Research graph
References from Diosgenin presents a novel role in promoting diabetic wound healing: A mechanism involving Sirt6/Nrf2-mediated inhibition of ferroptosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Clearance of senescent cells enhances skin wound healing in type 2 diabetic mice
10.7150/thno.100991 · 2024 · External reference
Analysis of the mechanism underlying diabetic wound healing acceleration by Calycosin-7-glycoside using network pharmacology and molecular docking
10.1016/j.phymed.2023.154773 · 2023 · External reference
Andrias davidianus derived glycosaminoglycans direct diabetic wound repair by reprogramming reparative macrophage glucolipid metabolism
2025 · External reference
Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway
10.1186/s12933-024-02469-8 · 2024 · External reference
Susceptibility of mitophagy-deficient tumors to ferroptosis induction by relieving the suppression of lipid peroxidation
2025 · External reference
Identification of essential sites of lipid peroxidation in ferroptosis
10.1038/s41589-022-01249-3 · 2023 · External reference
Insight into the mechanism of ferroptosis inhibition by ferrostatin-1
10.1016/j.redox.2019.101328 · 2020 · External reference
Ferroptosis-based advanced therapies as treatment approaches for metabolic and cardiovascular diseases
10.1038/s41418-024-01350-1 · 2024 · External reference
Artemisitene ameliorates diabetic wounds by inhibiting ferroptosis through activation of the Nrf2/GPX4 pathway
2025 · External reference
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
10.1016/j.molcel.2024.07.020 · 2024 · External reference
SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence
10.1038/s41392-023-01456-x · 2023 · External reference
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases
10.1126/scitranslmed.abn9674 · 2023 · External reference
SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation
10.1016/j.apsb.2020.06.016 · 2021 · External reference
The potential role of SIRT6 in regulating the crosstalk between Nrf2 and NF-κB pathways in cardiovascular diseases
10.1016/j.phrs.2022.106300 · 2022 · External reference
Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways
10.1016/j.biopha.2022.114048 · 2023 · External reference
Evaluation of proanthocyanidins in treating Type 2 diabetic osteoporosis via SIRT6/Nrf2/GPX4 pathways
10.1096/fj.202403032r · 2025 · External reference
Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways
10.1016/j.phymed.2022.153928 · 2022 · External reference
The origin and evolution of the diosgenin biosynthetic pathway in yam
2020 · External reference
Diosgenin revealed potential effect against cerebral ischemia reperfusion through HIKESHI/HSP70/NF-κB anti-inflammatory axis
10.1016/j.phymed.2022.153991 · 2022 · External reference
Diosgenin reduces acute kidney injury and ameliorates the progression to chronic kidney disease by modifying the NOX4/p65 signaling pathways
10.1021/acs.jafc.4c04183 · 2024 · External reference
Diosgenin attenuates non-alcoholic fatty liver disease in type 2 diabetes through regulating SIRT6-related fatty acid uptake
10.1016/j.phymed.2023.154661 · 2023 · External reference
Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6
10.1016/j.phymed.2022.154276 · 2022 · External reference
The potential of diosgenin in treating psoriasis: studies from HaCaT keratinocytes and imiquimod-induced murine model
10.1016/j.lfs.2019.117115 · 2020 · External reference
Piezo1-mediated ferroptosis delays wound healing in aging mice by regulating the transcriptional activity of SLC7A11 through activating transcription factor 3
10.34133/research.0718 · 2025 · External reference
A novel anti-osteoporosis mechanism of VK2: interfering with ferroptosis via AMPK/SIRT1 pathway in type 2 diabetic osteoporosis
10.1021/acs.jafc.2c05632 · 2023 · External reference
CXCL1 promotes osteoblast autophagy and inhibits ferroptosis through the activation of the TGF-β/smad signalling pathway
10.1111/jcmm.70883 · 2025 · External reference
Mechanism of the enterobacterial metabolite sodium butyrate mediating ferroptosis to affect osteogenic ability of BMSCs in mice with estrogen deficiency-caused osteoporosis via the PTEN/PI3K/AKT pathway
10.1007/s10495-025-02179-w · 2025 · External reference
Astaxanthin prevents glucocorticoid-induced femoral head osteonecrosis by targeting ferroptosis through the JAK2/STAT3 signaling pathway
10.1021/acs.jafc.4c09284 · 2025 · External reference
Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling
10.1038/s41467-023-44179-x · 2023 · External reference
Multifunctional PtCuTe nanosheets with strong ROS scavenging and ROS-independent antibacterial properties promote diabetic wound healing
2024 · External reference
A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis
10.1038/s41413-024-00319-7 · 2024 · External reference
Exosome/metformin-loaded self-healing conductive hydrogel rescues microvascular dysfunction and promotes chronic diabetic wound healing by inhibiting mitochondrial fission
2023 · External reference
A multifunctional hydrogel promotes diabetic wound healing by remodeling iron balance and energy metabolism
10.1016/j.biomaterials.2025.123640 · 2026 · External reference
Epidermal E-cadherin dependent β-catenin pathway is phytochemical inducible and accelerates anagen hair cycling
10.1016/j.ymthe.2017.07.010 · 2017 · External reference
Acrylamide exposure and oxidative DNA damage, lipid peroxidation, and fasting plasma glucose alteration: association and mediation analyses in Chinese urban adults
10.2337/dc19-2603 · 2020 · External reference
DFO-loaded PDA nanoparticles facilitated 3D stem cell spheroids for diabetic wound repair by normalizing the pathological microenvironment, Mater
2025 · External reference
Mitochondria as multifaceted regulators of cell death
10.1038/s41580-019-0173-8 · 2020 · External reference
Low-intensity pulsed ultrasound targeting ferroptosis to mitigate joint capsule fibrosis in a rat model of post-traumatic joint contracture
10.22203/ecm.v054a04 · 2025 · External reference
Nicotinamide mononucleotide mitigates hyperoxia-aggravated septic lung injury via the GPx4-mediated anti-ferroptosis signaling pathway in alveolar epithelial cells
10.1016/j.freeradbiomed.2025.04.021 · 2025 · External reference
Irisin liposomes inhibit ferroptosis and improve atherosclerosis in mouse models via the NRF2/HO-1 signaling pathway
10.22203/ecm.v054a02 · 2025 · External reference
Targeting NQO1 induces ferroptosis and triggers anti-tumor immunity in immunotherapy-resistant KEAP1-deficient cancers
10.1016/j.drup.2024.101160 · 2024 · External reference
10.1016/j.phymed.2025.157096
10.1016/j.phymed.2025.157096 · External reference
Diosgenin ameliorating non-alcoholic fatty liver disease via Nrf2-mediated regulation of oxidative stress and ferroptosis
10.1111/dom.15945 · 2024 · External reference
4-octyl itaconate promotes diabetic wound healing by enhancing pro-resolving macrophages via the efferocytosis-MCT1-lactate-GPR132 pathway and macrophage-independent synergistic effects
10.4093/dmj.2024.0579 · 2026 · External reference
Hypoxic adipose-derived stem cell exosomes as carriers of miR-100-5p to enhance angiogenesis and suppress inflammation in diabetic foot ulcers
10.1002/ccs3.70018 · 2025 · External reference
