Research graph
References from Exogenous pyruvate protects IMS32 Schwann cells from impairing the maturation process under hyperglycemia. Local targets link to admitted publications; unresolved targets remain external evidence.
Advantages of omics approaches for elucidating metabolic changes in diabetic peripheral neuropathy
10.3389/fendo.2023.1208441 · 2023 · External reference
Diabetic neuropathy: cutting-edge research and future directions
10.1038/s41392-025-02175-1 · 2025 · External reference
Development and in vitro differentiation of Schwann Cells
10.3390/cells11233753 · 2022 · External reference
Schwann cell precursors represent a neural crest-like state with biased multipotency
10.15252/embj.2021108780 · 2022 · External reference
Transcriptional regulation induced by cAMP elevation in mouse Schwann cells
10.1042/an20130031 · 2014 · External reference
Signaling axis in Schwann cell proliferation and differentiation
10.1385/mn:33:1:051 · 2006 · External reference
Hyperglycemia promotes Schwann Cell de-differentiation and de-myelination via sorbitol accumulation and Igf1 protein down-regulation
10.1074/jbc.m114.631291 · 2015 · External reference
Schwann cells contribute to demyelinating diabetic neuropathy and nerve terminal structures in white adipose tissue
10.1016/j.isci.2023.106189 · 2023 · External reference
Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy
10.1073/pnas.2121552119 · 2022 · External reference
High glucose-induced activation of the polyol pathway and changes of gene expression profiles in immortalized adult mouse Schwann cells IMS32
10.1111/j.1471-4159.2006.03885.x · 2006 · External reference
Immortalized adult rodent Schwann cells as in vitro models to study diabetic neuropathy
10.1155/2011/374943 · 2011 · External reference
Physiological and pathological roles of aldose reductase in Schwann cells
2014 · External reference
Recurrent short-term hypoglycemia and hyperglycemia induce apoptosis and oxidative stress via the ER stress response in immortalized adult mouse Schwann (IMS32) cells
10.1016/j.neures.2018.11.004 · 2019 · External reference
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions
10.1038/s41598-021-98082-w · 2021 · External reference
Hyperglycaemia aggravates oxidised low-density lipoprotein-induced Schwann cell death via hyperactivation of toll-like receptor 4
10.3390/neurolint16020027 · 2024 · External reference
Role of exogenous pyruvate in maintaining adenosine triphosphate production under high-glucose conditions through PARP-dependent glycolysis and PARP-independent tricarboxylic acid cycle
10.3390/ijms252011089 · 2024 · External reference
Immortalized Schwann cell lines as useful tools for pathogenesis-based therapeutic approaches to diabetic peripheral neuropathy
2024 · External reference
Epalrestat alleviates reactive oxygen species and endoplasmic reticulum stress by maintaining glycosylation in IMS32 Schwann cells under exposure to galactosemic conditions
10.3390/ijms26041529 · 2025 · External reference
Imeglimin improves hyperglycemia and hypoglycemia-induced cell death and mitochondrial dysfunction in immortalized adult mouse Schwann IMS32 cells
10.1111/jdi.70092 · 2025 · External reference
Oxidative, metabolic, and apoptotic responses of Schwann cells to high glucose levels
10.1002/jbt.21695 · 2015 · External reference
Reduced NGF secretion by Schwann cells under the high glucose condition decreases neurite outgrowth of DRG neurons
10.1016/j.expneurol.2008.06.017 · 2008 · External reference
Glucose-induced metabolic memory in Schwann cells: prevention by PPAR agonists
10.1210/en.2013-1097 · 2013 · External reference
SMTP-44D improves diabetic neuropathy symptoms in mice through its antioxidant and anti-inflammatory activities
10.1002/prp2.648 · 2020 · External reference
Alpha-tocopherol-loaded liposomes reduce high glucose induced oxidative stress in Schwann cells: a proof of concept study
10.4093/dmj.2024.0489 · 2025 · External reference
Aldose reductase and the polyol pathway in Schwann cells: old and new problems
10.3390/ijms22031031 · 2021 · External reference
Differential effects of high glucose and methylglyoxal on viability and polyol metabolism in immortalized adult mouse Schwann cells
10.2174/1876524600801010001 · 2008 · External reference
Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial
10.2337/dc05-2370 · 2006 · External reference
Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats
