Research graph
References from Cyclic stretch increases transglutaminase 2-mediated serotonylation of extracellular fibronectin in cultured optic nerve head astrocytes: a pilot study. Local targets link to admitted publications; unresolved targets remain external evidence.
Retinal phototransduction
10.17712/1658-3183.2094 · 2014 · External reference
Functional circuitry of the retina
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Visual functions of the thalamus
10.1146/annurev-vision-082114-035920 · 2015 · External reference
Concentration of astrocytic filaments at the retinal optic nerve junction is coincident with the absence of intra-retinal myelination: comparative and developmental evidence
10.1023/a:1010835404754 · 2000 · External reference
Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes
10.1016/j.isci.2022.105568 · 2022 · External reference
Computational study of the mechanical behavior of the astrocyte network and axonal compartments in the mouse optic nerve head
10.1007/s10237-023-01752-z · 2023 · External reference
The optic nerve head as a robust biomechanical system
10.1167/iovs.11-9303 · 2012 · External reference
Aqueous humor dynamics: a review
10.2174/1874364101004010052 · 2010 · External reference
Aqueous outflow - a continuum from trabecular meshwork to episcleral veins
10.1016/j.preteyeres.2016.12.004 · 2017 · External reference
The trabecular meshwork: a basic review of form and function
2014 · External reference
Pathogenesis of glaucoma: extracellular matrix dysfunction in the trabecular meshwork-a review
10.1111/ceo.14027 · 2022 · External reference
Current understanding of conventional outflow dysfunction in glaucoma
10.1097/icu.0b013e32834ff23e · 2012 · External reference
Biomechanics of the sclera and effects on intraocular pressure
2016 · External reference
IOP and glaucoma damage: the essential role of optic nerve head and retinal mechanosensors
10.1016/j.preteyeres.2023.101232 · 2024 · External reference
Predicted extension, compression and shearing of optic nerve head tissues
10.1016/j.exer.2007.05.005 · 2007 · External reference
Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma
10.1016/0002-9394(83)90389-6 · 1983 · External reference
Astrocytes of the eye and optic nerve: heterogeneous populations with unique functions mediate axonal resilience and vulnerability to glaucoma
2023 · External reference
Mechanobiological responses of astrocytes in optic nerve head due to biaxial stretch
10.1186/s12886-022-02592-8 · 2022 · External reference
The neurobiology of cell death in glaucoma
10.1038/sj.eye.6702880 · 2007 · External reference
The molecular basis of retinal ganglion cell death in glaucoma
10.1016/j.preteyeres.2011.11.002 · 2012 · External reference
The role of astrocytes in optic nerve head fibrosis in glaucoma
10.1016/j.exer.2015.08.014 · 2016 · External reference
The fibro-inflammatory response in the glaucomatous optic nerve head
10.3390/ijms241713240 · 2023 · External reference
Glaucoma
10.1016/s0140-6736(10)61423-7 · 2011 · External reference
The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma
10.1001/archopht.120.6.714 · 2002 · External reference
Neuroprotection of rodent and human retinal ganglion cells in vitro/ex vivo by the hybrid small molecule SA-2
10.3390/cells11233741 · 2022 · External reference
Neuroprotection in glaucoma
10.4103/ijo.ijo_1158_21 · 2022 · External reference
Neuroprotective agents in the management of glaucoma
10.1038/s41433-018-0050-2 · 2018 · External reference
The optic nerve head in glaucoma
2021 · External reference
Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma
10.1016/j.exer.2010.08.005 · 2011 · External reference
Tissue transglutaminase, not Lysyl oxidase, dominates early calcium-dependent remodeling of fibroblast-populated collagen lattices
10.1159/000381015 · 2014 · External reference
Lysyl oxidases in the trabecular meshwork
10.1097/ijg.0000000000000127 · 2014 · External reference
Tissue transglutaminase expression and activity in normal and glaucomatous human trabecular meshwork cells and tissues
