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References from Arctigenin discovered by high-throughput screening ameliorates doxorubicin-induced cardiotoxicity as a novel natural KEAP1-NRF2 inhibitor. Local targets link to admitted publications; unresolved targets remain external evidence.
Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway
10.1016/j.redox.2020.101747 · 2020 · External reference
Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis
10.1038/s41401-024-01367-9 · 2025 · External reference
Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
10.1038/s41569-020-0348-1 · 2020 · External reference
Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer
10.1200/jco.1997.15.4.1318 · 1997 · External reference
Navigating cancer therapy induced cardiotoxicity: from pathophysiology to treatment innovations
10.1016/j.addr.2024.115361 · 2024 · External reference
Critical role of the cGAS-STING pathway in doxorubicin-induced cardiotoxicity
10.1161/circresaha.122.321587 · 2023 · External reference
Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities
10.1016/j.jacc.2014.06.1167 · 2014 · External reference
Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
10.1172/jci72931 · 2014 · External reference
Magnesium hexacyanoferrate nanocatalysts attenuate chemodrug-induced cardiotoxicity through an anti-apoptosis mechanism driven by modulation of ferrous iron
10.1038/s41467-022-35503-y · 2022 · External reference
Herbacetin mitigates oxidative stress and ferroptosis to protect against doxorubicin-induced cardiotoxicity
10.1016/j.bcp.2025.117117 · 2025 · External reference
Nrf2 for cardiac protection: pharmacological options against oxidative stress
10.1016/j.tips.2021.06.005 · 2021 · External reference
Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
10.1016/j.redox.2022.102389 · 2022 · External reference
Canonical and non-canonical mechanisms of Nrf2 activation
10.1016/j.phrs.2018.06.013 · 2018 · External reference
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation
10.7150/thno.110324 · 2025 · External reference
Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy
10.1007/s13238-021-00843-w · 2022 · External reference
Erianin alleviates doxorubicin-induced cardiotoxicity by activating the Keap1-Nrf2 signaling pathway
10.1016/j.phymed.2025.156684 · 2025 · External reference
Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer
10.1016/j.canlet.2020.08.033 · 2020 · External reference
Thousand and one amino acid protein kinase 1 suppression improves doxorubicin-induced cardiomyopathy by preventing cardiomyocyte death and dysfunction
10.1093/cvr/cvaf022 · 2025 · External reference
BRD4770 protects against DOX-induced cardiotoxicity by inhibiting apoptosis and ferroptosis
10.1126/sciadv.adw1720 · 2025 · External reference
EBBP-mediated integrated stress response attenuates anthracycline-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes
2025 · External reference
Kaempferol protects against doxorubicin-induced myocardial damage by inhibiting mitochondrial ROS-dependent ferroptosis
10.1080/13510002.2025.2503130 · 2025 · External reference
Identification of the molecular basis of doxorubicin-induced cardiotoxicity
10.1038/nm.2919 · 2012 · External reference
KEAP1-NRF2 protein-protein interaction inhibitors: design, pharmacological properties and therapeutic potential
10.1002/med.21925 · 2023 · External reference
Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53
10.1093/cvr/cvr022 · 2011 · External reference
Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
10.1016/j.apsb.2018.10.008 · 2019 · External reference
Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways
10.1111/bph.15261 · 2020 · External reference
Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation
10.1016/j.freeradbiomed.2013.10.004 · 2014 · External reference
Intramyocardial delivery of injectable hydrogel with arctigenin alleviated myocardial ischemia-reperfusion injury in rats
10.1002/bab.2554 · 2024 · External reference
Arctigenin attenuates diabetic kidney disease through the activation of PP2A in podocytes
10.1038/s41467-019-12433-w · 2019 · External reference
Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells
10.1038/s41401-022-00992-6 · 2023 · External reference
Arctigenin attenuates breast cancer progression through decreasing GM-CSF/TSLP/STAT3/β-catenin signaling
10.3390/ijms21176357 · 2020 · External reference
Arctigenin alleviates cadmium-induced nephrotoxicity: targeting endoplasmic reticulum stress, Nrf2 signaling, and the associated inflammatory response
10.1016/j.lfs.2021.120121 · 2021 · External reference
Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L
10.1038/aps.2018.32 · 2018 · External reference
Elucidation of arctigenin pharmacokinetics and tissue distribution after intravenous, oral, hypodermic and sublingual administration in rats and beagle dogs: integration of in vitro and in vivo findings
10.3389/fphar.2017.00376 · 2017 · External reference
Elucidation of arctigenin pharmacokinetics after intravenous and oral administrations in rats: integration of in vitro and in vivo findings via semi-mechanistic pharmacokinetic modeling
10.1208/s12248-014-9664-x · 2014 · External reference
Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis
10.1016/j.apsb.2023.08.016 · 2023 · External reference
Gastrodin protects H9c2 cardiomyocytes against oxidative injury by ameliorating imbalanced mitochondrial dynamics and mitochondrial dysfunction
10.1038/s41401-020-0382-x · 2020 · External reference
Natural compounds against doxorubicin-induced cardiotoxicity: a review on the involvement of Nrf2/ARE signaling pathway
10.1002/ptr.6882 · 2021 · External reference
BNIP3-mediated mitophagy attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting ferroptosis through P62-KEAP1-NRF2 pathway activation to maintain iron and redox homeostasis
10.1038/s41401-024-01365-x · 2025 · External reference
Nrf2 signaling pathway in chemoprotection and doxorubicin resistance: potential application in drug discovery
10.3390/antiox10030349 · 2021 · External reference
A point mutation at C151 of Keap1 of mice abrogates NRF2 signaling, cytoprotection in vitro, and hepatoprotection in vivo by bardoxolone methyl (CDDO-me)
10.1124/molpharm.123.000671 · 2023 · External reference
Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells
10.1016/j.bbrc.2013.02.065 · 2013 · External reference
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a “tethering” mechanism: a two-site interaction model for the Nrf2-Keap1 complex
10.1074/jbc.m601119200 · 2006 · External reference
Artemisinin inhibits neuronal ferroptosis in Alzheimer's disease models by targeting KEAP1
10.1038/s41401-024-01378-6 · 2025 · External reference
Overlooked and valuable facts to know in the NRF2/KEAP1 field
10.1016/j.freeradbiomed.2022.08.044 · 2022 · External reference
Development of noncovalent small-molecule Keap1-Nrf2 inhibitors by fragment-based drug discovery
10.1021/acs.jmedchem.2c00830 · 2022 · External reference
Use of deep-learning assisted assessment of cardiac parameters in zebrafish to discover cyanidin chloride as a novel Keap1 inhibitor against doxorubicin-induced cardiotoxicity
10.1002/advs.202370206 · 2023 · External reference
Optimization efforts for identification of novel highly potent Keap1-Nrf2 protein-protein interaction inhibitors
10.1021/acs.jmedchem.3c02171 · 2024 · External reference
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction
10.1016/j.bmcl.2013.03.013 · 2013 · External reference
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism
10.1016/j.bmc.2013.04.019 · 2013 · External reference