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References from Advanced analytical approaches for endocannabinoids and endocannabinoid-like substances: Applications in liver disease research. Local targets link to admitted publications; unresolved targets remain external evidence.
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Unresolved reference
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Hair levels of steroid, endocannabinoid, and the ratio biomarkers predict viral suppression among people living with HIV/AIDS in China
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Endocannabinoid and steroid analysis in infant and adult nails by LC-MS/MS
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Characterization of cerebral cortical endocannabinoid levels in a rat inguinal surgery model using liquid chromatography-tandem mass spectrometry (LC-MS/MS)
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UPLC-MS/MS method for analysis of endocannabinoid and related lipid metabolism in mouse mucosal tissue
10.3389/fphys.2021.699712 · 2021 · External reference
Differential modulation of white adipose tissue endocannabinoid levels by n-3 fatty acids in obese mice and type 2 diabetic patients
2018 · External reference
Set up and validation of a sensitive method to quantify prostaglandins, prostaglandin-glycerol esters and prostaglandin-ethanolamides, as well as their respective precursors
10.1016/j.prostaglandins.2023.106763 · 2023 · External reference
Human milk endocannabinoid levels as a function of obesity and diurnal rhythm
10.3390/nu13072297 · 2021 · External reference
A disposable pipette extraction-UHPLC-MS/MS method based on removal of phospholipids to determine anandamide, 2-arachidonoylglycerol, cannabidiol, and Δ9-tetrahydrocannabidiol in plasma samples
10.1002/jssc.70068 · 2025 · External reference
UHPLC-ESI-MS/MS assay for quantification of endocannabinoids in cerebrospinal fluid using surrogate calibrant and surrogate matrix approaches
10.1016/j.jpba.2022.115090 · 2023 · External reference
Simultaneous quantification of endocannabinoids, oleoylethanolamide and steroid hormones in human plasma and saliva
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Synthesis of a deuterated standard for the quantification of 2-arachidonoylglycerol in Caenorhabditis elegans
2019 · External reference
Tricks and Tracks in the Identification and Quantification of Endocannabinoids
2013 · External reference
Quantification of endocannabinoids in biological systems by chromatography and mass spectrometry: a comprehensive review from an analytical and biological perspective
2011 · External reference
Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors
10.1038/bjp.2008.324 · 2008 · External reference
Cannabinoids and the expanded endocannabinoid system in neurological disorders
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Comprehensive analysis of structure-activity relationships of α-ketoheterocycles as sn-1-diacylglycerol lipase α inhibitors
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Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases
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Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy
10.1111/bcp.13020 · 2016 · External reference
Oleoylethanolamide supplementation in obese patients newly diagnosed with non-alcoholic fatty liver disease: effects on metabolic parameters, anthropometric indices, and expression of PPAR-α, UCP1, and UCP2 genes
10.1016/j.phrs.2020.104770 · 2020 · External reference
Administration of linoleoylethanolamide reduced weight gain, dyslipidemia, and inflammation associated with high-fat-diet-induced obesity
10.3390/nu15204448 · 2023 · External reference
Clinical efficacy and biological regulations of ω-3 PUFA-derived endocannabinoids in major depressive disorder
10.1159/000501158 · 2019 · External reference
GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine
10.1186/s12974-019-1621-2 · 2019 · External reference
Wholistic endocannabinoidome-microbiome-axis modulation through nutrition (WHEN) to curb obesity and related disorders
10.1186/s12944-021-01609-3 · 2022 · External reference
An integrated strategy for in-depth profiling of N-acylethanolamines in biological samples by UHPLC-HRMS
10.1016/j.aca.2024.343262 · 2024 · External reference
Construction of machine learning tools to predict threatened miscarriage in the first trimester based on AEA, progesterone and β-hCG in China: a multicentre, observational, case-control study
10.1186/s12884-022-05025-y · 2022 · External reference
Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry
10.1002/jms.1701 · 2010 · External reference
Plasma and serum oxylipin, endocannabinoid, bile acid, steroid, fatty acid and nonsteroidal anti-inflammatory drug quantification in a 96-well plate format
10.1016/j.aca.2020.11.019 · 2021 · External reference
A simple LC-MS/MS method for the simultaneous quantification of endocannabinoids in biological samples
10.1016/j.jchromb.2020.122371 · 2020 · External reference
Quantitative lipidomic analysis of osteosarcoma cell-derived products by UHPLC-MS/MS
10.3390/biom10091302 · 2020 · External reference
A micro salting-out assisted liquid-liquid extraction combined with ultra-high performance liquid chromatography tandem mass spectrometry to determine anandamide and 2-arachidonoylglycerol in rat brain samples
10.1016/j.jchromb.2020.122351 · 2020 · External reference
Association of anandamide with altered binocular depth inversion illusion in schizophrenia
10.1080/15622975.2016.1246750 · 2017 · External reference
Endocannabinoid reactivity to acute stress: investigation of the relationship between salivary and plasma levels
10.1016/j.biopsycho.2021.108022 · 2021 · External reference
Effects of environmental heat load on endocannabinoid system components in adipose tissue of high yielding dairy cows
10.3390/ani12060795 · 2022 · External reference
Comparison of conventional and supported liquid extraction methods for the determination of sitagliptin and simvastatin in rat plasma by LC-ESI-MS/MS
10.1016/j.jpha.2014.11.003 · 2015 · External reference
In vivo solid phase microextraction for bioanalysis
10.1016/j.trac.2022.116656 · 2022 · External reference
In vivo sampling: a promising technique for detecting and profiling endogenous substances in living systems
10.1021/acs.jafc.8b06981 · 2019 · External reference
Polymeric ionic liquid open tubular capillary column for on-line in-tube SPME coupled with UHPLC-MS/MS to determine endocannabinoids in plasma samples
10.1016/j.aca.2018.08.062 · 2019 · External reference
A dual ligand sol-gel organic-silica hybrid monolithic capillary for in-tube SPME-MS/MS to determine amino acids in plasma samples
10.3390/molecules24091658 · 2019 · External reference
Analysis of endocannabinoids in plasma samples by biocompatible solid-phase microextraction devices coupled to mass spectrometry
10.1016/j.aca.2019.09.002 · 2019 · External reference
Application of a rapid μ-SPE clean-up for multiclass quantitative analysis of sixteen new psychoactive substances in whole blood by LC–MS/MS
10.1016/j.talanta.2017.02.019 · 2017 · External reference
Determination of endocannabinoids and their conjugated congeners in the brain by means of μSPE combined with UHPLC-MS/MS
10.1016/j.talanta.2023.124392 · 2023 · External reference
Effects of rare phytocannabinoids on the endocannabinoid system of human keratinocytes
10.3390/ijms23105430 · 2022 · External reference
Determination of endocannabinoids and N-acylethanolamines in human hair with LC-MS/MS and their relation to symptoms of depression, burnout, and anxiety
10.1016/j.talanta.2020.121006 · 2020 · External reference
Study of sample preparation for determination of endocannabinoids and analogous compounds in human serum by LC–MS/MS in MRM mode
10.1016/j.talanta.2018.04.033 · 2018 · External reference
A column switching ultrahigh-performance liquid chromatography-tandem mass spectrometry method to determine anandamide and 2-arachidonoylglycerol in plasma samples
10.1007/s00216-017-0300-3 · 2017 · External reference
Analysis of 14 endocannabinoids and endocannabinoid congeners in human plasma using column switching high-performance atmospheric pressure chemical ionization liquid chromatography–mass spectrometry
10.1007/s00216-021-03280-0 · 2021 · External reference
Microdialysis as an important technique in systems pharmacology-a historical and methodological review
10.1208/s12248-017-0108-2 · 2017 · External reference
Overview of brain microdialysis
2009 · External reference
Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake
10.1038/s41386-018-0055-3 · 2018 · External reference
Chemical derivatization strategy for mass spectrometry-based lipidomics
10.1002/mas.21729 · 2023 · External reference
Accurate quantification of endogenous N-acylethanolamides by chemical isotope labeling coupled with liquid chromatography-tandem mass spectrometry
10.1016/j.aca.2021.338839 · 2021 · External reference
Four-dimensional untargeted profiling of N-acylethanolamine lipids in the mouse brain using ion mobility-mass spectrometry
10.1021/acs.analchem.2c02650 · 2022 · External reference
Investigation of changes in endocannabinoids and N-acylethanolamides in biofluids, and their correlations with female infertility
