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References from Probucol inhibits palmitic acid-mediated renal calcium oxalate stone formation by targeting KLF5-PPARγ axis-mediated lipotoxicity. Local targets link to admitted publications; unresolved targets remain external evidence.
The genetics of kidney stone disease and nephrocalcinosis
10.1038/s41581-021-00513-4 · 2022 · External reference
Management of kidney stones in 2020
10.1001/jama.2020.0662 · 2020 · External reference
Kidney stone pathophysiology, evaluation and management: core curriculum 2023
10.1053/j.ajkd.2023.03.017 · 2023 · External reference
Kidney stones
10.1038/nrdp.2016.8 · 2016 · External reference
Determining the true burden of kidney stone disease
10.1038/s41581-020-0320-7 · 2020 · External reference
Dyslipidemia is associated with an increased risk of nephrolithiasis
10.1007/s00240-014-0719-3 · 2015 · External reference
Association between dyslipidemia and nephrolithiasis risk in a Chinese population
10.1159/000496208 · 2019 · External reference
The impacts of metabolic syndrome on the risk of severe urolithiasis
10.1007/s00240-022-01328-z · 2022 · External reference
Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid
10.1007/s00018-024-05145-y · 2024 · External reference
Krϋppel-like factors (KLFs) in renal physiology and disease
10.1016/j.ebiom.2019.01.021 · 2019 · External reference
Matrix-stiffness–regulated inverse expression of Krüppel-like factor 5 and Krüppel-like factor 4 in the pathogenesis of renal fibrosis
10.1016/j.ajpath.2015.05.019 · 2015 · External reference
Prevention of LPS-induced acute kidney injury in mice by bavachin and its potential mechanisms
10.3390/antiox11112096 · 2022 · External reference
Lactate drives epithelial-mesenchymal transition in diabetic kidney disease via the H3K14la/KLF5 pathway
10.1016/j.redox.2024.103246 · 2024 · External reference
Transcriptional regulation of adipogenesis, Compr
2017 · External reference
Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy
10.1093/eurheartj/ehy903 · 2019 · External reference
Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: involvement of reduced PPARγ expression
10.1016/j.redox.2019.101412 · 2020 · External reference
Epigenetic histone modulations of PPARγ and related pathways contribute to olanzapine-induced metabolic disorders
10.1016/j.phrs.2020.104703 · 2020 · External reference
The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases
10.1186/s40035-024-00398-w · 2024 · External reference
Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc
10.1016/j.redox.2017.07.002 · 2017 · External reference
Effect of probucol in a murine model of slowly progressive polycystic kidney disease
10.1016/s0272-6386(00)70330-1 · 2000 · External reference
Probucol protects against contrast-induced acute kidney injury via the extracellular signal-regulated kinases 1 and 2 (ERK1/2)/JNK-caspase 3 pathway in diabetic rats
10.12659/msm.913106 · 2019 · External reference
Antioxidants, statins, and atherosclerosis
10.1016/s0735-1097(03)00082-2 · 2003 · External reference
Probucol alleviates atherosclerosis and improves high density lipoprotein function
10.1186/1476-511x-10-210 · 2011 · External reference
Cross-talk between renal lithogenesis and atherosclerosis: an unveiled link between kidney stone formation and cardiovascular diseases
10.1042/cs20171574 · 2018 · External reference
Sirtuin1 suppresses calcium oxalate nephropathy via inhibition of renal proximal tubular cell ferroptosis through PGC-1α-mediated transcriptional coactivation
2024 · External reference
Mechanism of calcium oxalate renal stone formation and renal tubular cell injury
10.1111/j.1442-2042.2007.01953.x · 2008 · External reference
Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation
10.1038/s41581-020-00392-1 · 2021 · External reference
Identification of biomarkers and potential therapeutic targets of kidney stone disease using bioinformatics
10.1007/s00345-023-04704-5 · 2024 · External reference
Mycobacterium tuberculosis 19-kDa lipoprotein induces toll-like receptor 2-dependent peroxisome proliferator-activated receptor γ expression and promotes inflammatory responses in human macrophages
10.3892/mmr.2014.3070 · 2015 · External reference
Transcriptome analysis after PPARγ activation in human meibomian gland epithelial cells (hMGEC)
10.1016/j.jtos.2019.02.003 · 2019 · External reference
Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease
10.1016/j.kint.2021.10.039 · 2022 · External reference
Elevation of JAML promotes diabetic kidney disease by modulating podocyte lipid metabolism
10.1016/j.cmet.2020.10.019 · 2020 · External reference
Lipid metabolism in sickness and in health: emerging regulators of lipotoxicity
10.1016/j.molcel.2021.08.027 · 2021 · External reference
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells
10.1186/s40104-024-01064-x · 2024 · External reference
Perilipin 2 and age-related metabolic diseases: a new perspective, trends endocrin
2016 · External reference
A transcriptional regulatory loop of master regulator transcription factors, PPARG, and fatty acid synthesis promotes esophageal adenocarcinoma
10.1158/0008-5472.can-20-0652 · 2021 · External reference
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation
10.1016/j.cmet.2004.11.005 · 2005 · External reference
Keep your fingers off my DNA: protein–protein interactions mediated by C2H2 zinc finger domains
10.1007/s12013-008-9008-5 · 2008 · External reference
Hepatic peroxisome proliferator-activated receptor-γ–fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals
10.1093/eurheartj/ehr265 · 2012 · External reference
Effects of fatty acids on inducing endoplasmic reticulum stress in bovine mammary epithelial cells
10.3168/jds.2019-18080 · 2020 · External reference
Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways
10.1016/j.atherosclerosis.2009.10.032 · 2010 · External reference
Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity
10.1152/ajpendo.00076.2013 · 2013 · External reference
SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway
10.1038/ncomms16016 · 2017 · External reference
Palmitate acid promotes gastric cancer metastasis via FABP5/SP1/UCA1 pathway
10.1186/s12935-019-0787-0 · 2019 · External reference
Probucol therapy improves long-term (>10-year) survival after complete revascularization: a propensity analysis
10.1016/j.atherosclerosis.2011.09.051 · 2012 · External reference
Did we abandon probucol too soon?
10.1097/mol.0000000000000199 · 2015 · External reference
New horizons for probucol, an old, mysterious drug
10.5551/jat.ed132 · 2021 · External reference
Probucol inhibits ABCA1-mediated cellular lipid efflux
10.1161/01.atv.0000148706.15947.8a · 2004 · External reference
An in vivo pharmacological study: variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques
10.1371/journal.pone.0214984 · 2019 · External reference
Pharmacokinetics and tolerability of probucol after multiple oral administrations in healthy volunteers
10.5414/cp201525 · 2011 · External reference