Research graph
References from Structure of the MurA-LpxC enzyme complex in modulating peptidoglycan and lipopolysaccharide biosynthesis. Local targets link to admitted publications; unresolved targets remain external evidence.
PHENIX: a comprehensive Python-based system for macromolecular structure solution
10.1107/s0907444909052925 · 2010 · External reference
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: time-dependent inhibition and specificity in ligand binding
10.1073/pnas.0709412104 · 2007 · External reference
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America
10.1086/595011 · 2009 · External reference
Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer
10.1074/jbc.m113.513028 · 2013 · External reference
Pymol: an open-source molecular graphics tool
2002 · External reference
Induced conformational changes activate the peptidoglycan synthase PBP1B
10.1111/mmi.14082 · 2018 · External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
Comparative X-ray analysis of the un-liganded fosfomycin-target MurA
10.1002/(sici)1097-0134(20000801)40:2<290::aid-prot90>3.0.co;2-0 · 2000 · External reference
Evidence that the Fosfomycin target Cys115 in UDP-N-acetylglucosamine Enolpyruvyl transferase (MurA) is essential for product release *
10.1074/jbc.m411325200 · 2005 · External reference
The topography of the bacterial cell wall
10.1146/annurev.mi.23.100169.001111 · 1969 · External reference
YejM modulates activity of the YciM/FtsH protease complex to prevent lethal accumulation of lipopolysaccharide
10.1128/mbio.00598-20 · 2020 · External reference
The fungal product Terreic acid is a covalent inhibitor of the bacterial Cell Wall biosynthetic enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA)
10.1021/bi100365b · 2010 · External reference
The Ramachandran plots of glycine and pre-proline
10.1186/1472-6807-5-14 · 2005 · External reference
Coordination of bacterial cell wall and outer membrane biosynthesis
10.1038/s41586-023-05750-0 · 2023 · External reference
Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid a biosynthesis pathway
10.1128/jb.179.6.2029-2037.1997 · 1997 · External reference
UDP-3-O-(R-3-Hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc Metalloenzyme
10.1021/bi982339s · 1999 · External reference
Potent LpxC inhibitors with in vitro activity against multidrug-resistant Pseudomonas aeruginosa
10.1128/aac.00977-19 · 2019 · External reference
Inference of macromolecular assemblies from crystalline state
10.1016/j.jmb.2007.05.022 · 2007 · External reference
ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures
10.1093/nar/gki370 · 2005 · External reference
Control of lipopolysaccharide biosynthesis by FtsH-mediated proteolysis of LpxC is conserved in Enterobacteria but not in all gram-negative Bacteria
10.1128/jb.01043-10 · 2011 · External reference
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase
10.1128/jb.174.17.5748-5752.1992 · 1992 · External reference
LapB (YciM) orchestrates protein–protein interactions at the interface of lipopolysaccharide and phospholipid biosynthesis
10.1111/mmi.15005 · 2023 · External reference
Small molecule LpxC inhibitors against gram-negative bacteria: advances and future perspectives
10.1016/j.ejmech.2023.115326 · 2023 · External reference
UCSF ChimeraX: structure visualization for researchers, educators, and developers
10.1002/pro.3943 · 2021 · External reference
Design, synthesis, and properties of a potent inhibitor of Pseudomonas aeruginosa deacetylase LpxC
10.1021/acs.jmedchem.7b00377 · 2017 · External reference
Leaks in the pipeline: a failure analysis of gram-negative antibiotic development from 2010 to 2020
10.1128/aac.00054-22 · 2022 · External reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · 2017 · External reference
Structural insights into polyamine spermidine uptake by the ABC transporter PotD-PotABC
10.1126/sciadv.ado8107 · 2024 · External reference
Lipopolysaccharide Endotoxins
10.1146/annurev.biochem.71.110601.135414 · 2002 · External reference
A smoothed backbone-dependent Rotamer library for proteins derived from adaptive kernel density estimates and regressions
10.1016/j.str.2011.03.019 · 2011 · External reference
The hit-and-run of cell wall synthesis: LpoB transiently binds and activates PBP1b through a conserved allosteric switch
10.1038/s41467-025-62051-y · 2025 · External reference
Dual function of LapB (YciM) in regulating Escherichia coli lipopolysaccharide synthesis
10.1073/pnas.2321510121 · 2024 · External reference
The bacterial cell envelope
10.1101/cshperspect.a000414 · 2010 · External reference
Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis
10.1073/pnas.1432990100 · 2003 · External reference
Using evolutionary data to make sense of macromolecules with a “face-lifted” ConSurf
10.1002/pro.4582 · 2023 · External reference
Preclinical safety and efficacy characterization of an LpxC inhibitor against gram-negative pathogens
10.1126/scitranslmed.adf5668 · 2023 · External reference
Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA) *
10.1074/jbc.m112.342725 · 2012 · External reference
