Research graph
References from PKM2: A gatekeeper in macrophage metabolic reprogramming. Local targets link to admitted publications; unresolved targets remain external evidence.
On the origin of cancer cells
10.1126/science.123.3191.309 · 1956 · External reference
Pyruvate kinase M2: a simple molecule with complex functions
10.1016/j.freeradbiomed.2019.08.007 · 2019 · External reference
HIF1α and metabolic reprogramming in inflammation
10.1172/jci84431 · 2016 · External reference
The role of lipid metabolic reprogramming in tumor microenvironment
10.7150/thno.82920 · 2023 · External reference
Amino acid metabolism in immune cells: Essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
10.1186/s13045-023-01453-1 · 2023 · External reference
Metabolic regulation of the immune system in health and diseases: Mechanisms and interventions
10.1038/s41392-024-01954-6 · 2024 · External reference
Metabolic reprograming in macrophage polarization
2014 · External reference
The metabolic signature of macrophage responses
10.3389/fimmu.2019.01462 · 2019 · External reference
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
10.1016/j.cmet.2006.05.011 · 2006 · External reference
Fatty acid oxidation in macrophage polarization
10.1038/ni.3366 · 2016 · External reference
Macrophage immunometabolism: Where are we (going)?
10.1016/j.it.2017.03.001 · 2017 · External reference
Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity
10.1016/j.cmet.2016.10.008 · 2016 · External reference
Immunometabolism governs dendritic cell and macrophage function
10.1084/jem.20151570 · 2016 · External reference
Isozymes of mammalian hexokinase: Structure, subcellular localization and metabolic function
10.1242/jeb.00241 · 2003 · External reference
Pyruvate kinase: function, regulation and role in cancer
10.1016/j.semcdb.2015.08.004 · 2015 · External reference
PKM2, function and expression and regulation
10.1186/s13578-019-0317-8 · 2019 · External reference
Targeting pyruvate kinase M2 for the treatment of kidney disease
10.3389/fphar.2024.1376252 · 2024 · External reference
Multiple functions of pyruvate kinase M2 in various cell types
10.1002/jcp.30536 · 2022 · External reference
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
10.1021/bi0474923 · 2005 · External reference
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
10.1038/nature11540 · 2012 · External reference
SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions
10.1126/science.1224409 · 2012 · External reference
Mechanistic and structural insights into cysteine-mediated inhibition of pyruvate kinase muscle isoform 2
10.1021/acs.biochem.9b00349 · 2019 · External reference
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
10.7554/elife.45068 · 2019 · External reference
An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate
10.1021/bi00243a010 · 1991 · External reference
M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation
10.1073/pnas.1217157110 · 2013 · External reference
The third international consensus definitions for sepsis and septic shock (sepsis-3)
10.1001/jama.2016.0287 · 2016 · External reference
PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis
10.1038/ncomms5436 · 2014 · External reference
Plumbagin protects mice from lethal sepsis by modulating immunometabolism upstream of PKM2
10.2119/molmed.2015.00250 · 2016 · External reference
Deoxyelephantopin decreases the release of inflammatory cytokines in macrophage associated with attenuation of aerobic glycolysis via modulation of PKM2
10.1016/j.intimp.2019.106048 · 2020 · External reference
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis
10.1016/j.fitote.2021.104922 · 2021 · External reference
Eriocitrin attenuates sepsis-induced acute lung injury in mice by regulating MKP1/MAPK pathway mediated-glycolysis
10.1016/j.intimp.2023.110021 · 2023 · External reference
Xijiao Dihuang decoction improves prognosis of sepsis via inhibition of aerobic glycolysis
10.1016/j.biopha.2020.110501 · 2020 · External reference
Angiotensin-(1-7) Modulates the warburg effect to alleviate inflammation in LPS-induced macrophages and septic mice
10.2147/jir.s446013 · 2024 · External reference
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages
10.1016/j.cmet.2014.12.005 · 2015 · External reference