10.1167/iovs.07-0835 · 2008 · External reference
Transforming growth factor-beta 2 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes
10.1167/iovs.04-0649 · 2005 · External reference
Transforming growth factor beta2 (TGFbeta2) signaling plays a key role in glucocorticoid-induced ocular hypertension
10.1074/jbc.ra118.002540 · 2018 · External reference
Transforming growth factor-beta2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway
2011 · External reference
Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2
10.1006/exer.1994.1158 · 1994 · External reference
Aqueous humor TGF-beta2 levels in patients with open-angle glaucoma: a meta-analysis
2015 · External reference
Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells
10.1016/j.exer.2011.06.011 · 2011 · External reference
Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma
10.1167/iovs.06-0296 · 2007 · External reference
Transforming growth factor beta isoforms in human optic nerve heads
10.1136/bjo.83.2.209 · 1999 · External reference
Focus on molecules: transglutaminase 2
10.1016/j.exer.2010.06.006 · 2011 · External reference
Tissue transglutaminase: a multifunctional and multisite regulator in health and disease
10.1152/physrev.00003.2023 · 2024 · External reference
Transglutaminases: crosslinking enzymes with pleiotropic functions
10.1038/nrm1014 · 2003 · External reference
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury
10.1371/journal.pone.0001861 · 2008 · External reference
Structural and mechanistic analysis of ca(2+)-dependent regulation of transglutaminase 2 activity using a ca(2+)-bound intermediate state
10.1073/pnas.2407066121 · 2024 · External reference
Novel roles for biogenic monoamines: from monoamines in transglutaminase-mediated post-translational protein modification to monoaminylation deregulation diseases
10.1111/j.1742-4658.2011.08347.x · 2011 · External reference
The presence of serotonin-immunoreactive nerve fibers in the optic nerve of the mouse
10.1016/0304-3940(88)90026-2 · 1988 · External reference
Serotonergic retinopetal axons in the monkey retina
10.1080/02713680500371532 · 2005 · External reference
Retinal and optic nerve head ischemic disorders and atherosclerosis: role of serotonin
10.1016/s1350-9462(98)00016-0 · 1999 · External reference
The expanded biology of serotonin
10.1146/annurev.med.60.042307.110802 · 2009 · External reference
The role of serotonin during skin healing in post-thermal injury
10.3390/ijms19041034 · 2018 · External reference
Serotonin paracrine signaling in tissue fibrosis
10.1016/j.bbadis.2012.09.009 · 2013 · External reference
Serotonin--more than a neurotransmitter: transglutaminase-mediated serotonylation of C6 glioma cells and fibronectin
10.1016/j.neuint.2010.04.020 · 2010 · External reference
Role of protein transamidation in serotonin-induced proliferation and migration of pulmonary artery smooth muscle cells
10.1165/rcmb.2010-0078oc · 2011 · External reference
Transglutaminase 2-mediated serotonylation in pulmonary hypertension
2014 · External reference
Isolation and characterization of human optic nerve head astrocytes and lamina cribrosa cells
10.1016/j.exer.2020.108103 · 2020 · External reference
Phenethylaminylation: preliminary in vitro evidence for the covalent transamidation of psychedelic phenethylamines to glial proteins using 3,5-dimethoxy-4-(2-propynyloxy)-phenethylamine as a model compound
2025 · External reference
Samples in many cell-based experiments are matched/paired but taking this into account does not always increase power of statistical tests for differences in means
10.1091/mbc.e23-05-0159 · 2024 · External reference
Serotonin levels in the rabbit retina are elevated following intraocular injection of forskolin
10.1111/j.1471-4159.1989.tb09267.x · 1989 · External reference
Postnatal development of serotonin-accumulating neurones in the rabbit retina and an immunohistochemical analysis of the uptake and release of serotonin
10.1016/0014-4835(84)90179-9 · 1984 · External reference
Proteomics analyses of human optic nerve head astrocytes following biomechanical strain
