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References from Integrating high-resolution proximity labelling with orthogonal interactome benchmarks: Insights from Kinetoplastid systems. Local targets link to admitted publications; unresolved targets remain external evidence.
Analysis of protein complexes using mass spectrometry
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Beyond immunoprecipitation: exploring new interaction spaces with proximity biotinylation
2017 · External reference
The development of proximity labeling technology and its applications in mammals, plants, and microorganisms
10.1186/s12964-023-01310-1 · 2023 · External reference
Proximity dependent biotinylation: key enzymes and adaptation to proteomics approaches
10.1074/mcp.r120.001941 · 2020 · External reference
A comparison of two-hybrid approaches for detecting protein–protein interactions
2017 · External reference
Tag thy neighbour: nanometre-scale insights into kinetoplastid parasites with proximity dependent biotinylation
10.3389/fcimb.2022.894213 · 2022 · External reference
A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells
10.1083/jcb.201112098 · 2012 · External reference
Efficient proximity labeling in living cells and organisms with TurboID
10.1038/nbt.4201 · 2018 · External reference
In vivo interactome profiling by enzyme-catalyzed proximity labeling
10.1186/s13578-021-00542-3 · 2021 · External reference
MicroID2: a novel biotin ligase enables rapid proximity-dependent proteomics
10.1016/j.mcpro.2022.100256 · 2022 · External reference
Engineering of UltraID, a compact and hyperactive enzyme for proximity-dependent biotinylation in living cells
10.1038/s42003-022-03604-5 · 2022 · External reference
Recent advances in proximity labeling-based subcellular proteomic mapping
10.1016/j.mcpro.2026.101520 · 2026 · External reference
LeishGEM: genome-wide deletion mutant fitness and protein localisations in leishmania
10.1016/j.pt.2024.06.003 · 2024 · External reference
APEX2 proximity proteomics resolves flagellum subdomains and identifies flagellum tip-specific proteins in Trypanosoma brucei
10.1128/msphere.01090-20 · 2021 · External reference
Identification of Cdc45-interacting partners uncovers two Leishmania donovani proteins involved in DNA replication
2025 · External reference
Proteomics of plasma-derived extracellular vesicles from human patients identifies biomarkers for monitoring visceral leishmaniasis therapy
10.3389/fimmu.2025.1646335 · 2025 · External reference
Contribution of proteomics of Leishmania spp. to the understanding of differentiation, drug resistance mechanisms, vaccine and drug development
10.1016/j.jprot.2011.05.005 · 2011 · External reference
Moving from unsequenced to sequenced genome: reanalysis of the proteome of Leishmania donovani
10.1016/j.jprot.2013.04.021 · 2014 · External reference
The protein map of the protozoan parasite leishmania (leishmania) amazonensis, leishmania (Viannia) braziliensis and leishmania (leishmania) infantum during growth phase transition and temperature stress
10.1016/j.jprot.2024.105088 · 2024 · External reference
Membrane domains and flagellar pocket boundaries are influenced by the cytoskeleton in African trypanosomes
10.1073/pnas.0909289106 · 2009 · External reference
A global protein interaction network of Leishmania donovani
2025 · External reference
Global protein interaction network for Trypanosoma cruzi
10.1021/acs.jproteome.5c00649 · 2025 · External reference
State-of-the-art and future directions in structural proteomics
10.1016/j.mcpro.2025.101065 · 2025 · External reference
Functional and protein interaction analysis of Nop7 in trypanosomatid parasites
10.1016/j.jprot.2026.105675 · 2026 · External reference
Quantitative proteomics of intracellular and axenic amastigote-like forms of Trypanosoma cruzi under replicative and non-replicative conditions
2026 · External reference
An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems
10.1038/s41467-025-65405-8 · 2025 · External reference
PerTurboID, a targeted in situ method reveals the impact of kinase deletion on its local protein environment in the cytoadhesion complex of malaria-causing parasites
10.7554/elife.86367 · 2023 · External reference
Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes