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
10.1038/ncomms13280 · 2016 · External reference
The circadian clock protein BMAL1 acts as a metabolic sensor in macrophages to control the production of pro IL-1β
10.3389/fimmu.2021.700431 · 2021 · External reference
Protein 4.1R regulates M1 macrophages polarization via glycolysis, alleviating sepsis-induced liver injury in mice
10.1016/j.intimp.2024.111546 · 2024 · External reference
Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2
10.1016/j.celrep.2020.02.007 · 2020 · External reference
Activator-mediated pyruvate kinase M2 activation contributes to endotoxin tolerance by promoting mitochondrial biogenesis
10.3389/fimmu.2020.595316 · 2021 · External reference
PKM2-mediated STAT3 phosphorylation promotes acute liver failure via regulating NLRP3-dependent pyroptosis
10.1038/s42003-024-07227-w · 2024 · External reference
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
10.1093/emboj/cdg516 · 2003 · External reference
Fibrinogen-like protein 2 regulates macrophage glycolytic reprogramming by directly targeting PKM2 and exacerbates alcoholic liver injury
10.1016/j.intimp.2023.110957 · 2023 · External reference
Role of Selenoprotein W in participating in the progression of non-alcoholic fatty liver disease
10.1016/j.redox.2024.103114 · 2024 · External reference
Downregulation of miR-122-5p activates glycolysis via PKM2 in kupffer cells of rat and mouse models of non-alcoholic steatohepatitis
10.3390/ijms23095230 · 2022 · External reference
Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH
10.1016/j.redox.2020.101634 · 2020 · External reference
Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis
10.1038/s41467-024-45167-5 · 2024 · External reference
HSPA12A is a novel player in nonalcoholic steatohepatitis via promoting nuclear PKM2-mediated M1 macrophage polarization
10.2337/db18-0035 · 2019 · External reference
FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2
10.1136/gutjnl-2021-325150 · 2022 · External reference
High expression of glycolytic genes in cirrhosis correlates with the risk of developing liver cancer
10.3389/fcell.2018.00138 · 2018 · External reference
Clinicopathological and prognostic significance of PKM2 protein expression in cirrhotic hepatocellular carcinoma and non-cirrhotic hepatocellular carcinoma
10.1038/s41598-017-14813-y · 2017 · External reference
Overexpression of pyruvate kinase M2 in tumor tissues is associated with poor prognosis in patients with hepatocellular carcinoma
10.1007/s12253-019-00630-3 · 2020 · External reference
Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: From gene expression to drug discovery
10.1186/s12885-018-5023-0 · 2018 · External reference
PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma
10.1136/gutjnl-2021-326350 · 2022 · External reference
Spleen tyrosine kinase: A novel pharmacological target for sepsis-induced cardiac dysfunction and multi-organ failure
10.3389/fimmu.2024.1447901 · 2024 · External reference
SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence
10.1186/s10020-024-00907-7 · 2024 · External reference
Pyruvate kinase M2 contributes to TLR-mediated inflammation and autoimmunity by promoting Pyk2 activation
10.3389/fimmu.2021.680068 · 2021 · External reference
DRAM1 increases the secretion of PKM2-enriched EVs from hepatocytes to promote macrophage activation and disease progression in ALD
10.1016/j.omtn.2021.12.017 · 2022 · External reference
Selenoprotein W deficiency does not affect oxidative stress and insulin sensitivity in the skeletal muscle of high-fat diet-fed obese mice
10.1152/ajpcell.00064.2019 · 2019 · External reference
Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation
10.1016/j.redox.2022.102571 · 2023 · External reference
Annexin A protein family in atherosclerosis
10.1016/j.cca.2022.05.009 · 2022 · External reference
Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
10.1002/hep.22569 · 2008 · External reference
Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases
10.1002/hep.25873 · 2012 · External reference
Ectosomal PKM2 promotes HCC by inducing macrophage differentiation and remodeling the tumor microenvironment
10.1016/j.molcel.2020.05.004 · 2020 · External reference
Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells, cell
