Research graph
References from Exploring the potential of natural products in treating alopecia areata. Local targets link to admitted publications; unresolved targets remain external evidence.
Mesenchymal stem cell therapy in alopecia areata: visual and molecular evidence from a mouse model
10.3390/ijms25179236 · 2024 · External reference
Alopecia areata treatment with baricitinib: different relapse phenotypes
2024 · External reference
Atopic dermatitis and risk of autoimmune conditions: population-based cohort study
10.1016/j.jaci.2022.03.030 · 2022 · External reference
Cancer risks among patients with alopecia areata: a population-based case-control study in Korea
10.1016/j.jaad.2017.08.011 · 2018 · External reference
Time-dependent risk of acute myocardial infarction in patients with alopecia areata in Korea
10.1001/jamadermatol.2020.1133 · 2020 · External reference
Patients with alopecia areata show signs of insulin resistance
10.1007/s00403-019-01929-6 · 2019 · External reference
Inflammatory ocular comorbidities in alopecia areata: a retrospective cohort study of a single academic center
10.1016/j.jaad.2022.06.018 · 2023 · External reference
Pregnancy outcomes in female patients with alopecia areata: a nationwide population-based study
10.1016/j.jid.2020.12.014 · 2021 · External reference
Exploring the effects of Chinese herbal ingredients on the signaling pathway of alopecia and the screening of effective Chinese herbal compounds
10.1016/j.jep.2022.115320 · 2022 · External reference
The anti-inflammatory and immunomodulatory activities of natural products to control autoimmune inflammation
10.3390/ijms24010095 · 2023 · External reference
Amentoflavone induces ferroptosis to alleviate proliferation, migration, invasion and inflammation in rheumatoid arthritis fibroblast-like synoviocytes by inhibiting PIN1
10.1007/s12013-024-01563-8 · 2025 · External reference
Galangin: a promising flavonoid for the treatment of rheumatoid arthritis: mechanisms, evidence, and therapeutic potential
10.3390/ph17070963 · 2024 · External reference
Inflammatory auto-immune diseases of the intestine and their management by natural bioactive compounds
10.1016/j.biopha.2022.113158 · 2022 · External reference
Deciphering the complex immunopathogenesis of alopecia areata
10.3390/ijms25115652 · 2024 · External reference
European expert consensus statement on the systemic treatment of alopecia areata
10.1111/jdv.19768 · 2024 · External reference
Properties of FDA-approved small molecule protein kinase inhibitors: a 2025 update
10.1016/j.phrs.2025.107723 · 2025 · External reference
Unresolved reference
External reference
Familial risk and incidence of alopecia areata among first degree relatives: a nationwide population-based study in Korea
10.1016/j.jaad.2020.10.063 · 2021 · External reference
Two episodes of simultaneous identical alopecia areata in identical twins
10.4103/0974-7753.179398 · 2016 · External reference
Identical alopecia areata in identical twin sisters
10.4103/ijt.ijt_120_20 · 2020 · External reference
Co-existent presence of alopecia areata in siblings: a rare presentation
10.4103/0974-7753.138591 · 2014 · External reference
Alopecia areata
10.1038/nrdp.2017.11 · 2017 · External reference
Alopecia areata
10.1056/nejmra1103442 · 2012 · External reference
Alopecia areata
10.1016/j.jaad.2017.04.1141 · 2018 · External reference
Alopecia areata: an update on etiopathogenesis, diagnosis, and management
10.1007/s12016-021-08883-0 · 2021 · External reference
Alopecia areata: an autoimmune disease of multiple players
10.2147/itt.s266409 · 2021 · External reference
Lifestyle factors involved in the pathogenesis of alopecia areata
10.3390/ijms23031038 · 2022 · External reference
How our microbiome influences the pathogenesis of alopecia areata
10.3390/genes13101860 · 2022 · External reference
Oxidative stress and alopecia areata
10.3389/fmed.2023.1181572 · 2023 · External reference
Hair follicle immune privilege and its collapse in alopecia areata
10.1111/exd.14155 · 2020 · External reference
Inhibition of T-cell activity in alopecia areata: recent developments and new directions
10.3389/fimmu.2023.1243556 · 2023 · External reference
Molecular principles of hair follicle induction and morphogenesis
10.1002/bies.20184 · 2005 · External reference
Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata
10.1155/2013/348546 · 2013 · External reference
Diagnosis and management of alopecia in children
10.1016/j.pcl.2013.12.002 · 2014 · External reference
Interleukin-15 is a hair follicle immune privilege guardian
10.1016/j.jaut.2024.103217 · 2024 · External reference
The hair follicle as a dynamic miniorgan
10.1016/j.cub.2008.12.005 · 2009 · External reference
Psychological effect, pathophysiology, and management of androgenetic alopecia in men
10.4065/80.10.1316 · 2005 · External reference
Getting under the skin of hair aging: the impact of the hair follicle environment
10.1111/exd.14109 · 2020 · External reference
Immune privilege collapse and alopecia development: is stress a factor
10.1159/000485080 · 2018 · External reference
Current research in immunology inaugural editorial
10.1016/j.crimmu.2020.11.001 · 2020 · External reference
Collapse and restoration of MHC class-I-dependent immune privilege
10.1016/s0002-9440(10)63151-3 · 2004 · External reference
An overview of JAK/STAT pathways and JAK inhibition in alopecia areata
10.3389/fimmu.2022.955035 · 2022 · External reference
Immunopathogenesis of alopecia areata
10.1016/j.crimmu.2021.02.001 · 2021 · External reference
Functions of representative terpenoids and their biosynthesis mechanisms in medicinal plants
10.3390/biom13121725 · 2023 · External reference
6-gingerol inhibits hair shaft growth in cultured human hair follicles and modulates hair growth in mice
10.1371/journal.pone.0057226 · 2013 · External reference
Ginger (Zingiber officinale (L.) Rosc) improves oxidative stress and trace elements status in patients with alopecia areata, Niger
2020 · External reference
Cedrol in ginger (Zingiber officinale) as a promising hair growth drug: the effects of oral and external administration on hair regeneration and its mechanism
10.1016/j.bioorg.2024.107709 · 2024 · External reference
Ginsenosides in Panax ginseng extract promote anagen transition by suppressing BMP4 expression and promote human hair growth by stimulating follicle-cell proliferation
10.1248/bpb.b23-00276 · 2024 · External reference
Ginsenoside Rg4 enhances the inductive effects of human dermal papilla spheres on hair growth via the AKT/GSK-3β/β-catenin signaling pathway
10.4014/jmb.2101.01032 · 2021 · External reference
Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β-catenin and p53 signaling pathways in AGA mice
10.1002/fft2.272 · 2023 · External reference
Panax notoginseng saponins promote hair follicle growth in mice via Wnt/β-Catenin signaling pathway
10.1111/cbdd.14224 · 2023 · External reference
Bilobalide: a review of its pharmacology, pharmacokinetics, toxicity, and safety
10.1002/ptr.7220 · 2021 · External reference
Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks
10.1002/biof.1562 · 2019 · External reference
β-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model
10.1016/j.fitote.2017.07.007 · 2017 · External reference
Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice
10.1111/jocd.12674 · 2019 · External reference
Ent-kaurane-type diterpenoids from Isodonis Herba activate human hair follicle dermal papilla cells proliferation via the Akt/GSK-3β/β-catenin transduction pathway
10.1007/s11418-020-01477-8 · 2021 · External reference
Monoterpenoid loliolide regulates hair follicle inductivity of human dermal papilla cells by activating the Akt/β-catenin signaling pathway
10.4014/jmb.1908.08018 · 2019 · External reference
Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention
2013 · External reference
Potential of cucurbitacin as an anticancer drug
10.1016/j.biopha.2023.115707 · 2023 · External reference
Cucurbitacin promotes hair growth in mice by inhibiting the expression of fibroblast growth factor 18
10.21037/atm-22-4423 · 2022 · External reference
In vitro hair growth-promoting effects of araliadiol via the p38/PPAR-γ signaling pathway in human hair follicle stem cells and dermal papilla cells
10.3389/fphar.2024.1482898 · 2024 · External reference
Phytochemistry of ginsenosides: recent advancements and emerging roles
10.1080/10408398.2021.1952159 · 2023 · External reference
Ginsenoside Rb1 retards aging process by regulating cell cycle, apoptotic pathway and metabolism of aging mice
10.1016/j.jep.2020.112746 · 2020 · External reference
