Research graph
References from Proton pump inhibitor use was not associated with reduced gastrointestinal bleeding risk in ischemic stroke patients treated with dual antiplatelet therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the global burden of disease study 2021
10.1016/s1474-4422(24)00369-7 · 2024 · External reference
Pragmatic solutions to reduce the global burden of stroke: a world stroke organization-lancet neurology commission
10.1016/s1474-4422(23)00277-6 · 2023 · External reference
Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA
10.1056/nejmoa1800410 · 2018 · External reference
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
10.1056/nejmoa060989 · 2006 · External reference
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack
10.1056/nejmoa1215340 · 2013 · External reference
Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study
10.1136/bmj.38947.697558.ae · 2006 · External reference
2025 ACC/AHA/ACEP/NAEMSP/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American college of cardiology/American heart association joint committee on clinical practice guidelines
2025 · External reference
Clopidogrel with or without omeprazole in coronary artery disease
10.1056/nejmoa1007964 · 2010 · External reference
Proton-pump inhibitors reduce gastrointestinal events regardless of aspirin dose in patients requiring dual antiplatelet therapy
10.1016/j.jacc.2015.12.068 · 2016 · External reference
Impact of proton pump inhibitors on clinical outcomes in patients after acute myocardial infarction: a propensity score analysis from China acute myocardial infarction (CAMI) registry
2020 · External reference
Randomized clinical trial: the impact of gastrointestinal risk factor screening and prophylactic proton pump inhibitor therapy in patients receiving dual antiplatelet therapy
10.1097/meg.0000000000000934 · 2017 · External reference
Impact of proton pump inhibitors and dual antiplatelet therapy cessation on outcomes following percutaneous coronary intervention: results from the PARIS registry
2017 · External reference
Proton pump inhibitors and in-hospital gastrointestinal bleeding in patients with acute coronary syndrome receiving dual antiplatelet therapy
10.1016/j.mayocp.2021.11.037 · 2022 · External reference
European stroke organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischaemic attack
10.1177/23969873221100032 · 2022 · External reference
2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American heart association/American stroke association
10.1161/str.0000000000000375 · 2021 · External reference
Classification of subtype of acute ischemic stroke. definitions for use in a multicenter clinical trial. TOAST. Trial of org 10172 in acute stroke treatment
10.1161/01.str.24.1.35 · 1993 · External reference
Treatment and prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy
10.5492/wjccm.v4.i1.40 · 2015 · External reference
Proton pump inhibitors use in patients with ischemic stroke on dual antiplatelet therapy at low risk of upper gastrointestinal bleeding
10.1161/jaha.124.035239 · 2025 · External reference
The clinical impact of proton pump inhibitors when co-administered with dual antiplatelet therapy in patients having acute myocardial infarction with low risk of gastrointestinal bleeding: insights from the China acute myocardial infarction registry
10.3389/fcvm.2021.685072 · 2021 · External reference
An aspirin-free strategy for percutaneous coronary intervention in patients with diabetes: a pre-specified subgroup analysis of the STOPDAPT-3 trial
10.1093/ehjcvp/pvae075 · 2025 · External reference
Impact of proton pump inhibitors on clinical outcomes in patients treated with a 6- or 24-month dual-antiplatelet therapy duration: insights from the PROlonging dual-antiplatelet treatment after grading stent-induced intimal hyperplasia studY trial
10.1016/j.ahj.2016.01.015 · 2016 · External reference
Temporal trends in use of antisecretory agents among patients administered clopidogrel-based dual antiplatelet therapy after percutaneous coronary intervention
10.1002/pds.5816 · 2024 · External reference
Potential risks associated with long-term use of proton pump inhibitors and the maintenance treatment modality for patients with mild gastroesophageal reflux disease
10.5056/jnm24059 · 2024 · External reference
Nonsteroidal anti-inflammatory drugs and lower gastrointestinal complications
10.1016/j.gtc.2009.03.007 · 2009 · External reference
Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy
10.1016/j.cgh.2009.12.022 · 2010 · External reference
Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis
10.1053/j.gastro.2011.06.075 · 2011 · External reference
Proton pump inhibitors increase incidence of nonsteroidal anti-inflammatory drug-induced small bowel injury: a randomized, placebo-controlled trial
10.1016/j.cgh.2015.10.022 · 2016 · External reference
Hospitalizations for upper and lower GI events associated with traditional NSAIDs and acetaminophen among the elderly in Quebec, Canada
10.1111/j.1572-0241.2008.01811.x · 2008 · External reference