Comparative X-ray analysis of the un-liganded fosfomycin-target MurA
10.1002/(sici)1097-0134(20000801)40:2<290::aid-prot90>3.0.co;2-0 · ExternalCitation · doi-reference
UCSF ChimeraX: structure visualization for researchers, educators, and developers
10.1002/pro.3943 · ExternalCitation · doi-reference
Using evolutionary data to make sense of macromolecules with a “face-lifted” ConSurf
10.1002/pro.4582 · ExternalCitation · doi-reference
Small molecule LpxC inhibitors against gram-negative bacteria: advances and future perspectives
10.1016/j.ejmech.2023.115326 · ExternalCitation · doi-reference
Inference of macromolecular assemblies from crystalline state
10.1016/j.jmb.2007.05.022 · ExternalCitation · doi-reference
A smoothed backbone-dependent Rotamer library for proteins derived from adaptive kernel density estimates and regressions
10.1016/j.str.2011.03.019 · ExternalCitation · doi-reference
Design, synthesis, and properties of a potent inhibitor of Pseudomonas aeruginosa deacetylase LpxC
10.1021/acs.jmedchem.7b00377 · ExternalCitation · doi-reference
The fungal product Terreic acid is a covalent inhibitor of the bacterial Cell Wall biosynthetic enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA)
10.1021/bi100365b · ExternalCitation · doi-reference
UDP-3-O-(R-3-Hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc Metalloenzyme
10.1021/bi982339s · ExternalCitation · doi-reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · ExternalCitation · doi-reference
The hit-and-run of cell wall synthesis: LpoB transiently binds and activates PBP1b through a conserved allosteric switch
10.1038/s41467-025-62051-y · ExternalCitation · doi-reference
Coordination of bacterial cell wall and outer membrane biosynthesis
10.1038/s41586-023-05750-0 · ExternalCitation · doi-reference
Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: time-dependent inhibition and specificity in ligand binding
10.1073/pnas.0709412104 · ExternalCitation · doi-reference
Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis
10.1073/pnas.1432990100 · ExternalCitation · doi-reference
Dual function of LapB (YciM) in regulating Escherichia coli lipopolysaccharide synthesis
10.1073/pnas.2321510121 · ExternalCitation · doi-reference
Functional consequence of covalent reaction of phosphoenolpyruvate with UDP-N-acetylglucosamine 1-Carboxyvinyltransferase (MurA) *
10.1074/jbc.m112.342725 · ExternalCitation · doi-reference
Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer
10.1074/jbc.m113.513028 · ExternalCitation · doi-reference
Evidence that the Fosfomycin target Cys115 in UDP-N-acetylglucosamine Enolpyruvyl transferase (MurA) is essential for product release *
10.1074/jbc.m411325200 · ExternalCitation · doi-reference
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America
10.1086/595011 · ExternalCitation · doi-reference
ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures
10.1093/nar/gki370 · ExternalCitation · doi-reference
The bacterial cell envelope
10.1101/cshperspect.a000414 · ExternalCitation · doi-reference
PHENIX: a comprehensive Python-based system for macromolecular structure solution
10.1107/s0907444909052925 · ExternalCitation · doi-reference
Features and development of Coot
10.1107/s0907444910007493 · ExternalCitation · doi-reference
Induced conformational changes activate the peptidoglycan synthase PBP1B
10.1111/mmi.14082 · ExternalCitation · doi-reference
LapB (YciM) orchestrates protein–protein interactions at the interface of lipopolysaccharide and phospholipid biosynthesis
10.1111/mmi.15005 · ExternalCitation · doi-reference
Structural insights into polyamine spermidine uptake by the ABC transporter PotD-PotABC
10.1126/sciadv.ado8107 · ExternalCitation · doi-reference
Preclinical safety and efficacy characterization of an LpxC inhibitor against gram-negative pathogens
10.1126/scitranslmed.adf5668 · ExternalCitation · doi-reference
Leaks in the pipeline: a failure analysis of gram-negative antibiotic development from 2010 to 2020
10.1128/aac.00054-22 · ExternalCitation · doi-reference
Potent LpxC inhibitors with in vitro activity against multidrug-resistant Pseudomonas aeruginosa
10.1128/aac.00977-19 · ExternalCitation · doi-reference
Control of lipopolysaccharide biosynthesis by FtsH-mediated proteolysis of LpxC is conserved in Enterobacteria but not in all gram-negative Bacteria
10.1128/jb.01043-10 · ExternalCitation · doi-reference
Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase
10.1128/jb.174.17.5748-5752.1992 · ExternalCitation · doi-reference
Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid a biosynthesis pathway
10.1128/jb.179.6.2029-2037.1997 · ExternalCitation · doi-reference
YejM modulates activity of the YciM/FtsH protease complex to prevent lethal accumulation of lipopolysaccharide
10.1128/mbio.00598-20 · ExternalCitation · doi-reference
Lipopolysaccharide Endotoxins
10.1146/annurev.biochem.71.110601.135414 · ExternalCitation · doi-reference
The topography of the bacterial cell wall
10.1146/annurev.mi.23.100169.001111 · ExternalCitation · doi-reference
The Ramachandran plots of glycine and pre-proline
10.1186/1472-6807-5-14 · ExternalCitation · doi-reference