Ginsenosides Rb1 and rd regulate proliferation of mature keratinocytes through induction of p63 expression in hair follicles
10.1002/ptr.4828 · 2013 · External reference
The ginsenosides of Panax ginseng promote hair growth via similar mechanism of minoxidil
10.1016/j.jdermsci.2014.12.007 · 2015 · External reference
Hair-growth potential of ginseng and its major metabolites: a review on its molecular mechanisms
10.3390/ijms19092703 · 2018 · External reference
Fructus Panax ginseng extract promotes hair regeneration in C57BL/6 mice
10.1016/j.jep.2011.08.013 · 2011 · External reference
Hair growth-promoting mechanisms of red ginseng extract through stimulating dermal papilla cell proliferation and enhancing skin health
10.3746/pnf.2021.26.3.275 · 2021 · External reference
Red ginseng oil promotes hair growth and protects skin against UVC radiation
10.1016/j.jgr.2020.12.008 · 2021 · External reference
Pharmacological action and mechanisms of ginkgolide B
10.1097/00029330-200705020-00013 · 2007 · External reference
Oleanolic acid: extraction, characterization and biological activity
10.3390/nu14030623 · 2022 · External reference
Costunolide: a bioactive sesquiterpene lactone with diverse therapeutic potential
10.3390/ijms20122926 · 2019 · External reference
Enmein decreases synaptic glutamate release and protects against kainic acid-induced brain injury in rats
10.3390/ijms222312966 · 2021 · External reference
Loliolide, a carotenoid metabolite, is a potential endogenous inducer of herbivore resistance
10.1104/pp.18.00837 · 2019 · External reference
Biotechnological production of lycopene by microorganisms
10.1007/s00253-020-10967-4 · 2020 · External reference
Recent research on flavonoids and their biomedical applications
10.2174/0929867327666200713184138 · 2021 · External reference
Association of flavonoid-rich foods and flavonoids with risk of all-cause mortality
10.1017/s0007114517001325 · 2017 · External reference
Epigallocatechin-3 gallate inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and reduces CD8 MKG2D lymphocytes of alopecia areata patients
10.3390/ijerph15122882 · 2018 · External reference
Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG)
10.1016/j.phymed.2006.09.009 · 2007 · External reference
Dietary soy oil content and soy-derived phytoestrogen genistein increase resistance to alopecia areata onset in C3H/HeJ mice
10.1034/j.1600-0625.2003.120104.x · 2003 · External reference
Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia
10.1016/j.ghir.2007.04.009 · 2007 · External reference
Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice
10.1016/j.jnutbio.2010.01.008 · 2011 · External reference
Isoquercitrin promotes hair growth through induction of autophagy and angiogenesis by targeting AMPK and IGF-1R
10.1016/j.phymed.2024.156289 · 2025 · External reference
Flavonoid silibinin increases hair-inductive property via Akt and Wnt/β-catenin signaling activation in 3-dimensional-spheroid cultured human dermal papilla cells
10.4014/jmb.1810.10050 · 2019 · External reference
Sophoricoside, a genistein glycoside from Fructus Sophorae, promotes hair growth via activation of M4 muscarinic AChR in dermal papilla cells
10.1016/j.jep.2024.118585 · 2024 · External reference
Quercitrin stimulates hair growth with enhanced expression of growth factors via activation of MAPK/CREB signaling pathway
10.3390/molecules25174004 · 2020 · External reference
Topical treatment of hair loss with formononetin by modulating apoptosis
10.1055/s-0035-1557897 · 2016 · External reference
Nature-derived lignan compound VB-1 exerts hair growth-promoting effects by augmenting Wnt/β-catenin signaling in human dermal papilla cells
10.7717/peerj.4737 · 2018 · External reference
Potential therapeutic targets of epigallocatechin gallate (EGCG), the most abundant catechin in green tea, and its role in the therapy of various types of cancer
10.3390/molecules25143146 · 2020 · External reference
Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits
10.1155/2021/3268136 · 2021 · External reference
Isoflavones
10.3390/molecules24061076 · 2019 · External reference
Silibinin attenuates silica dioxide nanoparticles-induced inflammation by suppressing TXNIP/MAPKs/AP-1 signaling
10.3390/cells9030678 · 2020 · External reference
Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury in rats by targeting the JAK2/STAT3 signaling pathway