10.1074/mcp.m111.012302 · 2012 · External reference
Effect of changing heart rate on the ocular pulse and dynamic biomechanical behavior of the optic nerve head
10.1167/iovs.61.4.27 · 2020 · External reference
Features of ZED1227: the first-in-class tissue transglutaminase inhibitor undergoing clinical evaluation for the treatment of celiac disease
10.3390/cells11101667 · 2022 · External reference
Concentration of dilute protein solutions prior to sodium dodecyl sulfate-polyacrylamide gel electrophoresis
10.1006/abio.1997.2248 · 1997 · External reference
A GAPDH serotonylation system couples CD8(+) T cell glycolytic metabolism to antitumor immunity
10.1016/j.molcel.2023.12.015 · 2024 · External reference
Interactive peptide spectral annotator: a versatile web-based tool for proteomic applications
10.1074/mcp.tir118.001209 · 2019 · External reference
Descriptive statistics and normality tests for statistical data
10.4103/aca.aca_157_18 · 2019 · External reference
Further evidence for the specificity of anti-5-HT (serotonin)-like antisera in immunocytochemistry. Existence of cyclic secondary amino groups in the immunogen
10.1007/bf00508655 · 1986 · External reference
A guide to selecting high-performing antibodies for protein-glutamine gamma-glutamyltransferase 2 (TGM2) for use in western blot, immunoprecipitation and immunofluorescence
10.12688/f1000research.150684.2 · 2024 · External reference
Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells
10.4049/jimmunol.1300183 · 2013 · External reference
Reactivity of the N-terminal region of fibronectin protein to transglutaminase 2 and factor XIIIA
10.1074/jbc.m111.255562 · 2011 · External reference
Serotonylation: serotonin signaling and epigenetics
10.3389/fnmol.2019.00288 · 2019 · External reference
Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells
10.1074/jbc.m604195200 · 2007 · External reference
Transglutaminase-catalyzed transamidation: a novel mechanism for Rac1 activation by 5-hydroxytryptamine2A receptor stimulation
10.1124/jpet.107.135046 · 2008 · External reference
Intracellular serotonin modulates insulin secretion from pancreatic beta-cells by protein serotonylation
10.1371/journal.pbio.1000229 · 2009 · External reference
Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells
10.1016/j.cellsig.2014.09.002 · 2014 · External reference
Serotonin (5-HT) inhibits factor XIII-A-mediated plasma fibronectin matrix assembly and crosslinking in osteoblast cultures via direct competition with transamidation
10.1016/j.bone.2014.11.008 · 2015 · External reference
Serotonin mediates maternal effects and directs developmental and behavioral changes in the progeny of snails
10.1016/j.celrep.2015.07.022 · 2015 · External reference
Serotonin improves glucose metabolism by serotonylation of the small GTPase Rab4 in L6 skeletal muscle cells
10.1186/s13098-016-0201-1 · 2017 · External reference
Receptor-stimulated transamidation induces activation of Rac1 and Cdc42 and the regulation of dendritic spines
10.1016/j.neuropharm.2017.01.034 · 2017 · External reference
TG2 (transglutaminase 2) promotes PINK1/Parkin-dependent mitophagy in pulmonary hypertension by regulating the TRPC6
10.1016/j.freeradbiomed.2026.03.002 · 2026 · External reference
Fibronectin: molecular structure, Fibrillar structure and Mechanochemical signaling
10.3390/cells10092443 · 2021 · External reference
Fibronectin matrix assembly at a glance
10.1242/jcs.263834 · 2025 · External reference
Extracellular matrix of the human optic nerve head
10.1016/0002-9394(86)90134-0 · 1986 · External reference
The extracellular matrix of the human optic nerve
10.1001/archopht.1989.01070020291041 · 1989 · External reference
Age related changes in the non-collagenous components of the extracellular matrix of the human lamina cribrosa
10.1136/bjo.84.3.311 · 2000 · External reference
Adhesive glycoproteins of the extracellular matrix
1999 · External reference
Extracellular matrix of the human lamina cribrosa
10.1016/0002-9394(87)90165-6 · 1987 · External reference