10.1038/s41423-020-00572-w · 2021 · External reference
Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair
10.3390/cells10010051 · 2020 · External reference
Resident cardiac macrophages: heterogeneity and function in health and disease
10.1016/j.immuni.2022.08.009 · 2022 · External reference
Role of pyruvate kinase M2 (PKM2) in cardiovascular diseases
10.1007/s12265-022-10321-1 · 2023 · External reference
Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity
10.1126/scitranslmed.aau8866 · 2019 · External reference
Inhibiting the Pkm2/b-catenin axis drives in vivo replication of adult cardiomyocytes following experimental MI
10.1038/s41418-020-00669-9 · 2021 · External reference
Jmjd4 facilitates Pkm2 degradation in cardiomyocytes and is protective against dilated cardiomyopathy
10.1161/circulationaha.123.064121 · 2023 · External reference
M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics
10.1186/s12967-023-04780-6 · 2023 · External reference
Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition
10.15252/embj.2018100938 · 2019 · External reference
The protective effect of hydroxytyrosol acetate against inflammation of vascular endothelial cells partly through the SIRT6-mediated PKM2 signaling pathway
10.1039/c9fo00586b · 2019 · External reference
Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis
10.3389/fphar.2022.1009229 · 2022 · External reference
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence
10.1038/s41467-023-37094-8 · 2023 · External reference
The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease
10.1084/jem.20150900 · 2016 · External reference
Myeloid cell PKM2 deletion enhances efferocytosis and reduces atherosclerosis
10.1161/circresaha.121.320704 · 2022 · External reference
Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis, animal model
2023 · External reference
PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis
10.1007/s00109-018-1645-6 · 2018 · External reference
Shikonin attenuates hyperhomocysteinemia-induced CD4+ T cell inflammatory activation and atherosclerosis in ApoE-/- mice by metabolic suppression
10.1038/s41401-019-0308-7 · 2020 · External reference
T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2
10.1016/j.redox.2022.102257 · 2022 · External reference
Pyruvate kinase M2 sustains cardiac mitochondrial quality surveillance in septic cardiomyopathy by regulating prohibitin 2 abundance via S91 phosphorylation
10.1007/s00018-024-05253-9 · 2024 · External reference
Pyruvate kinase M2 sustains cardiac mitochondrial integrity in septic cardiomyopathy by regulating PHB2-dependent mitochondrial biogenesis
10.7150/ijms.94577 · 2024 · External reference
Pyruvate kinase M2 protects heart from pressure overload-induced heart failure by phosphorylating RAC1
10.1161/jaha.121.024854 · 2022 · External reference
TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure
10.1126/scitranslmed.abm3565 · 2022 · External reference
Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart
10.14814/phy2.70193 · 2025 · External reference
Plasma pyruvate kinase M2 as a marker of vascular inflammation in giant cell arteritis
10.1093/rheumatology/keab814 · 2022 · External reference
The impact of hyperglycaemia on PKM2-mediated NLRP3 inflammasome/stress granule signalling in macrophages and its correlation with plaque vulnerability: An in vivo and in vitro study
10.1016/j.metabol.2020.154231 · 2020 · External reference
Elevated plasma pyruvate kinase M2 concentrations are associated with the clinical severity and prognosis of coronary artery disease
2024 · External reference
Macrophages in atherosclerosis regression
10.1161/atvbaha.119.312802 · 2020 · External reference
Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages
10.1016/j.atherosclerosis.2022.05.015 · 2022 · External reference
Macrophage junctional adhesion molecule-like (JAML) protein promotes NLRP3 inflammasome activation in the development of atherosclerosis
10.1038/s41418-025-01489-5 · 2025 · External reference
Macrophages in cardiac remodelling after myocardial infarction
10.1038/s41569-022-00823-5 · 2023 · External reference
ω-Alkynyl arachidonic acid promotes anti-inflammatory macrophage M2 polarization against acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1α and iNOS
10.1016/j.bbalip.2017.09.009 · 2017 · External reference