10.1016/j.biopha.2022.112836 · 2022 · External reference
Review of the effects of vitexin in oxidative stress-related diseases
10.1002/fsn3.1567 · 2020 · External reference
Natural polyphenols in metabolic syndrome: protective mechanisms and clinical applications
10.3390/ijms22116110 · 2021 · External reference
Artepillin c and other Herbal pak1-blockers: effects on hair cell proliferation and related pak1-dependent biological function in cell culture: artepillin c and other herbal pak1-blockers
10.1002/ptr.5510 · 2016 · External reference
Efficacy of a mixed preparation containing piperine, capsaicin and curcumin in the treatment of alopecia areata
10.1111/jocd.14931 · 2022 · External reference
Hair growth-promoting effect of resveratrol in mice, human hair follicles and dermal papilla cells
10.2147/ccid.s335963 · 2021 · External reference
Salvianolic acid B reduces oxidative stress to promote hair-growth in mice, human hair follicles and dermal papilla cells
10.2147/ccid.s454844 · 2024 · External reference
Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects
10.3390/molecules24162930 · 2019 · External reference
Potential of curcumin in skin disorders
10.3390/nu11092169 · 2019 · External reference
Resveratrol (RV): a pharmacological review and call for further research
10.1016/j.biopha.2021.112164 · 2021 · External reference
Comparison of azelaic acid and anthralin for the therapy of patchy alopecia areata
10.2165/00128071-200506060-00007 · 2005 · External reference
The antiinflammatory effects of Xuefu Zhuyu decoction on C3H/HeJ mice with alopecia areata
10.1016/j.phymed.2020.153423 · 2021 · External reference
Amygdalin ameliorates alopecia areata on C3H/HeJ mice by inhibiting inflammation through JAK2/STAT3 pathway
10.1016/j.jep.2024.118317 · 2024 · External reference
Effect of leaves of Ginkgo biloba on hair regrowth in C3H strain mice
10.1248/yakushi1947.113.10_718 · 1993 · External reference
Extraction, purification, structural characterization, and bioactivities of Ginkgo biloba leave polysaccharides: a review
10.1016/j.ijbiomac.2024.136280 · 2024 · External reference
Hair-growth promoting effect and anti-inflammatory mechanism of Ginkgo biloba polysaccharides
10.1016/j.carbpol.2021.118811 · 2022 · External reference
Deoxyshikonin from Arnebiae Radix promotes hair growth by targeting the Wnt/β-catenin signaling pathway
10.1016/j.phymed.2025.156590 · 2025 · External reference
Cepharanthine induces the proliferation of human dermal papilla cells and stimulates vascular endothelial growth factor expression through increased intracellular calcium mobilization and hypoxia-inducible factor activation
10.1111/ced.14533 · 2021 · External reference
The versatility of azelaic acid in dermatology
10.1080/09546634.2020.1800579 · 2022 · External reference
Azelaic acid stimulates catalase activation and promotes hair growth through upregulation of Gli1 and Gli2 mRNA and Shh protein
2020 · External reference
Amygdalin - a pharmacological and toxicological review
10.1016/j.jep.2020.112717 · 2020 · External reference
Pharmacological effects and clinical prospects of cepharanthine
10.3390/molecules27248933 · 2022 · External reference
Centipeda minima extract inhibits inflammation and cell proliferation by regulating JAK/STAT signaling in macrophages and keratinocytes
10.3390/molecules28041723 · 2023 · External reference
Hair growth stimulation effect of Centipeda minima extract: identification of active compounds and anagen-activating signaling pathways
10.3390/biom11070976 · 2021 · External reference
Hair growth effect of DN106212 in C57BL/6 mouse and its network pharmacological mechanism of action
10.3390/cimb45060322 · 2023 · External reference
A hair growth-promoting effect of Chinese black tea extract in mice
10.1271/bbb.130298 · 2013 · External reference
Hair growth-promoting effect of Geranium sibiricum extract in human dermal papilla cells and C57BL/6 mice
10.1186/s12906-017-1624-4 · 2017 · External reference
Promotion effects of steam-dried Betula platyphylla extract on hair regrowth
2022 · External reference
Hair growth-promoting effects of rosehip (Rosa canina L.) seed oil in C57BL/6 mice
10.3746/pnf.2023.28.4.411 · 2023 · External reference
Genomic and transcriptomic studies on flavonoid biosynthesis in Lagerstroemia indica