Optic nerve head and intraocular pressure in the guinea pig eye
10.1016/j.exer.2015.12.007 · 2016 · External reference
Connective tissue structure of the tree shrew optic nerve and associated ageing changes
10.1167/iovs.06-0084 · 2007 · External reference
Extracellular matrix remodeling in the retina and optic nerve of a novel Glaucoma mouse model
2021 · External reference
CCN2/CTGF-A modulator of the optic nerve head astrocyte
10.3389/fcell.2022.864433 · 2022 · External reference
TLR4 signaling modulates extracellular matrix production in the lamina cribrosa
2022 · External reference
pH-controlled Chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of Serotonylation proteome in Cancer cells
10.1021/acs.jproteome.4c00409 · 2024 · External reference
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3
10.1038/s41586-019-1024-7 · 2019 · External reference
Serotonylation of vascular proteins important to contraction
10.1371/journal.pone.0005682 · 2009 · External reference
Identification of the fibronectin sequences required for assembly of a fibrillar matrix
10.1083/jcb.113.6.1463 · 1991 · External reference
Arrangement of attachment-promoting, self-association, and heparin-binding sites in horse serum fibronectin
10.1016/s0021-9258(18)34388-6 · 1982 · External reference
Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure
10.1186/s13024-023-00658-9 · 2023 · External reference
Glaucoma--1: diagnosis
10.1136/bmj.328.7431.97 · 2004 · External reference
Finite element modeling of optic nerve head biomechanics
10.1167/iovs.04-0133 · 2004 · External reference
Reconstruction of human optic nerve heads for finite element modeling
10.3233/thc-2005-13410 · 2005 · External reference
Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry
10.1007/s10237-008-0120-7 · 2009 · External reference
Modeling individual-specific human optic nerve head biomechanics. Part II: influence of material properties
10.1007/s10237-008-0119-0 · 2009 · External reference
3D morphometry of the human optic nerve head
10.1016/j.exer.2009.09.013 · 2010 · External reference
Finite element modeling of the human sclera: influence on optic nerve head biomechanics and connections with glaucoma
10.1016/j.exer.2010.09.014 · 2011 · External reference
Stretch stress propels glutamine dependency and glycolysis in optic nerve head astrocytes
10.3389/fnins.2022.957034 · 2022 · External reference
Glaucoma and biomechanics
10.1097/icu.0000000000000829 · 2022 · External reference
The effects of Glaucoma on the pressure-induced strain response of the human Lamina Cribrosa
10.1167/iovs.61.4.41 · 2020 · External reference
Effects of scleral stiffness properties on optic nerve head biomechanics
10.1007/s10439-009-9879-7 · 2010 · External reference
Factors influencing optic nerve head biomechanics
10.1167/iovs.05-0541 · 2005 · External reference
Biaxial mechanical testing of human sclera
10.1016/j.jbiomech.2010.02.031 · 2010 · External reference
A method to estimate biomechanics and mechanical properties of optic nerve head tissues from parameters measurable using optical coherence tomography
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Increased substrate stiffness elicits a myofibroblastic phenotype in human lamina cribrosa cells
10.1167/iovs.17-22400 · 2018 · External reference
Ultrastructural location of extracellular matrix components in the optic nerve head
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Fibronectin and collagens modulate the proliferation and morphology of astroglial cells in culture
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Serotonin released from amacrine neurons is scavenged and degraded in bipolar neurons in the retina
10.1111/j.1471-4159.2009.06270.x · 2009 · External reference
Serotonin in retina
10.1016/j.biochi.2018.11.006 · 2019 · External reference
Dopamine signaling and myopia development: what are the key challenges
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Novel insight of histamine and its receptor ligands in Glaucoma and retina neuroprotection
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