10.1038/s41467-025-62756-0 · 2025 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Method of the year 2024: spatial proteomics
10.1038/s41592-024-02565-3 · 2024 · External reference
BioID: a screen for protein–protein interactions
2018 · External reference
2C-BioID: an advanced two component BioID system for precision mapping of protein interactomes
10.1016/j.isci.2018.11.023 · 2018 · External reference
Protein translocation as a tool: the current rapamycin story
10.1016/j.febslet.2012.04.061 · 2012 · External reference
Rapamycin-induced oligomer formation system of FRB–FKBP fusion proteins
10.1016/j.jbiosc.2015.12.004 · 2016 · External reference
Filling the void: proximity-based labeling of proteins in living cells
10.1016/j.tcb.2016.09.004 · 2016 · External reference
Comparative application of BioID and TurboID for protein-proximity biotinylation
10.3390/cells9051070 · 2020 · External reference
Recent advances in proximity-based labeling methods for interactome mapping
10.12688/f1000research.16903.1 · 2019 · External reference
Split-BioID: a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes
10.1038/ncomms15690 · 2017 · External reference
Establishment of in vivo proximity labeling with biotin using TurboID in the filamentous fungus Sordaria macrospora
10.1038/s41598-022-22545-x · 2022 · External reference
Split-TurboID enables contact-dependent proximity labeling in cells
10.1073/pnas.1919528117 · 2020 · External reference
Bromodomain factor 5 is an essential regulator of transcription in leishmania
10.1038/s41467-022-31742-1 · 2022 · External reference
CLK1/CLK2-driven signalling at the leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics
10.1038/s42003-022-04280-1 · 2022 · External reference
AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions
10.7554/elife.54983 · 2020 · External reference
A comparison of three approaches for the discovery of novel tripartite attachment complex proteins in Trypanosoma brucei
10.1371/journal.pntd.0008568 · 2020 · External reference
When less is more—a fast TurboID knock-in approach for high-sensitivity endogenous interactome mapping
10.1242/jcs.261952 · 2024 · External reference
Spatiotemporal-resolved protein networks profiling with photoactivation-dependent proximity labeling
10.1038/s41467-022-32689-z · 2022 · External reference
An improved smaller biotin ligase for BioID proximity labeling
10.1091/mbc.e15-12-0844 · 2016 · External reference
Directed evolution of APEX2 for electron microscopy and proximity labeling
10.1038/nmeth.3179 · 2015 · External reference
An approach to spatiotemporally resolve protein interaction networks in living cells
10.1016/j.cell.2017.03.022 · 2017 · External reference
Multidimensional tracking of GPCR signaling via peroxidase-catalyzed proximity labeling
10.1016/j.cell.2017.03.028 · 2017 · External reference
Segregation of lipid rafts revealed by the EMARS method using GPI-anchored HRP fusion proteins
10.4052/tigg.26.59 · 2014 · External reference
Biotinylation by antibody recognition—a method for proximity labeling
10.1038/nmeth.4533 · 2018 · External reference
Chimeric molecules employing horseradish peroxidase as reporter enzyme for protein localization in the electron microscope
10.1016/s0076-6879(00)27265-0 · 2000 · External reference
Identification of interacting proteins using proximity-dependent biotinylation with BioID2 in Trypanosoma brucei
2020 · External reference
A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids
10.1098/rsos.170095 · 2017 · External reference
A high-throughput protein tagging toolkit that retains endogenous untranslated regions for studying gene regulation in kinetoplastids
10.1098/rsob.240334 · 2025 · External reference
Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages
10.1371/journal.pone.0036619 · 2012 · External reference
CRISPR-mediated tagging with BirA allows proximity labeling in Toxoplasma gondii
10.21769/bioprotoc.2768 · 2018 · External reference
The CRISPR/Cas9 system sheds new lights on the biology of protozoan parasites
10.1007/s00253-018-8927-3 · 2018 · External reference
Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei
10.1038/s41564-022-01295-6 · 2023 · External reference
Novel bilobe components in Trypanosoma brucei identified using proximity-dependent biotinylation