10.1016/j.chroma.2017.06.029 · 2017 · External reference
Boronic derivatization of monoacylglycerol and monitoring in biofluids
10.1021/acs.analchem.9b00805 · 2019 · External reference
Boronic derivatization-based strategy for monoacylglycerol identification, isomer annotation and quantification
10.1016/j.aca.2021.339233 · 2022 · External reference
Endocannabinoids as potential biomarkers: it's all about pre-analytics
10.1016/j.jmsacl.2021.11.001 · 2021 · External reference
Quantification of 24 circulating endocannabinoids, endocannabinoid-related compounds, and their phospholipid precursors in human plasma by UHPLC-MS/MS
10.1194/jlr.d094680 · 2019 · External reference
Mechanisms underlining inflammatory pain sensitivity in mice selected for high and low stress-induced analgesia-the role of endocannabinoids and microglia
10.3390/ijms231911686 · 2022 · External reference
Optimization and validation of online column-switching assisted HPLC-spectrometric method for quantification of dansylated endocannabinoids and neurotransmitters in animal models of brain diseases
10.17352/ojabc.000016 · 2019 · External reference
HPLC fluorescence assay for measuring the activity of NAPE-PLD and the action of inhibitors affecting this enzyme
10.1016/j.jpba.2023.115354 · 2023 · External reference
Recent HPLC-UV approaches for cannabinoid analysis: from extraction to method validation and quantification compliance
10.3390/ph18060786 · 2025 · External reference
An inverse agonist of estrogen-related receptor γ regulates 2-arachidonoylglycerol synthesis by modulating diacylglycerol lipase expression in alcohol-intoxicated mice
10.1007/s00204-019-02648-7 · 2020 · External reference
Simultaneous determination of endocannabinoids (arachidonylethanolamide and 2-arachidonylglycerol) and isoprostane (8-epiprostaglandin F2α) by gas chromatography–mass spectrometry-selected ion monitoring for medical samples
10.1016/s1570-0232(03)00311-8 · 2003 · External reference
Analysis of anandamide, an endogenous cannabinoid substance, and of other natural N-acylethanolamines, Prostaglandins Leukot. Essent
10.1016/0952-3278(95)90130-2 · 1995 · External reference
Isotope dilution mass spectrometric measurements indicate that arachidonylethanolamide, the proposed endogenous ligand of the cannabinoid receptor, accumulates in rat brain tissue post mortem but is contained at low levels in or is absent from fresh tissue
10.1074/jbc.271.29.17287 · 1996 · External reference
The effects of systemic and local fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on the metabolomic profile of lungs
10.1002/bmc.5231 · 2022 · External reference
Recent applications of microextraction sample preparation techniques in biological samples analysis
10.1002/bmc.5105 · 2021 · External reference
Comparison of APPI, APCI and ESI for the LC-MS/MS analysis of bezafibrate, cyclophosphamide, enalapril, methotrexate and orlistat in municipal wastewater
10.1002/jms.1904 · 2011 · External reference
Application to several suspected poisoning cases of a validated analytical method for the determination of muscarine in human biological matrices using liquid chromatography with high-resolution mass spectrometry detection
10.1002/dta.3542 · 2024 · External reference
Modified metabolites mapping by liquid chromatography-high resolution mass spectrometry using full scan/all ion fragmentation/neutral loss acquisition
10.1016/j.chroma.2018.11.014 · 2019 · External reference
Quantitative profiling of endocannabinoids and related N-acylethanolamines in human CSF using nano LC-MS/MS
10.1194/jlr.d070433 · 2017 · External reference
Quantification of endocannabinoids in human cerebrospinal fluid using a novel micro-flow liquid chromatography-mass spectrometry method
10.1016/j.aca.2022.339888 · 2022 · External reference
Profiling the chemical differences of diterpenoid alkaloids in different processed products of aconiti lateralis radix praeparata by UHPLC-LTQ-Orbitrap mass spectrometry combined with untargeted metabolomics and mass spectrometry imaging
2025 · External reference
Stress upregulates 2-arachidonoylglycerol levels in the hypothalamus, midbrain, and hindbrain, and it is sustained by green nut oil supplementation in SAMP8 mice revealed by DESI-MSI
10.1016/j.bbrc.2022.04.004 · 2022 · External reference
Endocannabinoid 2-arachidonoylglycerol levels in the anterior cingulate cortex, caudate putamen, nucleus accumbens, and piriform cortex were upregulated by chronic restraint stress
10.3390/cells12030393 · 2023 · External reference
