Research graph
References from Multiplexed 3D virtual histology enables in situ mapping of meibomian gland innervation. Local targets link to admitted publications; unresolved targets remain external evidence.
Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study
10.1097/ico.0b013e318225415a · 2012 · External reference
The prevalence of meibomian gland dysfunction, tear film and ocular surface parameters in an Austrian dry eye clinic population
10.1111/aos.13732 · 2018 · External reference
Prevalence of diagnosed dry eye disease in the United States among adults aged 18 years and older
10.1016/j.ajo.2017.06.033 · 2017 · External reference
Tfos DEWS III: Management and therapy
10.1016/j.ajo.2025.05.039 · 2025 · External reference
Dry eye disease associated with meibomian Gland dysfunction: focus on tear film characteristics and the therapeutic landscape
10.1007/s40123-023-00669-1 · 2023 · External reference
The international workshop on Meibomian Gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the Meibomian Gland
10.1167/iovs.10-6997c · 2011 · External reference
Functional morphology of the lipid layer of the tear film
10.1097/ico.0000000000001367 · 2017 · External reference
Complexity of the tear film: importance in homeostasis and dysfunction during disease
10.1016/j.exer.2013.10.008 · 2013 · External reference
High resolution microscopy of the lipid layer of the tear film
10.1016/s1542-0124(11)70033-7 · 2011 · External reference
Effect of desiccating stress on Mouse Meibomian Gland function
10.1016/j.jtos.2013.08.002 · 2014 · External reference
Meibom-Drüsen: teil I: Anatomie, Embryologie und Histologie der Meibom-Drüsen
10.1007/s00347-009-2006-1 · 2009 · External reference
Volumetric reconstruction of the mouse Meibomian Gland using high‐resolution nonlinear optical imaging
10.1002/ar.21305 · 2011 · External reference
Deficiency in acyl-coa:wax Alcohol Acyltransferase 2 causes evaporative dry eye disease by abolishing biosynthesis of wax esters
10.1096/fj.202001191r · 2020 · External reference
The development of meibomian glands in mice
2010 · External reference
Neurotransmitter influence on human Meibomian gland epithelial cells
10.1167/iovs.11-8113 · 2011 · External reference
Characterization of the innervation of the meibomian glands in humans, rats and mice
10.1016/j.aanat.2020.151609 · 2021 · External reference
The neurobiology of the Meibomian glands
10.1016/j.jtos.2014.01.005 · 2014 · External reference
Noncontact infrared meibography to document age-related changes of the Meibomian glands in a normal population
10.1016/j.ophtha.2007.06.031 · 2008 · External reference
Meibography: a review of techniques and technologies
10.1016/j.sjopt.2012.08.007 · 2012 · External reference
Three-dimensional volumetric human meibomian gland investigation using polarization-sensitive optical coherence tomography
10.1117/1.jbo.19.3.030503 · 2014 · External reference
In vivo confocal microscopy of Meibomian glands in Sjögren’s syndrome
10.1167/iovs.10-5995 · 2011 · External reference
A Survey of methods for 3D histology reconstruction
10.1016/j.media.2018.02.004 · 2018 · External reference
Tissue histology in 3D
2024 · External reference
NOV03 for signs and symptoms of dry eye disease associated with Meibomian Gland dysfunction: the randomized phase 3 MOJAVE Study
10.1016/j.ajo.2023.03.008 · 2023 · External reference
Perfluorohexyloctane eye drops for dry eye disease associated with Meibomian Gland dysfunction in Chinese patients: a randomized clinical trial
10.1001/jamaophthalmol.2023.0270 · 2023 · External reference
Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study
10.1136/bjophthalmol-2018-312470 · 2019 · External reference
A review on evidence-based treatments for Meibomian Gland dysfunction
10.1097/icl.0000000000000680 · 2020 · External reference
The growing need for validated biomarkers and endpoints for dry eye clinical research
