Research graph
References from PPAR-γ alleviates preeclampsia-associated placental oxidative stress with involvement of the PI3K/Akt signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Hypertensive disorders of pregnancy
2023 · External reference
Preeclampsia-Pathophysiology and Clinical Presentations: JACC State-of-the-Art Review
10.1016/j.jacc.2020.08.014 · 2020 · External reference
Update on Preeclampsia and Hypertensive Disorders of Pregnancy
10.1016/j.ecl.2024.05.012 · 2024 · External reference
Postpartum preeclampsia or eclampsia: defining its place and management among the hypertensive disorders of pregnancy
10.1016/j.ajog.2020.10.027 · 2022 · External reference
The Role of Peroxisome Proliferator-Activated Receptors in Preeclampsia
10.3390/cells12040647 · 2023 · External reference
MicroRNAs targeting peroxisome proliferator-activated receptor (PPAR) gene are differentially expressed in low birth weight placentae
10.1016/j.placenta.2023.06.006 · 2023 · External reference
Differences in expression of Peroxisome Proliferator-activated Receptor-γ in early-onset preeclampsia and late-onset preeclampsia
10.1186/s13104-020-05029-x · 2020 · External reference
Expression and role of peroxisome proliferator-activated receptors in the porcine early placenta trophoblast
10.1016/j.domaniend.2018.12.001 · 2019 · External reference
Therapeutic Opportunities for Intestinal Angioectasia- Targeting PPARγ and Oxidative Stress
10.1111/cts.12899 · 2021 · External reference
Regulation of PI3K/Akt in preeclampsia: an examination of its pathological role and therapeutic potential
10.1007/s00210-025-04472-6 · 2026 · External reference
Isorhynchophylline alleviates preeclampsia via PI3K/AKT/mTOR-mediated trophoblast oxidative stress inhibition
10.1016/j.ejphar.2025.178076 · 2025 · External reference
STX2 Promotes Trophoblast Growth, Migration, and Invasion Through Activation of the PI3K-AKT Pathway in Preeclampsia
2021 · External reference
Apelin/APJ system protects placental trophoblasts from hypoxia-induced oxidative stress through activating PI3K/Akt signaling pathway in preeclampsia
10.1016/j.freeradbiomed.2023.09.030 · 2023 · External reference
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway
2020 · External reference
The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice
10.1016/j.preghy.2021.09.008 · 2022 · External reference
Sodium dichloroacetate improves migration ability by suppressing LPS-induced inflammation in HTR-8/SVneo cells via the TLR4/NF-κB pathway
2024 · External reference
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia
10.1177/09636897221145682 · 2023 · External reference
The Protective Benefit of Heme Oxygenase-1 Gene-Modified Human Placenta-Derived Mesenchymal Stem Cells in a N-Nitro-L-Arginine Methyl Ester-Induced Preeclampsia-Like Rat Model: Possible Implications for Placental Angiogenesis
10.1089/scd.2021.0174 · 2021 · External reference
PPARgamma alleviates preeclampsia development by regulating lipid metabolism and ferroptosis
10.1038/s42003-024-06063-2 · 2024 · External reference
Comparison of Normal and Pre-Eclamptic Placental Gene Expression: A Systematic Review with Meta-Analysis
10.1371/journal.pone.0161504 · 2016 · External reference
Bioinformatics analysis combined with clinical sample screening reveals that leptin may be a biomarker of preeclampsia
2022 · External reference
Preeclampsia epidemiology(ies) and pathophysiology(ies), Best practice & research
2024 · External reference
A Narrative Review on the Pathophysiology of Preeclampsia
10.3390/ijms25147569 · 2024 · External reference
PPAR-γ -- a possible drug target for complicated pregnancies
10.1111/bph.12069 · 2013 · External reference
Understanding PPARgamma and Its Agonists on Trophoblast Differentiation and Invasion: Potential Therapeutic Targets for Gestational Diabetes Mellitus and Preeclampsia
