Research graph
References from The deubiquitinase OTUD6B regulates cardiac hypertrophy by stabilizing TNF receptor associated factor 2. Local targets link to admitted publications; unresolved targets remain external evidence.
Mechanisms of physiological and pathological cardiac hypertrophy
10.1038/s41569-018-0007-y · 2018 · External reference
Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential
10.1038/s41569-022-00806-6 · 2023 · External reference
Polyubiquitin chains: functions, structures, and mechanisms
10.1007/s00018-008-8090-6 · 2008 · External reference
Advances in deubiquitinating enzyme inhibition and applications in cancer therapeutics
10.3390/cancers12061579 · 2020 · External reference
Mechanisms of deubiquitinase specificity and regulation
10.1146/annurev-biochem-061516-044916 · 2017 · External reference
USP25 ameliorates pathological cardiac hypertrophy by stabilizing SERCA2a in cardiomyocytes
10.1161/circresaha.122.321849 · 2023 · External reference
Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes
10.1038/s44161-023-00313-y · 2023 · External reference
Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in male mice
10.1038/s41467-025-61028-1 · 2025 · External reference
The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor
10.1126/sciadv.aax4826 · 2020 · External reference
Deubiquitinating enzyme OTUDs: focus on cancers and antiviral response
10.32604/or.2025.063644 · 2025 · External reference
OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes
10.7150/thno.83340 · 2023 · External reference
Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING
10.1016/j.bbadis.2024.167061 · 2024 · External reference
OTUD7a accelerates pathological cardiac hypertrophy via TAK1 activation
2025 · External reference
Identification of OTUD6B as a new biomarker for prognosis and immunotherapy by pan-cancer analysis
2022 · External reference
Deubiquitinase OTUD6B isoforms are important regulators of growth and proliferation
10.1158/1541-7786.mcr-16-0281-t · 2017 · External reference
Otud6b induces pulmonary arterial hypertension by mediating the Calpain-1/HIF-1α signaling pathway
10.1007/s00018-024-05291-3 · 2024 · External reference
Acacetin ameliorates pressure overload-induced cardiac remodeling by targeting USP10 and inhibiting maladaptive cardiomyocyte autophagy
10.1016/j.phymed.2025.156588 · 2025 · External reference
Emergence of members of TRAF and DUB of ubiquitin proteasome system in the regulation of hypertrophic cardiomyopathy
2018 · External reference
TNF receptor associated factor 2 (TRAF2) signaling in cancer
10.3390/cancers14164055 · 2022 · External reference
Tumor necrosis factor receptor-associated factor 2 signaling provokes adverse cardiac remodeling in the adult mammalian heart
10.1161/circheartfailure.112.000080 · 2013 · External reference
Cardiac-specific Traf2 overexpression enhances cardiac hypertrophy through activating AKT/GSK3β signaling
10.1016/j.gene.2013.12.052 · 2014 · External reference
Deubiquitylase OTUD6B governs pVHL stability in an enzyme-independent manner and suppresses hepatocellular carcinoma metastasis
2020 · External reference
Ubiquitination in disease pathogenesis and treatment
10.1038/nm.3739 · 2014 · External reference
Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3
10.1128/mbio.00332-23 · 2023 · External reference
OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
10.1038/s44319-024-00361-w · 2025 · External reference
Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma
10.1038/s41419-021-04135-3 · 2022 · External reference
OTUD6B promotes cholangiocarcinoma growth by regulating STAT3 phosphorylation through deubiquitination of PTK2
10.1002/cbin.12234 · 2024 · External reference
Proteasomal degradation of TRAF2 mediates mitochondrial dysfunction in doxorubicin-cardiomyopathy
10.1161/circulationaha.121.058411 · 2022 · External reference