10.1128/ec.00326-12 · 2013 · External reference
Stable endocytic structures navigate the complex pellicle of apicomplexan parasites
10.1038/s41467-023-37431-x · 2023 · External reference
ZapE/Afg1 interacts with Oxa1 and its depletion causes a multifaceted phenotype
10.1371/journal.pone.0234918 · 2020 · External reference
TriTrypDB: an integrated functional genomics resource for Kinetoplastida
10.1371/journal.pntd.0011058 · 2023 · External reference
The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function
10.1016/j.str.2024.03.010 · 2024 · External reference
Proximity-dependent biotinylation and identification of flagellar proteins in Trypanosoma cruzi
10.1128/msphere.00088-23 · 2023 · External reference
A systematic analysis of Trypanosoma brucei chromatin factors identifies novel protein interaction networks associated with sites of transcription initiation and termination
10.1101/gr.275368.121 · 2021 · External reference
Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation
10.1038/s41467-017-00959-w · 2017 · External reference
The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes
10.1016/j.molbiopara.2010.11.004 · 2011 · External reference
TrypsNetDB: an integrated framework for the functional characterization of trypanosomatid proteins
10.1371/journal.pntd.0005368 · 2017 · External reference
Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection
10.1186/1471-2105-11-484 · 2010 · External reference
Meet the neighbors: mapping local protein interactomes by proximity-dependent labeling with BioID
10.1002/pmic.201600123 · 2016 · External reference
Predictomes, a classifier-curated database of AlphaFold-modeled protein–protein interactions
10.1016/j.molcel.2025.01.034 · 2025 · External reference
AlphaFold2 predicts whether proteins interact amidst confounding structural compatibility
10.1021/acs.jcim.3c01805 · 2024 · External reference
A resource for improved predictions of Trypanosoma and leishmania protein three-dimensional structure
10.1371/journal.pone.0259871 · 2021 · External reference
Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in Trypanosoma brucei
10.1091/mbc.e15-04-0219 · 2015 · External reference
The trypanosome-specific proteins FPRC and CIF4 regulate cytokinesis initiation by recruiting CIF1 to the cytokinesis initiation site
10.1074/jbc.ra119.010538 · 2019 · External reference
An EF-hand-containing protein in Trypanosoma brucei regulates cytokinesis initiation by maintaining the stability of the cytokinesis initiation factor CIF1
10.1074/jbc.m116.726133 · 2016 · External reference
Characterization of RBP9 and RBP10, two developmentally regulated RNA-binding proteins in Trypanosoma brucei
10.1098/rsob.160159 · 2017 · External reference
Faithful chromosome segregation in Trypanosoma brucei requires a cohort of divergent spindle-associated proteins with distinct functions
10.1093/nar/gky557 · 2018 · External reference
Identification of TOEFAZ1-interacting proteins reveals key regulators of Trypanosoma brucei cytokinesis
10.1111/mmi.13986 · 2018 · External reference
The CIF1 protein is a master orchestrator of trypanosome cytokinesis that recruits several cytokinesis regulators to the cytokinesis initiation site
10.1074/jbc.ra118.004888 · 2018 · External reference
FAZ27 cooperates with FLAM3 and ClpGM6 to maintain cell morphology in Trypanosoma brucei
10.1242/jcs.245258 · 2020 · External reference
Basal body protein TbSAF1 is required for microtubule quartet anchorage to the basal bodies in Trypanosoma brucei
10.1128/mbio.00668-20 · 2020 · External reference
Flagellar targeting of an arginine kinase requires a conserved lipidated protein intraflagellar transport pathway in Trypanosoma brucei
10.1074/jbc.ra120.014287 · 2020 · External reference
Detailed characterisation of the trypanosome nuclear pore architecture reveals conserved asymmetrical functional hubs that drive mRNA export
10.1371/journal.pbio.3003024 · 2025 · External reference
Evolutionary remodeling of a remnant GET pathway factor into PEX38, an essential peroxin
10.1073/pnas.2533726123 · 2026 · External reference
Exploring protein interactomes using TurboID-directed proximity labeling and mass spectrometry
2026 · External reference
