Research graph
References from Petromurin C modulates ERα-dependent gene expression in MCF-7 breast cancer cells via probably interactions with estrogen receptor alpha in AF-2 location. Local targets link to admitted publications; unresolved targets remain external evidence.
Marine-derived indole alkaloids and their biological and pharmacological activities
2022 · External reference
Asterriquinones produced by Aspergillm candidus inhibit binding of the Grb-2 adapter to phosphorylated EGF receptor tyrosine kinase
10.7164/antibiotics.52.215 · 1999 · External reference
Asteriquinones from Aspergillus sp. GZWMJZ-258 and their derivatives
10.1021/acs.jnatprod.3c00732 · 2023 · External reference
Signaling effects of Demethylasterriquinone B1, a selective insulin receptor modulator
10.1002/cbic.200200468 · 2003 · External reference
Interaction of asterriquinone with deoxyribonucleic acid in Vitro
10.1248/cpb.38.2617 · 1990 · External reference
Inhibition of HIV-reverse transcriptase activity by asterriquinone and its analogues
10.1016/0006-291x(91)90484-o · 1991 · External reference
Secondary Metabolites of the Marine Sponge-Derived Fungus Aspergillus subramanianii 1901NT-1.40.2 and Their Antimicrobial and Anticancer Activities
10.3390/md23090353 · 2025 · External reference
SwissDock, a protein-small molecule docking web service based on EADock DSS
10.1093/nar/gkr366 · 2011 · External reference
The Kelch/Nrf2 antioxidant system as a target for some marine fungal metabolites
10.3390/oxygen3040024 · 2023 · External reference
Diverse ligands for mycobacterial CYP124 identified from plant and marine compounds
10.1016/j.biochi.2026.02.019 · 2026 · External reference
Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium
10.1038/s41467-018-07175-0 · 2018 · External reference
Molecular basis of agonism and antagonism in the oestrogen receptor
10.1038/39645 · 1997 · External reference
Surface Plasmon Resonance Based Assay for the Detection and Characterization of Promiscuous Inhibitors
10.1021/jm700952v · 2008 · External reference
Connections and Regulation of the Human Estrogen Receptor
10.1126/science.1071884 · 2002 · External reference
Estrogen Receptor Signaling in Breast Cancer
10.3390/cancers15194689 · 2023 · External reference
Understanding the interaction of estrogenic ligands with estrogen receptors: a survey of the functional and binding kinetic studies
10.1080/26896583.2020.1761204 · 2020 · External reference
SPR-based biosensors: a tool for biodetection of hormonal compounds
10.1007/s00216-006-0958-4 · 2007 · External reference
Kinetic analysis of estrogen receptor/ligand interactions
10.1073/pnas.142288199 · 2002 · External reference
Estrogen receptor binding assay of chemicals with a surface plasmon resonance biosensor
10.1016/s0960-0760(02)00046-8 · 2002 · External reference
Label-Free Biosensor Detection of Endocrine Disrupting Compounds Using Engineered Estrogen Receptors
2018 · External reference
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
10.1186/s12915-022-01293-4 · 2022 · External reference
Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells
1992 · External reference
Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains
10.1038/s41467-018-06034-2 · 2018 · External reference
The N-terminal activation function AF-1 domain of ERα interacts directly with the C-terminal AF-2-holding ligand-binding domain to recruit the coactivator proteins
2024 · External reference
Handbook of surface plasmon resonance
2017 · External reference
Adsorption mechanisms of small aromatic compounds in cross-linked dextran gel
10.1016/j.chroma.2025.466162 · 2025 · External reference
Reaction of quinones with proteins: Kinetics of adduct formation, effects on enzymatic activity and protein structure, and potential reversibility of modifications
10.1016/j.freeradbiomed.2019.04.026 · 2019 · External reference
Combining Fundamental Kinetics and Standard Alkylation Assays to Prioritize Lead-Like KRAS G12C Inhibitors
10.1021/acsomega.4c08774 · 2024 · External reference
Estrogen receptor: current understanding of its activation and modulation
2001 · External reference
Mechanisms of estrogen action
10.1152/physrev.2001.81.4.1535 · 2001 · External reference
Discovery of estrogen receptor α target genes and response elements in breast tumor cells
10.1186/gb-2004-5-9-r66 · 2004 · External reference
Novel estrogen-responsive genes (ERGs) for the evaluation of estrogenic activity
10.1371/journal.pone.0273164 · 2022 · External reference
Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator
10.1073/pnas.93.19.10069 · 1996 · External reference
4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ
10.1073/pnas.151244398 · 2001 · External reference
An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens
10.1073/pnas.96.12.6947 · 1999 · External reference
Analysis of Estrogen Receptor Interaction with a Repressor of Estrogen Receptor Activity (REA) and the Regulation of Estrogen Receptor Transcriptional Activity by REA
10.1074/jbc.m001327200 · 2000 · External reference
Expression of a Repressor of Estrogen Receptor Activity in Human Breast Tumors: Relationship to Some Known Prognostic Markers1
2000 · External reference
Prohibitin, an Evolutionarily Conserved Intracellular Protein That Blocks DNA Synthesis in Normal Fibroblasts and HeLa Cells
1991 · External reference
Mitochondrial Functions and Estrogen Receptor-dependent Nuclear Translocation of Pleiotropic Human Prohibitin 2
10.1074/jbc.m605260200 · 2006 · External reference
Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer
10.1038/npre.2009.2834.1 · 2009 · External reference
A Repressive Role for Prohibitin in Estrogen Signaling
10.1210/me.2007-0400 · 2008 · External reference
Pan-cancer Analysis Combined with Experiments Deciphers PHB Regulation for Breast Cancer Cell Survival and Predicts Biomarker Function
10.2174/0113862073266248231024113533 · 2024 · External reference
Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions
1995 · External reference
Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype
10.1210/en.2003-0567 · 2003 · External reference
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis
10.1038/nature07027 · 2008 · External reference
GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome
10.1158/1541-7786.mcr-15-0433 · 2016 · External reference
Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis
10.1093/nar/gky589 · 2018 · External reference
Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression
10.1186/s12943-017-0722-8 · 2017 · External reference
Estrogen-occupied Estrogen Receptor Represses Cyclin G2 Gene Expression and Recruits a Repressor Complex at the Cyclin G2 Promoter
10.1074/jbc.m513405200 · 2006 · External reference
Estrogen and IGF-I Independently Down-Regulate Critical Repressors of Breast Cancer Growth
10.1158/0008-5472.sabcs-09-1126 · 2009 · External reference
Control of Cyclin G2 mRNA Expression by Forkhead Transcription Factors: Novel Mechanism for Cell Cycle Control by Phosphoinositide 3-Kinase and Forkhead
10.1128/mcb.24.5.2181-2189.2004 · 2004 · External reference
Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells
10.1158/1535-7163.mct-07-0109 · 2007 · External reference
Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival
10.1080/15384101.2016.1243189 · 2016 · External reference
GREB1 is a critical regulator of hormone dependent breast cancer growth
10.1007/s10549-005-1483-4 · 2005 · External reference
Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor
10.1016/j.celrep.2013.01.010 · 2013 · External reference
GREB1 regulates PI3K/Akt signaling to control hormone-sensitive breast cancer proliferation
10.1093/carcin/bgaa096 · 2020 · External reference