2017 · External reference
Effective melanin depigmentation of human and murine ocular tissues: an improved method for paraffin and frozen sections
10.1371/journal.pone.0102512 · 2014 · External reference
Light transmission/absorption characteristics of the meibomian gland
10.1016/j.jtos.2018.07.001 · 2018 · External reference
Clarifying tissue clearing
10.1016/j.cell.2015.06.067 · 2015 · External reference
Tissue clearing and its applications in neuroscience
10.1038/s41583-019-0250-1 · 2020 · External reference
A simple and fast optical clearing method for Whole‐Mount Fluorescence in Situ hybridization (FISH) imaging
10.1002/jbio.202400258 · 2025 · External reference
A beginner's guide to tissue clearing
10.1016/j.biocel.2016.12.009 · 2017 · External reference
Advances in CLARITY-based tissue clearing and imaging
2018 · External reference
Structural and molecular interrogation of intact biological systems
10.1038/nature12107 · 2013 · External reference
Chemical landscape for tissue clearing based on hydrophilic reagents
10.1016/j.celrep.2018.07.056 · 2018 · External reference
A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous System
10.1016/j.celrep.2014.10.037 · 2014 · External reference
A guidebook for DISCO tissue clearing
10.15252/msb.20209807 · 2021 · External reference
iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging
10.1016/j.cell.2014.10.010 · 2014 · External reference
Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging
10.1038/nprot.2015.085 · 2015 · External reference
Whole-Brain imaging with single-cell resolution using chemical cocktails and computational analysis
10.1016/j.cell.2014.03.042 · 2014 · External reference
ScaleS: an optical clearing palette for biological imaging
10.1038/nn.4107 · 2015 · External reference
FalseColor-Python: a rapid intensity-leveling and digital-staining package for fluorescence-based slide-free digital pathology
10.1371/journal.pone.0233198 · 2020 · External reference
Virtual histological staining of unlabelled tissue-autofluorescence images via deep learning
10.1038/s41551-019-0362-y · 2019 · External reference
Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens
10.1038/s41551-017-0084 · 2017 · External reference
Deep learning-enabled virtual histological staining of biological samples
10.1038/s41377-023-01104-7 · 2023 · External reference
Objective imaging diagnostics for dry eye disease
2020 · External reference
In vivo 3D meibography of the human eyelid using real time imaging fourier-domain OCT
2013 · External reference
Digital labeling for 3D histology: segmenting blood vessels without a vascular contrast agent using deep learning
10.1364/boe.480230 · 2023 · External reference
Effect of different melanin-bleaching methods on staining
10.1097/pai.0000000000001291 · 2026 · External reference
Melanin bleaching with Dilute hydrogen peroxide: a simple and rapid method
10.1097/pai.0b013e31826d81db · 2013 · External reference
Optimized protocol for whole-mount RNA fluorescent in situ hybridization using oxidation-mediated autofluorescence reduction on mouse embryos
10.1016/j.xpro.2023.102603 · 2023 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation
10.1038/s41592-020-01008-z · 2021 · External reference
A hybrid method to enhance thick and thin vessels for blood vessel segmentation
10.3390/diagnostics11112017 · 2021 · External reference
clDice - a novel topology-preserving loss function for tubular structure segmentation
2021 · External reference
Methods to label, image, and analyze the complex structural architectures of microvascular networks
10.1111/micc.12520 · 2019 · External reference
Meibomian Gland disease
10.1016/j.ophtha.2017.05.031 · 2017 · External reference
Anatomy and histopathology of Human Meibomian gland
10.1097/01.ico.0000263122.45898.09 · 2002 · External reference
Meibomian gland dysfunction: hyperkeratinization or atrophy?