10.1254/jphs.08061fp · 2008 · External reference
Ranirestat for the management of diabetic sensorimotor polyneuropathy
10.2337/dc08-2110 · 2009 · External reference
Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats
10.1155/2013/175901 · 2013 · External reference
Effect of ranirestat on sensory and motor nerve function in japanese patients with diabetic polyneuropathy: a randomized double-blind placebo-controlled study
10.1155/2016/5383797 · 2016 · External reference
Ranirestat improved nerve conduction velocities, sensory perception, and intraepidermal nerve fiber density in rats with overt diabetic polyneuropathy
10.1155/2019/2756020 · 2019 · External reference
Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG
2019 · External reference
Characterization of polyol pathway in Schwann cells isolated from adult rat sciatic nerves
10.1002/(sici)1097-4547(19990815)57:4<495::aid-jnr9>3.0.co;2-y · 1999 · External reference
Efficacy and safety of the combination of superoxide dismutase, alpha lipoic acid, vitamin B12, and carnitine for 12 months in patients with diabetic neuropathy
10.3390/nu12113254 · 2020 · External reference
Bcl2l12, a novel protein interacting with Arf6, triggers Schwann cell differentiation program
2024 · External reference
Pyruvate administration restores impaired nociception by enhancing neurite outgrowth in streptozotocin-induced diabetic mice
10.3390/ijms26104666 · 2025 · External reference
Development of selective axonopathy in adult sensory neurons isolated from diabetic rats: role of glucose-induced oxidative stress
10.2337/db09-0034 · 2009 · External reference
Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment
10.2337/db09-1299 · 2010 · External reference
Nrf2: a potential therapeutic target for diabetic neuropathy
10.1007/s10787-017-0339-y · 2017 · External reference
Nrf2 signaling in coordinated activation of antioxidant gene expression
10.1016/j.freeradbiomed.2004.02.074 · 2004 · External reference
Phenotypic and functional characteristics of human Schwann Cells as revealed by cell-based assays and RNA-SEQ
10.1007/s12035-017-0837-3 · 2018 · External reference
Schwann cell dedifferentiation is independent of mitogenic signaling and uncoupled to proliferation: role of cAMP and JNK in the maintenance of the differentiated state
10.1074/jbc.m110.116970 · 2010 · External reference
Actin plays a role in both changes in cell shape and geneexpression associated with Schwann cell myelination
10.1523/jneurosci.17-01-00241.1997 · 1997 · External reference
MLCK regulates Schwann cell cytoskeletal organization, differentiation and myelination
10.1242/jcs.080200 · 2011 · External reference
Acidic fibroblast growth factor attenuates type 2 diabetes-induced demyelination via suppressing oxidative stress damage
10.1038/s41419-021-03407-2 · 2021 · External reference
Nrf2 mitigates RANKL and M-CSF induced osteoclast differentiation via ROS-dependent mechanisms
10.3390/antiox12122094 · 2023 · External reference
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
10.1172/jci18127 · 2003 · External reference
Protection by exogenous pyruvate through a mechanism related to monocarboxylate transporters against cell death induced by hydrogen peroxide in cultured rat cortical neurons
10.1111/j.1471-4159.2005.02999.x · 2005 · External reference
Artefacts in cell culture: pyruvate as a scavenger of hydrogen peroxide generated by ascorbate or epigallocatechin gallate in cell culture media
10.1016/j.bbrc.2009.08.069 · 2009 · External reference
Pyruvate antioxidant roles in human fibroblasts and embryonic stem cells
10.1007/s11010-017-2942-z · 2017 · External reference
Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms
10.1016/j.neuint.2012.04.005 · 2012 · External reference
Exogenous pyruvate in defense against human-exposure toxicants: a review of in vitro and in vivo evidence
10.3390/ijms26178316 · 2025 · External reference
Physiology of PNS axons relies on glycolytic metabolism in myelinating Schwann cells
10.1371/journal.pone.0272097 · 2022 · External reference
Metabolic interaction between schwann cells and axons under physiological and disease conditions
10.3389/fncel.2020.00148 · 2020 · External reference
Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration
10.7150/thno.40919 · 2020 · External reference
Schwann cell plasticity is regulated by a weakened intrinsic antioxidant defense system in acute peripheral nerve injury
10.1016/j.neuroscience.2018.04.018 · 2018 · External reference