A cytoskeletal protein complex is essential for division of intracellular amastigotes of leishmania mexicana
10.1074/jbc.ra120.014065 · 2020 · External reference
Proteomic analysis of Trypanosoma cruzi spliceosome complex
10.1016/j.jprot.2020.103822 · 2020 · External reference
Identification of the interactomes associated with SCD6 and RBP42 proteins in leishmania braziliensis
10.1016/j.jprot.2020.104066 · 2021 · External reference
Computational and informatics strategies for identification of specific protein interaction partners in affinity purification mass spectrometry experiments
10.1002/pmic.201100537 · 2012 · External reference
A proximity-dependent biotinylation map of a human cell
10.1038/s41586-021-03592-2 · 2021 · External reference
DIP-MS: ultra-deep interaction proteomics for the deconvolution of protein complexes
10.1038/s41592-024-02211-y · 2024 · External reference
Discovery and significance of protein–protein interactions in health and disease
10.1016/j.cell.2024.10.038 · 2024 · External reference
AlphaFold3: an overview of applications and performance insights
10.3390/ijms26083671 · 2025 · External reference
Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases
10.1039/d0md00122h · 2020 · External reference
Proteomics: an in-depth review on recent technical advances and their applications in biomedicine
10.1002/med.22098 · 2025 · External reference
The future of a myriad of accelerated biodiscoveries lies in AI-powered mass spectrometry and multiomics integration
10.1002/jms.5157 · 2025 · External reference
Generating high quality libraries for DIA MS with empirically corrected peptide predictions
2024 · External reference
Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition
10.1038/s41587-023-02099-7 · 2024 · External reference
Complex-centric proteome profiling by SEC-SWATH-MS for the parallel detection of hundreds of protein complexes
10.1038/s41596-020-0332-6 · 2020 · External reference
Cross-linking mass spectrometry (XL-MS): an emerging technology for interactomics and structural biology
10.1021/acs.analchem.7b04431 · 2018 · External reference
Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry
10.1073/pnas.2023360118 · 2021 · External reference
Mapping a Toxoplasma gondii interactome by crosslinking mass spectrometry and machine learning
2025 · External reference
Next-generation Interactomics: considerations for the use of co-elution to measure protein interaction networks
10.1074/mcp.r119.001803 · 2020 · External reference
Meta-analysis defines principles for the design and analysis of co-fractionation mass spectrometry experiments
10.1038/s41592-021-01194-4 · 2021 · External reference
Reliable identification of protein-protein interactions by crosslinking mass spectrometry
10.1038/s41467-021-23666-z · 2021 · External reference
CRISPR-guided proximity labeling of RNA–protein interactions
10.3390/genes13091549 · 2022 · External reference
CBRPP: a new RNA-centric method to study RNA–protein interactions
10.1080/15476286.2021.1873620 · 2021 · External reference
A new method for studying RNA-binding proteins on specific RNAs
10.21769/bioprotoc.4022 · 2021 · External reference
In vivo discovery of RNA proximal proteins via proximity-dependent biotinylation
10.1080/15476286.2021.1917215 · 2021 · External reference
Off-the-shelf proximity biotinylation using ProtA-TurboID
10.1038/s41596-022-00748-w · 2023 · External reference
Bioorthogonal photocatalytic decaging-enabled mitochondrial proteomics
10.1021/jacs.1c09171 · 2021 · External reference
Recent advances in proximity labeling for chemical proteomics: paving the way for in vivo applications
2025 · External reference
Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia
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Proteomics advances in immunology and infection research
2025 · External reference
Architecture of a host–parasite interface: complex targeting mechanisms revealed through proteomics
10.1074/mcp.m114.047647 · 2015 · External reference
Cell surface proteomics provides insight into stage-specific remodeling of the host–parasite interface in Trypanosoma brucei
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Machine learning and its applications for protozoal pathogens and protozoal infectious diseases
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