10.1186/s12886-015-0132-x · 2015 · External reference
Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases
10.1016/j.preteyeres.2009.04.003 · 2009 · External reference
Parasympathetic innervation of the meibomian glands in rats
2001 · External reference
In vivo confocal microscopy of corneal nerves in health and disease
10.1016/j.jtos.2016.09.004 · 2017 · External reference
Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction
10.1136/bjophthalmol-2015-307415 · 2016 · External reference
Perfluorohexyloctane eye drops for dry eye disease associated with Meibomian Gland dysfunction in Chinese patients: a randomized clinical trial
10.1001/jamaophthalmol.2023.0270 · ExternalCitation · doi-reference
Volumetric reconstruction of the mouse Meibomian Gland using high‐resolution nonlinear optical imaging
10.1002/ar.21305 · ExternalCitation · doi-reference
A simple and fast optical clearing method for Whole‐Mount Fluorescence in Situ hybridization (FISH) imaging
10.1002/jbio.202400258 · ExternalCitation · doi-reference
Meibom-Drüsen: teil I: Anatomie, Embryologie und Histologie der Meibom-Drüsen
10.1007/s00347-009-2006-1 · ExternalCitation · doi-reference
Dry eye disease associated with meibomian Gland dysfunction: focus on tear film characteristics and the therapeutic landscape
10.1007/s40123-023-00669-1 · ExternalCitation · doi-reference
Characterization of the innervation of the meibomian glands in humans, rats and mice
10.1016/j.aanat.2020.151609 · ExternalCitation · doi-reference
Prevalence of diagnosed dry eye disease in the United States among adults aged 18 years and older
10.1016/j.ajo.2017.06.033 · ExternalCitation · doi-reference
NOV03 for signs and symptoms of dry eye disease associated with Meibomian Gland dysfunction: the randomized phase 3 MOJAVE Study
10.1016/j.ajo.2023.03.008 · ExternalCitation · doi-reference
Tfos DEWS III: Management and therapy
10.1016/j.ajo.2025.05.039 · ExternalCitation · doi-reference
A beginner's guide to tissue clearing
10.1016/j.biocel.2016.12.009 · ExternalCitation · doi-reference
Whole-Brain imaging with single-cell resolution using chemical cocktails and computational analysis
10.1016/j.cell.2014.03.042 · ExternalCitation · doi-reference
iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging
10.1016/j.cell.2014.10.010 · ExternalCitation · doi-reference
Clarifying tissue clearing
10.1016/j.cell.2015.06.067 · ExternalCitation · doi-reference
A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous System
10.1016/j.celrep.2014.10.037 · ExternalCitation · doi-reference
Chemical landscape for tissue clearing based on hydrophilic reagents
10.1016/j.celrep.2018.07.056 · ExternalCitation · doi-reference
Complexity of the tear film: importance in homeostasis and dysfunction during disease
10.1016/j.exer.2013.10.008 · ExternalCitation · doi-reference
Effect of desiccating stress on Mouse Meibomian Gland function
10.1016/j.jtos.2013.08.002 · ExternalCitation · doi-reference
The neurobiology of the Meibomian glands
10.1016/j.jtos.2014.01.005 · ExternalCitation · doi-reference
In vivo confocal microscopy of corneal nerves in health and disease
10.1016/j.jtos.2016.09.004 · ExternalCitation · doi-reference
Light transmission/absorption characteristics of the meibomian gland
10.1016/j.jtos.2018.07.001 · ExternalCitation · doi-reference
A Survey of methods for 3D histology reconstruction
10.1016/j.media.2018.02.004 · ExternalCitation · doi-reference
Noncontact infrared meibography to document age-related changes of the Meibomian glands in a normal population
10.1016/j.ophtha.2007.06.031 · ExternalCitation · doi-reference
Meibomian Gland disease
10.1016/j.ophtha.2017.05.031 · ExternalCitation · doi-reference
Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases
10.1016/j.preteyeres.2009.04.003 · ExternalCitation · doi-reference
Meibography: a review of techniques and technologies
10.1016/j.sjopt.2012.08.007 · ExternalCitation · doi-reference
Optimized protocol for whole-mount RNA fluorescent in situ hybridization using oxidation-mediated autofluorescence reduction on mouse embryos
10.1016/j.xpro.2023.102603 · ExternalCitation · doi-reference
High resolution microscopy of the lipid layer of the tear film