10.1186/s12870-024-04776-4 · 2024 · External reference
Lagerstroemia indica extract regulates human hair dermal papilla cell growth and degeneration via modulation of β-catenin, Stat6, and TGF-β signaling pathway
10.1111/jocd.15081 · 2022 · External reference
Chemical composition of Miscanthus sinensis var. purpurascens flower absolute and its beneficial effects on skin wound healing and melanogenesis-related cell activities
10.1002/cbdv.202100383 · 2021 · External reference
Effect of Miscanthus sinensis var. purpurascens flower extract on proliferation and molecular regulation in human dermal papilla cells and stressed C57BL/6 mice, Chin
2018 · External reference
Lotus seeds (Nelumbinis semen) as an emerging therapeutic seed: a comprehensive review
10.1002/fsn3.2313 · 2021 · External reference
Hair growth promotion effect of nelumbinis semen extract with high antioxidant activity, Evid. Based Complementary
2021 · External reference
Water extract of cacumen platycladi promotes hair growth through the Akt/GSK3β/β-catenin signaling pathway
2023 · External reference
Propolis: types, composition, biological activities, and veterinary product patent prospecting
10.1002/jsfa.10024 · 2020 · External reference
The Philippines stingless bee Propolis promotes hair growth through activation of Wnt/β-catenin signaling pathway
10.1538/expanim.22-0092 · 2023 · External reference
Stimulatory effect of Brazilian Propolis on hair growth through proliferation of keratinocytes in mice
10.1021/jf503184s · 2014 · External reference
Terminalia bellirica (Gaertn.) Roxb. Extracts reshape the perifollicular microenvironment and regulate the MAPK pathway for androgenetic alopecia treatment
10.1016/j.jep.2024.118778 · 2025 · External reference
Isolation and characterization of iron chelators from turmeric (Curcuma longa): selective metal binding by curcuminoids
10.1007/s10534-017-0038-6 · 2017 · External reference
Comparison of the antioxidant effects of quercitrin and isoquercitrin: understanding the role of the 6″-OH group
10.3390/molecules21091246 · 2016 · External reference
Review of metal–polyphenol self-assembled nanoparticles: synthesis, properties, and biological applications in inflammatory diseases
10.1021/acsbiomaterials.4c02366 · 2025 · External reference
Botanical extract combined with minoxidil improve hidrotic ectodermal dysplasia caused by p.G11R mutations: a case report
10.1080/09546634.2024.2378163 · 2024 · External reference
Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study
10.3109/09546634.2011.568470 · 2012 · External reference
The emergent power of human cellular vs mouse models in translational hair research
10.1093/stcltm/szac059 · 2022 · External reference
The challenge of reproducibility and accuracy in nutrition research: resources and pitfalls
10.3945/an.115.010595 · 2016 · External reference
The essential medicinal chemistry of curcumin: miniperspective
10.1021/acs.jmedchem.6b00975 · 2017 · External reference
The metabolic characteristics and bioavailability of resveratrol based on metabolic enzymes
10.1093/nutrit/nuae161 · 2025 · External reference
Non-clinical pharmacokinetic behavior of ginsenosides
10.1016/j.jgr.2018.06.001 · 2019 · External reference
Epigallocatechin gallate: phytochemistry, bioavailability, utilization challenges, and strategies
10.1111/jfbc.14189 · 2022 · External reference
Herb-drug interactions and their impact on pharmacokinetics: an update
10.2174/1389200224666230116113240 · 2023 · External reference
Development of an HPTLC-based dynamic reference standard for the analysis of complex natural products using Jarrah honey as test sample
10.1371/journal.pone.0254857 · 2021 · External reference
Accuracy, precision, and reliability of chemical measurements in natural products research
10.1016/j.fitote.2010.09.011 · 2011 · External reference
Methodologies to evaluate the hair follicle-targeted drug delivery provided by nanoparticles
10.3390/pharmaceutics15072002 · 2023 · External reference
Curcumin-zinc framework encapsulated microneedle patch for promoting hair growth
10.7150/thno.84118 · 2023 · External reference
Liposomes enhance the hair follicle delivery of minoxidil sulfate with improved treatment of androgenic alopecia
10.1016/j.ijpharm.2025.125642 · 2025 · External reference