multifunctional nanoparticles facilitate enhanced mRNA delivery and immune stimulation for melanoma gene therapy
10.1021/acs.molpharmaceut.3c00826 · 2024 · External reference
The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses
10.1038/s41418-020-00658-y · 2021 · External reference
The roles of neutrophil-derived myeloperoxidase (MPO) in diseases: The new progress
10.3390/antiox13010132 · 2024 · External reference
Neutrophils and renal failure
10.1016/s0272-6386(99)70375-6 · 1999 · External reference
Adipose-derived biogenic nanoparticles for suppression of inflammation
10.1002/smll.201904064 · 2020 · External reference
Adipose tissue-derived extracellular matrix hydrogels as a release platform for secreted paracrine factors
10.1002/term.2843 · 2019 · External reference
Role of extracellular matrix and its regulators in human airway smooth muscle biology
10.1385/cbb:44:1:139 · 2006 · External reference
The effect of a local application of fibroblast growth factor-2 on tendon-to-bone remodeling in rats with acute injury and repair of the supraspinatus tendon
10.1016/j.jse.2009.01.013 · 2009 · External reference
Regulation of FGF-2, FGF-18 and transcription factor activity by perlecan in the maturational development of transitional rudiment and growth plate cartilages and in the maintenance of permanent cartilage homeostasis
10.3390/ijms23041934 · 2022 · External reference
Osteocyte-mediated translation of mechanical stimuli to cellular signaling and its role in bone and non-bone-related clinical complications
10.1007/s11914-020-00564-9 · 2020 · External reference
Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation
10.1016/j.bbrc.2006.07.146 · 2006 · External reference
Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes
10.1002/jor.20888 · 2009 · External reference
Review: Bone tissue engineering: the role of interstitial fluid flow
10.1002/bit.260430706 · 1994 · External reference
Immunomodulation of the tumor microenvironment: turn foe into friend
10.3389/fimmu.2018.02909 · 2018 · External reference
Role of macrophages in uveal melanoma
10.1586/eop.11.45 · 2011 · External reference
M2/M1 ratio of tumor associated macrophages and PPAR-gamma expression in uveal melanomas with class 1 and class 2 molecular profiles
10.1016/j.exer.2012.11.012 · 2013 · External reference
Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma
10.1016/j.jhep.2014.10.029 · 2015 · External reference
The anti-tumor effects of M1 macrophage-loaded poly (ethylene glycol) and gelatin-based hydrogels on hepatocellular carcinoma
10.7150/thno.20251 · 2017 · External reference
A cross-linked macropore hydrogel based on M1 macrophage lysate and alginate regulates tumor-associated macrophages for the treatment of melanoma
10.1016/j.ijbiomac.2024.132089 · 2024 · External reference
M1 macrophage-derived nanovesicles potentiate the anticancer efficacy of immune checkpoint inhibitors
10.1021/acsnano.8b02446 · 2018 · External reference
M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages
10.1016/j.biomaterials.2021.121137 · 2021 · External reference
Cryo-thermal therapy induces macrophage polarization for durable anti-tumor immunity
10.1038/s41419-019-1459-7 · 2019 · External reference
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10.1038/ni.2366 · 2012 · External reference
Yin and Yang interplay of IFN-gamma in inflammation and autoimmune disease
10.1172/jci31860 · 2007 · External reference
IFNγ: Signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
10.1038/s41577-018-0029-z · 2018 · External reference
Regulation of tumour necrosis factor signalling: live or let die
10.1038/nri3834 · 2015 · External reference
The interleukin-1 family: 10 years of discovery
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Understanding the mechanism of IL-1β secretion
10.1016/j.cytogfr.2011.10.001 · 2011 · External reference
Polyvalent mechanical bacterial lysate for the prevention of recurrent respiratory infections: a meta-analysis, Pulm
2012 · External reference
Unresolved reference
External reference
Efficacy and safety of OM-85 in paediatric recurrent respiratory tract infections which could have a possible protective effect on COVID-19 pandemic: a meta-analysis
10.1111/ijcp.13981 · 2021 · External reference
Prevention of recurrent respiratory tract infections: a literature review of the activity of the bacterial lysate Lantigen B
2023 · External reference
T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx
10.1002/ijc.21565 · 2006 · External reference
Bacterial therapy of cancer: promises, limitations, and insights for future directions
10.3389/fmicb.2018.00016 · 2018 · External reference
BCG immunotherapy of bladder cancer: 20 years on
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Bacillus Calmette-Guérin immunotherapy for genitourinary cancer
10.1111/j.1464-410x.2012.11754.x · 2013 · External reference
Metallic nanoparticles: their potential role in breast cancer immunotherapy via trained immunity provocation