10.1016/s1542-0124(11)70033-7 · ExternalCitation · doi-reference
Structural and molecular interrogation of intact biological systems
10.1038/nature12107 · ExternalCitation · doi-reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · ExternalCitation · doi-reference
ScaleS: an optical clearing palette for biological imaging
10.1038/nn.4107 · ExternalCitation · doi-reference
Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging
10.1038/nprot.2015.085 · ExternalCitation · doi-reference
Deep learning-enabled virtual histological staining of biological samples
10.1038/s41377-023-01104-7 · ExternalCitation · doi-reference
Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens
10.1038/s41551-017-0084 · ExternalCitation · doi-reference
Virtual histological staining of unlabelled tissue-autofluorescence images via deep learning
10.1038/s41551-019-0362-y · ExternalCitation · doi-reference
Tissue clearing and its applications in neuroscience
10.1038/s41583-019-0250-1 · ExternalCitation · doi-reference
nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation
10.1038/s41592-020-01008-z · ExternalCitation · doi-reference
Deficiency in acyl-coa:wax Alcohol Acyltransferase 2 causes evaporative dry eye disease by abolishing biosynthesis of wax esters
10.1096/fj.202001191r · ExternalCitation · doi-reference
Anatomy and histopathology of Human Meibomian gland
10.1097/01.ico.0000263122.45898.09 · ExternalCitation · doi-reference
A review on evidence-based treatments for Meibomian Gland dysfunction
10.1097/icl.0000000000000680 · ExternalCitation · doi-reference
Functional morphology of the lipid layer of the tear film
10.1097/ico.0000000000001367 · ExternalCitation · doi-reference
Distribution of aqueous-deficient and evaporative dry eye in a clinic-based patient cohort: a retrospective study
10.1097/ico.0b013e318225415a · ExternalCitation · doi-reference
Effect of different melanin-bleaching methods on staining
10.1097/pai.0000000000001291 · ExternalCitation · doi-reference
Melanin bleaching with Dilute hydrogen peroxide: a simple and rapid method
10.1097/pai.0b013e31826d81db · ExternalCitation · doi-reference
The prevalence of meibomian gland dysfunction, tear film and ocular surface parameters in an Austrian dry eye clinic population
10.1111/aos.13732 · ExternalCitation · doi-reference
Methods to label, image, and analyze the complex structural architectures of microvascular networks
10.1111/micc.12520 · ExternalCitation · doi-reference
Three-dimensional volumetric human meibomian gland investigation using polarization-sensitive optical coherence tomography
10.1117/1.jbo.19.3.030503 · ExternalCitation · doi-reference
Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction
10.1136/bjophthalmol-2015-307415 · ExternalCitation · doi-reference
Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study
10.1136/bjophthalmol-2018-312470 · ExternalCitation · doi-reference
In vivo confocal microscopy of Meibomian glands in Sjögren’s syndrome
10.1167/iovs.10-5995 · ExternalCitation · doi-reference
The international workshop on Meibomian Gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the Meibomian Gland
10.1167/iovs.10-6997c · ExternalCitation · doi-reference
Neurotransmitter influence on human Meibomian gland epithelial cells
10.1167/iovs.11-8113 · ExternalCitation · doi-reference
Meibomian gland dysfunction: hyperkeratinization or atrophy?
10.1186/s12886-015-0132-x · ExternalCitation · doi-reference
Digital labeling for 3D histology: segmenting blood vessels without a vascular contrast agent using deep learning
10.1364/boe.480230 · ExternalCitation · doi-reference
Effective melanin depigmentation of human and murine ocular tissues: an improved method for paraffin and frozen sections
10.1371/journal.pone.0102512 · ExternalCitation · doi-reference
FalseColor-Python: a rapid intensity-leveling and digital-staining package for fluorescence-based slide-free digital pathology
10.1371/journal.pone.0233198 · ExternalCitation · doi-reference
A guidebook for DISCO tissue clearing
10.15252/msb.20209807 · ExternalCitation · doi-reference
A hybrid method to enhance thick and thin vessels for blood vessel segmentation
10.3390/diagnostics11112017 · ExternalCitation · doi-reference