Iminostilbene, a novel small-molecule modulator of PKM2, suppresses macrophage inflammation in myocardial ischemia-reperfusion injury
10.1016/j.jare.2020.09.001 · 2021 · External reference
Inhibition of pyruvate kinase M2 (PKM2) by shikonin attenuates isoproterenol-induced acute myocardial infarction via reduction in inflammation, hypoxia, apoptosis, and fibrosis
10.1007/s00210-023-02593-4 · 2024 · External reference
M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2/HIF-1α axis mediated metabolic reprogramming of macrophages
10.1016/j.redox.2023.103016 · 2024 · External reference
MEK1/2-PKM2 pathway modulates the immunometabolic reprogramming of proinflammatory allograft-infiltrating macrophages during heart transplant rejection
10.1097/tp.0000000000004899 · 2024 · External reference
Pathogenesis of pneumonia and acute lung injury
10.1042/cs20210879 · 2022 · External reference
Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury
10.3389/fimmu.2020.01722 · 2020 · External reference
Inhibition of glycolysis alleviates lipopolysaccharide-induced acute lung injury in a mouse model
10.1002/jcp.27261 · 2019 · External reference
Iridin prevented against lipopolysaccharide-induced inflammatory responses of macrophages via inactivation of PKM2-mediated glycolytic pathways
10.2147/jir.s292244 · 2021 · External reference
Pyruvate kinase M2 nuclear translocation regulate ferroptosis-associated acute lung injury in cytokine storm
10.1007/s10753-024-02000-x · 2024 · External reference
Changes in energy metabolism and macrophage polarization: Potential mechanisms of arsenic-induced lung injury
10.1016/j.ecoenv.2020.110948 · 2020 · External reference
Glycolytic reprogramming in silica-induced lung macrophages and silicosis reversed by Ac-SDKP treatment
10.3390/ijms221810063 · 2021 · External reference
A novel role for the ROS-ATM-Chk2 axis mediated metabolic and cell cycle reprogramming in the M1 macrophage polarization
10.1016/j.redox.2024.103059 · 2024 · External reference
Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
10.1016/j.ejphar.2022.175352 · 2022 · External reference
Norisoboldine attenuates sepsis-induced acute lung injury by modulating macrophage polarization via PKM2/HIF-1α/PGC-1α pathway
10.1248/bpb.b21-00457 · 2021 · External reference
SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury
10.1177/17534259231166212 · 2023 · External reference
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease
10.1016/j.cmet.2022.02.013 · 2022 · External reference
Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to disease-associated microglia stage 1
10.1523/jneurosci.1563-23.2024 · 2024 · External reference
Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling
10.1016/j.biopha.2022.113479 · 2022 · External reference
PKM2 nuclear translocation promotes glial cell activation and aggravates the brain injury of intracerebral hemorrhage
10.31083/j.jin2206168 · 2023 · External reference
Suppressing nuclear translocation of microglial PKM2 confers neuroprotection via downregulation of neuroinflammation after mouse cerebral ischemia-reperfusion injury
10.1016/j.intimp.2024.112880 · 2024 · External reference
Tetramerization of PKM2 alleviates traumatic brain injury by ameliorating mitochondrial damage in microglia
2024 · External reference
Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway
10.1186/s12974-021-02279-9 · 2021 · External reference
LncRNA-AC020978 promotes metabolic reprogramming in M1 microglial cells in postoperative cognitive disorder via PKM2
10.1007/s12035-023-03729-6 · 2024 · External reference
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia
10.1016/j.molimm.2021.10.017 · 2021 · External reference
Sirt5-mediated polarization and metabolic reprogramming of macrophage sustain brain function following ischemic stroke
10.1016/j.brainres.2025.149613 · 2025 · External reference
Amyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future
10.1038/s41392-023-01484-7 · 2023 · External reference
Neurotoxic effects of triclosan in adolescent mice: Pyruvate kinase M2 dimer regulated Signal transducer and activator of transcription 3 phosphorylation mediated microglia activation and neuroinflammation
10.1016/j.scitotenv.2024.173739 · 2024 · External reference
