Research graph
References from TrenibotulinumtoxinE: Pharmacology, clinical evidence, and emerging role in aesthetic medicine. Local targets link to admitted publications; unresolved targets remain external evidence.
Novel native and engineered botulinum neurotoxins
10.1007/164_2020_351 · 2021 · External reference
Facial aesthetic priorities and concerns: a physician and patient perception Global Survey
10.1093/asj/sjab358 · 2022 · External reference
Botulinum toxin for cosmetic treatments in young adults: an evidence-based review and survey on current practice among aesthetic practitioners
10.1111/jocd.15513 · 2023 · External reference
Unresolved reference
External reference
Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans
10.1016/s0304-3940(98)00775-7 · 1998 · External reference
Dynamics of motor nerve terminal remodeling unveiled using SNARE-cleaving botulinum toxins: the extent and duration are dictated by the sites of SNAP-25 truncation
10.1016/s1044-7431(02)00016-7 · 2003 · External reference
Evaluation of botulinum neurotoxin type E preparation (trenibotulinumtoxinE) in the mouse digit abduction score (DAS) assay
2024 · External reference
Preclinical evaluation of botulinum toxin type E (TrenibotulinumtoxinE) using the mouse digit abduction score (DAS) assay
10.3390/toxins17050230 · 2025 · External reference
Light chain diversity among the botulinum neurotoxins
10.3390/toxins10070268 · 2018 · External reference
Plasma membrane localization signals in the light chain of botulinum neurotoxin
10.1073/pnas.0400229101 · 2004 · External reference
Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication
10.1073/pnas.1621076114 · 2017 · External reference
Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability
2014 · External reference
Structural analysis of botulinum neurotoxins type B and E by Cryo-EM
10.3390/toxins14010014 · 2021 · External reference
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
10.1038/s41467-023-37860-8 · 2023 · External reference
Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation
10.1016/j.jmb.2008.12.027 · 2009 · External reference
On the action of botulinum neurotoxins A and E at cholinergic terminals
10.1016/s0928-4257(98)80151-4 · 1998 · External reference
Botulinal neurotoxins: revival of an old killer
10.1016/j.coph.2004.12.006 · 2005 · External reference
SNARE complexes and neuroexocytosis: how many, how close?
10.1016/j.tibs.2005.05.002 · 2005 · External reference
Intramuscular botulinum neurotoxin serotypes E and A elicit distinct effects on SNAP25 protein fragments, muscular histology, spread and neuronal transport: an integrated histology-based study in the rat
10.3390/toxins16050225 · 2024 · External reference
Diffusion of botulinum toxins
2012 · External reference
Safety and efficacy of EB-001, a novel type E botulinum toxin, in subjects with glabellar frown lines: results of a phase 2, randomized, placebo-controlled, ascending-dose study
10.1097/prs.0000000000005029 · 2018 · External reference
Safety and efficacy of TrenibotulinumtoxinE for moderate-to-severe glabellar lines: a phase 2b, double-blind, placebo-controlled, dose-escalation study
10.1093/asj/sjag126 · 2026 · External reference
10.1016/j.toxicon.2025.108815
10.1016/j.toxicon.2025.108815 · External reference
Rapid results with TrenibotulinumtoxinE for the treatment of glabellar lines in toxin-naive adults: safety, efficacy, and satisfaction findings from a pivotal phase 3 study
10.1093/asj/sjag154 · 2026 · External reference
Sequential administration of trenibotulinumtoxinE and onabotulinumtoxinA for glabellar lines: a phase 1 evaluation
2026 · External reference
Integrated immunogenicity assessment of a novel, first-in-class trenibotulinumtoxinE across 5 clinical trials for glabellar lines
10.1016/j.toxicon.2025.108913 · 2026 · External reference
Beyond structural divergence: multiscale computational immunogenicity modelling of botulinum neurotoxin E and cross-reactivity in botulinum neurotoxin A primed hosts
10.1016/j.toxicon.2025.108946 · 2026 · External reference
Novel native and engineered botulinum neurotoxins
10.1007/164_2020_351 · ExternalCitation · doi-reference
Botulinal neurotoxins: revival of an old killer
10.1016/j.coph.2004.12.006 · ExternalCitation · doi-reference
Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation
10.1016/j.jmb.2008.12.027 · ExternalCitation · doi-reference
SNARE complexes and neuroexocytosis: how many, how close?
10.1016/j.tibs.2005.05.002 · ExternalCitation · doi-reference
10.1016/j.toxicon.2025.108815
10.1016/j.toxicon.2025.108815 · ExternalCitation · doi-reference
Integrated immunogenicity assessment of a novel, first-in-class trenibotulinumtoxinE across 5 clinical trials for glabellar lines
10.1016/j.toxicon.2025.108913 · ExternalCitation · doi-reference
Beyond structural divergence: multiscale computational immunogenicity modelling of botulinum neurotoxin E and cross-reactivity in botulinum neurotoxin A primed hosts
10.1016/j.toxicon.2025.108946 · ExternalCitation · doi-reference
Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans
10.1016/s0304-3940(98)00775-7 · ExternalCitation · doi-reference
On the action of botulinum neurotoxins A and E at cholinergic terminals
10.1016/s0928-4257(98)80151-4 · ExternalCitation · doi-reference
Dynamics of motor nerve terminal remodeling unveiled using SNARE-cleaving botulinum toxins: the extent and duration are dictated by the sites of SNAP-25 truncation
10.1016/s1044-7431(02)00016-7 · ExternalCitation · doi-reference
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2
10.1038/s41467-023-37860-8 · ExternalCitation · doi-reference
Plasma membrane localization signals in the light chain of botulinum neurotoxin
10.1073/pnas.0400229101 · ExternalCitation · doi-reference
Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication
10.1073/pnas.1621076114 · ExternalCitation · doi-reference
Facial aesthetic priorities and concerns: a physician and patient perception Global Survey
10.1093/asj/sjab358 · ExternalCitation · doi-reference
Safety and efficacy of TrenibotulinumtoxinE for moderate-to-severe glabellar lines: a phase 2b, double-blind, placebo-controlled, dose-escalation study
10.1093/asj/sjag126 · ExternalCitation · doi-reference
Rapid results with TrenibotulinumtoxinE for the treatment of glabellar lines in toxin-naive adults: safety, efficacy, and satisfaction findings from a pivotal phase 3 study
10.1093/asj/sjag154 · ExternalCitation · doi-reference
Safety and efficacy of EB-001, a novel type E botulinum toxin, in subjects with glabellar frown lines: results of a phase 2, randomized, placebo-controlled, ascending-dose study
10.1097/prs.0000000000005029 · ExternalCitation · doi-reference
Botulinum toxin for cosmetic treatments in young adults: an evidence-based review and survey on current practice among aesthetic practitioners
10.1111/jocd.15513 · ExternalCitation · doi-reference
Light chain diversity among the botulinum neurotoxins
10.3390/toxins10070268 · ExternalCitation · doi-reference
Structural analysis of botulinum neurotoxins type B and E by Cryo-EM
10.3390/toxins14010014 · ExternalCitation · doi-reference
Intramuscular botulinum neurotoxin serotypes E and A elicit distinct effects on SNAP25 protein fragments, muscular histology, spread and neuronal transport: an integrated histology-based study in the rat
10.3390/toxins16050225 · ExternalCitation · doi-reference
Preclinical evaluation of botulinum toxin type E (TrenibotulinumtoxinE) using the mouse digit abduction score (DAS) assay
10.3390/toxins17050230 · ExternalCitation · doi-reference
