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References from Altered cardiac progenitor transcriptional program accompanies NOS-associated DNA damage in a human Duchenne muscular dystrophy organoid model. Local targets link to admitted publications; unresolved targets remain external evidence.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
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Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells
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Uncovering the Embryonic Origins of Duchenne Muscular Dystrophy
2024 · External reference
Dystrophin is required for the formation of stable muscle attachments in the zebrafish embryo
10.1242/dev.00799 · 2003 · External reference
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
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Involvement of Extracellular Signal-Regulated Kinases 1/2 in Cardiac Hypertrophy and Cell Death
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Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases
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HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment
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Age, corticosteroid treatment and site of mutations affect motor functional changes in young boys with Duchenne Muscular Dystrophy
10.1371/journal.pone.0271681 · 2022 · External reference
DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice
10.1111/acel.13768 · 2023 · External reference
Nitric oxide effects depend on different mechanisms in different regions of the rat heart
10.1007/s00380-011-0116-6 · 2012 · External reference
Duchenne muscular dystrophy
2021 · External reference
Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy
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Dystrophin, its interactions with other proteins, and implications for muscular dystrophy
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Biology of the Striated Muscle Dystrophin–Glycoprotein Complex
10.1016/s0074-7696(07)65005-0 · 2008 · External reference
PTEN contributes to profound PI3K/Akt signaling pathway dysregulation in dystrophin-deficient dog muscle
10.2353/ajpath.2009.080460 · 2009 · External reference
Cardiac involvement in Becker muscular dystrophy
2008 · External reference
Both Hypoxia-Inducible Factor 1 and MAPK Signaling Pathway Attenuate PI3K/AKT via Suppression of Reactive Oxygen Species in Human Pluripotent Stem Cells
10.3389/fcell.2020.607444 · 2021 · External reference
FGF2 supports NANOG expression via pyruvate dehydrogenase–dependent histone acetylation under low oxygen conditions
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Selective inhibition of constitutive nitric oxide synthase by l-NG-nitroarginine
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Hypertrophic cardiomyopathy in Duchenne muscular dystrophy: a case series
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Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen
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The Vascular Niche for Adult Cardiac Progenitor Cells
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Matrix Metalloproteinase-9 Inhibition Improves Proliferation and Engraftment of Myogenic Cells in Dystrophic Muscle of mdx Mice
10.1371/journal.pone.0072121 · 2013 · External reference
Dystrophin Deficiency Leads to Genomic Instability in Human Pluripotent Stem Cells via NO Synthase-Induced Oxidative Stress
10.3390/cells8010053 · 2019 · External reference
Generation of two Duchenne muscular dystrophy patient-specific induced pluripotent stem cell lines DMD02 and DMD03 (MUNIi001-A and MUNIi003-A)
10.1016/j.scr.2019.101562 · 2019 · External reference
Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart
10.3390/ijms22095025 · 2021 · External reference
DMD patient-specific pluripotent stem cell derived-cardiomyocytes show reduced contractility and arrhythmia-like events
2020 · External reference
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
10.1016/j.stemcr.2016.07.018 · 2016 · External reference
Evolution of life expectancy of patients with Duchenne muscular dystrophy at AFM Yolaine de Kepper centre between 1981 and 2011
10.1016/j.rehab.2013.06.002 · 2013 · External reference
Ligase 3–mediated end-joining maintains genome stability of human embryonic stem cells
10.1096/fj.201801877rr · 2019 · External reference
L-NAME in the cardiovascular system - Nitric oxide synthase activator?