Understanding the molecular pathway of triclosan-induced ADHD-like behaviour: Involvement of the hnRNPA1-PKM2-STAT3 feedback loop
10.1016/j.envint.2024.108966 · 2024 · External reference
Alpha-synuclein induces microglial migration via PKM2-dependent glycolysis
10.1016/j.ijbiomac.2019.02.029 · 2019 · External reference
Microglia PKM2 mediates neuroinflammation and neuron loss in mice epilepsy through the astrocyte C3-neuron C3R signaling pathway
10.3390/brainsci13020262 · 2023 · External reference
The Warburg effect then and now: from cancer to inflammatory diseases
10.1002/bies.201300084 · 2013 · External reference
Evolving cognition of the JAK-STAT signaling pathway: Autoimmune disorders and cancer
10.1038/s41392-023-01468-7 · 2023 · External reference
Novel targets for treating neurodegenerative diseases: The PKM2-STAT3-hnRNPA1 feedback loop
10.1016/j.phrs.2025.107840 · 2025 · External reference
Pharmacological properties and derivatives of shikonin-a review in recent years
10.1016/j.phrs.2019.104463 · 2019 · External reference
Shikonin inhibits immune checkpoint PD-L1 expression on macrophage in sepsis by modulating PKM2
10.1016/j.intimp.2023.110401 · 2023 · External reference
Inflammatory choroidal neovascularization: an evidence-based update
10.1016/j.survophthal.2024.12.004 · 2025 · External reference
Shikonin alleviates choroidal neovascularization by inhibiting proangiogenic factor production from infiltrating macrophages
10.1016/j.exer.2021.108823 · 2021 · External reference
Plumbagin, a natural compound with several biological effects and anti-inflammatory properties
2023 · External reference
Deoxyelephantopin and its isomer isodeoxyelephantopin: Anti-cancer natural products with multiple modes of action
10.3390/molecules27072086 · 2022 · External reference
The role of celastrol in inflammation and diseases
10.1007/s00011-024-01983-5 · 2025 · External reference
Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
2022 · External reference
Capsaicin from chili peppers and its analogues and their valued applications: An updated literature review
10.1016/j.foodres.2025.116034 · 2025 · External reference
Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis
10.1016/j.chembiol.2022.06.011 · 2022 · External reference
Natural sources, biological effects, and pharmacological properties of cynaroside
10.1016/j.biopha.2023.114337 · 2023 · External reference
Flavonoids regulate tumor-associated macrophages – From structure-activity relationship to clinical potential (Review)
10.1016/j.phrs.2022.106419 · 2022 · External reference
Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review
10.1016/j.jep.2016.03.046 · 2016 · External reference
Network pharmacology based research into the effect and mechanism of Xijiao Dihuang decoction against sepsis
10.1016/j.biopha.2019.109777 · 2020 · External reference
Network and experimental pharmacology on mechanism of Si-Wu-tang improving ovarian function in a mouse model of premature ovarian failure induced by cyclophosphamide
10.1016/j.jep.2022.115842 · 2023 · External reference
Si-Wu-Tang attenuates hepatocyte PANoptosis and M1 polarization of macrophages in non-alcoholic fatty liver disease by influencing the intercellular transfer of mtDNA
10.1016/j.jep.2024.118057 · 2024 · External reference
Bioactive sulforaphane from cruciferous vegetables: Advances in biosynthesis, metabolism, bioavailability, delivery, health benefits, and applications
10.1080/10408398.2024.2354937 · 2025 · External reference
Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages
10.3389/fimmu.2022.935692 · 2022 · External reference
The current landscape of the antimicrobial peptide melittin and its therapeutic potential
10.3389/fimmu.2024.1326033 · 2024 · External reference
Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect
10.1038/s41401-020-00516-0 · 2021 · External reference
New uses for an old remedy: digoxin as a potential treatment for steatohepatitis and other disorders
10.3748/wjg.v29.i12.1824 · 2023 · External reference
Digoxin suppresses pyruvate kinase M2-promoted HIF-1α transactivation in steatohepatitis
10.1016/j.cmet.2018.01.007 · 2018 · External reference
Production and pharmaceutical research of minor saponins in Panax notoginseng (Sanqi): Current status and future prospects
10.1016/j.phytochem.2024.114099 · 2024 · External reference