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References from Mechanisms underlying the inhibition of chondrocyte apoptosis and inflammatory cytokine expression in knee osteoarthritis by rehmannia glutinosa polysaccharides via PI3K/AKT pathway activation at different concentrations. Local targets link to admitted publications; unresolved targets remain external evidence.
Evaluation and management of knee osteoarthritis
10.1111/jebm.12627 · 2024 · External reference
How do muscle function and quality affect the progression of KOA? A narrative review
10.1111/os.14022 · 2024 · External reference
MAPK signaling pathway-based glioma subtypes, machine-learning risk model, and key hub proteins identification
10.1038/s41598-023-45774-0 · 2023 · External reference
Potential roles of Cornichon family AMPA receptor auxiliary protein 4 (CNIH4) in head and neck squamous cell carcinoma
10.3233/cbm-220143 · 2022 · External reference
Cancer treatments: past, present, and future
10.1016/j.cancergen.2024.06.002 · 2024 · External reference
TRIM29 promotes glioblastoma progression via ubiquitinating NEFL and activating the PI3K/AKT signaling pathway
10.1016/j.cancergen.2025.06.008 · 2025 · External reference
Integrated network pharmacology and experimental validation approach to investigate the mechanisms of radix rehmanniae praeparata - angelica sinensis - radix achyranthis bidentatae in treating knee osteoarthritis
10.2147/dddt.s455006 · 2024 · External reference
Network pharmacology of the Yigu Decoction empirical formula on the treatment of knee osteoarthritis
2023 · External reference
Effect of rehmanniae radix extract on chondrocyte apoptosis in the rabbit model of knee osteoarthritis
2025 · External reference
Xibining inhibition of the PI3K-AKT pathway reduces M1 macrophage polarization to ameliorate KOA synovial inflammation and nociceptive sensitization
10.1016/j.phymed.2024.156281 · 2025 · External reference
Swimming prevents cell death of chondrocytes via PI3K/AKT pathway in an experimental model
10.1186/s13018-023-03815-4 · 2023 · External reference
Gentiopicroside ameliorates synovial inflammation and fibrosis in KOA rats by modulating the HMGB1-mediated PI3K/AKT signaling axis
2025 · External reference
Casticin ameliorates osteoarthritic cartilage damage in rats through PI3K/AKT/HIF-1α signaling
2024 · External reference
Medicinal plants and their secondary metabolites in alleviating knee osteoarthritis: a systematic review
10.1016/j.phymed.2022.154347 · 2022 · External reference
Chrysin mitigated neuropathic pain and peripheral sensitization in knee osteoarthritis rats by repressing the RAGE/PI3K/AKT pathway regulated by HMGB1
10.1016/j.cyto.2024.156635 · 2024 · External reference
Effect of Duhuo Jisheng Decoction on knee osteoarthritis model rabbits through regulation of cell pyroptosis mediated by PI3K/Akt/mTOR signaling pathway
2025 · External reference
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
10.1038/s41413-024-00333-9 · 2024 · External reference
Mechanism of regulating PI3K-Akt signaling pathway and inhibiting chondrocyte apoptosis to improve inflammation levels in rats with knee osteoarthritis by Shenzhuo Decoction
2025 · External reference
Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritis
2025 · External reference
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism
10.1186/s12891-025-08906-3 · 2025 · External reference
Mediating role of the ANGPTL3/TFPI protein ratio in regulating T-cell surface glycoprotein CD5 levels on Knee Osteoarthritis (KOA): a mendelian randomization study
10.3390/ijms26104471 · 2025 · External reference
Integrating acupuncture and acupotomy in the neuro-immune-musculoskeletal axis
2026 · External reference