10.1016/s1734-1140(12)70846-0 · 2012 · External reference
Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy
10.1093/hmg/ddu029 · 2014 · External reference
Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis
10.1007/s10654-020-00613-8 · 2020 · External reference
Orientin reduces myocardial infarction size via eNOS/NO signaling and thus mitigates adverse cardiac remodeling
10.3389/fphar.2017.00926 · 2017 · External reference
Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair
10.1093/cvr/cvq251 · 2011 · External reference
The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
10.1186/s13395-021-00273-6 · 2021 · External reference
A systematic review and meta-analysis on the epidemiology of Duchenne and Becker muscular dystrophy
10.1016/j.nmd.2014.03.008 · 2014 · External reference
Subcellular localization of dystrophin isoforms in cardiomyocytes and phenotypic analysis of dystrophin-deficient mice reveal cardiac myopathy is predominantly caused by a deficiency in full-length dystrophin
10.1538/expanim.62.211 · 2013 · External reference
Nitric oxide synthase-independent release of nitric oxide induced by KCl in the perfused mesenteric bed of the rat
10.1016/s0014-2999(00)00789-5 · 2000 · External reference
Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation
10.1242/dmm.001008 · 2009 · External reference
Cardiac Pathophysiology and the Future of Cardiac Therapies in Duchenne Muscular Dystrophy
10.3390/ijms20174098 · 2019 · External reference
Progression of dystrophic features and activation of mitogen-activated protein kinases and calcineurin by physical exercise, in hearts of mdx mice
10.1016/s0014-5793(02)02739-4 · 2002 · External reference
Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway
10.1016/j.cellsig.2020.109812 · 2021 · External reference
PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium
10.1038/ncomms7930 · 2015 · External reference
Functional and Morphological Improvement of Dystrophic Muscle by Interleukin 6 Receptor Blockade
10.1016/j.ebiom.2015.02.014 · 2015 · External reference
Cardiovascular progenitor cells and tissue plasticity are reduced in a myocardium affected by Becker muscular dystrophy
10.1186/s13023-019-1257-4 · 2020 · External reference
Human induced pluripotent stem cell models for the study and treatment of Duchenne and Becker muscular dystrophies
10.1177/1756286419833478 · 2019 · External reference
The dystrophin–glycoprotein complex, cellular signaling, and the regulation of cell survival in the muscular dystrophies
10.1002/mus.1192 · 2001 · External reference
Antioxidants for Treatment of Duchenne Muscular Dystrophy: A Systematic Review and Meta-Analysis
10.1159/000525045 · 2022 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin
10.1152/ajpheart.00386.2008 · 2008 · External reference
Therapeutic aspects of cell signaling and communication in Duchenne muscular dystrophy
10.1007/s00018-021-03821-x · 2021 · External reference
Cellular pathology of the human heart in Duchenne muscular dystrophy (DMD): lessons learned from in vitro modeling
10.1007/s00424-021-02589-0 · 2021 · External reference
Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82
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Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice
10.1172/jci32024 · 2007 · External reference
Cardioprotective Effect of Whole Body Periodic Acceleration in Dystrophic Phenotype mdx Rodent
10.3389/fphys.2021.658042 · 2021 · External reference
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage
10.1016/j.cell.2012.01.040 · 2012 · External reference
Glutathione Peroxidase 1 Protects Against Peroxynitrite-Induced Spiral Ganglion Neuron Damage Through Attenuating NF-κB Pathway Activation
2022 · External reference
Expression of Dp260 in muscle tethers the actin cytoskeleton to the dystrophin–glycoprotein complex and partially prevents dystrophy
10.1093/hmg/11.9.1095 · 2002 · External reference
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival
10.1002/stem.2282 · 2016 · External reference
Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
10.1016/s0891-5849(98)00092-6 · 1998 · External reference
Emergency department care of patients with Duchenne muscular dystrophy
10.1016/j.ajem.2022.07.056 · 2022 · External reference
Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts
10.1186/s12964-021-00785-0 · 2021 · External reference
Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells
10.1152/ajpcell.00397.2020 · 2021 · External reference
JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes
10.1074/jbc.m212321200 · 2003 · External reference
Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo
10.1161/jaha.115.001993 · 2015 · External reference
Pravastatin alleviates intracellular calcium dysregulation induced by Interleukin-6 via the mitochondrial ROS pathway in adult ventricular myocytes
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