Research graph
References from Loss of Cotl1 disrupts mitochondrial fission and impairs learning and memory in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Mitochondrial fusion and fission in cell life and death
10.1038/nrm3013 · 2010 · External reference
Fusion and fission: interlinked processes critical for mitochondrial health
10.1146/annurev-genet-110410-132529 · 2012 · External reference
Mitochondrial fission, fusion, and stress
10.1126/science.1219855 · 2012 · External reference
Mammalian dynamin-like protein DLP1 tubulates membranes
10.1091/mbc.12.9.2894 · 2001 · External reference
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
10.1091/mbc.12.8.2245 · 2001 · External reference
The phosphorylation state of Drp1 determines cell fate
10.1038/sj.embor.7401077 · 2007 · External reference
Abnormal mitochondrial quality control in neurodegenerative diseases
10.3389/fncel.2020.00138 · 2020 · External reference
Pathology of neurodegenerative diseases
10.1101/cshperspect.a028035 · 2017 · External reference
Hallmarks of neurodegenerative diseases
10.1016/j.cell.2022.12.032 · 2023 · External reference
Neurodegenerative diseases
10.1038/539179a · 2016 · External reference
The axonal cytoskeleton: from organization to function
10.3389/fnmol.2015.00044 · 2015 · External reference
Integrating mitochondrial organization and dynamics with cellular architecture
10.1016/j.ceb.2013.09.002 · 2014 · External reference
Novel roles for actin in mitochondrial fission
2014 · External reference
Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission
10.1083/jcb.201404050 · 2015 · External reference
Mitochondrial function and actin regulate dynamin-related protein 1-dependent mitochondrial fission
10.1016/j.cub.2005.02.064 · 2005 · External reference
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2
10.1126/science.1228360 · 2013 · External reference
Regulation of the actin cytoskeleton in dendritic spines
10.1007/978-3-7091-0932-8_4 · 2012 · External reference
Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of Alzheimer-like neuritic cytoskeletal striations
10.1523/jneurosci.3531-09.2009 · 2009 · External reference
Actin dynamics and cofilin-actin rods in Alzheimer disease
10.1002/cm.21282 · 2016 · External reference
Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75
10.1042/bj3590255 · 2001 · External reference
The role of human coactosin-like protein in neurodegenerative disorders
2017 · External reference
Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins
10.1186/s13024-018-0266-4 · 2018 · External reference
Coactosin accelerates cell dynamism by promoting actin polymerization
10.1016/j.ydbio.2013.04.006 · 2013 · External reference
Crystal structure of human coactosin-like protein
10.1016/j.jmb.2004.09.036 · 2004 · External reference
Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours
2026 · External reference
Coactosin-like protein 1 regulates integrity and repair of model intestinal epithelial barriers via actin binding dependent and independent mechanisms
10.3389/fcell.2024.1405454 · 2024 · External reference
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain
10.1523/jneurosci.3362-09.2009 · 2009 · External reference
Neurogenesis in the adult hippocampus
10.1101/cshperspect.a018812 · 2015 · External reference
Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering
10.1523/jneurosci.3064-12.2013 · 2013 · External reference
Hippocampus-based contextual memory alters the morphological characteristics of astrocytes in the dentate gyrus
10.1186/s13041-016-0253-z · 2016 · External reference
Doublecortin (dcx) family proteins regulate filamentous actin structure in developing neurons
10.1523/jneurosci.4603-12.2013 · 2013 · External reference
Doublecortin-like kinases promote neuronal survival and induce growth cone reformation via distinct mechanisms
10.1016/j.neuron.2015.10.005 · 2015 · External reference
Actin-depolymerizing factor homology domain: a conserved fold performing diverse roles in cytoskeletal dynamics
10.1002/cm.20530 · 2011 · External reference
Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse
10.1371/journal.pone.0085090 · 2014 · External reference
The role of ADF/cofilin in synaptic physiology and Alzheimer's disease
10.3389/fcell.2020.594998 · 2020 · External reference
Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway
10.1186/1478-811x-11-50 · 2013 · External reference
Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
10.18632/oncotarget.2795 · 2015 · External reference
Functional versatility of transcription factors in the nervous system: the SRF paradigm
10.1016/j.tins.2009.05.004 · 2009 · External reference
Serum response factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics
10.1073/pnas.1208141109 · 2012 · External reference
Mitochondrial fission and fusion in secondary brain damage after CNS insults
10.1177/0271678x16671528 · 2016 · External reference
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
10.1074/jbc.m700679200 · 2007 · External reference
Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1
10.1242/jcs.059246 · 2010 · External reference
Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease
2013 · External reference
Properties of doublecortin expressing neurons in the adult mouse dentate gyrus
10.1371/journal.pone.0041029 · 2012 · External reference
Actin-ATP hydrolysis is a major energy drain for neurons
10.1523/jneurosci.23-01-00002.2003 · 2003 · External reference
Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain
10.1523/jneurosci.4972-13.2014 · 2014 · External reference
Inflammation, mitochondria, and the inhibition of adult neurogenesis
10.1002/jnr.22768 · 2011 · External reference
Coactosin-like protein (COTL1) promotes glioblastoma (GBM) growth in vitro and in vivo
10.2147/cmar.s246030 · 2020 · External reference
Coactosin-like F-actin binding protein (Cotl1) plays a key role in adipocyte differentiation and obesity
10.1038/s42003-025-08062-3 · 2025 · External reference
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
10.1038/nature23282 · 2017 · External reference
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis
10.1038/ni.3133 · 2015 · External reference
Functional neurogenesis in the adult hippocampus
10.1038/4151030a · 2002 · External reference
TopHat: discovering splice junctions with RNA-Seq
10.1093/bioinformatics/btp120 · 2009 · External reference
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
10.1038/nbt.1621 · 2010 · External reference
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and cufflinks
10.1038/nprot.2012.016 · 2012 · External reference
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
10.1038/nm.3639 · 2014 · External reference
Soyasaponins ab and bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase
10.1021/jf4046528 · 2014 · External reference