10.3390/nu15112459 · 2023 · External reference
Rosiglitazone-Mediated Activation of PPARgamma Restores HO1 Expression in the Human Preeclamptic Placenta
10.1161/hypertensionaha.123.21645 · 2023 · External reference
Peroxisome proliferator-activated receptor-gamma as a potential therapeutic target in the treatment of preeclampsia
10.1161/hypertensionaha.111.172627 · 2011 · External reference
Role of leptin in the pathophysiology of preeclampsia
10.1016/j.placenta.2023.09.005 · 2023 · External reference
Emerging Role of Leptin in Vascular and Placental Dysfunction in Preeclampsia
10.1161/atvbaha.124.321676 · 2025 · External reference
Oxidative Stress in Preeclampsia and Placental Diseases
10.3390/ijms19051496 · 2018 · External reference
Immune cellular homeostasis and its breakdown at the maternal-fetal interface
10.1016/j.it.2025.11.006 · 2026 · External reference
CD4(+) T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing
10.3389/fimmu.2024.1401738 · 2024 · External reference
Trophoblast Cell Subtypes and Dysfunction in the Placenta of Individuals with Preeclampsia Revealed by Single‑Cell RNA Sequencing
10.14348/molcells.2021.0211 · 2022 · External reference
Decreased miR-486-5p is involved in lipopolysaccharide-induced HTR-8/SVneo cell dysfunction by promoting SMAD2 expression
10.1530/rep-23-0502 · 2025 · External reference
Overexpressed Trophoblast Glycoprotein Contributes to Preeclampsia Development by Inducing Abnormal Trophoblast Migration and Invasion Toward the Uterine Spiral Artery
10.1161/hypertensionaha.124.22923 · 2024 · External reference
miR-146a-5p-mediated suppression on trophoblast cell progression and epithelial-mesenchymal transition in preeclampsia
10.1186/s40659-021-00351-5 · 2021 · External reference
Corrigendum to Isorhynchophylline alleviates preeclampsia via PI3K/AKT/mTOR-mediated trophoblast oxidative stress inhibition Eur J Pharmacol. 1005 (2025)178076
10.1016/j.ejphar.2025.178228 · 2025 · External reference
OLFML3 suppresses trophoblast apoptosis via the PI3K/AKT pathway: A possible therapeutic target in preeclampsia
10.1016/j.placenta.2024.01.008 · 2024 · External reference
The Effect of FPR2 on the Regulation of Trophoblast Autophagy via the PI3K/AKT/mTOR Signaling Pathway in Preeclampsia
10.1096/fj.202402938rr · 2025 · External reference
Placenta‐derived extracellular vesicles: Signal messengers shuttling across the maternal‐fetal barrier
10.1002/inmd.70111 · 2026 · External reference
Exploring vaginal microbiota–tissue resident stem cell crosstalk: VCAM1/Akt signaling ‐mediated enhancement of regenerative capacity
10.1002/inmd.70167 · 2026 · External reference
Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model
10.1002/jev2.12328 · 2023 · External reference
Preeclampsia: Pathophysiology, Challenges, and Perspectives
10.1161/circresaha.118.313276 · 2019 · External reference
The expression of Sirt1/FoxO1 pathway in the placenta of patients with preeclampsia and its connection with prognosis
10.1080/01443615.2022.2151347 · 2022 · External reference
Metformin attenuates placental oxidative stress through Nrf2/Keap1 signaling in preeclampsia rats
10.1016/j.abb.2025.110622 · 2025 · External reference
Astragalus ameliorates oxidative stress in rat models of preeclampsia through the Nrf2/Keap1/NQO1 pathway
10.1016/j.placenta.2025.07.004 · 2025 · External reference
Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model
10.1007/s43032-021-00743-8 · 2022 · External reference
Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines
10.2215/cjn.12081115 · 2016 · External reference
Mechanistic Insights into Side Effects of Troglitazone and Rosiglitazone Using a Novel Inverse Molecular Docking Protocol
10.3390/pharmaceutics13030315 · 2021 · External reference