10.3390/biomedicines11051245 · 2023 · External reference
BCG-induced trained immunity: history, mechanisms and potential applications
10.1186/s12967-023-03944-8 · 2023 · External reference
Isolation and FTIR-ATR and 1H NMR characterization of alginates from the main alginophyte species of the Atlantic coast of Morocco
10.3390/molecules25184335 · 2020 · External reference
Alginate-based hydrogels mediated biomedical applications: A review
10.1016/j.ijbiomac.2024.135019 · 2024 · External reference
Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: part 1. Structure, gelation rate and mechanical properties
10.1016/s0142-9612(00)00201-5 · 2001 · External reference
Development of a Spirulina extract/alginate-imbedded PCL nanofibrous cosmetic patch
10.4014/jmb.1701.01025 · 2017 · External reference
Sequence analysis of alginate-derived oligosaccharides by negative-ion electrospray tandem mass spectrometry
10.1016/j.jasms.2006.01.002 · 2006 · External reference
Effects of molecular weight and guluronic acid/mannuronic acid ratio on the rheological behavior and stabilizing property of sodium alginate
10.3390/molecules24234374 · 2019 · External reference
Chitosan: a natural biopolymer with a wide and varied range of applications
10.3390/molecules25173981 · 2020 · External reference
Polysaccharides for medical technology: properties and applications
10.1002/mabi.202200372 · 2023 · External reference
A biomimetic hydrogel based on methacrylated dextran-graft-lysine and gelatin for 3D smooth muscle cell culture
10.1016/j.biomaterials.2009.10.040 · 2010 · External reference
Hyaluronic acid in the third millennium
10.3390/polym10070701 · 2018 · External reference
Hyaluronic acid in inflammation and tissue regeneration
2016 · External reference
Proteomics: a pragmatic perspective
10.1038/nbt.1658 · 2010 · External reference
Hyaluronic acid: a key molecule in skin aging
10.4161/derm.21923 · 2012 · External reference
Injectable self-healing adhesive chitosan hydrogel with antioxidative, antibacterial, and hemostatic activities for rapid hemostasis and skin wound healing
10.1021/acsami.2c08870 · 2022 · External reference
One-step synthesis of multifunctional chitosan hydrogel for full-thickness wound closure and healing
10.1002/adhm.202101808 · 2022 · External reference
Platelet lysate functionalized gelatin methacrylate microspheres for improving angiogenesis in endodontic regeneration
10.1016/j.actbio.2021.09.024 · 2021 · External reference
Advanced platelet lysate aerogels: biomaterials for regenerative applications
10.3390/jfb15020049 · 2024 · External reference
Tunable double-network GelMA/alginate hydrogels for platelet lysate-derived protein delivery
10.3390/bioengineering10091044 · 2023 · External reference
Controversial issue: Is it safe to employ mesenchymal stem cells in cell-based therapies?
10.1016/j.exger.2008.07.004 · 2008 · External reference
An injectable platelet lysate-hyaluronic acid hydrogel supports cellular activities and induces chondrogenesis of encapsulated mesenchymal stem cells
10.1016/j.actbio.2018.10.031 · 2019 · External reference
Cellular membrane enrichment of self-assembling D-peptides for cell surface engineering
10.1021/am502250r · 2014 · External reference
Retaining antibodies in tumors with a self-assembling injectable system
10.1021/mp300504z · 2013 · External reference
Sustained release of tumor cell lysate and CpG from an injectable, cytotoxic hydrogel for melanoma immunotherapy
10.1039/d2na00911k · 2023 · External reference
Injectable polypeptide hydrogel for dual delivery of antigen and TLR3 agonist to modulate dendritic cells in vivo and enhance potent cytotoxic T-lymphocyte response against melanoma
10.1016/j.biomaterials.2018.01.004 · 2018 · External reference
Tumor lysates-constructed hydrogel to potentiate tumor immunotherapy
10.1016/j.jconrel.2023.05.005 · 2023 · External reference
Lipopeptide liposomes-loaded hydrogel for multistage transdermal chemotherapy of melanoma
10.1016/j.jconrel.2022.09.014 · 2022 · External reference
Oscillating fluid flow activated osteocyte lysate-based hydrogel for regulating osteoblast/osteoclast homeostasis to enhance bone repair
2023 · External reference
Sodium alginate hydrogel encapsulating microglia cell lysate subjected to serum starvation for mitigating glioma cells
10.1177/08853282241268694 · 2024 · External reference
Regulation of tumor antigens-dependent immunotherapy via the hybrid M1 macrophage/tumor lysates hydrogel
2024 · External reference
An injectable nanocomposite hydrogel improves tumor penetration and cancer treatment efficacy
10.1016/j.actbio.2022.05.042 · 2022 · External reference
BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma
10.1136/jitc-2021-004133 · 2022 · External reference
Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel
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Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis
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