Research graph
References from DT-TRAP enables accurate target recognition via simplified dosing and low-temperature incubation. Local targets link to admitted publications; unresolved targets remain external evidence.
Chemoproteomic mapping of the glycolytic targetome in cancer cells
10.1038/s41589-023-01355-w · 2023 · External reference
Living cell-target responsive accessibility profiling reveals silibinin targeting ACSL4 for combating ferroptosis
10.1021/acs.analchem.2c03515 · 2022 · External reference
Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice
10.1016/j.apsb.2020.12.008 · 2021 · External reference
Targeting MAPK14 by lobeline upregulates Slurp1-mediated inhibition of alternative activation of TAM and retards colorectal cancer growth
2025 · External reference
Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation
10.1136/jitc-2022-004874 · 2022 · External reference
Emerging trends in chemoproteomics: mapping the landscape of protein-metabolite interactions
10.1016/j.cbpa.2025.102631 · 2025 · External reference
The emerging role of mass spectrometry-based proteomics in drug discovery
10.1038/s41573-022-00409-3 · 2022 · External reference
Decoding protein dynamics with limited proteolysis coupled to mass spectrometry: a comprehensive review
10.1016/j.jpha.2025.101319 · 2025 · External reference
Global analysis of protein structural changes in complex proteomes
10.1038/nbt.2999 · 2014 · External reference
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay
10.1126/science.1233606 · 2013 · External reference
Tracking cancer drugs in living cells by thermal profiling of the proteome
10.1126/science.1255784 · 2014 · External reference
A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes
10.1038/s41467-020-18071-x · 2020 · External reference
A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands
10.1038/s41592-024-02553-7 · 2025 · External reference
Ligand and target discovery by fragment-based screening in human cells
10.1016/j.cell.2016.12.029 · 2017 · External reference
Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
10.1016/j.celrep.2024.114272 · 2024 · External reference
Proteome-wide dose-response measurements for the characterization of drug mechanism of action
10.48130/targetome-0025-0011 · 2026 · External reference
Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
10.1038/s41467-017-02258-w · 2017 · External reference
Protein activity regulation by conformational entropy
10.1038/nature11271 · 2012 · External reference
Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3
10.1021/ja105852y · 2010 · External reference
Temperature artifacts in protein structures bias ligand-binding predictions
10.1039/d1sc02751d · 2021 · External reference
A structural perspective on the temperature dependent activity of enzymes
10.1016/j.str.2025.02.013 · 2025 · External reference
Small-molecule probes based on natural products: elucidation of drug-target mechanisms in stroke
10.1016/j.jpha.2025.101290 · 2025 · External reference
Improved in situ characterization of protein complex dynamics at scale with thermal proximity co-aggregation
10.1038/s41467-023-43526-2 · 2023 · External reference
Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat
10.1038/nchembio.2185 · 2016 · External reference
Matrix thermal shift assay for fast construction of multidimensional ligand-target space
10.1021/acs.analchem.1c04627 · 2022 · External reference
DiffDock: diffusion steps, twists, and turns for molecular docking
2023 · External reference
Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics
10.1038/s41587-024-02218-y · 2025 · External reference
A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles
10.1038/s41467-020-19529-8 · 2020 · External reference
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
10.1038/nchembio.1060 · 2012 · External reference
DIA mass spectrometry
10.1038/nmeth.3234 · 2015 · External reference
The use of nanocrystals in biological detection
10.1038/nbt927 · 2004 · External reference
Protein painting for structural and binding site analysis via intracellular lysine reactivity profiling with o-phthalaldehyde
10.1039/d4sc00032c · 2024 · External reference
Proteome-wide deconvolution of drug targets and binding sites by lysine reactivity profiling
10.1021/acs.analchem.1c05455 · 2022 · External reference
Solvent-induced protein precipitation for drug target discovery on the proteomic scale
10.1021/acs.analchem.9b04531 · 2020 · External reference
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
10.1038/s41467-023-38732-x · 2023 · External reference
A novel approach to the discovery of small-molecule ligands of CDK2
10.1002/cbic.201200316 · 2012 · External reference
Proliferation of cancer cells despite CDK2 inhibition
10.1016/s1535-6108(03)00053-9 · 2003 · External reference
Structural basis for CEP192-mediated regulation of centrosomal AURKA
10.1126/sciadv.adf8582 · 2023 · External reference
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity
10.1126/sciadv.aaw9298 · 2019 · External reference
Molecular targets of aspirin and cancer prevention
10.1038/bjc.2014.271 · 2014 · External reference
An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells
10.1021/ja408322b · 2013 · External reference
Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP)
10.1038/srep07896 · 2015 · External reference
A proteomic approach to analyze the aspirin-mediated lysine acetylome
10.1074/mcp.o116.065219 · 2017 · External reference