Modulation of neurolipid signaling and specific lipid species in the triple transgenic mouse model of Alzheimer's disease
10.3390/ijms222212256 · 2021 · External reference
Enhanced visualization of endocannabinoids spatial distribution in mouse brain via MALDI-2 mass spectrometry imaging
10.1016/j.talanta.2025.127811 · 2025 · External reference
Bioconjugation of 2-arachidonoyl glycerol (2-AG) biotinylated antibody with gold nano-flowers toward immunosensing of 2-AG in human plasma samples: a novel immuno-platform for the screening of immunomodulation and neuroprotection using biosensing
10.1039/d0ay02135k · 2021 · External reference
An innovative electrochemical immuno-platform towards ultra-sensitive monitoring of 2-arachidonoyl glycerol in samples from rats with sleep deprivation: bioanalysis of endogenous cannabinoids using biosensor technology
10.1039/d2ra00380e · 2022 · External reference
An innovative sandwich type biosensor towards sensitive and selective monitoring of 2-arachidonoylglycerol in human plasma samples using P(β-CD)-AuNPs-DDT as amplificant agent: a new immuno-platform for the recognition of endocannabinoids in real samples
10.3390/bios12100791 · 2022 · External reference
BIONOTE as an innovative biosensor for measuring endocannabinoid levels
10.3390/s21020489 · 2021 · External reference
Circulating endocannabinoid levels in pregnant women with gestational diabetes mellitus: a case-control study
10.1186/s12902-022-01182-5 · 2022 · External reference
Endocannabinoid system and metabolism: the influences of sex
10.3390/ijms252211909 · 2024 · External reference
The role of sex steroid hormones, cytokines and the endocannabinoid system in female fertility
10.1093/humupd/dmq058 · 2011 · External reference
Dynamic changes in the endocannabinoid system during the aging process: focus on the middle-age crisis
10.3390/ijms231810254 · 2022 · External reference
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2025 · External reference
Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol
10.1210/jc.2014-3455 · 2015 · External reference
Endocannabinoid signalling: has it got rhythm?
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The endocannabinoid system: pivotal orchestrator of obesity and metabolic disease
10.1016/j.tem.2015.07.007 · 2015 · External reference
Endocannabinoids and liver disease. I. endocannabinoids and their receptors in the liver
10.1152/ajpgi.00467.2007 · 2008 · External reference
Endocannabinoid receptors gene expression in morbidly obese women with nonalcoholic fatty liver disease
10.1155/2014/502542 · 2014 · External reference
Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration
10.1002/hep.23779 · 2010 · External reference
Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver
10.1002/hep.26598 · 2014 · External reference
F2-isoprostanes and 2-arachidonylglycerol as biomarkers of lipid peroxidation in pigs with hepatic ischemia/reperfusion injury
10.1016/j.jss.2009.01.026 · 2010 · External reference
A UPLC-MS/MS method for simultaneous determination of arachidonic acid, stearic acid, and related endocannabinoids in human plasma
10.1016/j.heliyon.2024.e28467 · 2024 · External reference
Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease
10.1002/oby.21687 · 2017 · External reference
N-3 polyunsaturated fatty acids in phospholipid or triacylglycerol form attenuate nonalcoholic fatty liver disease via mediating cannabinoid receptor 1/adiponectin/ceramide pathway
10.1016/j.jnutbio.2023.109484 · 2024 · External reference
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease
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Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis
10.1172/jci.insight.92989 · 2017 · External reference
Differential effect of interferon-alpha treatment on AEA and 2-AG levels
10.1016/j.bbi.2020.08.024 · 2020 · External reference
Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation
10.3390/ijms16047057 · 2015 · External reference
4-O’-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice
10.1007/s00109-017-1556-y · 2017 · External reference
Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis
10.1111/j.1478-3231.2009.02137.x · 2010 · External reference
The endocannabinoid 2-arachidonoyl glycerol induces death of hepatic stellate cells via mitochondrial reactive oxygen species
10.1096/fj.06-7717com · 2007 · External reference
The endocannabinoid system in cholestasis
10.1016/j.dld.2011.05.005 · 2011 · External reference
Opposite roles of cannabinoid receptors 1 and 2 in hepatocarcinogenesis
10.1136/gutjnl-2015-310212 · 2016 · External reference
Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma
2019 · External reference
Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry
10.1021/pr300683a · 2012 · External reference
Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice
10.1016/j.nbd.2005.07.008 · 2006 · External reference
Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis
10.1189/jlb.0307180 · 2007 · External reference
Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury
10.1096/fj.06-7451com · 2007 · External reference
Hepatic cannabinoid signaling in the regulation of alcohol-associated liver disease
10.35946/arcr.v41.1.12 · 2021 · External reference
The endocannabinoid-alcohol crosstalk: recent advances on a bi-faceted target
10.1111/1440-1681.12967 · 2018 · External reference
The epidemiology, pathogenesis and histopathology of fatty liver disease
10.1111/j.1365-2559.2011.04145.x · 2012 · External reference
Honokiol acts as an AMPK complex agonist therapeutic in non-alcoholic fatty liver disease and metabolic syndrome
10.1186/s13020-023-00729-5 · 2023 · External reference
The liver as an endocrine organ: linking NAFLD and insulin resistance
10.1210/er.2019-00034 · 2019 · External reference
Human liver fatty acid binding protein-1 T94A variant, nonalcohol fatty liver disease, and hepatic endocannabinoid system
10.1002/lipd.12008 · 2018 · External reference
Cannabinoid-2 receptor depletion promotes non-alcoholic fatty liver disease in mice via disturbing gut microbiota and tryptophan metabolism
10.1038/s41401-025-01495-w · 2025 · External reference
Anti-hepatitis B virus activities of natural products and their antiviral mechanisms
2023 · External reference
Pathobiology of liver fibrosis: a translational success story
10.1136/gutjnl-2014-306842 · 2015 · External reference
Cirrhosis and chronic liver failure: part I. Diagnosis and evaluation
2006 · External reference
Cannabinoid receptor type I modulates alcohol-induced liver fibrosis
10.2119/molmed.2011.00149 · 2011 · External reference
Liver cancer epidemic in China: past, present and future
10.1016/j.semcancer.2010.11.002 · 2011 · External reference
The endocannabinoid system, a new gatekeeper in the pharmacology of human hepatocellular carcinoma
10.1016/j.envres.2023.115914 · 2023 · External reference
Glutamate signaling in hepatic stellate cells drives alcoholic steatosis
10.1016/j.cmet.2019.08.001 · 2019 · External reference
Recent advances in the understanding of the role of the endocannabinoid system in liver diseases
10.1016/j.dld.2010.08.010 · 2011 · External reference
Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP-activated protein kinase
10.1096/fj.06-7705com · 2007 · External reference
Cardiomyocyte apoptosis contributes to pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated mice
10.1042/cs20130642 · 2014 · External reference
Oleoylethanolamide: a new player in peripheral control of energy metabolism. Therapeutic implications
10.1016/j.ddmec.2011.02.001 · 2010 · External reference
The endocannabinoid system in advanced liver cirrhosis: pathophysiological implication and future perspectives
10.1111/liv.12263 · 2013 · External reference
Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat
10.1053/gast.2002.30305 · 2002 · External reference
Bile acid levels are increased in the liver of patients with steatohepatitis
10.1097/meg.0b013e3282f4710a · 2008 · External reference
Potentiation of anandamide effects in mesenteric beds isolated from bile duct-ligated rats: role of nitric oxide
10.1016/j.ejphar.2003.12.004 · 2004 · External reference
2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease
10.1016/j.plefa.2008.07.003 · 2008 · External reference
Autoimmune hepatitis: a review of current diagnosis and treatment
2011 · External reference
Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells
10.1124/mol.108.047035 · 2008 · External reference
The effect of oleoylethanolamide (OEA) add-on treatment on inflammatory, oxidative stress, lipid, and biochemical parameters in the acute ischemic stroke patients: randomized double-blind placebo-controlled study
10.1155/2022/5721167 · 2022 · External reference
Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats
10.1016/j.jphs.2014.12.001 · 2015 · External reference
Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells
10.18632/oncotarget.6466 · 2015 · External reference
Chronic oleoylethanolamide treatment decreases hepatic triacylglycerol level in rat liver by a PPARγ/SREBP-mediated suppression of fatty acid and triacylglycerol synthesis
10.3390/nu13020394 · 2021 · External reference
Anandamide induces cell death through lipid rafts in hepatic stellate cells
10.1111/j.1440-1746.2009.06122.x · 2010 · External reference